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Regulation of Stem Cells Gene Expression using Apatite nanocarriers coated with Cell-reconizable chimeric Protein.

Research Project

Project/Area Number 19200038
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Institute of Technology

Principal Investigator

AKAIKE Toshihiro  Tokyo Institute of Technology, フロンティア研究センター, 教授 (30101207)

Co-Investigator(Kenkyū-buntansha) 長岡 正人  東京工業大学, 大学院・生命理工学研究科, 特別研究員 (90397050)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2009: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2008: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2007: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Keywords薬物伝達システム再生医療 / 炭酸アパタイト / ナノキャリアー / 細胞認識性バイオマテリアル / ES細胞 / m / Si-RNAデリバリー / DNAデリバリー / GFP遺伝子 / フィブロネクチン / 制ガン剤、DDS / 糖鎖高分子 / 遺伝子デリバリー / プロテインデリバリー / E-カドヘリン-FCキメラタンパク質 / ナノキャリア / 細胞認識性 / バイオマテリアル
Research Abstract

Targeted genes and relatives DNA RNA protein and drug involved delivery has received much attention throughout the world. In this study, we show for the first time pH-sensitive delivery of gene and relatives based on biocompatible inorganic nanoparticles of carbonate apatite being highly stable at the typical physiological pH and quickly degradable at the typical pH of endosomal compartment. This nano sized (100-300nm) apatite-gene conjugates demonstrated huge uptake of drug to various cells as determined by Florescence microscopy and flow cytometry. The application of carbonate apatite nanocarriers systems to stem-cells (ES, EC Cells) are successfully done with aid of cell-recogonizable nano-biomaterials such as chimeric antibodies as well as sugar-carrying polymers design.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (64 results)

All 2010 2009 2008 2007 Other

All Journal Article (34 results) (of which Peer Reviewed: 34 results) Presentation (24 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] pH-sensitive carbonate apatite as an intracellular protein transporter2010

    • Author(s)
      Tada S, Chowdhury EH, Cho CS, Akaike T.
    • Journal Title

      Biomaterials 31

      Pages: 1453-1459

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influences of electrolytes and glucose on formulation of carbonate apatite nanocrystals for efficient gene delivery to mammalian cells2010

    • Author(s)
      Hossain S, Tada S, Akaike T, Chowdhury EH
    • Journal Title

      Anal. Biochem. 397

      Pages: 56-161

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An artificial extracellular matrix created by hepatocyte growth factor fused to IgG-Fc.2010

    • Author(s)
      Azuma K, Nagaoka M, Cho CS, Akaike T.
    • Journal Title

      Biomaterials 31

      Pages: 802-809

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influences of electrolytes and glucose on formulation of carbonate apatite nanocrystals for efficient gene delivery to mammalian cells.2010

    • Author(s)
      Hossain S, Tada S, Akaike T, Chowdhury EH.
    • Journal Title

      Anal. Biochem. 397

      Pages: 156-161

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of Recombinant Fusion Proteins for Tissue Engineering.2010

    • Author(s)
      Nagaoka M, Jiang HL, Hoshiba T., Akaike T., Cho CS.
    • Journal Title

      Annals of Biomedical Enginering 38

      Pages: 683-693

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] eprogramming of somatic cells induced by fusion of embryonic stem cells using hemagglutinating virus of Japan envelope (HVJ-E).2010

    • Author(s)
      Yue XS, Fujishiro M, Toyoda M, Akaike T, Ito Y
    • Journal Title

      Biochem Biophys Res Commun. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vimentin and desmin possess GlcNAc-binding lectin-like properties on cell surfaces.2010

    • Author(s)
      Ise H, Kobayashi S, Goto M, Sato T, Kawakubo M, Takahashi M, Ikeda U, Akaike T.
    • Journal Title

      Glycobiology 38(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disrupting actin filaments promotes efficient transfection of a leukemia cell line using cell adhesive protein-embedded carbonate apatite particles Anal2009

    • Author(s)
      K. Kutsuzawa, S. Tada, S. Hossain, K. Fukuda, K. Maruyama, Y. Akiyama, T. Akaike, E.H. Chowdhury
    • Journal Title

      Biochem. 388

      Pages: 164-166

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akaike High performance mRNA transfection through carbonate apatite-cationic liposome conjugates.2009

    • Author(s)
      F.T. Zohra, E.H. Chowdhury, T. Akaike
    • Journal Title

      Biomaterials 30

      Pages: 4006-4013

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface coating of bone marrow cell with N-acetylglucosamine for bone marrow implantation therapy2009

    • Author(s)
      S.Kobayashi, H.Ise, M.Takahasi, M.Goto, T.Akaike, U.Ikeda
    • Journal Title

      Biomaterials 30

      Pages: 574-582

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of nucleobase transport by mouse Sertoli cell line TM42009

    • Author(s)
      Kato R, Maeda T, Akaike T, Tamai I.
    • Journal Title

      Biol Pharm Bull. 32

      Pages: 450-455

    • NAID

      110007122709

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disrupting actin filaments promotes efficient transfection of a leukemia cell line using cell adhesive protein-embedded carbonate apatite particles2009

    • Author(s)
      K.Kutsuzawa, S.Tada, S.Hossain, K.Fukuda, K.Maruyama, Y.Akiyama, T.Akaike, E.H.Chowdhury,
    • Journal Title

      Anal. Biochem. 388, 164-166, (2009) 388

      Pages: 164-166

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High performance mRNA transfection through carbonate apatite-cationic liposome conjugates2009

    • Author(s)
      F.T.Zohra, E.H.Chowdhury, T.Akaike
    • Journal Title

      Biomaterials 30

      Pages: 4006-4013

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Degradable polyethylenimines as DNA and small interfering RNA carriers.2009

    • Author(s)
      Jere D, Jiang HL, Arote R, Kim YK, Choi YJ, Cho MH, Akaike T, Cho CS.
    • Journal Title

      Expert Opin Drug Deliv.2009 6

      Pages: 827-834

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Superparamagnetic Iron Oxide Nanoparticles Coated with Galactose-Carrying Polymer for Hepatocyte Targeting.2009

    • Author(s)
      K. Yamaki, I. Harada, M. Goto, C-S. Cho, T. Akaike
    • Journal Title

      Biomaterials 30

      Pages: 1421-142

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copolymers for Hepatocyte-Specific Targeting Carrying Galactose and Hydrophobic Alkyl Groups.2008

    • Author(s)
      T. Hiratsuka, M. Goto, Y. Kondo, C-S. Cho, T. Akaike
    • Journal Title

      Macromol. Biosci. 8

      Pages: 231-238

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of the artificial acellular feeder layer for the efficient propagation of mouse ES cells.2008

    • Author(s)
      Nagaoka M, Hagiwara Y, Takemura K, Murakami Y, Li J, Duncan SA, Akaike T.
    • Journal Title

      J Biol Chem. 283

      Pages: 26468-26476

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient transfection of mouse embryonic stem cells with cell-adhesive protein-embedded inorganic nanocarrier.2008

    • Author(s)
      Kutsuzawa K, Maruyama K, Akiyama Y, Akaike T, Chowdhury EH
    • Journal Title

      Anal Biochem 372(1)

      Pages: 122-4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The influence of the cell-adhesive proteins E-cadherin and fibronectin embedded in carbonate-apatite DNA carrier on transgene delivery and expression in a mouse embryonic stem cell line.2008

    • Author(s)
      Kutsuzawa K, Akaike T, Chowdhury EH.
    • Journal Title

      Biomaterials. 29(3)

      Pages: 370-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Embryonic Undifferentiated Cells Show Scattering Activity on a Surface Coated With Immobilized E-Cadherin.2008

    • Author(s)
      Nagaoka M, Ise H, Harada I, Koshimizu U, Maruyama A, Akaike T.
    • Journal Title

      J. Cell Biochem 103

      Pages: 296-310

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different regulation of hepatocyte behaviors b etween natural extracellular matrices and synthetic extracellular matrices by hepatocyte growth factor.2008

    • Author(s)
      Hoshiba T, Wakejima M, Cho CS, Shiota G, Akaike T
    • Journal Title

      J Biomed. Maere. Res. 85A

      Pages: 228-235

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of the artificial acellular feeder layer for the efficient propagation of mouse ES cells2008

    • Author(s)
      Nagaoka M, Hagiwara Y, Takemura K, Murakami Y, Li J, Duncan SA, Akaike T
    • Journal Title

      J Biol Chem.. 283

      Pages: 26468-26476

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient transfection of mouse embryonic stem cells with cell-adhesive protein-embedded inorganic nanocarrier.2008

    • Author(s)
      Kutsuzawa K, Maruyama K, Akiyama Y, Akaike T, Chowdhury EH
    • Journal Title

      Anal Biochem. 372

      Pages: 122-124

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of the cell-adhesive proteins E-cadherin and fibronectin embedded in carbonate-apatite DNA carrier on transgene delivery and expression in a mouse embryonic stem cell line2008

    • Author(s)
      Kutsuzawa K, Akaike T, Chowdhury EH.
    • Journal Title

      Biomaterials 29

      Pages: 370-376

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of cellular morphology using temperature-responsive hydrogel for integrin-mediated mechanical force stimulation2008

    • Author(s)
      Akaike, T. Hoshiba, T, Kim, S-H. Kobayashi, K. Goto, M. Jiang, H-L. Cho C-S.
    • Journal Title

      "Tissue Engineering ; Roles, Materials and Applications" S. J. Barners and L. P. Harries Eds, Nova Science Pubishers, Inc

      Pages: 99-118

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of Artificial Extracellular Matrices and Their Application for Regenerative Medicine.2008

    • Author(s)
      Yue X., Nagaoka M., Akaike T.
    • Journal Title

      Biomaterials in Asia

      Pages: 143-158

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Embryonic Undifferentiated Cells Show Scattering Activity on a Surface Coated With Immobilized E-Cadherin2008

    • Author(s)
      M. Nagaoka, H. Ise, I. Harada, U. Koshimizu, A. Maruyama, T. Akaike
    • Journal Title

      J. Cell Biochem. 103

      Pages: 296-310

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] pH-Sensitive Inorganic Nano-Particles and Their Precise Cell Targetibility: An Efficient Gene Delivery and Expression System.2007

    • Author(s)
      E.H. Chowdhury, T. Akaike
    • Journal Title

      Current Chemical Biology 1

      Pages: 201-213

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effective delivery with enhanced translation activity synergistically accelerates mRNA-based transfection.2007

    • Author(s)
      F.T. Zohra, E.H. Chowdhoury, S. Tada, T. Hoshiba, T. Akaike
    • Journal Title

      Biochem. Biophys. Res. Commun. 358

      Pages: 373-378

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] High performance DNA nano-carriers of carbonate apatite: multiple factors in regulation of particle synthesis and transfection efficiency.2007

    • Author(s)
      Chowdhury EH, Akaike T.
    • Journal Title

      Int J Nanomedicine. 2(1)

      Pages: 101-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体適合性ナノキャリアの設計とDNA・RNA・蛋白質の高効率細胞内デリバリー2007

    • Author(s)
      多田誠一、E.H. Chowdhury、沓沢好一、赤池敏宏
    • Journal Title

      再生医療 6

      Pages: 64-71

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞接着分子の利用による細胞制御-細胞生物学/遺伝子工学/材料工学/物理学間の学際的融合による細胞認識材料設計とその再生医療への応用2007

    • Author(s)
      赤池敏宏、長岡正人、E.H. Chowdhoury、原田伊知郎
    • Journal Title

      材料の科学と工学 44(1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] pH-Sensitive Inorganic Nano-Particles and Their Precise Cell Targetibility: An Efficient Gene Delivery and Expression System.2007

    • Author(s)
      E. H. Chowdhury, T. Akaike
    • Journal Title

      Current Chemical Biology 1

      Pages: 201-213

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor signaling for matrix-dependent cell proliferation and differentiation in primary cultured hepatocyte.2007

    • Author(s)
      Kim S-H., Akaike T.
    • Journal Title

      Tissue Engineering 13

      Pages: 601-609

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] E-カドヘリン-Fcキメラ抗体を用いたES細胞から肝細胞への高効率分化誘導2010

    • Author(s)
      赤池敏宏
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Biomaterials Design for ES/iPS Cells Engineering in Regenerative Medicine2010

    • Author(s)
      Toshihiro Akaike
    • Organizer
      APMT2010 Advanced Polymeric Materials and Technology Symposium (APMT 2010),
    • Place of Presentation
      The Shilla Jeju, Korea
    • Year and Date
      2010-01-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞間接着分子のモデルタンパク質E-cad-FcによるES/iPS細胞の新しい培養システムの開発2009

    • Author(s)
      赤池敏宏
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2009-11-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cell Recogonizable Bionanomaterials for ES/iPS Cells Engineering in Regenerative Medicine2009

    • Author(s)
      Toshihiro Akaike
    • Organizer
      (AEARU) 10th Workshop on Molecular Biology and Biotechnology organized for Association of East Asian Research Universities
    • Place of Presentation
      Taiwan
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Design of Biomimetic Glycopolymers and Chimeric Proteins for Regenerative Medicine2009

    • Author(s)
      Toshihiro Akaike
    • Organizer
      The 1st FAPS Polymer Congres
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Design of Biomimetic Glycopolymers and Chimeric Proteins for Regenerative Medicine2009

    • Author(s)
      Toshihiro Akaike
    • Organizer
      2009 Asia Conference for Biomaterials & Stem Cell Techniques
    • Place of Presentation
      Taipei Taiwan
    • Year and Date
      2009-09-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Design of Cell-recognition Biomaterials for Regenerative medicine and Cell-Targeting Medicine2009

    • Author(s)
      Toshihiro Akaike
    • Organizer
      2009 International Symposium on Crystal Engineering & Drug Delivery System
    • Place of Presentation
      Tianjin, China
    • Year and Date
      2009-09-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] New frontier of nanobiomaterials design for stem cell technology and regenerative medicine2009

    • Author(s)
      Toshihiro Akaike
    • Organizer
      2nd TERMIS World Congress in conjunction with 2009 Seoul Stem Cell Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] New frontier of nanobiomaterials design for stem cell technology and regenerative medicine2009

    • Author(s)
      Toshihiro Akaike
    • Organizer
      The 2nd Annual Congress of Regenerative Medicine & Stem Cell
    • Place of Presentation
      Dalian, China
    • Year and Date
      2009-08-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Design of Cell-recognition Biomaterials for Regenerative medicine and Cell-Targeting Medicine.2009

    • Author(s)
      T. Akaike
    • Organizer
      2009 International Symposium on Crystal Engineering & Drug Delivery System
    • Place of Presentation
      Tianjin, China
    • Year and Date
      2009-08-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Biomaterials Design for ES/iPS Cells Engineering in Regenerative Medicine2009

    • Author(s)
      Toshihiro Akaike
    • Organizer
      CTS-JSOPMB Joint Conference(国際細胞移植会議)
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2009-04-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Design of cell-specific glycopolymers and chimeric proteins for regenerative me dicine2009

    • Author(s)
      Toshihiro Akaike
    • Organizer
      Biomaterials Asia 2009
    • Place of Presentation
      Hong Kong
    • Year and Date
      2009-04-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] New Fontier of Nanobiomaterials for Regenerative Medicine2009

    • Author(s)
      赤池敏宏
    • Organizer
      China-Jpan Bio-forum of RegenerativeMedicine and Related Technoloy
    • Place of Presentation
      上海
    • Year and Date
      2009-03-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞認識機能性バイオマテリアルの新展開2008

    • Author(s)
      赤池敏宏
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京大学
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞認識機能性バイオマテリアルの新展開2008

    • Author(s)
      Akaike, T.
    • Organizer
      (2008 TERMIS-AP)2008 Annual Conference of Tissue Engineering and Regenerative Medicine International Society - Asian Pacific Region
    • Place of Presentation
      台北
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体異物反応と適合性2008

    • Author(s)
      赤池敏宏
    • Organizer
      ナノ粒子研究会 第44回公開講演会
    • Place of Presentation
      御茶ノ水
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] New Biocompatible Nano-carriers System for Targeted DNA/Drug Delivery and Regenerative Medicine2008

    • Author(s)
      Akaike, T.
    • Organizer
      2008 KCRS Annual Conference
    • Place of Presentation
      Chejudo Korea
    • Year and Date
      2008-09-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Design of Intracellular Protein Delivery System by Carbonate Apatite Carrier2008

    • Author(s)
      S. Tada, E. H. Chowdhury, H. Chen, T. Akaike
    • Organizer
      35th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      New York
    • Year and Date
      2008-07-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Design of an Efficient pH Sensitive Delivery System for Anti cancer Drugs Based on Inorganic Nanocrystals of Carbonate Apatite2008

    • Author(s)
      S. Hossain, E. H. Chowdhury, T. Akaike
    • Organizer
      35th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      New York
    • Year and Date
      2008-07-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Design of Biomimetic Glycopolymers and Chimeric Proteins for Regenerative Medicine2008

    • Author(s)
      Akaike, T.
    • Organizer
      42nd World Polymer Congress
    • Place of Presentation
      Taipei
    • Year and Date
      2008-07-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intracellular Protein Delivery by Carbonate Apatite Carrier2008

    • Author(s)
      S. Tada, E. H. Chowdhury, H. Chen, T. Akaike
    • Organizer
      8^<th> World Biomaterial Congress
    • Place of Presentation
      Amsterdam
    • Year and Date
      2008-05-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Design of a smart delivery system for anti cancer drugs based on inorganic nanocrystals of carbonate apatite2008

    • Author(s)
      S. Hossain, E. H. Chowdhury, T. Akaike
    • Organizer
      8^<th> World Biomaterial Congress
    • Place of Presentation
      Amsterdam
    • Year and Date
      2008-05-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell-recognizable Matrix-Engineering for Regenerative Medicine2007

    • Author(s)
      T. Akaike
    • Organizer
      BIO KOREA 2007
    • Place of Presentation
      COEX SEOUL
    • Year and Date
      2007-09-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 第4章セラミックス2.炭酸アパタイト生理活性分子の導入キャリアとしての炭酸アパタイトナノ粒子2007

    • Author(s)
      多田誠一・E.H. Chowdhury・沓沢好一・赤池敏宏
    • Organizer
      遺伝子医学MOOK別冊絵で見てわかるナノDDSマテリアルから見た治療・診断・予後・予防、ヘルスケア技術の最先端
    • Related Report
      2009 Final Research Report
  • [Book] 「炭酸アパタイトナノ粒子を利用した、新しい遺伝子・RNA・タンパク質の細胞内導入システム」分子細胞治療フロンティア20102010

    • Author(s)
      沓沢好一, 赤池敏宏
    • Total Pages
      8
    • Publisher
      外科分子細胞治療研究会
    • Related Report
      2009 Annual Research Report
  • [Book] 再生医療のためのバイオエンジニアリング(再生医療の基礎シリーズ4)2007

    • Author(s)
      赤池敏宏
    • Total Pages
      226
    • Publisher
      コロナ社
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.akaike-lab.bio.titech.ac.jp/

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 組織撮影用MRI造影剤2009

    • Inventor(s)
      赤池敏宏、篠田さやか、後藤光昭
    • Industrial Property Rights Holder
      東京工業大学・セラジックス
    • Filing Date
      2009-03-09
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞培養用基材2008

    • Inventor(s)
      佐竹真、福井三由紀、兼子博章、赤池敏宏、賀喜白乙
    • Industrial Property Rights Holder
      帝人株式会社、東京工業大学
    • Filing Date
      2008-09-11
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞培養用基材2008

    • Inventor(s)
      佐竹真, 赤池敏宏, 外
    • Industrial Property Rights Holder
      帝人株式会社, 国立大学法人東京工業大学
    • Industrial Property Number
      2008-233322
    • Filing Date
      2008-09-11
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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