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Development of method for evaluating the consistency between network model in the cell and the molecular measured data

Research Project

Project/Area Number 19201039
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 基礎ゲノム科学
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

HORIMOTO Katsuhisa  National Institute of Advanced Industrial Science and Technology, 生命情報工学研究センター, 研究チーム長 (40238803)

Co-Investigator(Kenkyū-buntansha) ABURATANI Sachiyo  独立行政法人産業技術総合研究所, 生命情報工学研究センター, 研究員 (10361627)
TOMINAGA Daisuke  独立行政法人産業技術総合研究所, 生命情報工学研究センター, 研究員 (20357578)
ANAI Hirokazu  株式会社富士通研究所, Tコア研究所, 研究員 (20417520)
YOSHIDA Hiroshi  九州大学, 数理科学研究院, 特任助教授 (60401262)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2009: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2008: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2007: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Keywordsシステム生物学 / ネットワーク解析 / グラフィカル・モデル / 記号計算 / グラフィカルモデル / 計算機代数 / 遺伝子制御ネットワーク / パラメータ最適化 / ネットワーク / 遺伝子制御 / タンパク質相互作用 / 国際研究者交流 / 多国籍
Research Abstract

We have developed two methods for evaluating the consistency between the given network structures and the measured data of constituent molecules, based on the statistical and symbolic-numeric approaches. By using these methods, the active networks can be detected under a particular condition, and furthermore, the changes of network structures can be traced, depending on the environmental changes.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (81 results)

All 2010 2009 2008 2007 Other

All Journal Article (42 results) (of which Peer Reviewed: 41 results) Presentation (30 results) Book (6 results) Remarks (3 results)

  • [Journal Article] Altered Hepatic Gene Expression Profiles Associated with Myocardial Ischemia.2010

    • Author(s)
      Ootsuji, H., Honda, M., Takamura, M., Usui, S., Okajima, M., D, Okada, H., Sakai, Y., Takamura, T., Horimoto, K., Kaneko, S
    • Journal Title

      Circ Cardiovasc Genet 3

      Pages: 68-77

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Period-Phase Map: Two-diemsional Selection of Circadian Rhythm-Related Genes.2009

    • Author(s)
      Morioka, R., Arita, M., Sakamoto, K., Kawaguchi, S., Tei, H., Horimoto, K
    • Journal Title

      IET Sys. Biol 3

      Pages: 487-495

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRAIL inhibited the cyclic AMP responsible element mediated gene expression.2009

    • Author(s)
      Tokumoto, Y., Horimoto, K., Miyake, J
    • Journal Title

      Biochem. Biophys. Res. Commun 381

      Pages: 533-536

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential miRNA expression between hepatitis B and hepatitis C leading disease progression to HCC.2009

    • Author(s)
      Ura, S., Honda, M., Yamashita, T., Ueda, T., Takatori, H., Nishino, R., Sunagozaka, H., Sakai, Y., Horimoto, K., Kaneko, S
    • Journal Title

      Hepatology 49

      Pages: 1098-1112

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of network structure changes by graphical chain modeling: a case study of hepatitis C virus-related hepatocellular carcinoma.2009

    • Author(s)
      Saito, S., Honda, M., Kaneko, S., Horimoto, K
    • Journal Title

      Proceedings of 48th IEEE Conference on Decision and Control

      Pages: 5624-5630

    • NAID

      120006655929

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-Expressed Gene Assessment Based on the Path Consistency Algorithm: Operon Detention in Escherichia coli. Proceedings of IEEE International Conference on Systems2009

    • Author(s)
      Saito, S., Horimoto, K
    • Journal Title

      Man and Cybernetics

      Pages: 4280-4286

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parameter Optimization in the network dynamics including unmeasured variables by the symbolic-numeric approach.2009

    • Author(s)
      Nakatsui, M., Horimoto, K
    • Journal Title

      Proceedings of the Third International Symposium on Optimization and Systems Biology (OSB'09)

      Pages: 245-253

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complementing Networks Using Observed Data.2009

    • Author(s)
      Akutsu, T., Tamura, T., Horimoto, K
    • Journal Title

      Lecture Notes in Artificial Intelligence 5809

      Pages: 126-140

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential miRNA expression between hepatitis B and hepatitis C leading disease progression to HCC2009

    • Author(s)
      Ura, S., et.al.
    • Journal Title

      Hepatology 49

      Pages: 1098-1112

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRAIL inhibited the cyclic AMP responsible element mediated gene expression.2009

    • Author(s)
      Tokumoto, Y., et.al.
    • Journal Title

      Biochem. Biophys. Res.Commun. 381

      Pages: 533-536

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Period-Phase Map : Two-diemsional Selection of Circadian Rhythm-Related Genes2009

    • Author(s)
      Morioka, R., et.al.
    • Journal Title

      IET Sys.Biol. 3

      Pages: 487-495

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inference of Probabilities over a Stochastic IL-System by Quantifier Elimination.2008

    • Author(s)
      Yoshida, H., Horimoto, K., Anai, H
    • Journal Title

      Math. Comput. Sci 1

      Pages: 473-485

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma.2008

    • Author(s)
      Nishino, R., Honda, M., Yamashita, T., Takatori, H., Minato, H., Zen, Y., Sasaki, M., Takamura, H., Horimoto, K., Ohta, T., Nakanuma, Y., Kaneko, S
    • Journal Title

      J. Hepatol 49

      Pages: 207-216

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integer Programming-based Approach to Allocation of Reporter Genes for Cell Array Analysis.2008

    • Author(s)
      Hayashida, M., Sun, F., Aburatani, S., Horimoto, K., Akutsu, T
    • Journal Title

      Int. J. Bioinformatics Research and Applications 4

      Pages: 385-399

    • NAID

      110006402728

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Network evaluation from the consistency of the graph structure with the measured data.2008

    • Author(s)
      Saito, S., Aburatani, S., Horimoto, K
    • Journal Title

      BMC Sys. Biol 2

      Pages: 84-84

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of network dynamics including hidden variables by symbolic-numeric approach.2008

    • Author(s)
      Tominaga, D., Tokumoto, Y., Nakatsui, M., Sun, F., Miyake, J., Horimoto, K
    • Journal Title

      Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08)

      Pages: 242-248

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase Shifts of Circadian Transcripts in Rat Suprachiasmatic Nucleus.2008

    • Author(s)
      Morioka, R., Arita, M., Sakamoto, K., Kawaguchi, S., Tei, H., Horimoto, K
    • Journal Title

      Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08)

      Pages: 109-114

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An Algebraic-Numeric Algorithm for the Model Selection in Network Motifs in Escherichia coli.2008

    • Author(s)
      Nakatsui, M., Yoshida, H., Horimoto, K
    • Journal Title

      Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08)

      Pages: 257-264

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Time Series Segmentation for Gene Regulatory Process with Time-Window-Extension Technique.2008

    • Author(s)
      Zhang, Z.Y., Horimoto, K., Liu, Z
    • Journal Title

      Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08)

      Pages: 198-203

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Revealing Disease Related Interactions by Correlation Analysis.2008

    • Author(s)
      Wu, Z.K., Zhang, Z.Y., Zhang, L.W., Horimoto, K
    • Journal Title

      Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08)

      Pages: 341-349

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inference of Probabilities over a Stochastic IL-System by Quantifier Elimination2008

    • Author(s)
      Yoshida, H.
    • Journal Title

      Math. Comput. Sci. 1

      Pages: 473-485

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma2008

    • Author(s)
      Nishino, R.
    • Journal Title

      J. Hepatol. 49

      Pages: 207-216

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integer Programming-based Approach to Allocation of Reporter Genes for Cell Array Analysis2008

    • Author(s)
      Hayashida, M.
    • Journal Title

      Int. J. Bioinformatics Research and Applications 4

      Pages: 385-399

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Network evaluation from the consistency of the graph structure with the measured data2008

    • Author(s)
      Saito, S.
    • Journal Title

      BMC Sys. Biol. 2

      Pages: 84-84

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase Shifts of Circadian Transcripts in Rat Suprachias matic Nucleus2008

    • Author(s)
      Morioka, R.
    • Journal Title

      Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2

      Pages: 109-114

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Algebraic-Numeric Algorithm for the Model Selection in Network Motifs in Escherichia coli2008

    • Author(s)
      Nakatsui, M.
    • Journal Title

      Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2

      Pages: 257-264

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time Series Segmentation for Gene Regulatory Process with Time-Window-Extension Technique2008

    • Author(s)
      Zhang, Z. Y.
    • Journal Title

      Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2

      Pages: 198-203

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of network dynamics including hidden variables by symbolic-numeric approach2008

    • Author(s)
      Tominaga, D.
    • Journal Title

      Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2

      Pages: 242-248

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Revealing Disease Related Interactions by Correlation Analysis2008

    • Author(s)
      Wu, Z. K.
    • Journal Title

      Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2

      Pages: 341-349

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene systems network inferred from expression profiles in hepatocellular carcinogenesis by graphical Gaussian model.2007

    • Author(s)
      Aburatani, S., Sun, F., Saito, S., Honda, M., Kaneko, S., Horimoto, K
    • Journal Title

      EURASIP J. Bioinfo. Systems Biol

      Pages: 47214-47214

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of rigorous conditions for high cell-type diversity by algebraic approach.2007

    • Author(s)
      Yoshida, H., Anai, H., Horimoto, K
    • Journal Title

      BioSystems 90

      Pages: 486-495

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inference of Protein-Protein Interactions by Using Co-evolutionary Information.2007

    • Author(s)
      Sato, T., Yamanishi, Y., Horimoto, K., Kanehisa, M., Toh, H
    • Journal Title

      Algebraic Biology, Lecture Notes in Computer Science(In Anai, H., Horimoto, K. and Kutsia, T. (eds)) 4545

      Pages: 322-333

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exact parameter determination for Parkinson's disease diagnosis with PET using an algebraic approach.2007

    • Author(s)
      Yoshida, H., Nakagawa, K., Anai, H., Horimoto, K
    • Journal Title

      Algebraic Biology, Lecture Notes in Computer Science(In Anai, H., Horimoto, K., Kutsia, T. (eds)) 4545

      Pages: 110-124

    • Related Report
      2009 Final Research Report
  • [Journal Article] An Algebraic-Numeric Algorithm for the Model Selection in Kinetic Networks.2007

    • Author(s)
      Yoshida, H., Nakagawa, K., Anai, H., Horimoto, K
    • Journal Title

      Proceedings of 10th CASC, LNCS(Springer, Heidelberg) 4770

      Pages: 433-447

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integer Programming-based Approach to Allocation of Reporter Genes for Cell Array Analysis.2007

    • Author(s)
      Hayashida, M., Sun, F., Aburatani, S., Horimoto, K., Akutsu, T
    • Journal Title

      Proceedings of 10th OSB, Lecture Notes in Operation Research(Publishing Corporation)

      Pages: 288-301

    • NAID

      110006402728

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene systems network inferred from expression profiles in hepatocellular carcinoffenesis by graphical Gaussian model.2007

    • Author(s)
      Aburatani, S.
    • Journal Title

      EURASIP J.Bioinfo.Systems Biol. 47214

      Pages: 1-11

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of rigorous conditions for high cell-type diversity by algebraic approach.2007

    • Author(s)
      Ybshida, H.
    • Journal Title

      BioSystems 90

      Pages: 486-495

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inference of Protein-Protein Interactions by Using Co-evolutionary Informatlon2007

    • Author(s)
      Sato, T.
    • Journal Title

      Algebraic Biology 2007, Lecture Notes in Computer Science 4545

      Pages: 322-333

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exact parameter determination for Parkinson's disease diagnosis wlth FET using an algebraic approach2007

    • Author(s)
      Yoshida, H.
    • Journal Title

      Algebraic Biology 2007, Lecture Notes in Computer Science 4545

      Pages: 110-124

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Algebraic-Numeric Algorithm for the Model Selection in Kinetic Net works2007

    • Author(s)
      Yoshida, H.
    • Journal Title

      Proceedings of 10th CASC, Lecture Notes in Computer Science 4770

      Pages: 433-447

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brute force meets Bruno force in parameter optimization: Introduction of novel constraints for parameter estimation by symbolic computation.

    • Author(s)
      Nakatsu, M., Horimoto, K., Lemaire, F., Urguplu, A., Sedoglavic, A., Boulier, F
    • Journal Title

      IET Sys. Biol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parameter Optimization by Using Differential Elimination: a General Approach for Introducing Constraints into Objective Function.

    • Author(s)
      Nakatsui, M., Horimoto, K., Okamoto, M., Tokumoto, Y., Miyake, J
    • Journal Title

      BMC Sys. Biol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Detection of network structure changes by graphical chain modeling: a case study of hepatitis C virus-related hepatocellular carcinoma.2009

    • Author(s)
      Saito, S., Honda, M., Kaneko, S., Horimoto, K
    • Organizer
      48th IEEE Conference on Decision and Control
    • Place of Presentation
      China
    • Year and Date
      2009-12-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Detection of network structure changes by graphical chain modeling : a case study of hepatitis C virus-related hepatocellular carcinoma2009

    • Author(s)
      Saito, S., Horimoto, K.
    • Organizer
      Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference
    • Place of Presentation
      Shanghai, China.
    • Year and Date
      2009-12-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Co-Expressed Gene Assessment Based on the Path Consistency Algorithm : Operon Detection in Escherichia coli2009

    • Author(s)
      Saito, S., Horimoto, K.
    • Organizer
      2009 IEEE International Conference on Systems, Man, and Cybernetics
    • Place of Presentation
      San Antonio, Texas, USA.
    • Year and Date
      2009-10-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Co-Expressed Gene Assessment Based on the Path Consistency Algorithm: Operon Detention in Escherichia coli.2009

    • Author(s)
      Saito, S., Horimoto, K
    • Organizer
      IEEE International Conference on Systems, Man and Cybernetics
    • Place of Presentation
      USA
    • Year and Date
      2009-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Parameter Optimization in the network dynamics including unmeasured variables by the symbolic-numeric approach.2009

    • Author(s)
      Nakatsui, M., Horimoto, K
    • Organizer
      The Third International Symposium on Optimization and Systems Biology (OSB'09)
    • Place of Presentation
      China
    • Year and Date
      2009-09-20
    • Related Report
      2009 Final Research Report
  • [Presentation] Parameter optimization in network dynamics including unmeasured variables by the symbolic-numeric approach2009

    • Author(s)
      Nakatsui, M., Horimoto, K.
    • Organizer
      The Third International Symposium on Optimization and Systems Biology
    • Place of Presentation
      Zhangjiajie, Hunan, China
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] "Network Screening"-Detection of Activated Pathways from the Data Measured in a Finite Condition2009

    • Author(s)
      Horimoto, K.
    • Organizer
      Computational Systems Biology Workshop
    • Place of Presentation
      Shanghai University
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 遺伝子発現プロファイルによるネットワーク構造評価2009

    • Author(s)
      齊藤秀、堀本勝久
    • Organizer
      電子情報通信学会
    • Place of Presentation
      キャンパスイノベーションセンター(田町)
    • Year and Date
      2009-08-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 代数的アプローチと遺伝的アルゴリズムの組み合わせによる計測不能変数を含むネットワークのパラメータ最適化2009

    • Author(s)
      中津井雅彦、堀本勝久
    • Organizer
      電子情報通信学会
    • Place of Presentation
      キャンパスイノベーションセンター(田町)
    • Year and Date
      2009-08-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2つアプローチによる時間発展するネットワーク構造変化解析2008

    • Author(s)
      堀本勝久
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 進展型疾患のネットワークモデル2008

    • Author(s)
      堀本勝久
    • Organizer
      医療と情報技術の連携イノベーショフォーラム
    • Place of Presentation
      東京大学本郷キャンパス工学部
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Phase Shifts of Circadian Transcripts in Rat Suprachiasmatic Nucleus2008

    • Author(s)
      Morioka, R.
    • Organizer
      The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      Lijiang, China
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] An Algebraic-Numeric Algorithm for the Model Selection in Network Motifs in Escherichia coli2008

    • Author(s)
      Nakatsui, M.
    • Organizer
      The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      Lijiang, China
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Time Series Segmentation for Gene Regulatory Process with Time-window-Extension Technique2008

    • Author(s)
      Zhang, Z. Y.
    • Organizer
      The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      Lijiang, China
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of network dynamics including hidden variables by symbolic-numeric approach2008

    • Author(s)
      Tominaga, D.
    • Organizer
      The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      Lijiang, China
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Revealing Disease Related Interactions by Correlation Analysis2008

    • Author(s)
      Wu, Z. K.
    • Organizer
      The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      Lijiang, China
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of network dynamics including hidden variables by symbolic-numeric approach.2008

    • Author(s)
      Tominaga, D., Tokumoto, Y., Nakatsui, M., Sun, F., Miyake, J., Horimoto, K
    • Organizer
      The Second International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      China
    • Year and Date
      2008-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Phase Shifts of Circadian Transcripts in Rat Suprachiasmatic Nucleus.2008

    • Author(s)
      Morioka, R., Arita, M., Sakamoto, K., Kawaguchi, S., Tei, H., Horimoto, K
    • Organizer
      The Second International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      China
    • Year and Date
      2008-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] An Algebraic-Numeric Algorithm for the Model Selection in Network Motifs in Escherichia coli.2008

    • Author(s)
      Nakatsui, M., Yoshida, H., Horimoto, K
    • Organizer
      The Second International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      China
    • Year and Date
      2008-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Time Series Segmentation for Gene Regulatory Process with Time-Window-Extension Technique.2008

    • Author(s)
      Zhang, Z.Y., Horimoto, K., Liu, Z
    • Organizer
      The Second International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      China
    • Year and Date
      2008-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Revealing Disease Related Interactions by Correlation Analysis.2008

    • Author(s)
      Wu, Z.K., Zhang, Z.Y., Zhang, L.W., Horimoto, K
    • Organizer
      The Second International Symposium on Optimization and Systems Biology (OSB'08)
    • Place of Presentation
      China
    • Year and Date
      2008-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Network Inference and Evaluation Based on Graphical Model2008

    • Author(s)
      Horimoto, K.
    • Organizer
      Seminar on Computational Systems Biology
    • Place of Presentation
      Shanghai University
    • Year and Date
      2008-08-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] An Algebraic-Numeric Algorithm for the Model Selection in Kinetic Networks.2007

    • Author(s)
      Yoshida, H., Nakagawa, K., Anai, H., Horimoto, K
    • Organizer
      10th CASC
    • Place of Presentation
      Germany
    • Year and Date
      2007-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Inference of Protein-Protein Interactions by Using Co-evolutionary Information2007

    • Author(s)
      Sato, T., Yamanishi, Y., Horimoto, K., Kanehisa, M., Toh, H
    • Organizer
      Algebraic Biology 2007
    • Place of Presentation
      Austria
    • Year and Date
      2007-07-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Exact parameter determination for Parkinson's disease diagnosis with PET using an algebraic approach2007

    • Author(s)
      Yoshida, H., Nakagawa, K., Anai, H., Horimoto, K
    • Organizer
      Algebraic Biology 2007
    • Place of Presentation
      Austria
    • Year and Date
      2007-07-02
    • Related Report
      2009 Final Research Report
  • [Presentation] 創薬・副作用予測にむけた生命分子ネットワーク解析法の開発2007

    • Author(s)
      堀本 勝久
    • Organizer
      日本バイオインフォマティクス学会, JSBi合同研究会
    • Place of Presentation
      東京大学医科学研究所
    • Related Report
      2007 Annual Research Report
  • [Presentation] Design of Analysis Tools for Network Inference and Evaluation2007

    • Author(s)
      Horimoto, K.
    • Organizer
      Systems Biology Workshop
    • Place of Presentation
      英国大使館
    • Related Report
      2007 Annual Research Report
  • [Presentation] 代数生物学-記号計算による生命現象解析2007

    • Author(s)
      堀本 勝久
    • Organizer
      Innovative Mathematical Approaches for Systems Biology:System Identification, Analysis, Control and Design
    • Place of Presentation
      九州大学産業技術数理研究センター
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dynamical analysis of biological networks by using reporter gene expressions in transfected cell microarray2007

    • Author(s)
      Horimoto, K.
    • Organizer
      DMHF2007
    • Place of Presentation
      九州大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] Consistency of causal graph with measured data2007

    • Author(s)
      Horimoto, K.
    • Organizer
      International Conference on Multiple Decision Theory, Statistical Inference and Applications
    • Place of Presentation
      Taiwan Science Academy
    • Related Report
      2007 Annual Research Report
  • [Book] Bioinformatics for Systems Biology: Second Edition, Introduction to Informatics(In Krawetz, S. (ed))2009

    • Author(s)
      Aburatani, S., Saito, S., Horimoto, K
    • Publisher
      Humana Press
    • Related Report
      2009 Final Research Report
  • [Book] Symbolic Computation in Biology, Math. Comput. Sci2009

    • Author(s)
      Anai, H., Horimoto, K. (eds)
    • Related Report
      2009 Final Research Report
  • [Book] Algebraic Biology, Lecture Notes in Computer Science2008

    • Author(s)
      Horimoto, K., Regensburger, G., Rosenkranz, M., Yoshida, H. (eds)
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Algebraic Biology, Lecture Notes in Computer Science2007

    • Author(s)
      Anai, H., Horimoto, K., Kutsia, T. (eds)
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Algebraic Biology, Lecture Notes in Computer Science 45452007

    • Author(s)
      Anai, H.
    • Total Pages
      377
    • Publisher
      Springer
    • Related Report
      2007 Annual Research Report
  • [Book] Applied statistics for Network Biology: Methods in Systems Biology(F., Dehmer, M., Salvador, A. and Graber, A. (eds))

    • Author(s)
      Saito, S., Horimoto, K. : Network Screening
    • Publisher
      Wiley(in press)
    • Related Report
      2009 Final Research Report
  • [Remarks] ネットワーク推定サーバ"ASIAN"

    • URL

      http://eureka.cbrc.jp/asian/

    • Related Report
      2009 Final Research Report
  • [Remarks] 研究会「生体モデリングの新展開-分子からネットワークへ」開催(産業技術総合研究所臨海別館11F第三会議室、2009年11月26日)発表者:岡本正宏(九大院農学研究科)、Francois Lemaire、Alexandre Sedoglavic (Computer Science Lab., Lille Univ.)、阿久津達也(京大化学研究所)、今田友樹、永持仁(京大院情報学研究科)、堀本勝久(産総研CBRC)

    • Related Report
      2009 Final Research Report
  • [Remarks] 本課題により開催した国際会議、Algebraic Biology 2007のwebページ

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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