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Neurochemical studies on molecules involved in social recognition and research on genes and therapy in autism.

Research Project

Project/Area Number 19200030
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKanazawa University

Principal Investigator

HIGASHIDA Haruhiro  Kanazawa University, 医学系, 教授 (30093066)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Shigeru  金沢大学, 医学系, 准教授 (00210633)
HASHII Minako  金沢大学, 医学系, 講師 (10272957)
KOIZUMI Keita  金沢大学, 子どものこころの発達研究センター, 特任准教授 (70377406)
MUNESUE Toshio  金沢大学, 子どものこころの発達研究センター, 特任准教授 (50293353)
KIKUCHI Mituru  金沢大学, 医学系, 特任助教 (00377384)
MINABE Yoshio  金沢大学, 医学系, 教授 (60181947)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥47,190,000 (Direct Cost: ¥36,300,000、Indirect Cost: ¥10,890,000)
Fiscal Year 2009: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2008: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2007: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Keywords脳・神経 / シグナル伝達 / ADP リボシルシクラーゼ / CD38 / 自閉症 / ADPリボシルシクラーゼ / NAD
Research Abstract

オキシトシンは信頼を基礎とする社会性行動に影響を与える。オキシトシンの脳内分泌を制御するCD38遺伝子の一塩基多型(SNP)を日本人およびアメリカ人の広汎性発達障害者や健常人で調査した。2箇所のSNPが自閉症の危険因子である可能性を見いだした。また、一例で、オキシトシンの投与により一部の症状の改善が見られた。CD38は良い対人関係を構築するのに必須で、一方その不全が社会性障害の原因ではないかと思われる。

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (53 results)

All 2010 2009 2008 2007 Other

All Journal Article (31 results) (of which Peer Reviewed: 31 results) Presentation (14 results) Book (2 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls2010

    • Author(s)
      Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AAMunesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K
    • Journal Title

      Neurosci. Res. 67

      Pages: 181-191

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular Calcium Elevation Induced by Extracellular Application of Cyclic-ADP-Ribose or Oxytocin is Temperature-Sensitive in Rodent NG108-15 Neuronal Cells with or without Exogenous Expression of Human Oxytocin Receptors2010

    • Author(s)
      Amina S, Hashii M, Ma WJ, Yokoyama S, Lopatina O, Liu HX, Islam MS, Higashida H.
    • Journal Title

      J Neuroendocrinol 22

      Pages: 460-466

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a Rho Guanine Nucleotide Exchange Factor, Ect2, in the Developing Mouse Pituitary2010

    • Author(s)
      Islam MS, Tsuji T, Higashida C, Takahashi M, Higashida H, Koizumi K.
    • Journal Title

      J Neuroendocrinol 22

      Pages: 477-482

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD38/cADPR-SYSTEM: A NEW PLAYER FOR OXYTOCIN SECRETION AND REGULATION OF SOCIAL BEHAVIOUR2010

    • Author(s)
      Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H.
    • Journal Title

      J Neuroendocrinol 22

      Pages: 380-392

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin Signal and Social Behaviour: Comparison among Adult and Infant Oxytocin, Oxytocin Receptor and CD38 Gene Knockout Mice2010

    • Author(s)
      Higashida H, Lopatina O, Yoshihara T, Pichugina YA, Soumarokov AA, Munesue T, Minabe Y, Kikuchi M, Ono Y, Korshunova N, Salmina AB.
    • Journal Title

      J Neuroendocrinol 22

      Pages: 373-379

    • NAID

      120002561624

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci. Res.2010

    • Author(s)
      Munesue T., et al.
    • Journal Title

      Neurosci.Res. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trafficking-Competent KCNQ1 Variably Influences the Function of HERG Long QT Alleles2010

    • Author(s)
      Hayashi K, Shuai W, Sakamoto Y, Higashida H, Yamagishi M, Kupershmidt S.
    • Journal Title

      Heart Rhythm (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular Calcium Elevation Induced by Extracellular Application of Cyclic-ADP-Ribose or Oxytocin is Temperature-Sensitive in Rodent NG108-15 Neuronal Cells with or without Exogenous Expression of Human Oxytocin Receptors2010

    • Author(s)
      Amina S, Hashii M, Ma WJ, Yokoyama S, Lopatina O, Liu HX, Islam MS, Higashida H.
    • Journal Title

      J Neuroendocrinol (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a Rho Guanine Nucleotide Exchange Factor, Ect2, in the Developing Mouse Pituitary2010

    • Author(s)
      Islam MS, Tsuji T, Higashida C, Takahashi M, Higashida H, Koizumi K.
    • Journal Title

      J Neuroendocrinol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD38/cADPR-SYSTEM : A NEW PLAYER FOR OXYTOCIN SECRETION AND REGULATION OF SOCIAL BEHAVIOUR2010

    • Author(s)
      Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H.
    • Journal Title

      J Neuroendocrinol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin Signal and Social Behaviour Comparison among Adult and Infant Oxytocin, Oxytocin Receptor and CD38 Gene Knockout Mice2010

    • Author(s)
      Higashida H, Lopatina O, Yoshihara T, Pichugina YA, Soumarokov AA, Munesue T, Minabe Y, Kikuchi M, Ono Y, Korshunova N, Salmina AB.
    • Journal Title

      J Neuroendocrinol. (in press)

    • NAID

      120002561624

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose or Ca(2+) concentrations is involved in autoregulation of oxytocin secretion in the hypothalamus and posterior pituitary in male mice2009

    • Author(s)
      Lopatina O, Liu HX, Amina S, Hashii M, Higashida H.
    • Journal Title

      Neuropharmacology 58

      Pages: 50-55

    • NAID

      120001451026

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long QT syndrome and associated gene mutation carriers in Japanese children : results from ECG screening examinations2009

    • Author(s)
      Hayashi K, Fujino N, Uchiyama K, Ino H, Sakata K, Konno T, Masuta E, Funada A, Sakamoto Y, Tsubokawa T, Nakashima K, Liu L, Higashida H, Hiramaru Y, Shimizu M, Yamagishi M.
    • Journal Title

      Clin Sci (Lond) 117

      Pages: 415-424

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice2008

    • Author(s)
      Liu HX, Lopatina O, Higashida C, Tsuji T, Kato I, Takasawa S, Okamoto H, Yokoyama S, Higashida H.
    • Journal Title

      Neurosci Lett. 448

      Pages: 67-70

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism2008

    • Author(s)
      Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N, Yoshikawa T, Mori N.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 147B

      Pages: 1019-1027

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice.2008

    • Author(s)
      Liu HX, Lopatina 0, ……Y okoyama S, Higashida H., 他5名
    • Journal Title

      Neurosci Lett. 448

      Pages: 67-70

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.2008

    • Author(s)
      Anitha A, Nakamura K, ……Koizumi K, Higashida H, ……Mori N., 他19名
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B

      Pages: 1019-1027

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of 4", 6"-unsaturated cyclic ADP-carbocyclic ribose as a Ca^<2+> -mobilizing agent.2008

    • Author(s)
      Kudou, T., Weber, K., ……Hashii, M., Higashida, H., ……Shuto, S., 他4名
    • Journal Title

      Tetrahedron Letters 49

      Pages: 3976-3979

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of 4", 6"-unsaturated cyclic ADP-carbocyclic-ribose, a Ca^<2+> -mobilizing agent selectively active in T cells.2008

    • Author(s)
      Kudou, T., Murakami, T., Hashii, M., Higashida, H., ……Shuto, S., 他8名
    • Journal Title

      Tetrahedron. 64

      Pages: 9754-9765

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.2007

    • Author(s)
      Higashida H, Salmina AB, Olovyannikova RY, Hashii M, Yokoyama S, Koizumi K, Jin D, Liu HX, Lopatina O, Amina S, Islam MS, Huang JJ, Noda M.
    • Journal Title

      Neurochem Int. 51

      Pages: 192-199

    • NAID

      120001141007

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RNA interference screen to identify genes required for Drosophila embryonic nervous system development2007

    • Author(s)
      Koizumi K, Higashida H, Yoo S, Islam MS, Ivanov AI, Guo V, Pozzi P, Yu SH, Rovescalli AC, Tang D, Nirenberg M.
    • Journal Title

      Proc Natl Acad Sci U S A. 104

      Pages: 5626-5631

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD38 is critical for social behaviour by regulating oxytocin secretion2007

    • Author(s)
      Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, OkaJin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M
    • Journal Title

      Nature 446

      Pages: 41-45

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca(2+) signalling in rodent NG108-15 neuroblastoma cells2007

    • Author(s)
      Higashida H, Bowden SE, Yokoyama S, Salmina A, Hashii M, Hoshi N, Zhang JS, Knijnik R, Noda M, Zhong ZG, Jin D, Higashida K, Takeda H, Akita T, Kuba K, Yamagishi S, Shimizu N, Takasawa S, Okamoto H, Robbins J.
    • Journal Title

      Neurosci Res. 57

      Pages: 339-346

    • NAID

      10024413034

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila2007

    • Author(s)
      Kuraishi T, Manaka J, Kono M, Ishii H, Yamamoto N, Koizumi K, Shiratsuchi A, Lee BL, Higashida H, Nakanishi Y.
    • Journal Title

      Exp Cell Res. 313

      Pages: 500-510

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD38 is critical for social behaviolour by regulating oxytocin secretion2007

    • Author(s)
      Jin, D., LIU, HX., ……YokoYama, S., Koizumi, K, …Hashii, M., ……Munesue, T., ……Higashida, H. (他24名)
    • Journal Title

      Nature 446

      Pages: 41-45

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA interference screen to identify genes required for Drosophia embryonic nervouS system developmnent.2007

    • Author(s)
      Koizumi K, Higashida, ……Nirenberg M. (他8名)
    • Journal Title

      Proc Natl Acad Sci U S A 104

      Pages: 5626-5631

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca(2+)signanillg in rodent NG108-15 neuroblastoma cells.2007

    • Author(s)
      Higashida H, ……Yokoyama S, ……Hashii M, (他17名)
    • Journal Title

      Neurosci Res. 57

      Pages: 339-346

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cychc ADP-ribose as a universal calcium signal molecule in tthe nervous system.2007

    • Author(s)
      Higashida H, ……Hashii M, Yokoyamas, Koizumi K, (他9名)
    • Journal Title

      Neurochem Int. 51

      Pages: 192-199

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of calreticulin as a marker for phagocytosis of apoptoti cells in Drosophila.2007

    • Author(s)
      Kuraishi T, ……Koiaumi K, ……Higashida H,. (他6名)
    • Journal Title

      Exp Cell Res. 313

      Pages: 500-510

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [Biological basis for social recognition: CD38 controls oxytocin secretion]2007

    • Author(s)
      Higashida H.
    • Journal Title

      Tanpakushitsu Kakusan Koso. Review. Japanese. 52

      Pages: 1832-1839

    • NAID

      40015676748

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased ADP-ribosyl cyclase activity in peripheral blood mononuclear cells from diabetic patients with nephropathy

    • Author(s)
      Ohtsuji M, Yagi K, Shintaku-Kubota M, Kojima-Koba Y, Ito N, Sugihara M, Yamaaki N, Chujo D, Nohara A, Takeda Y, Kobayashi J, Yamagishi M, Higashida H.
    • Journal Title

      Exp Diabetes Res

    • NAID

      120001491366

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 仔どもから大人までのマウスの社会認識行動と血清オキシトシン濃度は視床下部のCD38/ADP-リボース環状化酵素により制御される2009

    • Author(s)
      東田陽博
    • Organizer
      第32回日本神経科学会大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 仔どもから大人までのマウスの社会認識行動と血清オキシトシン濃度は視床下部のCD38/ADP-リボース環状化酵素により制御される2009

    • Author(s)
      東田陽博
    • Organizer
      第32回日本神経科学会大会
    • Place of Presentation
      名古屋国際会議場 (愛知)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD38は視床下部のオキシトシン分泌を介して、社会認識行動に関与する2009

    • Author(s)
      東田陽博
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-03-16
    • Related Report
      2009 Final Research Report
  • [Presentation] CD38は視床下部のオキシトシン分泌を介して、社会認識行動に関与する2009

    • Author(s)
      東田陽博
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      パシフイコ横浜
    • Year and Date
      2009-03-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Social and Autistic Beha vior Regulated by Oxytocin Release in a CD38, Cyclic ADP-ribose and Calcium-De pendent Fashion2008

    • Author(s)
      東田陽博
    • Organizer
      Korean Society of Medi cal Biochemistry and Molecuar Biology
    • Place of Presentation
      ホテルソウル教育文化会館(韓国)
    • Year and Date
      2008-10-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Social and Autistic Behavior Regulated by Oxytocin Release in a CD38, Cyclic ADP-ribose and Calcium-Dependent Fashion2008

    • Author(s)
      東田陽博
    • Organizer
      Korean Society of Medical Biochemistry and Molecuar Biology
    • Place of Presentation
      ホテルソウル教育文化会館(韓国)
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Social recognition, Oxyto cin, and CD382008

    • Author(s)
      東田陽博
    • Organizer
      World Congress on Psychia tric Genetics
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2008-10-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Social recognition, Oxytocin, and CD382008

    • Author(s)
      東田陽博
    • Organizer
      World Congress on Psychiatric Genetics
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2008-10-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] CD38 and social brain : Autistic behavior regulated by oxytocin release in a cyclic ADP-ribose-depende nt fashion2008

    • Author(s)
      東田陽博
    • Organizer
      NAD2008
    • Place of Presentation
      Elsa-Brandstrom-Haus, Hamburg-ablanken ese, (ドイツ)
    • Year and Date
      2008-09-14
    • Related Report
      2009 Final Research Report
  • [Presentation] CD38:オキシトシン遊離調節による社会認識行動、社会認識、オキシトシンとCD382008

    • Author(s)
      東田陽博
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山国際会議場(富山県)
    • Related Report
      2009 Final Research Report
  • [Presentation] CD38 : オキシトシン遊離調節による社会認識行動社会認識、オキシトシンとCD382008

    • Author(s)
      東田陽博
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] CD38 and social brain : Autistic behavior regulated by oxytocin release in a cyclic ADP-ribose-dependent fashion2008

    • Author(s)
      東田陽博
    • Organizer
      NAD2008
    • Place of Presentation
      Elsa-Brandstrom-Haus, Hamburg-ablankenese, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] CD38-Dependent Oxytocin Release on Social and Parental Behavior2007

    • Author(s)
      東田陽博
    • Organizer
      PARENTAL BRAIN CONFERENCE
    • Place of Presentation
      Back Bay Hilton Hotel-Boston, Massachusetts(アメリカ)
    • Year and Date
      2007-06-08
    • Related Report
      2009 Final Research Report
  • [Presentation] CD38-Dependent Oxytocin Release on Socialand Parental Behavior.2007

    • Author(s)
      東田 陽博
    • Organizer
      PARENTAL BRAIN CONFERENCE
    • Place of Presentation
      Back Bay Hilton Hotel-Boston, Massachusetts
    • Year and Date
      2007-06-08
    • Related Report
      2007 Annual Research Report
  • [Book] Social memory, maternal care, and oxytocin secretion, but not vasopressin release2008

    • Author(s)
      Higashida H, Jin D, Liu H, Lopatina O, Yokoyama S, Koizumi K, Hashii M, Islam MS, Hayashi K, Munesue T., Academic Press, San Diego,Neurobiology of the Parental Brain, Bridges, R. S. ed.
    • Publisher
      Academic Press
    • Related Report
      2009 Final Research Report
  • [Book] Neurobiology of the Parental Brain, Bridges, R. S. ed.2008

    • Author(s)
      Higashida, H., …… Yokoyama, S., Koizumi, K., Hashii, M., …… Munesue, T., 他5名
    • Publisher
      Academic Press, San Diego
    • Related Report
      2008 Annual Research Report
  • [Remarks] 医学系研究科脳細胞遺伝子学研究分野

    • URL

      http://web.kanazawa-u.ac.jp/~med37/

    • Related Report
      2009 Final Research Report
  • [Remarks] 21世紀COE革新脳科学

    • URL

      http://web.kanazawa-u.ac.jp/~med63/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks] 子どものこころの発達研究センター

    • URL

      http://kodomokokoro.w3.kanazawa-u.ac.jp/

    • Related Report
      2009 Final Research Report
  • [Remarks] 連合大学院小児発達学研究科

    • URL

      http://rengou.w3.kanazawa-u.ac.jp/

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] CD38による自閉症の診断と治療2007

    • Inventor(s)
      東田陽博
    • Industrial Property Rights Holder
      金沢大学TLO
    • Filing Date
      2007-11-15
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] CD38による自閉症の診断と治療2007

    • Inventor(s)
      東田 陽博
    • Industrial Property Rights Holder
      金沢大学TLO
    • Filing Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
    • Overseas

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Published: 2007-04-01   Modified: 2016-04-21  

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