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Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application

Research Project

Project/Area Number 19109008
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionOkayama University

Principal Investigator

TAKIGAWA Masaharu  岡山大学, 大学院・医歯薬学総合研究科, 教授 (20112063)

Co-Investigator(Kenkyū-buntansha) KUBOTA Satoshi  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90221936)
HATTORI Takako  岡山大学, 大学院・医歯薬学総合研究科, 助教 (00228488)
NISHIDA Takashi  岡山大学, 大学院・医歯薬学総合研究科, 助教 (30322233)
AOYAMA Eriko  岡山大学, 大学院・医歯薬学総合研究科, 助教 (10432650)
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥110,500,000 (Direct Cost: ¥85,000,000、Indirect Cost: ¥25,500,000)
Fiscal Year 2011: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2010: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2009: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2008: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2007: ¥33,930,000 (Direct Cost: ¥26,100,000、Indirect Cost: ¥7,830,000)
KeywordsCCNファミリー / シグナルコンダクター / 結合分子 / 遺伝子発現 / CCN2/CTGF / 分子間相互作用 / CCN3/Nov / 軟骨 / 骨 / ハルミン / シグナル伝達 / FGF2 / DC-STAMP / 軟骨細胞 / 破骨細胞 / トランスジェニックマウス / GAPDH / CTGF / CCN2 / Nov / FGF受容体 / アグリカン / 歯肉線維芽細胞 / RANK / ニコチン / 再生 / BMP-2 / ノックアウトマウス / 細胞分化
Research Abstract

We have established a novel concept that CCN family proteins should be considered a newly classified signaling molecules that comprehensively regulate extracellular signals, and thus should be entitled "Signal Conductors." Moreover, we have accumulated basic data for application of CCN proteins toward harmonized regenerative medicine and for therapeutics of diseases with their abnormal upregulation, leading to their medical applications.

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (339 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (99 results) (of which Peer Reviewed: 99 results) Presentation (214 results) Book (13 results) Remarks (8 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Role of low-density lipoprotein receptor related protein 1(LRP1) in CCN2/connective tissue growth factor(CTGF) protein transport in chondrocytes.2012

    • Author(s)
      Kawata., K., Kubota, S., (中4名), Nishida, T. and Takigawa, M.
    • Journal Title

      J Cell Sci.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity2012

    • Author(s)
      Surmann-Schmitt, C., et al
    • Journal Title

      J.Cell.Physiol.

      Volume: 27 Issue: 5 Pages: 2207-2216

    • DOI

      10.1002/jcp.22957

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN2 in orofacial tissue development and remodeling2012

    • Author(s)
      Kubota, S.
    • Journal Title

      Japanese Dental Science Review

      Volume: (in press) Issue: 2 Pages: 101-113

    • DOI

      10.1016/j.jdsr.2012.02.002

    • NAID

      10030957654

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes2012

    • Author(s)
      Kawata., K., et al
    • Journal Title

      J.Cell Sci.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in Ccn2 mRNA.2011

    • Author(s)
      Kondo, S., Kubota, S., Mukudai, Y., Nishida, T.(中3名), Takigawa M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 405 Pages: 382-387

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCN family 2/connective tissue growth factor(CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein(DC-STAMP)2011

    • Author(s)
      Nishida, T., Emura, K., Kubota, S., Lyons, K. M., Takigawa, M.
    • Journal Title

      J. Bone Miner. Res.

      Volume: 26 Pages: 351-363

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of CCN2 in cartilage and bone development.2011

    • Author(s)
      Kubota, S. and Takigawa, M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 5 Pages: 209-217

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of the metastatic phenotype with CCN family members among breast and oral cancer cell.2011

    • Author(s)
      Ohgawara, T., Kubota, S., (中8名), Takigawa, M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 5 Pages: 291-299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads.2011

    • Author(s)
      Janune, D., Kubota, S., (中3名), Takigawa M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 5 Pages: 167-171

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical strech increases CCN2/CTGF expression in anterior cruciate ligament-derived cells.2011

    • Author(s)
      Miyake, Y., (中1名), Kubota, S., (中2名), Takigawa M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 409 Pages: 247-252

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice.2011

    • Author(s)
      Kodama, T., (中12名), Kubota, S., Takigawa, M., 他6名
    • Journal Title

      J. Clin. Invest.

      Volume: 121 Pages: 3343-3356

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of CCN family proteis during osteoblast differentiation : involvement of Smad and MAPK signaling pathways.2011

    • Author(s)
      Kawaki, H., Kubota, S., (中10名), Takigawa, M.
    • Journal Title

      Bone

      Volume: 49 Pages: 975-989

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel effects of CCN3 that may direct the differentiation of chondrocytes.2011

    • Author(s)
      Janune, D., Kubota, S., Nishida, T., (中3名), Takigawa, M.
    • Journal Title

      FEBS Lett.

      Volume: 585 Pages: 3033-3040

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes2011

    • Author(s)
      Nishida, T., Kubota, S., (中3名), Takigawa, M.
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 4232-4241

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of CCN2 in cartilage and bone development2011

    • Author(s)
      Kubota, S., Takigawa, M.
    • Journal Title

      J.Cell Commun.Signal.

      Volume: 5 Issue: 3 Pages: 209-217

    • DOI

      10.1007/s12079-011-0123-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of the metastatic phenotype with CCN family members among breast and oral cancer cells2011

    • Author(s)
      Ohgawara T., et al
    • Journal Title

      J.Cell Commun.Signal.

      Volume: 5 Issue: 4 Pages: 291-299

    • DOI

      10.1007/s12079-011-0133-3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads2011

    • Author(s)
      Janune, D., et al
    • Journal Title

      J.Cell Commun.Signal.

      Volume: 5 Issue: 3 Pages: 167-171

    • DOI

      10.1007/s12079-011-0135-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical strech increases CCN2/CTGF expression in anterior cruciate ligament-derived cells2011

    • Author(s)
      Miyake, Y., et al
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 409 Pages: 247-252

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increases ill p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice2011

    • Author(s)
      Kodama, T., et al
    • Journal Title

      J.Clin.Invest.

      Volume: 121 Issue: 8 Pages: 3343-3356

    • DOI

      10.1172/jci44957

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of CCN family proteis during osteoblast differentiation : involvement of Smad and MAPK signaling pathways2011

    • Author(s)
      Kawaki, H., et al
    • Journal Title

      Bone

      Volume: 49 Issue: 5 Pages: 975-989

    • DOI

      10.1016/j.bone.2011.06.033

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel effects of CCN3 that may direct the differentiation of chondrocytes2011

    • Author(s)
      Janune, D., et al
    • Journal Title

      FEBS Lett.

      Volume: 585 Issue: 19 Pages: 3033-3040

    • DOI

      10.1016/j.febslet.2011.08.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel pathogenic role of fibrin as revealed by a case study on ligneous gingivitis2011

    • Author(s)
      Shimo, T.
    • Journal Title

      Oral Science International

      Volume: 8 Issue: 2 Pages: 44-49

    • DOI

      10.1016/s1348-8643(11)00025-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).2011

    • Author(s)
      Nishida T, et al.
    • Journal Title

      J.Bone Miner Res.

      Volume: 26 Pages: 351-363

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA.2011

    • Author(s)
      Kondo S, et al.
    • Journal Title

      Biochem.Biophys.Res.Common.

      Volume: 405 Pages: 382-387

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of CCN2 in cartilage and bone development.2011

    • Author(s)
      Kubota S, Takigawa M
    • Journal Title

      J.Cell Commun.Signal.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of the metastatic phenotype with CCN family members among breast and oral cancer cells.2011

    • Author(s)
      Ohgawara T, et al.
    • Journal Title

      J.Cell Commun.Signal.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombopoietic-mesenchymal interaction that my facilitate both endochondral ossification and platelet maturation via CCN2.2010

    • Author(s)
      Sumiyoshi, K., Kubota, S., (中7名), Takigawa, M.
    • Journal Title

      J. Cell Commun. Signal

      Volume: 4 Pages: 5-14

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine-induced CCN2 : from smoking to periodontal fibrosis.2010

    • Author(s)
      Takeuchi, H., Kubota, S., (中4名), Takigawa, M., Numabe, Y.
    • Journal Title

      J. Dent. Res.

      Volume: 89 Pages: 34-39

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and utility of CCN2 anchor peptide aptamers.2010

    • Author(s)
      Kawaki, H., Kubota, S., (中5名), Takigawa, M.
    • Journal Title

      Biochimie

      Volume: 92 Pages: 1010-1015

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of miR-1 as a micro RNA that supports late stage differentiation of growth cartilage cells.2010

    • Author(s)
      Sumiyoshi K, Kubota S, (中2名), Nishida T, (中2名), Takigawa M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 402 Pages: 286-290

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A coading RNA segment that enhances the ribosomal revruitment of chicken Ccn1 mRNA.2010

    • Author(s)
      Mukudai, Y., Kubota, S., (中5名), Takigawa, M.
    • Journal Title

      J. Cell Biochem.

      Volume: 111 Pages: 1607-1618

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and utility of CCN2 anchor peptide aptamers.2010

    • Author(s)
      Kawaki H, et al.
    • Journal Title

      Biochimie.

      Volume: 92(8) Pages: 1010-1015

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of miR-1 as an miRNA that supports late-stage differentiation of growth cartilage cells.2010

    • Author(s)
      Sumiyoshi K, et al.
    • Journal Title

      Bicochem.Biophys.Res.Commun.

      Volume: 402 Pages: 286-290

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A coding RNA segment that enhances the ribosomal recruitment of chicken ccn1 mRNA.2010

    • Author(s)
      Mukudai Y, et al.
    • Journal Title

      J.Cell Biochem.

      Volume: 111 Pages: 1607-1618

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the low-density lipoprotein-1 in regulation of chondrocyte differentiation.2010

    • Author(s)
      Kawata K., et al.
    • Journal Title

      J. Cell. Physiol. 222(1)

      Pages: 138-148

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and pletelet maturation via CCN2.2010

    • Author(s)
      Sumiyoshi K., et al.
    • Journal Title

      J. Cell Commun. Signal. 4

      Pages: 5-14

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine-induced CCN2 : from smoking to periodontal fibrosis.2010

    • Author(s)
      Takeuchi H., et al.
    • Journal Title

      J. Dent. Res. 89(1)

      Pages: 34-39

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of TGF-β1 on CCN2/CTGF in normal human gingival fibroblasts and periodontal ligament cells.2009

    • Author(s)
      Takeuchi, H., Kubota, S., (中3名), Takigawa, M., Numabe, Y.
    • Journal Title

      J. periodontal. Res.

      Volume: 44 Pages: 161-169

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCN family 2/Connective tissue growth factor(CCN2/CTGF) regulates the expression of Vegf through Hif-1αexpression in a chondrocytic cell line, HCS-2/8, under hypoxic condition.2009

    • Author(s)
      Nishida, T.(中2名), Kubota, S., Lyons, K. M., Takigawa, M.
    • Journal Title

      Bone

      Volume: 44(1) Pages: 24-31

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CTGF and apoptosis in mouse osteocytes induced by tooth movement.2009

    • Author(s)
      Sakai Y, (中4名), Takigawa M, Takano-Yamamoto T.
    • Journal Title

      J Dent Res.

      Volume: 88(4) Pages: 345-50

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCN family 2/connective tissue growth factor modulates BMP signaling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.2009

    • Author(s)
      Maeda, A., Nishida, T., Aoyama, E., Kubota, S., Lyons, K. M., Kuboki, T., Takigawa, M.
    • Journal Title

      J. Biochem

      Volume: 145(2) Pages: 207-216

    • NAID

      10026301620

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of chondrocytic phenotype by micro RNA 18a : Involvement of Ccn2/Ctgf as a major target gene2009

    • Author(s)
      Ohgawara, T., Kubota, S., (中6名), Takigawa, M.
    • Journal Title

      FEBS Lett.

      Volume: 583 Pages: 1006-1010

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan2009

    • Author(s)
      Aoyama, E., Hattori, T., Hoshijima, M., Araki, D., Nishida, T., Kubota, S., Takigawa, M.
    • Journal Title

      Biochem. J.

      Volume: 420 Pages: 413-420

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-Terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan2009

    • Author(s)
      Aoyama E., Hattori T., Hoshijima M., Araki D., Nishida T., Kubota S., Takigawa M.
    • Journal Title

      Biochem.J. 420

      Pages: 413-420

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan.2009

    • Author(s)
      Aoyama E., et al.
    • Journal Title

      Biochem. J. 420

      Pages: 413-420

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CTGF and apoptosis in mouse osteocytes induced by tooth movement.2009

    • Author(s)
      Sakai Y., et al.
    • Journal Title

      J. Dent. Res. 88(4)

      Pages: 345-350

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of TGF-βl on CCN2/CTGF in normal human gingival fibroblasts and periodontal ligament cells.2009

    • Author(s)
      Takeuchi, H., et al.
    • Journal Title

      J. periodontal. Res. 44

      Pages: 161-169

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN family 2/connective tissue growth factor (CCN2/CTGF)regulates the expression of Vegfthrough Hif-la expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition.2009

    • Author(s)
      Nishida, T., et al.
    • Journal Title

      Bone 44(1)

      Pages: 24-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN family 2/connective tissue growth factor modulates BMP signaling as a signal conductor. which action regulates the. proliferation and differentiation of chondrocytes.2009

    • Author(s)
      Maeda, A., et al.
    • Journal Title

      J. Biochem. 145(2)

      Pages: 207-216

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of chondrocytic phenotype by micro RNA 18a : Involvement of Ccn2/Ctgf as amajor target gene.2009

    • Author(s)
      Ohgawara, T., et al.
    • Journal Title

      FEBS Lett. 583

      Pages: 1006-1010

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan.2009

    • Author(s)
      Aoyama E., et al.
    • Journal Title

      Biochem. J. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN22008

    • Author(s)
      Ono M., Kubota S., (中5名), Nishida T., Yoshida Y., Suzuki K., Takigawa M., Kuboki T.
    • Journal Title

      Cell Transplantation

      Volume: 17(1-2) Pages: 231-240

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene2008

    • Author(s)
      Eguchi T, Kubota S, (中7名), Takigawa M.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 28 Pages: 2391-2413

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.2008

    • Author(s)
      Koitabashi N., (中11名), Nishida T., Kubota S., Takigawa M., Kurabayashi M.
    • Journal Title

      Eur. J. Heart Failure

      Volume: 10(4) Pages: 373-379

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCN family 2/Connective tissue growth factor(CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes2008

    • Author(s)
      Fujisawa T., (中3名), Kubota S., Kuboki T., Takigawa M.
    • Journal Title

      Osteoarthritis and Cartilage

      Volume: 16(7) Pages: 787-795

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional requirement of CCN2 for intramembranous bone formation in embryonic mice2008

    • Author(s)
      Kawaki H., Kubota S., (中7名), Takigawa M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 366(2) Pages: 450-456

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage.2008

    • Author(s)
      Kawaki H., Kubota S., (中8名), Takigawa M.
    • Journal Title

      J. Bone Miner. Res.

      Volume: 23(11) Pages: 1751-1764

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration :-Mechanical stress induces expression of Hcs24/CTGF/CCN2 in human chondrocytic cell line, HCS-2/8, rabbit hyaline costal chondrocytes and meniscus cells2008

    • Author(s)
      Nishida T., Maeda A., Kubota S., Takigawa M.
    • Journal Title

      Biorheology

      Volume: 45(3-4) Pages: 289-299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy2008

    • Author(s)
      Sun G., (中6名)., Takigawa M., Iinuma K., Tsuchiya S.
    • Journal Title

      J Neurol. Sci.

      Volume: 267(1-2) Pages: 48-56

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel.2008

    • Author(s)
      Kikuchi T., Kubota S., Asaumi K., Kawaki H., Nishida T., (中4名)、Takigawa M.
    • Journal Title

      Tissue Engineering Part A

      Volume: 14(6) Pages: 1089-1098

    • NAID

      120005345530

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.2008

    • Author(s)
      Mukudai, Y., Kubota, S., (中6名), Takigawa, M.
    • Journal Title

      Mol. Cell Biol.

      Volume: 28(19) Pages: 6134-6147

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance and pathogenic function of connective tissue growth factor(CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma.2008

    • Author(s)
      Shimo, T. Kubota, S., (中3名), Nishida, T., Ng, P. S., Endo, K., Takigawa, M. Sasaki, A.
    • Journal Title

      Anticancer Res.

      Volume: 28(4C) Pages: 2343-2348

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation2008

    • Author(s)
      Mukudai Y., Kubota S., Kawaki H., Kondo S., Eguchi T., Sumiyoshi K., Ohgawara T., Shimo T., Takigawa M.
    • Journal Title

      Mol.Cell.Biol. 28(19)

      Pages: 6134-6147

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel2008

    • Author(s)
      Kikuchi T., Kubota S., Asaumi K., Kawaki H., Nishida T., Kawata K., Mitani S., Tabata Y, Ozaki T., Takigawa M.
    • Journal Title

      Tissue Engineering Part A 14(6)

      Pages: 1089-1098

    • NAID

      120005345530

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage2008

    • Author(s)
      Kawaki H., Kubota S., Suzuki A., Lazar N., Yamada, T., Matsumura T., Ohgawara T., Maeda T., Perbal B., Lyons, K. M., Takigawa M.
    • Journal Title

      J.Bone Miner.Res. 23(11)

      Pages: 1751-1764

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene2008

    • Author(s)
      Eguchi T., Kubota S., Kawata K., Mukudai Y., Uehara J., Ohgawara T., Ibaragi S., Sasaki A., Kuboki T., Takigawa M.
    • Journal Title

      Mol.Cell.Biol. 28

      Pages: 2391-2413

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2.2008

    • Author(s)
      Ono M., et al.
    • Journal Title

      Cell Transplantation 17(1-2)

      Pages: 231-240

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.2008

    • Author(s)
      Koitabashi N., et al.
    • Journal Title

      Eur. J. Heart Failure 10(4)

      Pages: 373-379

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN family 2/Connective tissue growth factor (CCN2/CTGF)stimulates proliferation and differentiation of auricular chondrocytes.2008

    • Author(s)
      Fujisawa T., et al.
    • Journal Title

      Osteoarthritis and Cartilage 16(7)

      Pages: 787-795

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage.2008

    • Author(s)
      Kawaki H., et al.
    • Journal Title

      J. Bone Miner. Res. 23(11)

      Pages: 1751-1764

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 mcartilage growth and regeneration : -Mechanical stress induces expression of Hcs24/CTGF/CCN2 in human chondrocytic cell line, HCS-2/8, rabbit hyaline costal chondrocytes and meniscus cells-2008

    • Author(s)
      Nishida T., et al.
    • Journal Title

      Biorheology 45(3-4)

      Pages: 289-299

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel.2008

    • Author(s)
      Kikuchi T., et al.
    • Journal Title

      Tissue Engineering A14(6)

      Pages: 1089-1098

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondfocyte differentiation.2008

    • Author(s)
      Mukudai, Y., et al.
    • Journal Title

      Mol. Cell Biol. 28(19)

      Pages: 6134-6147

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance and pathogenic function of connective tissue growth factor(CTGF/CCN2)in osteolytic mandibular squamous cell carcinoma.2008

    • Author(s)
      Shimo, T., et al.
    • Journal Title

      Anticancer Res. 28 (4C)

      Pages: 2343-2348

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN22008

    • Author(s)
      Ono M., et. al.
    • Journal Title

      Cell Transplantation (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene2008

    • Author(s)
      Eguchi T., et. al.
    • Journal Title

      Mol. Cell. Biol. 28(7)

      Pages: 2391-413

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart2008

    • Author(s)
      Koitabashi N., et. al.
    • Journal Title

      J. Heart Failure (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN family 2/Connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes. Osteoarthritis and Cartilage2008

    • Author(s)
      Fujisawa T., et. al.
    • Journal Title

      Osteoarthritis and Cartilage (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional requirement of CCN2 for intramembranous bone formation in embryonic mice2008

    • Author(s)
      Kawaki H., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 366(2)

      Pages: 450-456

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration:-Mechanical stress induces expression of Hcs24/CTGF/CCN2 in human chondrocytic cell line, HCS-2/8, rabbit hyaline costal chondrocytes and meniscus cells-2008

    • Author(s)
      Nishida T., et. al.
    • Journal Title

      Biorheology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy2008

    • Author(s)
      Sun G., et. al.
    • Journal Title

      J. Neurol. Sci. 267(1-2)

      Pages: 48-56

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel2008

    • Author(s)
      Kikuchi T., et. al.
    • Journal Title

      Tissue Engineering (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of TGF-β1 on CCN2/CTGF in normal human gingival fibroblasts and periodontal ligament cells2008

    • Author(s)
      Takeuchi H., et. al.
    • Journal Title

      J. Periodonatal Res. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN family proteins and angiogenesis : from embryo to adulthood2007

    • Author(s)
      Kubota S., and Takigawa M.
    • Journal Title

      Angiogenesis

      Pages: 101-11

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes2007

    • Author(s)
      Yanagita T., Kubota S., (中5名), Takigawa M.
    • Journal Title

      FEBS J.

      Volume: 274(7) Pages: 1655-1665

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of attachment of human bone marrow stromal cells by CCN22007

    • Author(s)
      Ono M., Kubota S., (中5名), Nishida T., Yoshida Y., Suzuki K., Takigawa M., Kuboki T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 357(1) Pages: 20-25

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis.2007

    • Author(s)
      Koitabashi N., (中6名), Nishida T., Kubota S., Takigawa M., Kurabayashi M.
    • Journal Title

      Hypertension

      Volume: 49(5) Pages: 1120-1127

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.2007

    • Author(s)
      Eguchi T., Kubota S., (中6名), Takigawa M.
    • Journal Title

      Biochimie

      Volume: 89(3) Pages: 278-288

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCN2(Connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in chondrocytes2007

    • Author(s)
      Nishida T., (中3名)、Takigawa M., Lyons K. M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 1 Pages: 45-58

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis2007

    • Author(s)
      Miyamato Y., (中10名), Takigawa M., (他4名)
    • Journal Title

      Nat. Genet.

      Volume: 39 Pages: 529-533

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression and distribution of connective tissue growth factor(CCN2/CTGF) during secondary ossification center formation.2007

    • Author(s)
      Oka M., Kubota S., (中5名)., Takigawa M.
    • Journal Title

      J. Histochem. Cytochem.

      Volume: 55 Pages: 1245-1255

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCN family proteins and angiogenesis: from embryo to adulthood2007

    • Author(s)
      Kubota S., et. al.
    • Journal Title

      Angiogenesis (invited review) 10(1)

      Pages: 1-11

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes2007

    • Author(s)
      Yanagita T., et. al.
    • Journal Title

      FEBS J. 274(7)

      Pages: 1655-1655

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of attachment of human bone marrow stromal cells by CCN22007

    • Author(s)
      Ono M., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 357(1)

      Pages: 20-25

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased connective tissue growth factor relative to brain natriuretic Peptide as a determinant of myocardial fibrosis2007

    • Author(s)
      Koitabashi N., et. al.
    • Journal Title

      Hypertension 49(5)

      Pages: 1120-1127

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines2007

    • Author(s)
      Eguchi T., et. al.
    • Journal Title

      Biochimie 89(3)

      Pages: 278-288

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lyons K. M. CCN2 (Connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in2007

    • Author(s)
      Nishida T., et. al.
    • Journal Title

      J. Cell. Commun. Signal. 1

      Pages: 45-58

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis2007

    • Author(s)
      Miyamato Y., et. al.
    • Journal Title

      Nat. Genet. 39

      Pages: 529-533

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation2007

    • Author(s)
      Oka M., et. al.
    • Journal Title

      J. Histochem. Cytochem. 55

      Pages: 1245-1255

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] CCN2/CTGF-CCN3/NOVおよびCCN2-CCN2のダイマー形成が軟骨細胞の分化機能に及ぼす役割2012

    • Author(s)
      星島光博, 他
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] The glucocorticosteroid fluocinolone acetonide presents chondrogenic effect and synergisticallly enhances TGFb3-induced chondrogenesis of ATDC5 cells2012

    • Author(s)
      Hara, E.S., et al
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional characterization of CCN3 that may direct the differentiation of chondrocytes2012

    • Author(s)
      Janune, D., et al
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 解糖経路の阻害は重篤な軟骨変性を引き起こす2012

    • Author(s)
      西田崇, 他
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of the low-density lipoprotein receptor-related protein 1 in regulation of chondrocyte differentiation2011

    • Author(s)
      河田かずみ
    • Organizer
      第32回岡山歯学会総会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Receptor activator of NF-・B (RANK)結合タンパク質であるCCN2/CTGFのRANKL誘導性破骨細胞形成における機能2011

    • Author(s)
      青山絵理子, 他
    • Organizer
      第32回岡山歯学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 軟骨の生化学-CCN/CTGFの役割2011

    • Author(s)
      滝川正春
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島
    • Year and Date
      2011-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 軟骨の生化学-CCN2/CTGFの役割-2011

    • Author(s)
      滝川正春
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内軟骨性骨化におけるCCN2の役割解明-in vitro研究を中心として2011

    • Author(s)
      西田崇
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of the low-density lipoprotein receptor related protein 1 (LRP1) in CCN22011

    • Author(s)
      Kawata K, et al
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] 3' UTRを介したCCN1(Cyr61)遺伝子発現調節機構の解明2011

    • Author(s)
      住吉久美, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2 Promotes Osteoclastogenesis via Induction of and Interaction with DC-STAMP and via Interaction with RANK and Enhancing RANKL Signaling2011

    • Author(s)
      Takigawa, M., et al
    • Organizer
      Gordon Conference on Bones and Teeth
    • Place of Presentation
      Les Diablerets, Switzerland
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2/CTGF Promotes Osteoclastogenesis via Induction of and Interaction with Dendritic Cell-Specific Transmembrane Protein (DC-STAMP)2011

    • Author(s)
      Takigawa, M., et al
    • Organizer
      36th FEBS Congress
    • Place of Presentation
      Torino, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of the heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in matrix synthesis in chondrocytes2011

    • Author(s)
      Hoshijima, M., et al
    • Organizer
      The 33th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      San Diego, California
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel effects of CCN3 that may direct the differentiation of chondrocytes2011

    • Author(s)
      Janune, D., et al
    • Organizer
      Targets 2011 : Novel targets for cancer and connective tissues diseases. A meeting sponsored by the International CCN society
    • Place of Presentation
      Vancouver, BC, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes2011

    • Author(s)
      Nishida, T., et al
    • Organizer
      Targets 2011 : Novel targets for cancer and connective tissues diseases. A meeting sponsored by the International CCN society
    • Place of Presentation
      Vancouver, BC, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of the effect of CCN2 modules independently and in different combinations on chondrocytic cells2011

    • Author(s)
      Abd El Kader, T., et al
    • Organizer
      A meeting sponsored by the International CCN socie
    • Place of Presentation
      Vancouver, BC, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of CCN2 in the remodeling of periodontal tissue upon nicotine exposure2011

    • Author(s)
      Kubota, S., at al
    • Organizer
      A meeting sponsored by the International CCN socie
    • Place of Presentation
      Vancouver, BC, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2 Promotes Osteoclastogenesis via Induction of and Interaction with DC-STAMP and by Enhancing RANKL Signaling via Interaction with RANK and osteoprotegerin2011

    • Author(s)
      Takigawa, M., et al
    • Organizer
      the 13th IUBMB Conference, the 1st PABMB Conference and the 3rd Meetings of the Signal Transduction Branch & Oxidative Stress Branches of SMB
    • Place of Presentation
      Merida, Yucatan, Mexico
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of the low-density lipoprotein receptor related protein 1 (LRP1) in CCN2 protein transportation in chondrocytes2011

    • Author(s)
      Kawata, K., et al
    • Organizer
      the 13th IUBMB Conference, the 1st PABMB Conference and the 3rd Meetings of the Signal Transduction Branch & Oxidative Stress Branches of SMB
    • Place of Presentation
      Merida, Yucatan, Mexico
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低密度リポタンパク受容体関連クンパ1(LRP1)による軟骨細胞でのCCNファミリー2/結合組織成長因子(CCN2/CTGF)タンパク質輸送2011

    • Author(s)
      河田かずみ, 他
    • Organizer
      第43回日本結合組織学会学術大会・第58回マトリックス研究会大会合同学術集会
    • Place of Presentation
      大分
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前十字靭帯細胞におけるCCN2/CTGFの機能と周期的伸張刺激負荷の効果2011

    • Author(s)
      三宅由晃, 他
    • Organizer
      第43回日本結合組織学会学術大会・第58回マトリックス研究会大会合同学術集会
    • Place of Presentation
      大分
    • Related Report
      2011 Annual Research Report
  • [Presentation] RANK結合タンパク質CCN2/CTGFはRANK-RANKLシグナルを促進する2011

    • Author(s)
      青山絵理子, 他
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2/CTGFとCCN3/Novのヘテロダイマー、およびCCN2のホモグイマー形成が軟骨細胞の基質合成に及ぼす役割2011

    • Author(s)
      星島光博, 他
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前十字靭帯細胞におけるCTGF/CCN2の機能と周期的伸長負荷の効果2011

    • Author(s)
      三宅由晃, 他
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] 軟骨細胞分化を運命づける分子としてのCCN3の役割2011

    • Author(s)
      ジャヌネ ダニーロ, 他
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] valuation of independent and combinational effect of CCN2 modulates on chondrocytic cells2011

    • Author(s)
      Abd El Kader, et al
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] Harmine, an inducedr of CCN2/CTGF, promotes chondrogenesis and suppresses TNF-a-induced inflammatory response2011

    • Author(s)
      Hara, E.S., et al
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨格筋内異所性骨化におけるCCN2/CTGFの作用2011

    • Author(s)
      西田崇, 他
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2のRANK (receptor activator of nuclear kappa B)の結合とRANK-RANKLシグナル制御作用2011

    • Author(s)
      青山絵理子, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2/CTGFとCCN3/Novは、ヘテロダイマーを形成することにより、軟骨細胞の基質合成を厳密に制御する2011

    • Author(s)
      星島光博, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Glyceroaldehyde-3-phosphate dehydrogeneseはCCN2 mRNA結合タンパクである2011

    • Author(s)
      近藤誠二, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] 木質様歯肉炎患者におけるフィブリンの役割とCCN2の関与2011

    • Author(s)
      志茂剛, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of independent and combinational effect of each of CCN2 modulates on chondrocytic cells2011

    • Author(s)
      Abd El Kader, T., et al
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] 皮膚創傷治癒過程におけるCCN4/WISP-1遺伝子の役割2011

    • Author(s)
      正木明日香, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト前十字靭帯細胞におけるCCN2/CTGFの機能と周期的伸張刺激負荷の効果2011

    • Author(s)
      三宅由晃, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] 喫煙と歯肉線維化との関係-Nicotine誘導性CCN2/CTGFがヒト歯周組織由来培養細胞の線維化に与える影響2011

    • Author(s)
      五十嵐(武内)寛子, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCNファミリータンパク質によるMAPK経路を介した骨芽細胞増殖、分化調節2011

    • Author(s)
      川木晴美, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Harmine, an inducedr of CCN2/CTGF, promotes chondrogenesis and protection against TNF-a-induced inflammatory condition2011

    • Author(s)
      Hara, E.S., et al
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel effects of CCN3 that may direct the differentiation of chondrocytes2011

    • Author(s)
      Janune, D., et al
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2/CTGFはBMP2による骨格筋内異所性骨化に協調的に作用する2011

    • Author(s)
      西田崇, 他
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Expression of platelet-derived growth factor receptor-like (PDGFRL) gene in chondrocytes2011

    • Author(s)
      Kawata, K., et al
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Receptor activator of NF-・B (RANK)結合タンパク質であるCCN2/CTGFのRANKL誘導性破骨細胞形成における機能2011

    • Author(s)
      青山絵理子, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Assessment of combinational effect of independent CCN2 modules on chondrocytic cells2011

    • Author(s)
      Abd El Kader, T., et al
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2/CTGFはBMP2による骨格筋内異所性骨化に協調的に作用する2011

    • Author(s)
      西田崇, 他
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨芽細胞分化におけるCCNファミリータンパク質の分布と機能解析2011

    • Author(s)
      川木晴美, 他
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2/CTGFとCCN3/Novのヘテロダイマー形成が軟骨細胞の基質合成に及ぼす役割2011

    • Author(s)
      星島光博, 他
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス成長板におけるCa2+結合タンパクsorcinの局在について2011

    • Author(s)
      河井まりこ, 他
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 結合組織成長因子CCN2/CTGFは頭部神経堤由来の軟骨細胞分化に必須である2011

    • Author(s)
      服部高子, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] The low-density lipoprotein receptor related protein 1 (LRP1) deficiency in the cartilage tissue leads to skeletal dysmorphisms2011

    • Author(s)
      Kawata, K., et al
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2/CTGF-CCN2およびCCN2-CCN3/NOVのダイマー形成が、軟骨細胞の基質合成に及ぼす役割2011

    • Author(s)
      星島光博, 他
    • Organizer
      第24回日本軟骨代謝学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロRNAによる軟骨細胞形質制御とCCN1(Cyr61)の関与2011

    • Author(s)
      住吉久美, 他
    • Organizer
      第24回日本軟骨代謝学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節軟骨発生におけるCCN3の役割2011

    • Author(s)
      ジャヌネダニーロ, 他
    • Organizer
      第24回日本軟骨代謝学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2単独モジュールタンパク質の複合適用が軟骨細胞に与える効果の解析2011

    • Author(s)
      タレクアブドアルケイダー, 他
    • Organizer
      第24回日本軟骨代謝学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨分化促進、抗炎症作用を持つ天然物由来低分子化合物Harmine2011

    • Author(s)
      Emilio Satoshi Hara, 他
    • Organizer
      第24回日本軟骨代謝学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFとCCN3/NOVの結合と軟骨細胞におけるその生理的意義2010

    • Author(s)
      星島光博, 他
    • Organizer
      第1回骨バイオサイエンス研究会
    • Place of Presentation
      岡山
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCNファミリータンパク質:新規シグナルコンダクター2010

    • Author(s)
      滝川正春
    • Organizer
      先端歯学スクール2010
    • Place of Presentation
      三浦、神奈川
    • Related Report
      2011 Final Research Report
  • [Presentation] CCNファミリータンパク質:新規シグナルコンダクター2010

    • Author(s)
      滝川正春
    • Organizer
      先端歯学スクール2010
    • Place of Presentation
      三浦(教育講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cartilage-specific overexpression of CCN2/CTGF protects articular cartilage from age-related osteoarthritis-like changes.2010

    • Author(s)
      Itoh, S., et al.
    • Organizer
      The 6th International Workshop on the CCN Family of Genes
    • Place of Presentation
      Newcastle
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chondrocyte-haemopoietic cell interaction that inducea CCN2 and its physiological significance. Multiple regulation of human CCN1 via the 3' UTR untranslated region and its biological significance.2010

    • Author(s)
      Sumiyoshi K
    • Organizer
      The 6th International Workshop on the CCN Family of Genes.
    • Place of Presentation
      Newcastle
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of the Low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/Conncective tissue growth factor (CTGF) protein transportation in chondrocytes.2010

    • Author(s)
      Kawata K., et al.
    • Organizer
      The 6th International Workshop on the CCN Family of Genes
    • Place of Presentation
      Newcastle
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling2010

    • Author(s)
      Aoyama, E., et al.
    • Organizer
      The 6th International Workshop on the CCN Family of Genes
    • Place of Presentation
      Newcastle
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression and functional role of CCN3/Nov during articular cartilage development.2010

    • Author(s)
      Janune, D., et al.
    • Organizer
      The 6th International Workshop on the CCN Family of Genes
    • Place of Presentation
      Newcastle
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGF interacts with matrilin-3 and enhances assembly of a cartilage matrix protein and filamentous network.2010

    • Author(s)
      Hattori, T.
    • Organizer
      The 6th International Workshop on the CCN Family of Genes
    • Place of Presentation
      Newcastle
    • Related Report
      2010 Annual Research Report
  • [Presentation] Screening of CCN2-binding peptides and its scientific utility.2010

    • Author(s)
      Kuhota, S.
    • Organizer
      The 6th International Workshop on the CCN Family of Genes
    • Place of Presentation
      Newcastle
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of BMP-2-induced osteogenic differentiation of hBMSCs by TNF-α.2010

    • Author(s)
      Fujisawa, T., et al.
    • Organizer
      The International Association for Dental Research
    • Place of Presentation
      Barcelona
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of miR-181a in endochondral ossification : Possible involvement of CCN1.2010

    • Author(s)
      Kubota, S., et al.
    • Organizer
      The International Association for Dental Research
    • Place of Presentation
      Barcelona
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現による膝関節軟骨の加齢に伴う変性抑制効果2010

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第23回日本軟骨代謝学会
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sox9は血管侵入、骨髄形成および内軟骨性骨形成の最終段階を抑制する-Col10a1-BACトランスジェニックマウスを用いた解析-2010

    • Author(s)
      服部高子, 他
    • Organizer
      第23回日本軟骨代謝学会
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 線維芽細胞増殖因子(FGF)2刺激による軟骨細胞増殖促進作用に与える結合組織成長因子(CCN2/CTGF)の影響2010

    • Author(s)
      西田崇, 他
    • Organizer
      第23回日本軟骨代謝学会
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前十字靭帯細胞におけるCTGF/CCN2の発現2010

    • Author(s)
      三宅由晃, 他
    • Organizer
      第23回日本軟骨代謝学会
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成熟、分化に伴う軟骨細胞形成制御におけるマイクロRNAの役割2010

    • Author(s)
      住吉久美, 他
    • Organizer
      第23回日本軟骨代謝学会
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFはFGF2と結合するで軟骨細胞に対するFGF2作用を修飾する2010

    • Author(s)
      西田崇, 他
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低密度リポタンパク受容体関連タンパク-1(LRP1)による軟骨細胞でのタンパク質輸送2010

    • Author(s)
      河田かずみ, 他
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロRNA181-aよる軟骨細胞形質の制御とCCN1の関与2010

    • Author(s)
      住吉久美, 他
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFとRANKの分子間相互作用も解析と骨代謝における意義2010

    • Author(s)
      青山絵理子, 他
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFの核内移行とExportin-1による核-細胞質間分子輸送2010

    • Author(s)
      服部高子, 他
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFのホモダイマー形成、およびCCN3/NOVとのヘテロダイマーの形成とそれらの軟骨細胞における生理作用2010

    • Author(s)
      星島光博, 他
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression and functional role of NOV/CCN3 during articular cartilage development2010

    • Author(s)
      ジャヌネダニーロ, 他
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前十字靱帯細胞におけるCTGF/CCN2の発現と周期的伸張刺激負荷の効果2010

    • Author(s)
      三宅由晃, 他
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
    • Place of Presentation
      秋田
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFはマトリリン-3と結合して軟骨マトリックス成分のネットワーク形成を促進する2010

    • Author(s)
      服部高子, 他
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
    • Place of Presentation
      秋田
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFの関節軟骨アンチエイジング作用~軟骨組織特異的CCN2/CTGF過剰発現によりマウスの膝関節軟骨は加齢後もより正常に近い形質を維持する~2010

    • Author(s)
      伊藤慎将, 他
    • Organizer
      先端歯学スクール2010
    • Place of Presentation
      三浦
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨組織特異的CCN2/CTGF過剰発現によりマウスの膝関節軟骨は加齢後もより正常に近い形質を維持する2010

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN1遺伝子転写後調節に関与するmiRNAの機能解析2010

    • Author(s)
      住吉久美, 他
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨細胞におけるFGF2機能の新規モジュレーターとしてのCCN2/GTGFの作用2010

    • Author(s)
      西田崇, 他
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Exportin-1によるCCN2/CTGFの核-細胞質間分子輸送とその生理的意義2010

    • Author(s)
      内田瑤子, 他
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト前十字靱帯細胞におけするCTGF/CCN2の発現と周期的伸良負荷の効果2010

    • Author(s)
      三宅由晃, 他
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFのホモダイマー形成、およびCCN3/NOVとのヘテロダイマーの形成と、それらが軟骨細胞の基質合成に及ぼす役割2010

    • Author(s)
      星島光博, 他
    • Organizer
      BMB2010(第83回日本生化学会大会、第33回日本分子生物学会年会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨組織特異的CCN2/CTGF過剰発現による膝関節軟骨の加齢変性抑制効果2010

    • Author(s)
      伊藤慎将, 他
    • Organizer
      BMB2010(第83回日本生化学会大会、第33回日本分子生物学会年会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of the low-densitylipoprotein receptor-related protein 1 (LRP1) in CCN2 protein transportation in chondrocytes.2010

    • Author(s)
      Kawata, K., et al.
    • Organizer
      BMB2010(第83回日本生化学会大会、第33回日本分子生物学会年会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロRNAによる軟骨細胞形質制御とCCN1(Cyr61)の関与2010

    • Author(s)
      住吉久美, 他
    • Organizer
      BMB2010(第83回日本生化学会大会、第33回日本分子生物学会年会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of CCN2/CTGF binding to receptor activator of NF-κB (RANK) in the RANK-RANK ligand system.2010

    • Author(s)
      Aoyama, E., et al.
    • Organizer
      BMB2010(第83回日本生化学会大会、第33回日本分子生物学会年会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFはマトリリン-3と結合して軟骨マトリックス成分のネットワーク形成を促進する2010

    • Author(s)
      服部高子, 他
    • Organizer
      BMB2010(第83回日本生化学会大会、第33回日本分子生物学会年会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] FGF2刺激による軟骨細胞増殖促進及びMMP13酵素活性上昇に与えるCCN2/CTGFの影響2010

    • Author(s)
      西田崇, 他
    • Organizer
      BMB2010(第83回日本生化学会大会、第33回日本分子生物学会年会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFとCCN2/CTGF, およびCCN3/NOVとの結合とそれらの相互作用の解析2009

    • Author(s)
      星島光博, 他
    • Organizer
      第30回岡山歯学会総会 学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨軟骨再生因子であるCCN2/CTGFとFGFレセプターとの関連2009

    • Author(s)
      青山絵理子, 他
    • Organizer
      第19回中国、四国骨代謝研究会
    • Place of Presentation
      岡山
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCNファミリー遺伝子の転写後制御とその生物学的意義2009

    • Author(s)
      久保田聡, 他
    • Organizer
      第3回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN family 2/connective tissue growth factor(CCN2/CTGF)promotes osteoclastogenesis via interaction with dendritic cell-specific transmembrane protein(DC-STAMP)2009

    • Author(s)
      Nishida T., et al.
    • Organizer
      31th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation.2009

    • Author(s)
      Kawata K., et al.
    • Organizer
      The 2nd International Symposium of Medical and Dental Education in Okayama
    • Place of Presentation
      Okayama
    • Related Report
      2009 Annual Research Report
  • [Presentation] Distribution gene expression and functional role of EphA4 during ossification. The 2nd International2009

    • Author(s)
      Kuroda C., et al.
    • Organizer
      The 2nd International Symposium of Medical and Dental Education in Okayama
    • Place of Presentation
      Okayama
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chondrocyte-haemopoietic cell interaction that inducea CCN2 and its physiological significance.2009

    • Author(s)
      Sumiyoshi K., et al.
    • Organizer
      The 2nd International Symposium of Medical and Dental Education in Okayama
    • Place of Presentation
      Okayama
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN family 2/connective tissue growth factor modulates BMP signaling as asignal conductor which action regulates the proliferation and differentiation of chondrocytes.2009

    • Author(s)
      Maeda A., et al.
    • Organizer
      The 2nd International Symposium of Medical and Dental Education in Okayama
    • Place of Presentation
      Okayama
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of transgenic mice overexpressing Ccn2/ctgf in chondrocytes.2009

    • Author(s)
      Tomita N., et al.
    • Organizer
      The 2nd International Symposium of Medical and Dental Education in Okayama
    • Place of Presentation
      Okayama
    • Related Report
      2009 Annual Research Report
  • [Presentation] The regulation of Ccn2/Ctgf gene via micro RNA18a2009

    • Author(s)
      Ohgawara T., et al.
    • Organizer
      The 2nd International Symposium of Medical and Dental Education in Okayama
    • Place of Presentation
      Okayama
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN2/CTGFとFGF受容体との相互作用およびその生物学的意義2009

    • Author(s)
      青山絵理子, 他
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低密度リポタンパク受容体関連タンパク-1(LRP1)の軟骨細胞分化における機能とその作用機構2009

    • Author(s)
      河田かずみ, 他
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCNファミリー2/結合組織成長因子(CCN2/CTGF)はDC-STAMPの遺伝子発現レベルの上昇を介して破骨細胞形成を促進する。2009

    • Author(s)
      西田崇, 他
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 成長板軟骨細胞後期分化に関与するマイクロRNAの探索2009

    • Author(s)
      住吉久美, 他
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現は関節軟骨を加齢に伴う変形性関節炎様変化から防御する。2009

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN2/CTGFとFGFレセプターとの結合およびその意義の解析2009

    • Author(s)
      青山絵理子, 他
    • Organizer
      第3回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨細胞においてCC family2/connective tissue growth factor(CCN2/CTGF)は線維芽細胞増殖因子(FGF)-2に結合し、FGF-2によるマトリックスメタロプロテアーゼ(MMP)13発現を制御する。2009

    • Author(s)
      西田崇, 他
    • Organizer
      第3回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN2/CTGFはExportin-1と結合し、細胞核内外を行き来する。2009

    • Author(s)
      服部高子, 他
    • Organizer
      第3回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロRNAによる成長板軟骨細胞特異的な遺伝子制御2009

    • Author(s)
      住吉久美, 他
    • Organizer
      第3回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低密度リポタンパク受容体関連タンパク-1(LRP1)の軟骨細胞分化における多面的作用機構2009

    • Author(s)
      河田かずみ, 他
    • Organizer
      第3回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現マウスの膝関節軟骨は加齢後もより正常に近い形質を維持する。2009

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第3回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現は膝関節軟骨を加齢に伴う変性から保護する。2009

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第51回歯科基礎医学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nucleophosmin/B23によるChicken CCN2遺伝子の軟骨細胞特異的転写後調節2009

    • Author(s)
      住吉久美, 他
    • Organizer
      第51回歯科基礎医学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN2/CTGFとFGFレセプターとの分子間相互作用2009

    • Author(s)
      青山絵理子, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現マウスは膝関節軟骨の加齢性変化に抵抗性を示す2009

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨細胞におけるCCN2遺伝子の転写後調節機構におけるNucleophosmin/B23の機能的意義2009

    • Author(s)
      住吉久美, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 破骨細胞分化に与えるCCNファミリー2/結合組織成長因子(CCN2/CTGF)の促進作用2009

    • Author(s)
      西田崇, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低密度リポタンパク受容体関連タンパク-1(LRP1)の軟骨細胞分化における多面的作用機構2009

    • Author(s)
      河田かずみ, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現マウスは膝関節軟骨の加齢に伴う変形性膝関節症様軟骨変化が抑制され、より正常に近い形質を維持する。2009

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低密度リポタンパク受容体関連タンパク-1(LRP1)の軟骨細胞分化における作用機能2009

    • Author(s)
      河田かずみ, 他
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN2/CTGFのExportin-1による核-細胞質間分子輸送2009

    • Author(s)
      服部高子, 他
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨細胞においてMMP3は核移行しCCN2/CTGFの転写活性化因子として働く2009

    • Author(s)
      江口傑徳, 他
    • Organizer
      第22回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression and mechanisms of connective growth factor (CCN2/CTGF)induction in osteolytic jaw invasion of human squamous cell carcinoma.2009

    • Author(s)
      Shimo, t. et, al.
    • Organizer
      ORS 55th Annual Meeting
    • Place of Presentation
      Las Vegas
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCNファミリー2/結合組織成長因子はBMPシグナルを修飾し, 軟骨細胞増殖・分化を制御する2009

    • Author(s)
      前田あずさ, 他
    • Organizer
      第22回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFの軟骨特異的過剰発現は加齢に伴う膝関節軟骨の変性に対して抑制的に働く ?2009

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第22回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 軟骨・血球系細胞間相互作用によるCCN2の誘導とその生理的意義2009

    • Author(s)
      住吉久美, 他
    • Organizer
      第22回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFと結合するタンパク質の同定2008

    • Author(s)
      星島光博, 他
    • Organizer
      第29回岡山歯学会
    • Place of Presentation
      岡山
    • Year and Date
      2008-11-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニコチンがヒト歯周組織由来細胞に与える線維化への影響について2008

    • Author(s)
      武内寛子, 他
    • Organizer
      日本歯周病学会 秋季学術大会
    • Place of Presentation
      四日市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Interaction of CCN2/CTGF with BMP-2 regulate the differentiation of human chondrocytic andosteoblastic cell line2008

    • Author(s)
      Maeda A., et. al.
    • Organizer
      The 1st International Symposium of Medical and Dental Education in Okayama
    • Place of Presentation
      Okayama
    • Year and Date
      2008-02-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Generation and analysis of transgenic mice overexpressing ccn2/ctgf in chondrocytes2008

    • Author(s)
      Tomita N., et. al.
    • Organizer
      The 1st International Symposium of Medical and Dental Education in Okayama (Okayama)
    • Place of Presentation
      Okayama
    • Year and Date
      2008-02-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression and biological significance of CCN2-associated microRNAs in chondrocytic HCS-2/8 cells2008

    • Author(s)
      Ohgawara T., et. al.
    • Organizer
      The 1st International Symposium of Medical and Dental Education in Okayama
    • Place of Presentation
      Okayama
    • Year and Date
      2008-02-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] The roles of CCN family 2/c onnective tissue growth factor(CCN2/CTGF) in skeletal development., Generation and analysis of transgenic mice overexpressing CCN2/CTGF in cartilage-2008

    • Author(s)
      Takigawa, M.
    • Organizer
      13 World Congresson Advances in Oncology and 11th Inter-national Syposium on Molecular Medicine
    • Place of Presentation
      Hersonissos, Creta, Greece(invitation)
    • Related Report
      2011 Final Research Report
  • [Presentation] The roles of CCN family 2/connective tissue growth factor (CCN2/CTGF)in skeletal development. -Generation and analysis of transgenic mice overexpressing CCN2/CTGF in cartilage-2008

    • Author(s)
      Takigawa, M., et al.
    • Organizer
      13 World Congress on Advances in Oncology and 11th International Syposium on Molecular Medicine
    • Place of Presentation
      Hersonissos, Creta, Greece
    • Related Report
      2008 Annual Research Report
  • [Presentation] Roles of CCN2 in skeletal growth and regeneration. -Requirment for both endochondral and intramembranous bone formation-2008

    • Author(s)
      Takigawa, M., et al.
    • Organizer
      The 5th International Workishop on the CCN Family of Genes
    • Place of Presentation
      Toronto
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGF is transactivated through its enhancer element by Sox9 in fibroblasts : possibleroles in fibrosis2008

    • Author(s)
      Hattori, T., et al.
    • Organizer
      The 5th International Workishop on the CCN Family of Genes
    • Place of Presentation
      Toronto
    • Related Report
      2008 Annual Research Report
  • [Presentation] Nucleophhosmin/B23 : A multifunctional regulator that determines the fate of ccn2 mRNA2008

    • Author(s)
      Kubota, S., et al.
    • Organizer
      The 5th International Workishop on the CCN Family of Genes
    • Place of Presentation
      Toronto
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation of chondrocytic phenotype by micro RNA 18a : Involvement of Ccn/Ctgf as amajor target gene.2008

    • Author(s)
      Ohgawara, T., et al.
    • Organizer
      The 5th International Workishop on the CCN Family of Genes
    • Place of Presentation
      Toronto
    • Related Report
      2008 Annual Research Report
  • [Presentation] Novel transcriptional regulation of CCN2/CTGF by nuclear translocated MMP3.2008

    • Author(s)
      Eguchi, T., et al.
    • Organizer
      The 5th International Workishop on the CCN Family of Genes
    • Place of Presentation
      Toronto
    • Related Report
      2008 Annual Research Report
  • [Presentation] Uverexpression of CCN2/CTGF in cartilage shows prolonged bone length resulting from stimulation of chondrogenesis, chondrocyte growth, apoptosis, and bone mineralization during endochondralossification2008

    • Author(s)
      Tomita, N., et al.
    • Organizer
      30th Annual Meetingof the American Society for Bone and Mineral Research
    • Place of Presentation
      Montreal
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニコチンがヒト歯周組織由来胚葉培養細胞におけるCCN2/CTGF産生に与える影響2008

    • Author(s)
      武内寛子, 他
    • Organizer
      第51回春季日本歯周病学会学術集会
    • Place of Presentation
      大宮
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGF軟骨特異的過剰発現マウスの作製とその硬組織の解析2008

    • Author(s)
      冨田奈緒, 他
    • Organizer
      第49回日本生化学会中国・四国支部例会
    • Place of Presentation
      高松
    • Related Report
      2008 Annual Research Report
  • [Presentation] マイクロRNA18aによるCcn2/Ctgf遺伝子発現制御機構と、その軟骨細胞分化への関与2008

    • Author(s)
      大河原敏博, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFとBMP-2との結合による軟骨細胞増殖・分化促進作用の制御2008

    • Author(s)
      前田あずさ, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFのモジュール別結合ペプチド配列の探索とその応用2008

    • Author(s)
      青山絵理子, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 軟骨細胞および骨芽細胞における受容体型チロシンキナーゼEphA4の機能 : CCN2/CTGFとの関連2008

    • Author(s)
      黒田知沙, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 破骨細胞形成におけるCCN2/CTGFの役割2008

    • Author(s)
      西田崇, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス膜性骨化における全CCNファミリーメンバーの役割の包括的解析2008

    • Author(s)
      川木晴美, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGF軟骨特異的過剰発現が内軟骨性骨形成に及ばす影響2008

    • Author(s)
      冨田奈緒, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト歯周組織由来培養細胞における喫煙と線維化との関係へのニコチン誘導性CCN2/CTGFの関与 ぐ2008

    • Author(s)
      武内寛子, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Induction of CCN2/CTGF by fluid flow stress via Rho signaling in osteoblastic cells.2008

    • Author(s)
      Honjo, T., et al.
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血小板に含まれるCCN2の由来 : 造血・間葉系相互作用によるCCN2の蓄積2008

    • Author(s)
      住吉久美, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ccn2/ctgf遺伝子のSox9による転写活性化機構2008

    • Author(s)
      服部高子, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFの加齢に伴う膝関節軟骨変性抑制効果2008

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第2回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2ノックアウトマウスを用いた骨芽細胞分化におけるCCNタンパク質の機能解析2008

    • Author(s)
      川木晴美, 他
    • Organizer
      第67回日本矯正学会大会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] Phage Display法によるCCN2/CTGFのモジュール別結合ペプチド配列の探索とその有用性2008

    • Author(s)
      青山絵理子, 他
    • Organizer
      第50回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 乳癌および軟骨肉腫細胞におけるMicro RNA 18aのCCN2遺伝子発現抑制様態の比較解析2008

    • Author(s)
      大河原敏博, 他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFの関節軟骨アンチエイジング作用 : 軟骨組織特異的CCN2/CTGF過剰発現マウスを用いた解析2008

    • Author(s)
      伊藤慎将, 他
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨軟骨再生因子CCN2/CTGFのモジュール別結合ペプチド配列の探索とその応用2008

    • Author(s)
      青山絵理子, 他
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFによるBMP-2の軟骨細胞増殖、分化促進作用の制御2008

    • Author(s)
      前田あずさ, 他
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2欠損マウスを用いた、CCN2とCCN3によるPTHrP-Ihhループを介した軟骨細胞分化制御機構の解析2008

    • Author(s)
      川木晴美, 他
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] マイクロRNA18aによるCcn2/Ctgf遺伝子を介した軟骨細胞分化の制御機構の解明2008

    • Author(s)
      大河原敏博, 他
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFの軟骨特異的過剰発現が内軟骨性骨形成に及ばす影響2008

    • Author(s)
      冨田奈緒, 他
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 結合組織増殖因子(CCN2/CTGF)と歯周組織との関係2008

    • Author(s)
      武内寛子, 他
    • Organizer
      第21回日本歯科医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Nicotine Induction of CCN2 : from Smoking to Periodontal Fibrosis.2008

    • Author(s)
      Takeuchi, H., et al.
    • Organizer
      第56回国際歯科研究学会日本部会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] Design, synthesis and characterization of CCN2/CTGF anchor peptides.2008

    • Author(s)
      Aoyama, E., et al.
    • Organizer
      BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGFの過剰発現は骨延長を誘導する2008

    • Author(s)
      服部高子, 他
    • Organizer
      BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] マイクロRNA18aによるCcn2/Ctgf遺伝子の制御機構の解明とその軟骨分化における意義2008

    • Author(s)
      大河原敏博, 他
    • Organizer
      BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFとBMP-2の相互作用が軟骨細胞の増殖と分化を制御する2008

    • Author(s)
      西田崇, 他
    • Organizer
      BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCN2/CTGFの軟骨特異的過剰発現マウスモデルの作製と解析2008

    • Author(s)
      冨田奈緒, 他
    • Organizer
      第21回日本軟骨代謝学会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨細胞成熟における低密度リポ蛋白受容体関連タンパクー1(LRP1)の関与2008

    • Author(s)
      河田かずみ, 他
    • Organizer
      第21回日本軟骨代謝学会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] CCN2/CTGFとBMP-2との分子間相互作用はヒト軟骨細胞様細胞株HCS-2/8を制御する2008

    • Author(s)
      前田あずさ, 他
    • Organizer
      第21回日本軟骨代謝学会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] ノックアウトマウスを用いた顎顔面形成における軟骨由来成長因子CCN2/CTGFの機能解析2008

    • Author(s)
      川木晴美, 他
    • Organizer
      第21回日本軟骨代謝学会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] 2型コラーゲンプロモーターで誘導したCCN2/CTGF過剰発現トランスジェニックマウスの作製による軟骨分化におけるCCN2/CTGFの役割解析2007

    • Author(s)
      冨田奈緒, 他
    • Organizer
      第17回中国・四国骨代謝研究会
    • Place of Presentation
      岡山
    • Year and Date
      2007-07-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨細胞における低密度リポタンパク受容体関連タンパク1(LRP1)の機能の解析2007

    • Author(s)
      河田かずみ, 他
    • Organizer
      第17回中国・四国骨代謝研究会
    • Place of Presentation
      岡山
    • Year and Date
      2007-07-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] CTGF/CCN2 in bone metas-tasis and tumor angiogenesis2007

    • Author(s)
      Takigawa M.
    • Organizer
      Gordon ResearchC onference on SIBLING
    • Place of Presentation
      University of New England(invitation)
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of mechanical-stress induc ible protein HCS24/CTGF/CCN2 in carti-lage growth and regeneration2007

    • Author(s)
      Takigawa, M.
    • Organizer
      5th InternationalSy mposium on mechanobiology of cartilage and chondrocyte
    • Place of Presentation
      Athens, Greece
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of nicotine on CCN2/CTGF in human periodontal tissue2007

    • Author(s)
      Takeuchi H., et. al.
    • Organizer
      11th Biennial Congress of the International Academy of Periodontology.
    • Place of Presentation
      Berne, Switzerland
    • Related Report
      2007 Annual Research Report
  • [Presentation] Novel transcriptional factor-like function of MMP3/stromelysin-1 that regulates connective tissue growth factor (CTGF/CCN2) gene2007

    • Author(s)
      Eguchi T., et. al.
    • Organizer
      29th Annual meeting of American Society for Bone and Mineral Research
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of mechanical-stress inducible protein HCS24/CTGF/CCN2 in cartilage growth and regeneration2007

    • Author(s)
      Takigawa M., et. al.
    • Organizer
      5th International Symposium on mechanobiology of cartilage and chondrocyte. (invitation)
    • Place of Presentation
      Athens, Greece
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウサギ半月板細胞におけるCCNファミリー2/結合組織成長因子(CCN2/CTGF)発現に与えるメカニカルストレスの影響2007

    • Author(s)
      前田あずさ, 他
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 成長板軟骨細胞におけるCCN4/WISPI mRNAおよびそのスプライシングバリアントの発現とその機能2007

    • Author(s)
      柳田剛志, 他
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 結合組織成長因子(CCN2/CTGF)とアグリカンとの結合の生理的意義の解析2007

    • Author(s)
      青山絵理子, 他
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨細胞におけるCCNファミリー2/結合組織成長因子(CCN2/CTGF)によるVEGF遺伝子発現制御機構の解明2007

    • Author(s)
      西田 崇, 他
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] CCN2ノックアウトマウスを用いた骨芽細胞分化におけるCCNファミリータンパク質の機能解析2007

    • Author(s)
      川木晴美, 他
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] CCN2/CTGF過剰発現トランスジェニックマウスの作製によるCCN2/CTGFの内軟骨性骨化における役割解明2007

    • Author(s)
      冨田奈緒, 他
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] CTGF/CCN2 in bone metastasis and tumor angiogenesis. Gordon Research Conference on SIBLING, (invitation)2007

    • Author(s)
      Takigawa M.
    • Organizer
      Gordon Research Conference on SIBLING, (invitation)
    • Place of Presentation
      University of New England
    • Related Report
      2007 Annual Research Report
  • [Presentation] CCN2遺伝子関連ノンコーディングRNAの軟骨細胞様HCS-2/8細胞における発現2007

    • Author(s)
      大河原敏博, 他
    • Organizer
      第28回岡山歯学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] CCNファミリー2/結合組織成長因子(CCN2/CTGF)が骨芽細胞において骨形成因子(BMP)-2刺激による骨芽細胞分化を修飾する2007

    • Author(s)
      前田あずさ, 他
    • Organizer
      第28回岡山歯学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現トランスジェニックマウスの作製とCCN2/CTGFの内軟骨性骨化に及ぼす影響について2007

    • Author(s)
      冨田奈緒, 他
    • Organizer
      第49回歯科基礎医学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] CCN2ノックアウトマウスを用いたCCN2およびCCN3の軟骨分化における機能解析2007

    • Author(s)
      川木晴美, 他
    • Organizer
      第49回歯科基礎医学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット大腿骨骨折治癒過程におけるCTGF発現と破軟骨細胞の配置2007

    • Author(s)
      山合友一朗, 他
    • Organizer
      第49回歯科基礎医学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨成長・分化因子CCN2/CTGFとMatrilin3との相互作用2007

    • Author(s)
      荒木大介, 他
    • Organizer
      第49回歯科基礎医学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] CCNファミリー:新規シグナルコンダクター2007

    • Author(s)
      滝川正春
    • Organizer
      第1回日本CCNファミリー研究会(オーバービュー講演)
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] 癌の浸潤・腫瘍性血管新生における全CCNファミリーメンバーの果たす役割の包括的解析2007

    • Author(s)
      大河原敏博, 他
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨細胞におけるCCN2/CTGFの四つのモジュールの異なった役割2007

    • Author(s)
      青山絵理子, 他
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] CCNファミリー2/結合組織成長因子(CCN2/CTGF)と骨形成因子(BMP)-2の相互作用が軟骨細胞及び骨芽細胞分化に与える影響2007

    • Author(s)
      前田あずさ, 他
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] 圧負荷肥大心ではCCN2はBrain Natriuretic Peptideと拮抗して心臓線維化をもたらす2007

    • Author(s)
      新井昌史, 他
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット咬筋の持続反復電気刺激はCCN2の遺伝子発現を亢進する2007

    • Author(s)
      小野 剛, 他
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of TGF-β1 on CCN2/CTGF production by human gingival fibroblasts and periodontal ligament cells2007

    • Author(s)
      Takeuchi. H., et. al.
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] 癌顎骨切除標本におけるCCN2の臨床病理学的検討2007

    • Author(s)
      志茂 剛, 他
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] CCN2ノックアウトマウスを用いた骨芽細胞分化におけるCCNファミリータンパク質の機能解析2007

    • Author(s)
      川木晴美, 他
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional analysis of a CCN2/CTGF receptor, the low density lipoprotein receptor-related protein (LRP1), in chondrocytes2007

    • Author(s)
      Kawata K., et. al.
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨特異的にCCN2/CTGFを過剰発現したトランスジェニックマウスの作製と軟骨内骨化におけるCCN2/CTGFの役割解析2007

    • Author(s)
      冨田奈緒, 他
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of TGF-β1 on CCN2/CTGF in human gingival fibroblasts and periodontal ligament cells2007

    • Author(s)
      Takeuchi H., et. al.
    • Organizer
      第127回日本歯科保存学会秋季学術大会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨細胞においてマトリックス金属プロテアーゼー3(MMP3)は核移行し結合組織成長因子(CCN2/CTGF)の転写因子として働く2007

    • Author(s)
      江口 傑徳, 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学大会合同大会ワークショップ
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional analysis of the low density lipoprotein receptior-related protein (LRP1) in chondrocytes2007

    • Author(s)
      Kawata K., et. al.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨特異的にCCN2/CTGFを過剰発現したトランスジェニックマウスの作製と解析2007

    • Author(s)
      冨田奈緒, 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 結合組織成長因子(CCN2/CTGF)とアグリカンとの結合についての解析2007

    • Author(s)
      青山絵理子, 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression and biological significance of CCN2-associated noncoding RNAs in chondrocytic HCS-2/8 cells2007

    • Author(s)
      Ohgawara T., et. al.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 軟骨細胞におけるCCNファミリー2/結合組織成長因子(CCN2/CTGF)のオートクリン発現メカニズムの解明2007

    • Author(s)
      西田 崇, 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Book] CCN Proteins in Health and Disease2010

    • Author(s)
      Perbal A, Takigawa M, Perbal B.
    • Publisher
      Springer
    • Related Report
      2011 Final Research Report
  • [Book] CCN Proteins in Health and Disease2010

    • Author(s)
      Perbal A., et al.
    • Total Pages
      338
    • Publisher
      Springer (Dordrecht, Nertherlands)
    • Related Report
      2010 Annual Research Report
  • [Book] Novel Transcriptional Regulation of CCN2/CTGF by Nuclear Translocation of MMP3. in CCN Proteins in Health and Disease. A.Perbal, M.Takigawa & B.Perbal (eds)2010

    • Author(s)
      Eguchi T., et al.
    • Publisher
      Springer (Dordrecht, Nertherlands)
    • Related Report
      2010 Annual Research Report
  • [Book] Nucleophosmin/B23 : A Multifuctional Regulaytor That Determines the Fate of CCN2 mRNA. in CCN Proteins in Health and Disease. A.Perbal, M.Takigawa & B.Perbal (eds)2010

    • Author(s)
      Kubota S., et al.
    • Publisher
      Springer (Dordrecht, Nertherlands)
    • Related Report
      2010 Annual Research Report
  • [Book] Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3. in CCN Proteins in Health and Disease. A.Perbal, M.Takigawa & B.Perbal (ads)2010

    • Author(s)
      Takigawa M., et al.
    • Publisher
      Springer (Dordrecht, Nertherlands)
    • Related Report
      2010 Annual Research Report
  • [Book] CCN Proteins in Health and Disease2010

    • Author(s)
      Perbal A., et al.
    • Publisher
      Springer(Dordrecht, Nertherlands)(in press.)
    • Related Report
      2009 Annual Research Report
  • [Book] Novel Transcriptional Regulation of CCN2/CTGF by Nuclear Translocation of MMP3. in CCN Proteins in Health and Disease. A. Perbal, M. Takigawa & B. Perbal(eds)2010

    • Author(s)
      Eguchi T., et al.
    • Publisher
      Springer(Dordrecht, Nertherlands)(in press.)
    • Related Report
      2009 Annual Research Report
  • [Book] Nucleophosmin/B23 : A Multifuctional Regulaytor That Determines the Fate of CCN2 mRNA. in CCN Proteins in Health and Disease. A. Perbal, M. Takigawa & B. Perbal(eds)2010

    • Author(s)
      Kubota S., et al.
    • Publisher
      Springer(Dordrecht, Nertherlands)(in press.)
    • Related Report
      2009 Annual Research Report
  • [Book] Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3. in CCN Proteins in Health and Disease. A. Perbal, M. Takigawa & B. Perbal(eds)2010

    • Author(s)
      Takigawa M., et al.
    • Publisher
      Springer(Dordrecht, Nertherlands)(in press.)
    • Related Report
      2009 Annual Research Report
  • [Book] Novel Transcriptional Regulation of CCN2/CTGF by Nuclear Translocation of MMP3. In Proceedings of the 5th International Workshop of the CCN Family of Genes.2009

    • Author(s)
      Takanori Eguchi
    • Publisher
      Springer, Dordrecht, Nertherlands (in press)
    • Related Report
      2008 Annual Research Report
  • [Book] Nucleophosmin/B23 : A Multifuctional Regulaytor That Determines the Fate of CCN2mRNA. In Proceedings of the 5th International Workshop of the CCN Family of Genes.2009

    • Author(s)
      Satoshi Kubota, et al.
    • Publisher
      Springer, Dordrecht, Nertherlands (in press)
    • Related Report
      2008 Annual Research Report
  • [Book] International Review of Cytology2007

    • Author(s)
      Kubota S. and Takigawa M.
    • Publisher
      Elsevier Inc.
    • Related Report
      2011 Final Research Report
  • [Book] Role of CCN2/CTGF/Hcs24 in bone growth. In Internal Review of Cytology:A Survey of Cell Biology, Vol. 257(K.W. Jeon ed.)2007

    • Author(s)
      Kubota S. and Takigawa M.
    • Publisher
      Academic Press (Amsterdam)
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://atlasgeneticsoncology.org//Genes/CTGFID40192ch6q23.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.dent.okayama-u.ac.jp/seika/index_sc_j.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.dent.okayama-u.ac.jp/seika/inde_sc_j.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.okayama-u.ac.jp/seika/index_sc_j.html

    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.dent.okayama-u.ac.jp/seika/index_sc_j.html

    • Related Report
      2009 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.dent.okayama-u.ac.jp/seika/index_sc_j.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.okayama-u.ac.jp/seika/index_sc_j.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://AtlasGeneticsOncology.org/Genes/CTGFID40192ch6q23.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌の治療又は予防剤2012

    • Inventor(s)
      滝川正春、服部高子他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2012-009665
    • Filing Date
      2012-01-20
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] がんの治療又は予防剤2012

    • Inventor(s)
      滝川正春, 他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2012-009665
    • Filing Date
      2012-01-20
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] アポトーシス誘導剤と併用されるがんの治療又は予防剤2012

    • Inventor(s)
      滝川正春, 他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2012-009688
    • Filing Date
      2012-01-20
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 軟骨再生促進剤2011

    • Inventor(s)
      窪木拓男, 他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2011-037932
    • Filing Date
      2011-02-24
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 軟骨再生促進剤2010

    • Inventor(s)
      窪木拓男、滝川正春他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2011-037932
    • Filing Date
      2010-02-24
    • Related Report
      2011 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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