Creation of growth factors binding to metal or ceramic for and their medical applications
| Project/Area Number |
19200041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ITO Yoshihiro The Institute of Physical and Chemical Research, 伊藤ナノ医工学研究室, 主任研究員 (40192497)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Hiroshi 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 専任研究員 (80415067)
WADA Akira 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 研究員 (90443051)
YOSHIDA Yasuhiro 岡山大学, 医歯(薬)学総合研究科, 准教授 (90281162)
KITAJIMA Takashi 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 協力研究員 (40399556)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥49,270,000 (Direct Cost: ¥37,900,000、Indirect Cost: ¥11,370,000)
Fiscal Year 2009: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2008: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2007: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
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| Keywords | バイオマテリアル / 表面処理 / 成長因子 / タンパク質工学 / リボソーム・ディスプレイ / ケミカルライゲーション法 / ミスアシル化tRNA法 / 非天然アミノ酸 / キメラタンパク質 |
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| Research Abstract |
Design and synthesis for metal-or ceramic-binding growth factor proteins were performed. First, organic molecular coating was performed on titan or stainless steel for growth factor immobilization. Secondly, titan-or apatite-binding growth factor proteins were designed by molecular evolutionary engineering and chemical ligation using peptide carrying non-natural amino acid.
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Report
(4 results)
Research Products
(91 results)
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[Journal Article]2007
Author(s)
W. Meng, S.-Y. Kim, J. Yuan, J.C. Kim, O.H. Kwon, N. Kawazoe, G. Chen, Y. Ito, I.-K. Kang
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Journal Title
Electrospun PHBV/collagen composite nanofibrous scaffolds for tissue engineering(J. Biomater. Sci., Polym. Edn.) 18
Pages: 81-94
Related Report
Peer Reviewed
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