| Budget Amount *help |
¥49,010,000 (Direct Cost: ¥37,700,000、Indirect Cost: ¥11,310,000)
Fiscal Year 2009: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2008: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2007: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
|
|---|
| Research Abstract |
The issue of low-dose effects of endocrine disruptor bisphenol A (BPA) is currently immense social difficulty unsolved. In the present study, we clarified several transcription factors regulated by BPA's target estrogen-related receptor gamma (ERRγ), and found that BPA inhibits the Neuro2a's neuron projection mediated through ERRγ. We also elucidated that BPA administration on the fruit fly Drosophila afford the adverse effects on their circadian rhythms by eliciting a hyperactivity disorder.
|
