Creation of growth factors binding to metal or ceramic for and their medical applications

• Project/Area Number: 19200041
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: ITO Yoshihiro The Institute of Physical and Chemical Research, 伊藤ナノ医工学研究室, 主任研究員 (40192497)
• Co-Investigator(Kenkyū-buntansha): ABE Hiroshi 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 専任研究員 (80415067) ; WADA Akira 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 研究員 (90443051) ; YOSHIDA Yasuhiro 岡山大学, 医歯(薬)学総合研究科, 准教授 (90281162) ; KITAJIMA Takashi 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 協力研究員 (40399556)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥49,270,000 (Direct Cost: ¥37,900,000、Indirect Cost: ¥11,370,000); Fiscal Year 2009: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000); Fiscal Year 2008: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000); Fiscal Year 2007: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
• Keywords: バイオマテリアル / 表面処理 / 成長因子 / タンパク質工学 / リボソーム・ディスプレイ / ケミカルライゲーション法 / ミスアシル化tRNA法 / 非天然アミノ酸 / キメラタンパク質

Research Abstract

Design and synthesis for metal-or ceramic-binding growth factor proteins were performed. First, organic molecular coating was performed on titan or stainless steel for growth factor immobilization. Secondly, titan-or apatite-binding growth factor proteins were designed by molecular evolutionary engineering and chemical ligation using peptide carrying non-natural amino acid.

Research Products

• [Journal Article] Reprogramming of somatic cells induced by fusion of embryonic stem cells using hemagglutinating virus of Japan envelope (HVJ-E) (2010)
  • Author(s): X iao-shan Yue, Masako Fujishiro, Masashi Toyoda, Toshihiro Akaike, Yoshihiro Ito
  • Journal Title: Biophys. Biochem. Res. Commun. (in press)
  • Peer Reviewed
• [Journal Article] A photoimmobilizable sulfobetaine-based polymer for a nonbiofouling surface (2010)
  • Author(s): M akoto Sakuragi, Saki Tsuzuki, Sei Obuse, Akira Wada, Kenji Matoba, Izumi Kubo, Yoshihiro Ito
  • Journal Title: Mater. Sci. Eng. C 30 Pages: 316-322
  • Peer Reviewed
• [Journal Article] 生体分子の固定化による機能性材料の創成-細胞成長因子の固定化は隔靴掻痒か?- (2010)
  • Author(s): 伊藤嘉浩
  • Journal Title: バイオマテリアル 28(1) Pages: 9-17
  • NAID: 10026241579
• [Journal Article] A photoimmobilizable sulfobetaine-based polymer for a nonbiofouling surface (2010)
  • Author(s): Makoto Sakuragi, Saki Tsuzuki, Sei Obuse, Akira Wada, Kenji Matoba, Izumi Kubo, Yoshihiro Ito
  • Journal Title: Materials Science Engineering C 30 Pages: 316-322
  • Peer Reviewed
• [Journal Article] Preparation of photo-reactive azidophenyl chitosan derivative for immobilization of growth factors (2010)
  • Author(s): Kwang-Il Kim, Jae-Woo Lee, Jeong Hwa Kang, Kwang-Sup Song, Eui-Chan Jang, Yoshihiro Ito, Tae-Il Son
  • Journal Title: Journal of Applied Polymer Science (印刷中)
  • Peer Reviewed
• [Journal Article] 生体分子の固定化による機能性材料の創成―細胞成長因子の固定化は隔靴掻痒か?- (2010)
  • Author(s): 伊藤嘉浩
  • Journal Title: バイオマテリアル 28 Pages: 9-17
  • NAID: 10026241579
• [Journal Article] 幹細胞培養用人工フィーダーの設計 (2009)
  • Author(s): 伊藤嘉浩、北嶋隆
  • Journal Title: 再生医療 8(2) Pages: 34-42
• [Journal Article] Surface coating with a thermoresponsive copolymer for the culture and nonenzymatic recovery of mouse embryonic stem cells (2009)
  • Author(s): X ian Jun Loh, Jiansheng Gong, Makoto Sakuragi, Takashi Kitajima, Mingzhe Liu, Jun Li, Yoshihiro Ito
  • Journal Title: Macromol. Biosci. 9 Pages: 1069-1079
  • Peer Reviewed
• [Journal Article] A chimeric epidermal growth factor with fibrin-affinity promotes repair injured keratinocyte sheets (2009)
  • Author(s): Takashi Kitajima, Hirokazu Hasuda, Makoto Sakuragi, Takeshi Ozu, Yoshihiro Ito
  • Journal Title: Acta Biomater. 5 Pages: 2623-2632
  • Peer Reviewed
• [Journal Article] Novel poly(N-isopropylacrylamide)-poly[(R)-3-hydroxybutyrate]-poly(N-isopropylacrylamide) triblock copolymer surface as a culture substrate for human mesenchymal stem cells (2009)
  • Author(s): X ian Jun Loh, Wun Chet Davy Cheong, Jun Li, Yoshihiro Ito
  • Journal Title: Soft Matter 5 Pages: 2937-2946
  • Peer Reviewed
• [Journal Article] Photo-immobilization of biological components on gold-coated chips for measurements using surface plasmon resonance (SPR) and a quartz crystal microbalance (QCM) (2009)
  • Author(s): S aki Tsuzuki, Akira Wada, Yoshihiro Ito
  • Journal Title: Biotechnol. Bioeng. 102 Pages: 700-707
  • Peer Reviewed
• [Journal Article] Synthesis of a photoimmobilizable histidine polymer for surface modification (2009)
  • Author(s): M akoto Sakuragi, Saki Tsuzuki, Hirokazu Hasuda, Akira Wada, Kenji Matoba, Izumi Kubo, Yoshihiro Ito
  • Journal Title: J. Apply. Polym. Sci. 112 Pages: 315-319
  • Peer Reviewed
• [Journal Article] 細胞制御材料と再生医療 (2009)
  • Author(s): 伊藤嘉浩、北嶋隆、阿部洋
  • Journal Title: 高分子 58(3) Pages: 129-132
• [Journal Article] A chimeric epidermal growth factor with fibrin-affinity promotes repair injured keratinocyte sheets (2009)
  • Author(s): Takashi Kitajima, Hirokazu Hasuda, Makoto Sakuragi Takeshi Ozu, Yoshihiro Ito
  • Journal Title: Acta Biomaterialia 5 Pages: 2623-2632
  • Peer Reviewed
• [Journal Article] Surface coating with a thermoresponsive copolymer for the culture and nonenzymatic recovery of mouse embryonic stem cells (2009)
  • Author(s): Xian Jun Loh, Jiansheng Gong, Makoto Sakuragi, Takashi Kitajima, Mingzhe Liu, Jun Li, Yoshihiro Ito
  • Journal Title: Macromolecular Bioscience 9 Pages: 1069-1079
  • Peer Reviewed
• [Journal Article] Novel poly(N-isopropylacrylamide)-poly[(R)-3-hydroxybutyrate]-poly(N-isopropylacrylamide) triblock copolymer surface as a culture substrate for human mesenchymal stem cells (2009)
  • Author(s): Xian Jun Loh, Wun Chet Davy Cheong, Jun Li, Yoshihiro Ito
  • Journal Title: Soft Matter 5 Pages: 2937-2946
  • Peer Reviewed
• [Journal Article] 幹細胞培養用人工フィーダーの設計 (2009)
  • Author(s): 伊藤嘉浩、北嶋隆
  • Journal Title: 再生医療 8 Pages: 34-42
• [Journal Article] 幹細胞培養用人工フィーダーの設計 (2009)
  • Author(s): 伊藤嘉浩、北嶋隆
  • Journal Title: 高分子 58 Pages: 129-132
• [Journal Article] Peptide immobilized on gold particles enhances cell growth (2008)
  • Author(s): J iansheng Gong, Yoshihiro Ito
  • Journal Title: Cytotechnology 58 Pages: 141-144
  • Peer Reviewed
• [Journal Article] Ribosome display selection of a metal-binding motif from an artificial peptide library (2008)
  • Author(s): A kira Wada, Shinya Y. Sawata, Yoshihiro Ito
  • Journal Title: Biotechnol. Bioeng. 101 Pages: 1102-1107
  • Peer Reviewed
• [Journal Article] A Fusion Protein of Hepatocyte Growth Factor Enhances Reconstruction of Myocardium in a Cardiac Patch Derived from Porcine Urinary Bladder Matrix (2008)
  • Author(s): T akeyoshi Ota, Thomas W. Gilbert, David Schwartzman, Charles F. McTiernan, Takashi Kitajima, Yoshihiro Ito, Yoshiki Sawa, Stephen F. Badylak, Marco A. Zenati
  • Journal Title: J. Thora. Cardio. Surg. 136 Pages: 1309-1317
  • Peer Reviewed
• [Journal Article] Chondrogenic differentiation of human mesenchymal stem cells on photoreactive polymer-modified surfaces (2008)
  • Author(s): L. Guo, N. Kawazoe, Y. Fan, Y. Ito, J. Tanaka, T. Tateishi, X. Zhang, G. Chen
  • Journal Title: Biomaterials 29 Pages: 23-32
  • Peer Reviewed
• [Journal Article] ナノ界面テクノロジーによる機能表面創出 (2008)
  • Author(s): 伊藤嘉浩
  • Journal Title: 高分子論文集 65 Pages: 6-19
  • NAID: 10020123425
  • Peer Reviewed
• [Journal Article] Covalently immobilized biosignal molecule materials for tissue engineering (2008)
  • Author(s): Y. Ito
  • Journal Title: Soft Matter 4(1) Pages: 46-56
  • Peer Reviewed
• [Journal Article] 細胞成長因子の作用機序 (2008)
  • Author(s): 伊藤嘉浩
  • Journal Title: 日本臨床 66(5) Pages: 873-880
• [Journal Article] 幹細胞:再生医療への期待 (2008)
  • Author(s): 伊藤嘉浩、今中応亘、北嶋隆
  • Journal Title: バイオマテリアル 26(1) Pages: 11-22
  • NAID: 10021140329
• [Journal Article] Peptide immobilized on gold particles enhances cell growth (2008)
  • Author(s): Jiansheng Gong, Yoshihiro Ito
  • Journal Title: Cytotechnology 58 Pages: 141-144
  • Peer Reviewed
• [Journal Article] Ribosome display selection of a metal-binding motif from an artificial peptide library (2008)
  • Author(s): A. Wada, S. Y. Sawata, Y. Ito
  • Journal Title: Biotechnol. Bioeng. 101 Pages: 1102-1107
  • Peer Reviewed
• [Journal Article] A Fusion Protein of Hepatocyte Growth Factor Enhances Reconstruction of Myocardium in a Cardiac Patch Derived from Porcine Urinary Bladder Matrix (2008)
  • Author(s): T. Ota, T. W. Gilbert, D. Schwartzman, C. F. McTiernan, T. Kitajima, Y. Ito, Y. Sawa, S. F. Badylak, M. A. Zenati
  • Journal Title: J. Thora. Cardio. Surg. 136 Pages: 1309-1317
  • Peer Reviewed
• [Journal Article] Resorbable scaffolds generated by three different techniques : electrospun fabrics, salt-leaching porous films and smooth flat surfaces (2008)
  • Author(s): A. Finne-Wistrand, A.-C. Albertsson, O. H. Kwon, N. Kawazoe, G. Chen, I.-K. Kang, H. Hasuda, J. Gong, Y. Ito
  • Journal Title: Macromol. Biosci. 8 Pages: 951-959
  • Peer Reviewed
• [Journal Article] Intermolecular transfer of aminoacylated adenosine towards chemical aminozcylation of tRNA (2008)
  • Author(s): M. Liu, H. Jinmei, K. Furuzono, H. Abe, and Y. Ito,
  • Journal Title: Chem. Lett. 37 Pages: 102-103
  • Peer Reviewed
• [Journal Article] "Chondrogenic differentiation of human mesenchymal stem cells on photoreactive polymer-modified surfaces," (2008)
  • Author(s): L. Guo, N. Kawazoe, Y. Fan, Y. Ito, J. Tanaka, T. Tateshi, X. Zhang, and G. Chen
  • Journal Title: Biomaterials 29 Pages: 23-32
  • Peer Reviewed
• [Journal Article] Modification of the titan surface with photoreactive gelatin to regulate cell attachment (2007)
  • Author(s): H. Mojgan, H. Hasuda, M. Sakuragi, Y. Yoshida, K. Suzuki, Y. Ito
  • Journal Title: J. Biomed. Mater. Res. 83 Pages: 906-914
  • Peer Reviewed
• [Journal Article] A new nonbiofouling polyzwitterion including L-histidine (2007)
  • Author(s): T. Ishii, A. Wada, S. Tsuzuki, M. Casolaro, Y. Ito
  • Journal Title: Biomacromolecules 8 Pages: 3340-3344
  • Peer Reviewed
• [Journal Article] Surface modification of plastic, glass and titanium by photoimmobilization of polyethylene glycol for antibiofouling (2007)
  • Author(s): Y. Ito, H. Hasuda, M. Sakuragi, S. Tsuzuki
  • Journal Title: Acta Biomater. 3 Pages: 1024-1032
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor fusion protein having collagen-binding activity (CBD-HGF) accelerates re-endoethelialization and intimal hyperplasia in balloon-injured rat carotid artery (2007)
  • Author(s): N. Ohkawara, H. Ueda, S. Shinozaki, T. Kitajima, Y. Ito, H. Asaoka, A. Kawakami, E. Kaneko, K. Shimokado
  • Journal Title: J. Atheroscler Thromb. 14 Pages: 185-191
  • Peer Reviewed
• [Journal Article] Grid pattern of nanothick microgel network (2007)
  • Author(s): G. Chen, N. Kawazoe, Y. Fan, Y. Ito, T. Tateishi
  • Journal Title: Langmuir 23 Pages: 5864-5867
  • Peer Reviewed
• [Journal Article] A fusion protein of hepatocyte growth factor for immobilization to collagen (2007)
  • Author(s): T. Kitajima, H. Terai, Y. Ito
  • Journal Title: Biomaterials 28 Pages: 1989-1997
  • Peer Reviewed
• [Journal Article] The movement of a water droplet on a gradient surface prepared by photodegradation (2007)
  • Author(s): Y. Ito, M. Heydari, A. Hashimoto, T. Konno, A. Hirasawa, S. Hori, K. Kurita, A. Nakajima
  • Journal Title: Langmuir 23 Pages: 1845-1850
  • Peer Reviewed
• [Journal Article] Chemically fixed nurse cells for culturing murine or primate embryonic stem cells (2007)
  • Author(s): Y Ito, M. Kawamorita, T. Yamabe, T. Kiyono, K. Miyamoto
  • Journal Title: J. Biosci. Bioeng. 103 Pages: 113-121
  • NAID: 110006239218
  • Peer Reviewed
• [Journal Article] (2007)
  • Author(s): W. Meng, S.-Y. Kim, J. Yuan, J.C. Kim, O.H. Kwon, N. Kawazoe, G. Chen, Y. Ito, I.-K. Kang
  • Journal Title: Electrospun PHBV/collagen composite nanofibrous scaffolds for tissue engineering(J. Biomater. Sci., Polym. Edn.) 18 Pages: 81-94
  • Peer Reviewed
• [Journal Article] Electrospinning of microbial polyester for cell culture (2007)
  • Author(s): O. H. Kwon, I.S. Lee, Y.-G. Ko, W. Meng, K.-H. Jung, I.-K. Kang, Y. Ito
  • Journal Title: Biomed. Mater. 2 Pages: 1-7
  • Peer Reviewed
• [Journal Article] 再生医療のための幹細胞増殖基材 (2007)
  • Author(s): 伊藤嘉浩
  • Journal Title: 膜 32(5) Pages: 276-280
• [Journal Article] 幹細胞培養のためのナノ界面創成バイオリアクター (2007)
  • Author(s): 伊藤嘉浩
  • Journal Title: 化学 62(7) Pages: 38-41
• [Journal Article] "Surface modification of plastic, glass and titanium by photoimmobili zation of polyethylene glycol for antibiofouling" (2007)
  • Author(s): Y. Ito, H. Hasuda, M. Sakuragi, and S.Tsuzuki
  • Journal Title: Acta Biomaterials 3 Pages: 1024-1032
  • Peer Reviewed
• [Presentation] 結合性成長因子タンパク質の設計と合成 (2010)
  • Author(s): 伊藤嘉浩
  • Organizer: 物質材料研究機構セミナー
  • Place of Presentation: つくば市
  • Year and Date: 2010-01-29
• [Presentation] Design of biointerfaces for regenerative medicine (2010)
  • Author(s): 伊藤嘉浩
  • Organizer: RIKEN Conference
  • Place of Presentation: 兵庫県佐用郡
  • Year and Date: 2010-01-13
• [Presentation] Design of nano-biointerfaces for medical devices (2010)
  • Author(s): Y. Ito
  • Organizer: 3rd Conference on Nanostructures (Sharif University of Technology)
  • Place of Presentation: Kish Island, Iran
• [Presentation] 再生医療のための幹細胞 (2009)
  • Author(s): 伊藤嘉浩
  • Organizer: 北東北ナノメディカルクラスター研究会
  • Place of Presentation: 秋田県仙北市
  • Year and Date: 2009-12-25
• [Presentation] Gene-engineered binding growth factors (2009)
  • Author(s): 伊藤嘉浩
  • Organizer: 韓国バイオマテリアル学会
  • Place of Presentation: 韓国、ソウル
  • Year and Date: 2009-11-28
• [Presentation] Biomaterials with growth factors for tissue engineering (2009)
  • Author(s): 伊藤嘉浩
  • Organizer: Engineering Conference International
  • Place of Presentation: ポルトガル, トマール
  • Year and Date: 2009-07-30
• [Presentation] Differentiation control of stem cells by immobilized cytokines and chemical compounds (2009)
  • Author(s): 伊藤嘉浩
  • Organizer: The 10^<th> International Cell Transplant Congress
  • Place of Presentation: 岡山市
  • Year and Date: 2009-04-21
• [Presentation] 再生医療のための人工フィーダーレイヤーの設計 (2009)
  • Author(s): 伊藤嘉浩
  • Organizer: 東京工業大学バイオフォーラム
  • Place of Presentation: 東京工業大学すずかけ台キャンパス
  • Year and Date: 2009-01-23
• [Presentation] Gene-engineered binding growth factors (2009)
  • Author(s): Y. Ito
  • Organizer: 2009 Meeting of the Korea Society for Biomaterials (The Korean Society for Biomaterials)
  • Place of Presentation: Seoul, Korea
• [Presentation] Differentiation control of stem cells by immobilized cytokines and chemical compounds (2009)
  • Author(s): Y. Ito
  • Organizer: 2009 China-Japan Regenerated Medical techniques Forum (The Chinese Academy of Sciences)
  • Place of Presentation: Shanghai, China
• [Presentation] 血管細胞の培養における固定化因子の効果 (2009)
  • Author(s): 北嶋隆
  • Organizer: 第8回再生医療学会総会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 金属結合ペプチド融合蛋白質の創製と金属ナノ粒子への結合評価 (2009)
  • Author(s): 阿部祥子
  • Organizer: 日本化学会 第89春季年会
  • Place of Presentation: 日本大学
• [Presentation] Combination of bimateraisl with growth factors for tissue engineering (2008)
  • Author(s): Y. Ito
  • Organizer: International Workshop on Biomacromolecules 2008, (Royal Institute of Technology)
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Combination of biomaterials with growth factors for tissue engineering (2008)
  • Author(s): 伊藤嘉浩
  • Organizer: International Workshop on Biomacromolecules 2008
  • Place of Presentation: Royal Institute of Technology (Stockholm)
• [Presentation] 増殖因子を固定化した区画をもつ培養基材 (2008)
  • Author(s): 北嶋隆
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学
• [Presentation] 試験管内分子進化法による光応答性分子ピンセットの開発 (2008)
  • Author(s): 劉明哲
  • Organizer: 第57回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 光応答性核酸アプタマーの創成 (2008)
  • Author(s): 劉明哲
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学
• [Presentation] 双性イオンを持つ光反応性高分子のタンパク質吸着および細胞接着への効果 (2008)
  • Author(s): 櫻木誠
  • Organizer: 第37回医用高分子シンポジウム
  • Place of Presentation: 東京医科歯科大学
• [Presentation] 金属酵素機能を模倣する人工ペプチドの創製 (2008)
  • Author(s): 和田章
  • Organizer: 日本ケミカルバイオロジー研究会 第3回年会
  • Place of Presentation: 学術総合センター
• [Presentation] 機能性金属ペプチドの進化分子工学的設計と創製 (2008)
  • Author(s): 和田章
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学
• [Presentation] Nonbiofouling polymer matrices for photo-immobilized microarray (2008)
  • Author(s): 和田章
  • Organizer: The IUMRS-International Conference in Asia 2008
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Biofunctional peptides with metal-binding affinities selected by ribosome display technology (2008)
  • Author(s): 和田章
  • Organizer: The IUMRS-International Conference in Asia 2008
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Biological surface-modification of biomaterials for regenerative medicine (2007)
  • Author(s): Yoshihiro Ito
  • Organizer: IVC-17/ICSS-13
  • Place of Presentation: Stockholm,Sweden
  • Year and Date: 2007-07-04
• [Presentation] Biomaterials for culture of ES cells (2007)
  • Author(s): Y. Ito
  • Organizer: 1st Asian Biomaterials Congress
  • Place of Presentation: Tsukuba
• [Presentation] Biological surface-modification of biomaterials for regenerative medicine (2007)
  • Author(s): Y. Ito
  • Organizer: 17th International Vacuum Congress (IVC-17)/13th International Conference on Surface Science and Technology (ICN+T2007)
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Biocomposite Materials for Medical Applications (2007)
  • Author(s): Y. Ito
  • Organizer: 2007 International Advanced Drug Delivery Symposium (The industrial Technology Research Institute)
  • Place of Presentation: Taipei, Taiwan
• [Book] 幹細胞と再生医療、バイオマテリアルの基礎 (2010)
  • Author(s): 伊藤嘉浩
  • Publisher: 日本医学館(印刷中)
• [Book] Comprehensive Biomaterials(Growth Factors and Protein Modified Surfaces and Interfaces) (2010)
  • Author(s): Yoshihiro Ito
  • Publisher: Elsevier(in press)
• [Book] Design of binding growth factors(G. Khang, ed., The Handbook of Intelligent Scaffold for Regenerative Medicine) (2010)
  • Author(s): Yoshihiro Ito
  • Publisher: (印刷中)
• [Book] マイクロアレイによる生体の相互作用解析、シングルセル解析の最前線 (2010)
  • Author(s): 伊藤嘉浩
  • Publisher: シーエムシー出版
• [Book] Growth factors on biomaterial surfaces(Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell and Tissue Responses) (2009)
  • Author(s): Y. Ito
• [Book] ゲルコントロール-ゲルの上手な作り方とゲル化の抑制-(光架橋ゲルの応用-表面生体機能化-) (2009)
  • Author(s): 伊藤嘉浩
  • Publisher: 情報機構
• [Book] 幹細胞の化学固定化培養システム、幹細胞の分化誘導と応用 (2009)
  • Author(s): 伊藤嘉浩
  • Publisher: エヌ・ティー・エス
• [Book] Biological Interactions on Materials Surfaces : Understanding and Controlling Protein, Cell and Tissue Responses (2009)
  • Author(s): Y.Ito
  • Total Pages: 429
  • Publisher: Springer
• [Book] ますます重要になる細胞周辺環境の科学技術―細胞の生存、増殖、機能のコントロールから再生医療まで (2009)
  • Author(s): 櫻木誠、伊藤嘉浩
  • Total Pages: 369
  • Publisher: メディカルドウ
• [Book] Biomaterials in Asia(Biomaterials for stem cell cultures) (2008)
  • Author(s): Y. Ito
• [Book] 「幹細胞操作のためのバイオマテリアル」、「次世代医療のための高分子材料工学」 (2008)
  • Author(s): 伊藤嘉浩
  • Publisher: シーエムシー出版
• [Book] 「細胞認識インターフェイス」、「環境調和型シリーズ生体材料」 (2008)
  • Author(s): 伊藤嘉浩
  • Publisher: 日刊工業新聞
• [Book] 環境調和型シリーズ生体材料 (2008)
  • Author(s): 伊藤嘉浩
  • Total Pages: 295
  • Publisher: 日刊工業新聞社
• [Book] 「幹細胞操作のためのバイオマテリアル」,「次世代医療のための高分子材料工学」秋吉一成、岸田昌夫監修 (2008)
  • Author(s): 伊藤嘉浩
  • Total Pages: 286
  • Publisher: シーエムシー出版
• [Book] マイクロアレイ・バイオチップの最前線
  • Author(s): 伊藤嘉浩監修
  • Publisher: シーエムシー出版
• [Remarks]
  • URL: http://www.riken.jp/r-world/research/lab/wako/medical/index.html
• [Patent(Industrial Property Rights)] 静電インクジェット現象を利用した三次元構造を有する細胞組織の作成 (2008)
  • Inventor(s): 梅津信二郎、北嶋隆、片平和俊、大森整、伊藤嘉浩
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Industrial Property Number: 2008-186068
  • Filing Date: 2008-07-17
• [Patent(Industrial Property Rights)] 物質固定化用基板および物質固定化基板 (2008)
  • Inventor(s): 伊藤嘉浩、田代英夫
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Industrial Property Number: 2008-080292
  • Filing Date: 2008-03-26
• [Patent(Industrial Property Rights)] 可視光硬化型接着剤 (2008)
  • Inventor(s): 伊藤嘉浩、孫泰一、田島右副
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Industrial Property Number: 2008-027930
  • Filing Date: 2008-02-07
• [Patent(Industrial Property Rights)] 光反応性共重合体、表面改質剤、親水化処理剤、吸着抑制剤、物質固定化剤、表面改質方法、親水化方法、吸着抑制方法および物質固定化方法
  • Inventor(s): 伊藤嘉浩
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Industrial Property Number: 2008-027128