| Project/Area Number |
19200023
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
MURATA Satoshi Tokyo Institute of Technology, 大学院・総合理工学研究科, 准教授 (10334533)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Kenzo 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 教授 (90293894)
FUJII Teruo 東京大学, 生産技術研究所, 教授 (30251474)
NOJIMA Takahiko 東京大学, 生産技術研究所, 助教 (00291930)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥47,450,000 (Direct Cost: ¥36,500,000、Indirect Cost: ¥10,950,000)
Fiscal Year 2009: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2008: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2007: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
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| Keywords | DNAコンピュータ / マイクロ・ナノデバイス / 高精度セルフアセンブリ / 自己組織化 |
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| Research Abstract |
In this project, aiming at realization of high-precision molecular computing, we have investigated several aspects of molecular computing system based on algorithmic self-assembly of DNA tile. 1) A simulation model capable to explain details of self-assembly process of DNA tile has been developed. 2) We found a new phenomenon called substrate-assisted self-assembly, which enables us to make a large 2D crystal on substrate surface with less error compared with conventional assembly method in free solution. We have succeeded in algorithmic self-assembly using two types of T-motif tile and applied it to fabrication of protein array. Artificial base called C^<NVK> is developed, and its usefulness to stabilize DNA nanostructures and to extend the varieties of DNA nanostructure is verified. Stepwise DNA self-assembly by using micro-fluidic device is also developed, and feasibility of bulk evaluation of DNA tile nanostructure with fluorescent measurement has been shown by the method.
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