| Budget Amount *help |
¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2007: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
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| Research Abstract |
We used primary neuronal cell culture and knockout mice, and showed that the expression levels of spinal actin-binding proteins are related to the synaptic function, such as synaptic strength and plasticity. Then we analyzed the dynamics of spinal accumulation of actin-binding proteins, and found that glutamatergic fibers regulate the accumulation bi-directionally using two subtypes of glutamate receptors.
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