Elucidation of bisphenol A low-dose effects mediated through the nuclear receptor ERRγ
Project/Area Number |
19201012
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Kyushu University |
Principal Investigator |
SHIMOHIGASHI Yasuyuki Kyushu University, 大学院・理学研究院, 教授 (00211293)
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Co-Investigator(Kenkyū-buntansha) |
KAKUTA Yoshimitsu 九州大学, 大学院・農学研究院, 准教授 (00314360)
SHIMOHIGASHI Miki 福岡大学, 理学部, 講師 (60078590)
NOSE Takeru 九州大学, 大学院・理学研究院, 准教授 (10301334)
MATSUSHIMA Ayami 九州大学, 大学院・理学研究院, 助教 (60404050)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥49,010,000 (Direct Cost: ¥37,700,000、Indirect Cost: ¥11,310,000)
Fiscal Year 2009: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2008: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2007: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
|
Keywords | 内分泌かく乱物質 / 有害化学物質 / 核内受容体 / 低用量効果 / ビスフェノール / 内分泌撹乱作用 |
Research Abstract |
The issue of low-dose effects of endocrine disruptor bisphenol A (BPA) is currently immense social difficulty unsolved. In the present study, we clarified several transcription factors regulated by BPA's target estrogen-related receptor gamma (ERRγ), and found that BPA inhibits the Neuro2a's neuron projection mediated through ERRγ. We also elucidated that BPA administration on the fruit fly Drosophila afford the adverse effects on their circadian rhythms by eliciting a hyperactivity disorder.
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Report
(4 results)
Research Products
(142 results)
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[Journal Article] Structural Evidence for Endocrine Disruptor Bisphenol A Binding to Human Nuclear Receptor ERRγ2007
Author(s)
A. Matsushima, Y. Kakuta, T. Teramoto, Koshiba, T., X. Liu, H. Okada, T. Tokunaga, S. Kawabata, M. Kimura, Y. Shimohigashi
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Journal Title
Journal of Biochemistry 142(4)
Pages: 517-524
NAID
Related Report
Peer Reviewed
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[Journal Article]2007
Author(s)
X.Lui., A.Matsushima., H.Okada., T.Tokunaga., K.Isozaki, and Y.Shimohigashi
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Journal Title
FEBS Journal 274
Pages: 6340-6351
Related Report
Peer Reviewed
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[Presentation] PAP Peptide Coded in pdf Gene is Necessary to Persist the Circadian Locomotor Rhythm in Insect2009
Author(s)
Shimohigashi M., Itoh Q.T., Honda T., Tuzuki H., Saito M., Koga K., Takahashi K., Matsushima A., Ueda R., Tanimura T., Nakagawa H., Matsumoto A., Shimohigashi Y.
Organizer
The Third Asia-Pacific International Peptide Symposium
Place of Presentation
Shineville Luxury Resort, Jeju
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[Presentation] Estrogen-related receptorγ(ERRγ) as a special receptor for endocrine disruptor bisphenol A2007
Author(s)
Matsushima, A., Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Shimohigashi, Y.
Organizer
The 27th International Symposium on Halogenated Persistent Organic Pollutants- DIOXIN 2007
Place of Presentation
東京
Related Report
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[Presentation] Estogen-ralated receptor γ(ERRγ) as a special receptor for endocrine disruptor bisphenol A2007
Author(s)
Matsushima,a., takayanagi, s., tokunaga, t., liu, x., okada, h., and shimohigashi, Y.
Organizer
The 27th International Symposium on Halogena-ted persistet Organic Pollutans-DIOXIN 2007
Place of Presentation
東京ホテルオークラ
Related Report
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