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Development of an Exercise Program based on Gene/Protein expression and Metabolic Response during Exercise

Research Project

Project/Area Number 19200049
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionFukuoka University

Principal Investigator

TANAKA Hiroaki  Fukuoka University, スポーツ科学部, 教授 (00078544)

Co-Investigator(Kenkyū-buntansha) KIYONAGA Akira  福岡大学, スポーツ科学部, 教授 (70177955)
KUMAHARA Hideaki  福岡大学, スポーツ科学部, 助教 (40389367)
TOBINA Takuro  福岡大学, スポーツ科学部, 研究員 (60509678)
YAMADA Tatuo  福岡大学, 医学部, 教授 (60159217)
ANZAI Keizo  福岡大学, 医学部, 講師 (60258556)
YOSHIDA Hideyuki  福岡大学, 薬学部, 助教 (20301690)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000)
Fiscal Year 2009: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2008: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2007: ¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Keywordsメタボリックシンドローム / 肝臓内脂肪 / 骨格筋内脂肪 / 心音 / 骨格筋グリコーゲン / アディポネクチン / 前頭葉機能 / インスリン抵抗性 / 内臓脂肪 / 認知機能 / グリコーゲン / 生活習慣病 / 運動 / アディポサイトカイン / 骨格筋 / ミトコンドリア / 生理学 / 運動処方 / エネルギー代謝 / 運動療法 / 食事療法
Research Abstract

This study suggested that
1. The lactate threshold intensity exercise training improves insulin resistance. The reduction in ectopic lipids depends on intervention such as exercise and diet, or a combination of the two.
2. The heart sound provides valuable information for exercise prescription clinical fields.
3. Active rest with low intensity exercise prevents the decrease in exercise performance and increase muscle glycogen utilization that occurs during high-intensity intermittent exercise.
4. Adiponectin does not strongly contribute to the improvement in insulin resistance induced by exercise training.
5. The lactate threshold intensity exercise training may improve frontal lobe function.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (46 results)

All 2009 2008 2007 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (35 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 運動時心弛緩時間変動の3次回帰式による年齢および体力水準による相違の比較検討2009

    • Author(s)
      小原繁、松田拓朗、高橋将記、Peter H. Brubaker、田中宏暁
    • Journal Title

      信学技報 109(123)

      Pages: 33-37

    • NAID

      110007358880

    • Related Report
      2009 Final Research Report
  • [Journal Article] The utilization of a biopsy needle to obtain small muscle tissue specimens to analyze the gene and protein expression.2009

    • Author(s)
      Tobina T, Nakashima H, Mori S, Abe M, Kumahara H, Yoshimura E, Nishida Y, Kiyonaga A, Shono N, Tanaka H.
    • Journal Title

      J Surg Res 154

      Pages: 252-257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The First Heart Sound immediately after the Exercise as an Index of Exercise Stress.2008

    • Author(s)
      Matsuda Takuro, Kumahara Hideaki, Obara Shigeru, Kiyonaga Akira, Shindo Munehiro, Tanaka Hiroaki.
    • Journal Title

      Int J Sport Health Sci 6

      Pages: 213-218

    • NAID

      130000120799

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨格筋のPGC-1aとPDK発現を増強する運動条件からみたマラソントレーニング.2008

    • Author(s)
      田中宏暁, 飛奈卓郎, 井上彩, 中島裕之
    • Journal Title

      ランニング学研究 20

      Pages: 1-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨格筋のPGC-1αとPDK発現を増強する運動条件からみたマラソントレーニング2008

    • Author(s)
      田中宏暁, 飛奈卓郎, 井上彩, 中島裕之
    • Journal Title

      ランニング学研究 20

      Pages: 1-8

    • NAID

      40018709073

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Skeletal Muscle Genes by Moderate-Intensity Exercise.

    • Author(s)
      Nishida Yuichiro, Tanaka Hiroaki, Tobina Takuro, Murakami Kiyohide, Shono Naoko, Shindo Munehiro, Ogawa Wataru, Yoshioka Mayumi, St-Amand Jonny
    • Journal Title

      Int J Sport med (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] オーディオ機器を利用した心音測定システムの開発と第一

    • Author(s)
      松田拓朗、坂井洋子、平尾紀子、清永明、小原繁、田中宏暁
    • Journal Title

      心音振幅の屈曲点による運動処方の有効性健康支援 (印刷中)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The First Heart Sound immediately after the Exercise as an Index of Exercise Stress

    • Author(s)
      Matsuda T, Kumahara H, Obara S, Kiyonaga A, Shindo M, Tanaka H.
    • Journal Title

      Int J Sport Health Sci (印刷中)

    • NAID

      130000120799

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オーディオ機器を利用した心音測定システムの開発と第一心音振幅の屈曲点による運動処方の有効性

    • Author(s)
      松田拓朗, 坂井洋子, 平尾紀子, 清永明, 小原繁, 田中宏暁
    • Journal Title

      健康支援 (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The influence of adipocytokines, muscle and hepatic lipid content on insulin resistance in Japanese.2009

    • Author(s)
      Yoshimura Eiichi, Kumahara Hideaki, Tobina Takuro, Matono Sakiko, Kiyonaga Akira, Kimura Miyuki, Tsukikawa Hiroshi, Kawano Shinya, Etou Takashi, Irie Shin, Anzai Keizo, Tanaka Hiroaki.
    • Organizer
      20th International Diabetes Federation.
    • Place of Presentation
      Montreal
    • Year and Date
      2009-10-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Change in high molecular weight adiponectin and insulin resistance after exercise and/or diet treatment.2009

    • Author(s)
      Matono Sakiko, Yoshimura Eiichi, Kumahara Hideaki, Tobina Takuro, Koshimizu Takako, Kiyonaga Akira, Anzai Keizo, Tanaka Hiroaki.
    • Organizer
      20th International Diabetes Federation.
    • Place of Presentation
      Montreal
    • Year and Date
      2009-10-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 運動時心弛緩時間変動の年齢比較2009

    • Author(s)
      小原繁、高橋将記、松田拓朗、田中宏暁
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Relation between heart sound amplitude and diastolic time during exercise in persons with cardiac disease.2009

    • Author(s)
      Matsuda Takuro, Obara Shigeru, Brubaker Peter, Tanaka Hiroaki.
    • Organizer
      56th American College of Sports Medicine.
    • Place of Presentation
      Seattle
    • Year and Date
      2009-05-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Comparison of cardiac diastolic time in exercise among different fitness groups.2009

    • Author(s)
      Obara Shigeru, Takahashi Masaki, Matsuda Takuro, Brubaker Peter, Tanaka Hiroaki.
    • Organizer
      56th American College of Sports Medicine.
    • Place of Presentation
      Seattle
    • Year and Date
      2009-05-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 食事と運動による12週間の介入がインスリン抵抗性規定因子に及ぼす影響.2009

    • Author(s)
      吉村英一、安西慶三、熊原秀晃、飛奈卓郎、的野早希子、小清水孝子、清永明、明比祐子、田中宏暁
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 過体重者に対する運動・食事制限に伴う安静代謝と除脂肪体重の変化~レプチン濃度の変化に注目して~2009

    • Author(s)
      井上彩、熊原秀晃、吉村英一、飛奈卓郎、桧垣靖樹、清永明、田中宏暁
    • Organizer
      第10回日本健康支援学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-02-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Relation between heart sound amplitude and diastolic time during exercise in persons with cardiac disease2009

    • Author(s)
      Matsuda T, Obara S, Brubaker PH, Tanaka H.
    • Organizer
      56th American College of Sports Medicine
    • Place of Presentation
      Seattle/USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] The influence of adipocytokines, muscle and hepatic lipid content on insulin resistance in Japanese2009

    • Author(s)
      Yoshimura E, Kumahara H, Tobina T, Matono S, Kiyonaga A, Kimura M, Tsukikawa H, Kawano S, Eton T, Irie S, Anzai K, Tanaka H
    • Organizer
      20th International Diabetes Federation
    • Place of Presentation
      Montreal/Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Change in high molecular weight adiponectin and insulin resistance after exercise and/or diet treatment2009

    • Author(s)
      Matono S, Yoshimura E, Kumahara H, Tobina T, Koshimizu T, Kiyonaga A, Anzai K, Tanaka H.
    • Organizer
      20th International Diabetes Federation
    • Place of Presentation
      Montreal/Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Minute-by-minute Stepping Rate Of Daily Physical Activity In Normal And Overweight Adults2009

    • Author(s)
      Ayabe M, Aoki J, Yoshimura E, Matono S, Tobina T, Anzai K, Kiyonaga A, Tanaka H.
    • Organizer
      56th American College of Sports Medicine
    • Place of Presentation
      Seattle/USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 過体重者に対する運動、食事制限に伴う安静代謝と除体重の変プチン濃度の変化に注目して〜2009

    • Author(s)
      井上彩, 熊原秀晃, 吉村英一, 飛奈卓郎, 綾部誠也, 桧垣靖樹, 清永明, 田中宏暁
    • Organizer
      第10回日本健康支援学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] ウェイトジャケットとベンチステップ運動を組み合わせた運動法の提案2009

    • Author(s)
      的野早希子, 綾部誠也, 中山蕗, 田中宏暁
    • Organizer
      第10回日本健康支援学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] メタボリックシンドローム患者のインスリン抵抗性に寄与する因子の検討2008

    • Author(s)
      吉村英一、熊原秀晃、飛奈卓郎、的野早希子、小清水孝子、清永明、木村美由紀、月川洋、河野真也、江藤隆、入江伸、安西慶三、田中宏暁.
    • Organizer
      第29回日本肥満学会
    • Place of Presentation
      大分
    • Year and Date
      2008-10-18
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 心音屈曲点強度を用いた運動処方の有効性2008

    • Author(s)
      松田拓朗、坂井洋子、熊原秀晃、清永明、小原繁、田中宏暁.
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府
    • Year and Date
      2008-09-20
    • Related Report
      2009 Final Research Report
  • [Presentation] Ramp式漸増運動負荷試験における心音屈曲点発現の再現性2008

    • Author(s)
      矢野智子、松田拓朗、坂井洋子、清永明、小原繁、田中宏暁
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府
    • Year and Date
      2008-09-20
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] The automated determination of the heart sound breaking point during the ramp test.2008

    • Author(s)
      Tanaka Hiroaki, Matsuda Takuro, Sakai Yoko, Yano Satoko, Yoshimura Eiichi, Tobina Takuro, Kumahara Hideaki, Kiyonaga Akira, Shindo Munehiro.
    • Organizer
      13th European College of Sport Science.
    • Place of Presentation
      Estoril
    • Year and Date
      2008-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] βプロッカー投与が心音に及ぼす影響2008

    • Author(s)
      田中宏暁、松田拓朗、井上彩、小原繁
    • Organizer
      第16回日本運動生理学会
    • Place of Presentation
      奈良
    • Year and Date
      2008-08-02
    • Related Report
      2009 Final Research Report
  • [Presentation] 第一心音振幅の屈曲点は運動耐用能の評価に有効である.2008

    • Author(s)
      田中宏暁、松田拓朗、坂井洋子、矢野智子、吉村英一、熊原秀晃、清永明
    • Organizer
      第14回日本心臓リハビリテーション学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 食事と運動の介入による内臓脂肪減少および糖、脂質代謝改善効果.2008

    • Author(s)
      吉村英一、安西慶三、熊原秀晃、的野早希子、飛奈卓郎、小清水孝子、清永明、田中宏暁
    • Organizer
      第16回西日本肥満研究会
    • Place of Presentation
      宮崎
    • Year and Date
      2008-07-06
    • Related Report
      2009 Final Research Report
  • [Presentation] インスリン感受性とアディポネクチン濃度、内臓脂肪および体力の関係.2008

    • Author(s)
      的野早希子、吉村英一、熊原秀晃、飛奈卓郎、清永明、安西慶三、田中宏暁
    • Organizer
      第16回西日本肥満研究会
    • Place of Presentation
      宮崎
    • Year and Date
      2008-07-06
    • Related Report
      2009 Final Research Report
  • [Presentation] The heart sound breaking point is a good index of the catecholamine threshold during exercise.2008

    • Author(s)
      Matsuda Takuro, Sakai Yoko, Kumahara Hideaki, Kiyonaga Akira, Shindo Munehiro, Tanaka Hiroaki.
    • Organizer
      55th American College of Sports Medicine.
    • Place of Presentation
      Indianapolis
    • Year and Date
      2008-05-30
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of exercise and diet intervention on the anthropometric measures and metabolic risk factors in Japanese.2008

    • Author(s)
      Yoshimura Eiichi, Kumahara Hideaki, Tobina Takuro, Koshimizu Takako, Shindo Munehiro, Kiyonaga Akira, Anzai Keizo, Tanaka Hiroaki.
    • Organizer
      16th (ECO) European Congress on Obesity.
    • Place of Presentation
      Leusane
    • Year and Date
      2008-05-15
    • Related Report
      2009 Final Research Report
  • [Presentation] 食事と運動の介入による腹囲周囲径および内蔵脂肪減少効果の検討2008

    • Author(s)
      吉村 英一, 熊原 秀晃, 飛奈 卓郎, 小清水 孝子, 進藤 宗洋, 清永 明, 安西 慶三, 田中 宏暁
    • Organizer
      第11回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-01-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨格筋ミトコンドリア量とメタボリックシンドローム、最大酸素摂取量の関係2008

    • Author(s)
      中島裕之, 飛奈卓郎, 吉村英一, 熊原秀晃, 安西慶三, 清永明, 田中宏暁
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府
    • Related Report
      2008 Annual Research Report
  • [Presentation] 12週間の持続的な運動トレーニングと食事制限が基質脂質代謝量・骨格筋細胞内脂質に及ぼす影響2008

    • Author(s)
      井上彩, 吉村英一, 熊原秀晃, 飛奈卓慶三, 田中宏暁
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      別府
    • Related Report
      2008 Annual Research Report
  • [Presentation] βブロッカー投与が心音に及ぼす影響2008

    • Author(s)
      田中宏暁, 松田拓朗, 井上彩, 小原繁
    • Organizer
      第16回日本運動生理学会大会
    • Place of Presentation
      奈良
    • Related Report
      2008 Annual Research Report
  • [Presentation] 食事と運動の介入による内臓脂肪減少および脂質代謝改善効果2008

    • Author(s)
      安西慶三, 熊原秀晃, 的野早希子, 飛奈卓郎, 小清水孝子, 清永明, 田中宏暁
    • Organizer
      第16回西日本肥満研究会
    • Place of Presentation
      宮崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] インスリン感受性とアディポネクチン濃度、内臓脂肪および体力との関2008

    • Author(s)
      的野早希子, 吉村英一, 熊原秀晃, 飛奈卓郎, 清永明, 安西慶三, 田中宏暁
    • Organizer
      第16回西日本肥満研究会
    • Place of Presentation
      宮崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] 第一心音振幅の屈曲点は運動耐用能の評価に有効である2008

    • Author(s)
      田中宏暁, 松田拓朗, 坂井洋子, 矢野智子, 吉村英一, 熊原秀晃, 清永明
    • Organizer
      第14回心臓リハビリテーション学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] The automated determination of The Heart Sound Breaking Point dramp test.2008

    • Author(s)
      Tanaka. H, Matsuda. T, Sakai. Y, Kumahara. H, Kiyonaga. A, Shindo. M.
    • Organizer
      European College of Sport Science
    • Place of Presentation
      ポルトガル
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of exercise and diet intervention on the anthropometric measures and metabolic risk factors in Japanese2008

    • Author(s)
      Yoshimura E, Kumahara H, Tobina T, Koshimizu T, Shindo M, Kiyonaga A, Anzai K, Tanaka H
    • Organizer
      European Congress on Obesity
    • Place of Presentation
      スイス
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Heart Sound Breaking Point is a Good Index of The Catecholamine Threshold During Exercise.2008

    • Author(s)
      Matsuda. T, Sakai. Y, Kumahara. H, Kiyonaga. A, Shindo. M, Tanaka. H
    • Organizer
      American College of Sports Medicine
    • Place of Presentation
      アメリカ
    • Related Report
      2008 Annual Research Report
  • [Presentation] メタボリックシンドローム患者の中等度身体活動パターンに関する検討2007

    • Author(s)
      熊原 秀晃, 綾部 誠也, 飛奈 卓郎, 吉村 英一, 形本 静夫, 青木 純一郎, 清永 明, 安西 慶三, 田中 宏暁
    • Organizer
      第28回日本肥満学会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高齢者対象のレジスタンス運動による短期運動プログラムの効果2007

    • Author(s)
      井出 幸二郎, 槙本 真由美, 山元 理恵, 土井 由紀子, 清永 明, 進藤 宗洋, 田中 守, 田中 宏暁, 中野 正剛, 杉村 美佳, 山田 達夫
    • Organizer
      第56回九州体育・スポーツ学会大会
    • Place of Presentation
      佐賀
    • Year and Date
      2007-08-26
    • Related Report
      2007 Annual Research Report
  • [Book] 体育の科学2008

    • Author(s)
      飛奈卓郎, 田中宏暁
    • Publisher
      運動とアンチ・エイジング
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.cis.fukuoka-u.ac.jp/~htanaka

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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