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Study of Rhythm Formation Mechanism in Brainstem by Statistical Analysis of Spatio-Temporal Voltage Imaging Data

Research Project

Project/Area Number 19200021
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Statistical science
Research InstitutionThe Institute of Statistical Mathematics

Principal Investigator

ISHIGURO Makio  The Institute of Statistical Mathematics, 名誉教授 (10000217)

Co-Investigator(Kenkyū-buntansha) OKADA Yasumasa  慶應義塾大学, 医学部, 准教授 (80160688)
OKU Yoshitaka  兵庫医科大学, 医学部, 教授 (20252512)
TAMURA Yoshiyasu  統計数理研究所, データ科学系, 教授 (60150033)
MIWAKEICHI Fumikazu  統計数理研究所, モデリング研究系, 准教授 (30360647)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥34,710,000 (Direct Cost: ¥26,700,000、Indirect Cost: ¥8,010,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Keywords非線形入力モデル / 因果関係 / ニューロンの分類 / データ重ねあわせ / SN比の改善 / 過渡的現象の解析 / 情報量規準 / 画像データ解析 / データの重ねあわせ
Research Abstract

To assess the spatiotemporal dynamics of respiratory-related regions of the ventral medulla, we optically recorded the respiratory neuronal network activity of the ventral medulla of the in vitro brainstem-spinal cord preparation using a voltage-sensitive dye, and developed a novel non-linear response model called the Sigmoid and Transfer Function model (STF model) which regards the respiratory motor activity recorded from the fourth cervical ventral root (C4VR) of the spinal cord as the response to optical signals from pixels within respiratory-related regions. Then we developed a new filtering method to detect respiration-related activity in the area. The result was published in a top journal in medical imaging.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (85 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (36 results) (of which Peer Reviewed: 34 results) Presentation (43 results) Book (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Detection and Visualization Method of Dynamic State Transition for Biological Spatio-Temporal Imaging Data2011

    • Author(s)
      Miwakeichi F, Oku Y, Okada Y, Kawai S, Tamura Y, Ishiguro M
    • Journal Title

      IEEE Transaction on Medical Imaging 30(3)

      Pages: 859-866

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual oscillator model of the respiratory neuronal network generating quantal slowing of respiratory rhythm2011

    • Author(s)
      Lal A, Oku Y, Hlsmann S, Okada Y, Miwakeichi F, Kawai S, Tamura Y, Ishiguro M
    • Journal Title

      Journal of Computational Neuroscience 30

      Pages: 225-240

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection and Visualization Method of Dynamic State Transition for Biological Spatio-Temporal Imaging Data2011

    • Author(s)
      Miwakeichi F, Oku Y, Okada Y, Kawai S, Tamura Y, Ishiguro M
    • Journal Title

      IEEE Transaction on Medical Imaging

      Volume: 30(3) Pages: 859-866

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parametric modeling analysis of optical imaging data on neuronal activities in the brain.2010

    • Author(s)
      Kawai S, Oku Y, Miwakeichi F, Miwakeichi F, Ishiguro M, Tamura Y
    • Journal Title

      Optimization and Its Applications 38 part2

      Pages: 213-225

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] What Does the multi-peaked respiratory output pattern tell us about the respiratory pattern generating neuronal network?2010

    • Author(s)
      Ishiguro M, Kawai S, Okada Y, Oku Y, Miwakeichi F, Tamura Y, Lal A
    • Journal Title

      Advances in Experimental Medicine and Biology 669

      Pages: 163-166

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRP channels are involved in mediating hypercapnic Ca2+ responses in rat glia-rich medullary cultures independently of extracellular pH2010

    • Author(s)
      Hirata Y, Oku Y
    • Journal Title

      Cell calcium 48

      Pages: 124-132

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vesicular glutamate transporter 2-immunoreactive synapses onto phrenic motoneurons in the neonatal rat2010

    • Author(s)
      Yokota S, Shinozaki Y, Oku Y, Okada Y, Yasui Y
    • Journal Title

      Advances in Experimental Medicine and Biology 669

      Pages: 189-192

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical changes of phrenic motoneurons during development2010

    • Author(s)
      Okada Y, Yokota S, Shinozaki Y, Miwakeichi F, Oku Y, Yasui Y
    • Journal Title

      Advances in Experimental Medicine and Biology 669

      Pages: 33-36

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] What Does the multi-peaked respiratory output pattern tell us about the respiratory pattern generating neuronal network?2010

    • Author(s)
      Ishiguro M, Kawai S, Okada Y, Oku Y, Miwakeichi F, Tamura Y, Lal A
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 669 Pages: 163-166

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual oscillator model of the respiratory neuronal network generating quantal slowing of respiratory rhythm2010

    • Author(s)
      Lal A, Oku Y, H ulsm ann S, Okada Y, Miwakeichi F, Kawai S, Tamura Y, Ishiguro M
    • Journal Title

      Journal of Computational Neuroscience

      Volume: (Epub)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRP channels are involved in mediating hypercapnic Ca2+ responses in rat glia-rich medullary cultures independently of extracellular pH2010

    • Author(s)
      Hirata Y, Oku Y
    • Journal Title

      Cell Calcium

      Volume: (Epub)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesicular glutamate transporter 2-immunoreactive synapses onto phrenic motoneurons in the neonatal rat2010

    • Author(s)
      Yokota S, Shinozaki Y, Oku Y, Okada Y, Yasui Y
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 669 Pages: 189-192

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical changes of phrenic motoneurons during development2010

    • Author(s)
      Okada Y, Yokota S, Shinozaki Y, Miwakeichi F, Oku Y, Yasui Y
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 669 Pages: 33-36

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] What does the multi-peaked respiratory output pattern tell us about the respiratory pattern generating neuronal network?2010

    • Author(s)
      Ishiguro M, Kawai S, Okada Y, Oku Y, Miwakeichi F, Tamura Y, Lal A.
    • Journal Title

      Advances in Ekperimental Medicine and Biology 669

      Pages: 235-238

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesicular glutamate transporter 2-immunoreactive synapses onto phrenic motoneurons in the neonatal rat.2010

    • Author(s)
      Yokota S, Shinozaki Y, Oku Y, Okada Y, Yasui Y.
    • Journal Title

      Advances in Experimental Medicine and Biology 669

      Pages: 189-192

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical changes of phrenic motoneurons during development.2010

    • Author(s)
      Okada Y, Yokota S, Shinozaki Y, Miwakeichi F, Oku Y, Yasui Y.
    • Journal Title

      Advances in Experimental Medicine and Biology 669

      Pages: 33-36

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel statistical analysis of voltage-imaging data by structural time series modeling and its application to the respiratory neuronal network.2009

    • Author(s)
      Kawai S, Oku Y, Okada Y, Miwakeichi F, Tamura Y, Ishiguro M
    • Journal Title

      Neuroscience Research 63

      Pages: 165-171

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical architecture and responses to acidosis of a novel respiratory neuron group in the high cervical spinal cord (HCRG) of the neonatal rat.2009

    • Author(s)
      Okada Y, Yokota S, Shinozaki Y, Aoyama R, Yasui Y, Ishiguro M, Oku Y
    • Journal Title

      Advances in Experimental Medicine and Biology 648

      Pages: 387-394

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhomogeneous distribution of action potential characteristics in the rabbit sino-atrial node revealed by voltage imaging.2009

    • Author(s)
      Masumiya H, Oku Y, Okada Y.
    • Journal Title

      Journal of Physiological Sciences 59

      Pages: 227-241

    • NAID

      10025218875

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] What does the multi-peaked respiratory output pattern tell us about the respiratory pattern generating neuronal network?2009

    • Author(s)
      Ishiguro M, Kawai S, Okada Y, Oku Y, Miwakeichi F, Tamura Y, Lal A.
    • Journal Title

      Advances in Experimental Medicine and Biology 669

      Pages: 235-238

    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The central respiratory chemoreceptor : Where is it located?2009

    • Author(s)
      Okada Y, Kuwana S, Chen Z, Ishiguro M, Oku Y.
    • Journal Title

      Advances in Experimental Medicine and Biology 648

      Pages: 377-385

    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] 呼吸中枢2009

    • Author(s)
      岡田泰昌
    • Journal Title

      慶應医学 85

      Pages: 159-168

    • NAID

      120002469908

    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Fluorescence imaging of active respiratory networks2009

    • Author(s)
      Ruangkittisakua A, Okada Y, Oku Y, Koshiya N, Ballanyi K
    • Journal Title

      Respiration Physiology & Neurobiology 168

      Pages: 26-38

    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A novel statistical analysis of voltage-imaging data by structural time series modeling and its application to the respiratory neuronal network2009

    • Author(s)
      Kawai S, Oku Y, Okada Y, Miwakeichi F, Tamura Y, Ishiguro M
    • Journal Title

      Neuroscience Research 63

      Pages: 165-171

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Anatomical changes of phrenic motoneurons during development2009

    • Author(s)
      Okada Y, Yokota S, Shinozaki Y, Miwakeichi F, Oku Y, Yasui Y.
    • Journal Title

      Advances in Experimental Medicine and Biology 669

      Pages: 33-36

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Anatomical architecture and responses to acidosis of a novel respiratory neuron group in the high cervical spinal cord(HCRG)of the neonatal rat.2009

    • Author(s)
      Okada Y, Yokota S, Shinozaki Y, Aoyama R, Yasui Y, Ishiguro M, Oku Y.
    • Journal Title

      Advances in Experimental Medicine and Biology 648

      Pages: 387-394

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel statistical analysis of voltage-imaging data by structural time series modeling and its application to the respiratory neuronal network.2009

    • Author(s)
      Kawai S, Oku Y, Okada Y, Miwakeichi F, Tamura Y, Ishiguro M.
    • Journal Title

      Neuroscience Research 63

      Pages: 165-171

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 呼吸中枢.2009

    • Author(s)
      岡田泰昌.
    • Journal Title

      慶應医学 85

      Pages: 159-168

    • NAID

      120002469908

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence imaging of active respiratory networks.2009

    • Author(s)
      Ruangkittisakua A, Okada Y, Oku Y, Koshiya N, Ballanyi K
    • Journal Title

      Respiration Physiology & Neurobiology 168

      Pages: 26-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parametric modeling analysis of optical imaging data on neuronal activities in the brain.2009

    • Author(s)
      Kawai S, Oku Y, Okada Y Miwakeichi F, Ishiguro M, Tamura Y.
    • Journal Title

      Optimization and Its Applications. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel statistical analysis of voltage-imaging data by structural time series modeling and its application to the respiratory neuronal network.2009

    • Author(s)
      Kawai S, Oku Y, Okada Y, Miwakeichi F, Tamura, Ishiguro M.
    • Journal Title

      Neuroscience Research 63

      Pages: 165-171

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hodgkin-Huxleyモデルにおけるパラメータと外部入力電流の同時推定2008

    • Author(s)
      川合成治,石黒真木夫,越久仁敬
    • Journal Title

      計測自動制御学会論文集 Vol.44 No.10

      Pages: 838-845

    • NAID

      10024390529

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 確率過程としてみたHodgkin-Huxleyモデルの統計的推定方法2008

    • Author(s)
      川合成治,石黒真木夫
    • Journal Title

      物性研究 91

      Pages: 160-167

    • Related Report
      2010 Final Research Report
  • [Journal Article] Hodgkin-Huxleyモデルにおけるパラメータと外部入力電流の同時推定2008

    • Author(s)
      川合成治, 石黒真木夫, 越久仁敬
    • Journal Title

      計測自動制御学会論文集 Vol. 44, No. 10

      Pages: 838-845

    • NAID

      10024390529

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 確率過程としてみたHodgkin-Huxleyモデルの統計的推定方法2008

    • Author(s)
      川合成治, 石黒真木夫
    • Journal Title

      物性研究 Vol. 91

      Pages: 160-167

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Anatomical architecture and responses to acidosis of a novel respiratory neuron group in the high cervical spinal cord (HCRG) of the neonatal rat2007

    • Author(s)
      Okada Y, Yokota S, Shinozaki Y, Aoyama R, Yasui Y, Ishiguro M. Oku Y
    • Journal Title

      Advances in Experimental Medicine and Biology 648

      Pages: 387-394

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Presentation] 脳・神経データの時空間解析2010

    • Author(s)
      三分一史和
    • Organizer
      神経科学と統計科学の対話
    • Place of Presentation
      統計数理研究所
    • Year and Date
      2010-12-19
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] A standardization method of voltage-imaging data that enables to average and compare spatio-temporal neuronal activities obtained from different samples2010

    • Author(s)
      Fujiki Y, Yokota S, Okada Y, Oku Y, Miwakeichi F, Tamura Y, Ishiguro M
    • Organizer
      Neuro2010
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Advances in analyses of spatiotemporal respiratory network activities using voltage-sensitive dyes.2009

    • Author(s)
      Oku, Yoshitaka
    • Organizer
      XXXVIth International Congress of Physiological Sciences(IUPS2009)
    • Place of Presentation
      Kyoto, Japan.
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spatiotemporal activity of respiratory neurons in the cervical spinal cord at the level of the phrenic nucleus in neonatal rats2009

    • Author(s)
      Shinozaki Y, Miwakeichi F, Yokota S, Aoyama R, Oku Y, Okada Y.
    • Organizer
      The 11th Oxford Conference on Modeling and Control of Breathing.
    • Place of Presentation
      Nara, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Anatomical and functional correlates between phrenic and scalene motoneurons in the cervical spinal cord of neonatal rats.2009

    • Author(s)
      Yokota S, Shinozaki Y, Oku Y, Okada Y, Yasui Y.
    • Organizer
      The 11th Oxford Conference on Modeling and Control of Breathing.
    • Place of Presentation
      Nara, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] What does the multi-peaked respiratory output pattern tell us about the respiratory pattern generating neuronal network?2009

    • Author(s)
      Ishiguro M, Kawai S, Okada Y, Oku Y, Miwakeichi F, Tamura Y, Lal A
    • Organizer
      The 11th Oxford Conference on Modeling and Control of Breathing.
    • Place of Presentation
      Nara, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Non-deterministic breakdown of the preBotzinger complex neuronal synchronicity may lead to quantal slowing of respiratory rhythm.2009

    • Author(s)
      Lal A, Oku Y, Hlsmann S, Okada Y, Miwakeichi F, Kawai S, Tamura Y, Ishiguro M
    • Organizer
      XXXVIth International Union of Physiological Sciences (IUPS2009).
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Localization and mechanisms of central chemoreception. Symposium." Chemical Control of Breathing : Molecular and Systemic Mechanisms and Effects2009

    • Author(s)
      Okada Y, Kuwana S, Yokota S, Chen Z, Oku Y.
    • Organizer
      XXXVIth International Union of Physiological Sciences (IUPS2009).
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Advances in analyses of spatiotemporal respiratory network activities using voltage-sensitive dyes.2009

    • Author(s)
      Oku Y.
    • Organizer
      XXXVIth International Union of Physiological Sciences (IUPS2009).
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 頚髄呼吸関連運動ニューロンにおける自発呼吸神経活動時空間動態の高速膜電位イメージング解析)2009

    • Author(s)
      Shinozaki Y, Yokota S, Miwakeichi F, Aoyama R, Oku Y, Okada Y
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Spatio-temporal innovation approach for the analysis of optical voltage-imaging data2009

    • Author(s)
      Miwakeichi F, Oku Y, Okada Y, Kawai S, Tamura, Y, Ishiguro M
    • Organizer
      XXIV annual meeting Federation of Society of Experimental Biology
    • Place of Presentation
      guas de Lindia, So Paulo, Brazil
    • Related Report
      2010 Final Research Report
  • [Presentation] Spatiotemporal activity of respiratory neurons in the cervical spinal cord at the level of the phrenic nucleus in neonatal rats2009

    • Author(s)
      Shinozaki Y, Miwakeichi F, Yokota S, Aoyama R, Oku Y, Okada Y.
    • Organizer
      The 11th Oxford Conference on Modeling and Control of Breathing
    • Place of Presentation
      Nara, Japan.
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] What does the multi-peaked respiratory output pattern tell us about the respiratory pattern generating neuronal network?2009

    • Author(s)
      Ishiguro M, Kawai S, Okada Y, Oku Y, Miwakeichi F, Tamura Y, Lal A
    • Organizer
      The 11th Oxford Conference on Modeling and Control of Breathing
    • Place of Presentation
      Nara, Japan
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Non-deterministic breakdown of the preBotzinger complex neuronal synchronicity may lead to quantal slowing of respiratory rhythm2009

    • Author(s)
      Lal A, Oku Y, Hulsmann S, Okada Y, Miwakeichi F. Kawai S, Tamura Y. Ishiguro M
    • Organizer
      XXXVIth International Union of Physiological Sciences (IUPS2009)
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Localization and mechanisms of central chemoreception. Symposium. "Chemical Control of Breathing : Molecular and Systemic Mechanisms and Effects"2009

    • Author(s)
      Okada Y, Kuwana S, Yokota S, Chen Z, Oku Y.
    • Organizer
      XXXVIth International Union of Physiological Sciences (IUPS2009).
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Advances in analyses of spatiotemporal respiratory network activities using voltage-sensitive dyes2009

    • Author(s)
      Oku Y.
    • Organizer
      XXXVIth International Union of Physiological Sciences (IUPS2009)
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 頚髄呼吸関連運動ニューロンにおける自発呼吸神経活動時空間動態の高速膜電位イメージング解析2009

    • Author(s)
      Shinozaki Y, Yokota S, Miwakeichi F, Aoyama R, Oku Y, Okada Y.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Spatio-temporal innovation approach for the analysis of optical voltage-imaging data2009

    • Author(s)
      Miwakeichi F., Oku Y., Okada Y., Kawai S., Tamura, Y., Ishiguro M.
    • Organizer
      XXIV annual meeting Federation of Society of Experimental Biology
    • Place of Presentation
      Aguas de Lindoia, Sao Paulo, Brazil
    • Related Report
      2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] Spatiotemporal activity of respiratory neurons in the cervical spinal cord at the level of the phrenic nucleus in neonatal rats.2009

    • Author(s)
      Shinozaki Y, Miwakeichi F, Yokota S, Aoyama R, Oku Y, Okada Y.
    • Organizer
      The 11th Oxford Conference on Modeling and Control of Breathing.
    • Place of Presentation
      Nara, Japan.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Anatomical and functional correlates between phrenic and scalene motoneurons in the cervical spinal cord of neonatal rats.2009

    • Author(s)
      Yokota S, Shinozaki Y, Oku Y, Okada Y, Yasui Y.
    • Organizer
      The 11th Oxford Conference on Modeling and Control of Breathing.
    • Place of Presentation
      Nara, Japan.
    • Related Report
      2009 Annual Research Report
  • [Presentation] What does the multi-peaked respiratory output pattern tell us about the respiratory pattern generating neuronal network?2009

    • Author(s)
      Ishiguro M, Kawai S, Okada Y, Oku Y, Miwakeichi F, Tamura Y, Lal A.
    • Organizer
      The 11th Oxford Conference on Modeling and Control of Breathing.
    • Place of Presentation
      Nara, Japan.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Non-deterministic breakdown of the preBotzinger complex neuronal synchronicity may lead to quantal slowing of respiratory rhythm.2009

    • Author(s)
      Lal A, Oku Y, Hulsmann S, Okada Y, Miwakeichi F, Kawai S, Tamura Y, Ishiguro M.
    • Organizer
      XXXVIth International Union of Physiological Sciences(IUPS2009)
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Localization and mechanisms of central chemoreception. Symposium."Chemical Control of Breathing : Molecular and Systemic Mechanisms and Effects"2009

    • Author(s)
      Okada Y, Kuwana S, Yokota S, Chen Z, Oku Y.
    • Organizer
      XXXVIth International Union of Physiological Sciences(IUPS2009)
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spatiotemporal activity profile of respiratory-related motoneuron population analyzed by voltage-imaging in the cervical spine of the neonatal rat.(頚髄呼吸関連運動ニューロンにおける自発呼吸神経活動時空間動態の高速膜電位イメージング解析)2009

    • Author(s)
      Shinozaki Y, Yokota S, Miwakeichi F, Aoyama R, Oku Y, Okada Y.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] Desynchronization of bursting neurons in the preBotzinger complex may produce quantal slowing of the respiratory rhythm2008

    • Author(s)
      Lal A., Oku Y., Fresemann J., Hulsmann S., Okada, Y., Miwakeichi F, Kawai S., Tamura Y., Ishiguro, M.
    • Organizer
      The International Discussion Forum & the 242nd Tokyo Discussion Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-10-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Parametric modeling approach to optical imaging data finds close input output relation between the central neuronal activity and the respiratory motor output2008

    • Author(s)
      Kawai S, Oku Y, Okada Y, Miwakeichi F, Ishiguro M, Tamura Y
    • Organizer
      Computational Neuroscience 2008
    • Place of Presentation
      Florida
    • Year and Date
      2008-02-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Parametric modeling approach to optical imaging data finds close input output relation between the central neuronal activity and the respiratory motor output2008

    • Author(s)
      Shigeharu Kawai, Yositaka Oku Yasumasa Okada, Fumikazu Miwakeichi, Makio Ishiguro, and Yoshiyasu Tamura
    • Organizer
      Computational Neuroscience 2008
    • Place of Presentation
      University of Florida
    • Year and Date
      2008-02-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Innovation approach to detect the respiratory related neuronal activity in the brainstem based on optical imaging data2008

    • Author(s)
      Miwakeichi ,F., Oku Y., Okada, Y., Kawai S., Tamura Y., Ishiguro, M.
    • Organizer
      14th Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2010 Final Research Report
  • [Presentation] 呼吸ニューロンネットワークの光学的イメージングデータ時系列の統計数理学的解析とシミュレーション2008

    • Author(s)
      越久仁敬
    • Organizer
      第48回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Autoregressive and parametric modeling approaches to optical imaging data characterize the dynamic process of the respiratory central pattern generator in the neonatal rat brainstem2008

    • Author(s)
      Oku Y., Miwakeichi, F., Kawai S., Okada, Y., Ishiguro, M, Tamura Y.
    • Organizer
      6th Forum of European Neuroscience
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Assumption free and structural methods that characterize dynamics of optically recorded respiratory neuronal activity without averaging2008

    • Author(s)
      Oku Y., Miwakeichi, F., Kawai S., Okada, Y. Tamura Y., Ishiguro M.
    • Organizer
      International Symposium on Respiratory Control
    • Place of Presentation
      St.Maxmin, France
    • Related Report
      2010 Final Research Report
  • [Presentation] Innovation approach to detect the respiratory related neuronal activity in the brainstem based on optical imaging data2008

    • Author(s)
      Miwakeichi, F., Oku, Y., Okada, Y., Kawai, S., Tamura, Y., Ishiguro, M.
    • Organizer
      14th Annual Meeting of the Organization for Human Bram Mapping
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2008 Annual Research Report
  • [Presentation] Assumption free and structural methods that characterize dynamics of optically recorded respiratory neuronal activity without averaging2008

    • Author(s)
      Oku, Y., Miwakeichi, F., Kawai, S., Okada, Y, Tamura, Y., Ishiguro, M.
    • Organizer
      International Symposium on Respiratory Control
    • Place of Presentation
      St. Maximin, France.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hodgkin-Huxleyモデルにおけるモデルパラメータと外部入力電流の同時推定2007

    • Author(s)
      川合成治,石黒真木夫
    • Organizer
      統計数理研究所研究会「非線形科学と統計科学の対話」
    • Place of Presentation
      東京
    • Year and Date
      2007-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Hodgkin-Huxleyモデルにおけるモデルパラメータと外部入力電流の同時推定2007

    • Author(s)
      川合成治, 石黒真木夫
    • Organizer
      統計数理研究所研究会「非線形科学と統計科学の対話」
    • Place of Presentation
      統計数理研究所
    • Year and Date
      2007-11-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hodgkin-HuxleyモデルにおけるKalman filterの適用と入力電流・パラメータの推定2007

    • Author(s)
      川合成治,石黒真木夫
    • Organizer
      第50回自動制御連合講演会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Hodgkin-HuxleyモデルにおけるKalman filterの適用と入力電流・パラメータの推定2007

    • Author(s)
      川合成治, 石黒真木夫
    • Organizer
      第50回 自動制御連合講演会
    • Place of Presentation
      慶応大学
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] The simultaneous estimations of the trend input current and the model parameters in the Hodgkin-Huxley model2007

    • Author(s)
      Kawai S, Ishiguro M
    • Organizer
      39th ISCIE International Symposium on Stochastic Systems Theory and Its Applications
    • Place of Presentation
      Saga, Japan
    • Year and Date
      2007-11-08
    • Related Report
      2010 Final Research Report
  • [Presentation] The simultaneous estimations of the trend input current and the model parameters in the Hodgkin-Huxley model2007

    • Author(s)
      Shigeharu Kawai and Makio Ishiguro
    • Organizer
      39th ISCIE International Symposium on Stochastic Systems Theory and Its Applications
    • Place of Presentation
      Sage University
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hodgkin-Huxleyモデルの統計的パラメータ推定2007

    • Author(s)
      川合成治,石黒真木夫
    • Organizer
      2007年度統計関連学会連合大会
    • Place of Presentation
      神戸
    • Year and Date
      2007-09-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Hodgkin-Huxleyモデルの統計的パラメータ推定2007

    • Author(s)
      川合成治, 石黒真木夫
    • Organizer
      2007年度統計関連学会連合大会
    • Place of Presentation
      神戸大学
    • Year and Date
      2007-09-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経モデルの離散化と状態推定2007

    • Author(s)
      川合成治,石黒真木夫
    • Organizer
      第51回システム制御情報学会研究発表講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経モデルの離散化と状態推定2007

    • Author(s)
      川合成治, 石黒真木夫
    • Organizer
      第51回システム制御情報学会研究発表講演会
    • Place of Presentation
      京都テレサ
    • Year and Date
      2007-05-18
    • Related Report
      2007 Annual Research Report
  • [Book] Computational Neuroscience(Parametric modeling analysis of optical imaging data on neuronal activities in the brain.)2010

    • Author(s)
      Kawai S, Oku Y, Miwakeichi F, Miwakeichi F, Ishiguro M, Tamura Y.
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Parametric modeling analysis of optical imaging data on neuronal activities in the brain., in Springer Optimization and Its Applications Vol.38, Chaovalitwongse, W.A., Pardalos, P., Xanthopoulos, P.(Eds.)2010

    • Author(s)
      Kawai S, Oku Y, Okada Y, Miwakeichi F, Ishiguro M, Tamura Y
    • Publisher
      Springer, New York
    • Related Report
      2010 Annual Research Report
  • [Book] Parametric modeling analysis of optical imaging data on neuronal activities in the brain. in Computational Neuroscience2010

    • Author(s)
      Kawai S, Oku Y, Okada Y, Miwakeichi F, Ishiguro M, Tamura Y.
    • Publisher
      Springer
    • Related Report
      2009 Self-evaluation Report
  • [Book] Parametric modeling analysis of optical imaging data on neuronal activities in the brain.

    • Author(s)
      Kawai S, Oku Y, Okada Y, Miwakeichi F, Ishiguro M, Tamura Y.
    • Publisher
      In Computational Neuroscience(Springer Optimization and Its Applications)(edited by Wanpracha Chaovalitwongse, Panos Pardalos, Petros Xanthopoulos)Springer(in press)(掲載確定)
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] イメージングデータからの状態変化抽出方法,状態変化の可視化システム,および,コンピュータプログラム2008

    • Inventor(s)
      三分一史和,越久仁敬,岡田泰昌,石黒真木夫,田村義保,川合成治
    • Industrial Property Rights Holder
      情報・システム研究機構 千葉大学 兵庫医科大学 学校法人慶応義塾
    • Industrial Property Number
      2008-125453
    • Filing Date
      2008-05-13
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] イメージングデータからの状態変化検出方法、状態変化の可視化システム、および、コンピュータプログラム2008

    • Inventor(s)
      三分一史和, 越久仁敬, 岡田泰昌, 石黒真木夫, 田村義保, 川合成治
    • Industrial Property Number
      2008-125453
    • Filing Date
      2008-05-13
    • Related Report
      2009 Self-evaluation Report 2008 Annual Research Report

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Published: 2007-04-01   Modified: 2024-01-24  

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