Development of method for evaluating the consistency between network model in the cell and the molecular measured data

• Project/Area Number: 19201039
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 基礎ゲノム科学
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: HORIMOTO Katsuhisa National Institute of Advanced Industrial Science and Technology, 生命情報工学研究センター, 研究チーム長 (40238803)
• Co-Investigator(Kenkyū-buntansha): ABURATANI Sachiyo 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 研究員 (10361627) ; TOMINAGA Daisuke 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 研究員 (20357578) ; ANAI Hirokazu 株式会社富士通研究所, Tコア研究所, 研究員 (20417520) ; YOSHIDA Hiroshi 九州大学, 数理科学研究院, 特任助教授 (60401262)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000); Fiscal Year 2009: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2008: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2007: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
• Keywords: システム生物学 / ネットワーク解析 / グラフィカル・モデル / 記号計算 / グラフィカルモデル / 計算機代数 / 遺伝子制御ネットワーク / パラメータ最適化 / ネットワーク / 遺伝子制御 / タンパク質相互作用 / 国際研究者交流 / 多国籍

Research Abstract

We have developed two methods for evaluating the consistency between the given network structures and the measured data of constituent molecules, based on the statistical and symbolic-numeric approaches. By using these methods, the active networks can be detected under a particular condition, and furthermore, the changes of network structures can be traced, depending on the environmental changes.

Research Products

• [Journal Article] Altered Hepatic Gene Expression Profiles Associated with Myocardial Ischemia. (2010)
  • Author(s): Ootsuji, H., Honda, M., Takamura, M., Usui, S., Okajima, M., D, Okada, H., Sakai, Y., Takamura, T., Horimoto, K., Kaneko, S
  • Journal Title: Circ Cardiovasc Genet 3 Pages: 68-77
  • Peer Reviewed
• [Journal Article] Period-Phase Map: Two-diemsional Selection of Circadian Rhythm-Related Genes. (2009)
  • Author(s): Morioka, R., Arita, M., Sakamoto, K., Kawaguchi, S., Tei, H., Horimoto, K
  • Journal Title: IET Sys. Biol 3 Pages: 487-495
  • Peer Reviewed
• [Journal Article] TRAIL inhibited the cyclic AMP responsible element mediated gene expression. (2009)
  • Author(s): Tokumoto, Y., Horimoto, K., Miyake, J
  • Journal Title: Biochem. Biophys. Res. Commun 381 Pages: 533-536
  • Peer Reviewed
• [Journal Article] Differential miRNA expression between hepatitis B and hepatitis C leading disease progression to HCC. (2009)
  • Author(s): Ura, S., Honda, M., Yamashita, T., Ueda, T., Takatori, H., Nishino, R., Sunagozaka, H., Sakai, Y., Horimoto, K., Kaneko, S
  • Journal Title: Hepatology 49 Pages: 1098-1112
  • Peer Reviewed
• [Journal Article] Detection of network structure changes by graphical chain modeling: a case study of hepatitis C virus-related hepatocellular carcinoma. (2009)
  • Author(s): Saito, S., Honda, M., Kaneko, S., Horimoto, K
  • Journal Title: Proceedings of 48th IEEE Conference on Decision and Control Pages: 5624-5630
  • NAID: 120006655929
  • Peer Reviewed
• [Journal Article] Co-Expressed Gene Assessment Based on the Path Consistency Algorithm: Operon Detention in Escherichia coli. Proceedings of IEEE International Conference on Systems (2009)
  • Author(s): Saito, S., Horimoto, K
  • Journal Title: Man and Cybernetics Pages: 4280-4286
  • Peer Reviewed
• [Journal Article] Parameter Optimization in the network dynamics including unmeasured variables by the symbolic-numeric approach. (2009)
  • Author(s): Nakatsui, M., Horimoto, K
  • Journal Title: Proceedings of the Third International Symposium on Optimization and Systems Biology (OSB'09) Pages: 245-253
  • Peer Reviewed
• [Journal Article] Complementing Networks Using Observed Data. (2009)
  • Author(s): Akutsu, T., Tamura, T., Horimoto, K
  • Journal Title: Lecture Notes in Artificial Intelligence 5809 Pages: 126-140
  • Peer Reviewed
• [Journal Article] Differential miRNA expression between hepatitis B and hepatitis C leading disease progression to HCC (2009)
  • Author(s): Ura, S., et.al.
  • Journal Title: Hepatology 49 Pages: 1098-1112
  • Peer Reviewed
• [Journal Article] TRAIL inhibited the cyclic AMP responsible element mediated gene expression. (2009)
  • Author(s): Tokumoto, Y., et.al.
  • Journal Title: Biochem. Biophys. Res.Commun. 381 Pages: 533-536
  • Peer Reviewed
• [Journal Article] Period-Phase Map : Two-diemsional Selection of Circadian Rhythm-Related Genes (2009)
  • Author(s): Morioka, R., et.al.
  • Journal Title: IET Sys.Biol. 3 Pages: 487-495
  • Peer Reviewed
• [Journal Article] Inference of Probabilities over a Stochastic IL-System by Quantifier Elimination. (2008)
  • Author(s): Yoshida, H., Horimoto, K., Anai, H
  • Journal Title: Math. Comput. Sci 1 Pages: 473-485
  • Peer Reviewed
• [Journal Article] Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma. (2008)
  • Author(s): Nishino, R., Honda, M., Yamashita, T., Takatori, H., Minato, H., Zen, Y., Sasaki, M., Takamura, H., Horimoto, K., Ohta, T., Nakanuma, Y., Kaneko, S
  • Journal Title: J. Hepatol 49 Pages: 207-216
  • Peer Reviewed
• [Journal Article] Integer Programming-based Approach to Allocation of Reporter Genes for Cell Array Analysis. (2008)
  • Author(s): Hayashida, M., Sun, F., Aburatani, S., Horimoto, K., Akutsu, T
  • Journal Title: Int. J. Bioinformatics Research and Applications 4 Pages: 385-399
  • NAID: 110006402728
  • Peer Reviewed
• [Journal Article] Network evaluation from the consistency of the graph structure with the measured data. (2008)
  • Author(s): Saito, S., Aburatani, S., Horimoto, K
  • Journal Title: BMC Sys. Biol 2 Pages: 84-84
  • Peer Reviewed
• [Journal Article] Analysis of network dynamics including hidden variables by symbolic-numeric approach. (2008)
  • Author(s): Tominaga, D., Tokumoto, Y., Nakatsui, M., Sun, F., Miyake, J., Horimoto, K
  • Journal Title: Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08) Pages: 242-248
  • Peer Reviewed
• [Journal Article] Phase Shifts of Circadian Transcripts in Rat Suprachiasmatic Nucleus. (2008)
  • Author(s): Morioka, R., Arita, M., Sakamoto, K., Kawaguchi, S., Tei, H., Horimoto, K
  • Journal Title: Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08) Pages: 109-114
  • Peer Reviewed
• [Journal Article] An Algebraic-Numeric Algorithm for the Model Selection in Network Motifs in Escherichia coli. (2008)
  • Author(s): Nakatsui, M., Yoshida, H., Horimoto, K
  • Journal Title: Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08) Pages: 257-264
  • Peer Reviewed
• [Journal Article] Time Series Segmentation for Gene Regulatory Process with Time-Window-Extension Technique. (2008)
  • Author(s): Zhang, Z.Y., Horimoto, K., Liu, Z
  • Journal Title: Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08) Pages: 198-203
  • Peer Reviewed
• [Journal Article] Revealing Disease Related Interactions by Correlation Analysis. (2008)
  • Author(s): Wu, Z.K., Zhang, Z.Y., Zhang, L.W., Horimoto, K
  • Journal Title: Proceedings of the Second International Symposium on Optimization and Systems Biology (OSB'08) Pages: 341-349
  • Peer Reviewed
• [Journal Article] Inference of Probabilities over a Stochastic IL-System by Quantifier Elimination (2008)
  • Author(s): Yoshida, H.
  • Journal Title: Math. Comput. Sci. 1 Pages: 473-485
  • Peer Reviewed
• [Journal Article] Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma (2008)
  • Author(s): Nishino, R.
  • Journal Title: J. Hepatol. 49 Pages: 207-216
  • Peer Reviewed
• [Journal Article] Integer Programming-based Approach to Allocation of Reporter Genes for Cell Array Analysis (2008)
  • Author(s): Hayashida, M.
  • Journal Title: Int. J. Bioinformatics Research and Applications 4 Pages: 385-399
  • Peer Reviewed
• [Journal Article] Network evaluation from the consistency of the graph structure with the measured data (2008)
  • Author(s): Saito, S.
  • Journal Title: BMC Sys. Biol. 2 Pages: 84-84
  • Peer Reviewed
• [Journal Article] Phase Shifts of Circadian Transcripts in Rat Suprachias matic Nucleus (2008)
  • Author(s): Morioka, R.
  • Journal Title: Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2 Pages: 109-114
  • Peer Reviewed
• [Journal Article] An Algebraic-Numeric Algorithm for the Model Selection in Network Motifs in Escherichia coli (2008)
  • Author(s): Nakatsui, M.
  • Journal Title: Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2 Pages: 257-264
  • Peer Reviewed
• [Journal Article] Time Series Segmentation for Gene Regulatory Process with Time-Window-Extension Technique (2008)
  • Author(s): Zhang, Z. Y.
  • Journal Title: Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2 Pages: 198-203
  • Peer Reviewed
• [Journal Article] Analysis of network dynamics including hidden variables by symbolic-numeric approach (2008)
  • Author(s): Tominaga, D.
  • Journal Title: Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2 Pages: 242-248
  • Peer Reviewed
• [Journal Article] Revealing Disease Related Interactions by Correlation Analysis (2008)
  • Author(s): Wu, Z. K.
  • Journal Title: Proceedings of the 2nd International Symposium on Optimization and Systems Biology (OSB'08) 2 Pages: 341-349
  • Peer Reviewed
• [Journal Article] Gene systems network inferred from expression profiles in hepatocellular carcinogenesis by graphical Gaussian model. (2007)
  • Author(s): Aburatani, S., Sun, F., Saito, S., Honda, M., Kaneko, S., Horimoto, K
  • Journal Title: EURASIP J. Bioinfo. Systems Biol Pages: 47214-47214
  • Peer Reviewed
• [Journal Article] Derivation of rigorous conditions for high cell-type diversity by algebraic approach. (2007)
  • Author(s): Yoshida, H., Anai, H., Horimoto, K
  • Journal Title: BioSystems 90 Pages: 486-495
  • Peer Reviewed
• [Journal Article] Inference of Protein-Protein Interactions by Using Co-evolutionary Information. (2007)
  • Author(s): Sato, T., Yamanishi, Y., Horimoto, K., Kanehisa, M., Toh, H
  • Journal Title: Algebraic Biology, Lecture Notes in Computer Science(In Anai, H., Horimoto, K. and Kutsia, T. (eds)) 4545 Pages: 322-333
  • Peer Reviewed
• [Journal Article] Exact parameter determination for Parkinson's disease diagnosis with PET using an algebraic approach. (2007)
  • Author(s): Yoshida, H., Nakagawa, K., Anai, H., Horimoto, K
  • Journal Title: Algebraic Biology, Lecture Notes in Computer Science(In Anai, H., Horimoto, K., Kutsia, T. (eds)) 4545 Pages: 110-124
• [Journal Article] An Algebraic-Numeric Algorithm for the Model Selection in Kinetic Networks. (2007)
  • Author(s): Yoshida, H., Nakagawa, K., Anai, H., Horimoto, K
  • Journal Title: Proceedings of 10th CASC, LNCS(Springer, Heidelberg) 4770 Pages: 433-447
  • Peer Reviewed
• [Journal Article] Integer Programming-based Approach to Allocation of Reporter Genes for Cell Array Analysis. (2007)
  • Author(s): Hayashida, M., Sun, F., Aburatani, S., Horimoto, K., Akutsu, T
  • Journal Title: Proceedings of 10th OSB, Lecture Notes in Operation Research(Publishing Corporation) Pages: 288-301
  • NAID: 110006402728
  • Peer Reviewed
• [Journal Article] Gene systems network inferred from expression profiles in hepatocellular carcinoffenesis by graphical Gaussian model. (2007)
  • Author(s): Aburatani, S.
  • Journal Title: EURASIP J.Bioinfo.Systems Biol. 47214 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Derivation of rigorous conditions for high cell-type diversity by algebraic approach. (2007)
  • Author(s): Ybshida, H.
  • Journal Title: BioSystems 90 Pages: 486-495
  • Peer Reviewed
• [Journal Article] Inference of Protein-Protein Interactions by Using Co-evolutionary Informatlon (2007)
  • Author(s): Sato, T.
  • Journal Title: Algebraic Biology 2007, Lecture Notes in Computer Science 4545 Pages: 322-333
  • Peer Reviewed
• [Journal Article] Exact parameter determination for Parkinson's disease diagnosis wlth FET using an algebraic approach (2007)
  • Author(s): Yoshida, H.
  • Journal Title: Algebraic Biology 2007, Lecture Notes in Computer Science 4545 Pages: 110-124
  • Peer Reviewed
• [Journal Article] An Algebraic-Numeric Algorithm for the Model Selection in Kinetic Net works (2007)
  • Author(s): Yoshida, H.
  • Journal Title: Proceedings of 10th CASC, Lecture Notes in Computer Science 4770 Pages: 433-447
  • Peer Reviewed
• [Journal Article] Brute force meets Bruno force in parameter optimization: Introduction of novel constraints for parameter estimation by symbolic computation.
  • Author(s): Nakatsu, M., Horimoto, K., Lemaire, F., Urguplu, A., Sedoglavic, A., Boulier, F
  • Journal Title: IET Sys. Biol (in press)
  • Peer Reviewed
• [Journal Article] Parameter Optimization by Using Differential Elimination: a General Approach for Introducing Constraints into Objective Function.
  • Author(s): Nakatsui, M., Horimoto, K., Okamoto, M., Tokumoto, Y., Miyake, J
  • Journal Title: BMC Sys. Biol (in press)
  • Peer Reviewed
• [Presentation] Detection of network structure changes by graphical chain modeling: a case study of hepatitis C virus-related hepatocellular carcinoma. (2009)
  • Author(s): Saito, S., Honda, M., Kaneko, S., Horimoto, K
  • Organizer: 48th IEEE Conference on Decision and Control
  • Place of Presentation: China
  • Year and Date: 2009-12-17
• [Presentation] Detection of network structure changes by graphical chain modeling : a case study of hepatitis C virus-related hepatocellular carcinoma (2009)
  • Author(s): Saito, S., Horimoto, K.
  • Organizer: Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference
  • Place of Presentation: Shanghai, China.
  • Year and Date: 2009-12-17
• [Presentation] Co-Expressed Gene Assessment Based on the Path Consistency Algorithm : Operon Detection in Escherichia coli (2009)
  • Author(s): Saito, S., Horimoto, K.
  • Organizer: 2009 IEEE International Conference on Systems, Man, and Cybernetics
  • Place of Presentation: San Antonio, Texas, USA.
  • Year and Date: 2009-10-14
• [Presentation] Co-Expressed Gene Assessment Based on the Path Consistency Algorithm: Operon Detention in Escherichia coli. (2009)
  • Author(s): Saito, S., Horimoto, K
  • Organizer: IEEE International Conference on Systems, Man and Cybernetics
  • Place of Presentation: USA
  • Year and Date: 2009-10-11
• [Presentation] Parameter Optimization in the network dynamics including unmeasured variables by the symbolic-numeric approach. (2009)
  • Author(s): Nakatsui, M., Horimoto, K
  • Organizer: The Third International Symposium on Optimization and Systems Biology (OSB'09)
  • Place of Presentation: China
  • Year and Date: 2009-09-20
• [Presentation] Parameter optimization in network dynamics including unmeasured variables by the symbolic-numeric approach (2009)
  • Author(s): Nakatsui, M., Horimoto, K.
  • Organizer: The Third International Symposium on Optimization and Systems Biology
  • Place of Presentation: Zhangjiajie, Hunan, China
  • Year and Date: 2009-09-20
• [Presentation] "Network Screening"-Detection of Activated Pathways from the Data Measured in a Finite Condition (2009)
  • Author(s): Horimoto, K.
  • Organizer: Computational Systems Biology Workshop
  • Place of Presentation: Shanghai University
  • Year and Date: 2009-09-19
• [Presentation] 遺伝子発現プロファイルによるネットワーク構造評価 (2009)
  • Author(s): 齊藤秀、堀本勝久
  • Organizer: 電子情報通信学会
  • Place of Presentation: キャンパスイノベーションセンター(田町)
  • Year and Date: 2009-08-06
• [Presentation] 代数的アプローチと遺伝的アルゴリズムの組み合わせによる計測不能変数を含むネットワークのパラメータ最適化 (2009)
  • Author(s): 中津井雅彦、堀本勝久
  • Organizer: 電子情報通信学会
  • Place of Presentation: キャンパスイノベーションセンター(田町)
  • Year and Date: 2009-08-06
• [Presentation] 2つアプローチによる時間発展するネットワーク構造変化解析 (2008)
  • Author(s): 堀本勝久
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2008-12-12
• [Presentation] 進展型疾患のネットワークモデル (2008)
  • Author(s): 堀本勝久
  • Organizer: 医療と情報技術の連携イノベーショフォーラム
  • Place of Presentation: 東京大学本郷キャンパス工学部
  • Year and Date: 2008-12-02
• [Presentation] Phase Shifts of Circadian Transcripts in Rat Suprachiasmatic Nucleus (2008)
  • Author(s): Morioka, R.
  • Organizer: The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: Lijiang, China
  • Year and Date: 2008-11-01
• [Presentation] An Algebraic-Numeric Algorithm for the Model Selection in Network Motifs in Escherichia coli (2008)
  • Author(s): Nakatsui, M.
  • Organizer: The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: Lijiang, China
  • Year and Date: 2008-11-01
• [Presentation] Time Series Segmentation for Gene Regulatory Process with Time-window-Extension Technique (2008)
  • Author(s): Zhang, Z. Y.
  • Organizer: The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: Lijiang, China
  • Year and Date: 2008-11-01
• [Presentation] Analysis of network dynamics including hidden variables by symbolic-numeric approach (2008)
  • Author(s): Tominaga, D.
  • Organizer: The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: Lijiang, China
  • Year and Date: 2008-11-01
• [Presentation] Revealing Disease Related Interactions by Correlation Analysis (2008)
  • Author(s): Wu, Z. K.
  • Organizer: The 2nd International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: Lijiang, China
  • Year and Date: 2008-11-01
• [Presentation] Analysis of network dynamics including hidden variables by symbolic-numeric approach. (2008)
  • Author(s): Tominaga, D., Tokumoto, Y., Nakatsui, M., Sun, F., Miyake, J., Horimoto, K
  • Organizer: The Second International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: China
  • Year and Date: 2008-10-18
• [Presentation] Phase Shifts of Circadian Transcripts in Rat Suprachiasmatic Nucleus. (2008)
  • Author(s): Morioka, R., Arita, M., Sakamoto, K., Kawaguchi, S., Tei, H., Horimoto, K
  • Organizer: The Second International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: China
  • Year and Date: 2008-10-18
• [Presentation] An Algebraic-Numeric Algorithm for the Model Selection in Network Motifs in Escherichia coli. (2008)
  • Author(s): Nakatsui, M., Yoshida, H., Horimoto, K
  • Organizer: The Second International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: China
  • Year and Date: 2008-10-18
• [Presentation] Time Series Segmentation for Gene Regulatory Process with Time-Window-Extension Technique. (2008)
  • Author(s): Zhang, Z.Y., Horimoto, K., Liu, Z
  • Organizer: The Second International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: China
  • Year and Date: 2008-10-18
• [Presentation] Revealing Disease Related Interactions by Correlation Analysis. (2008)
  • Author(s): Wu, Z.K., Zhang, Z.Y., Zhang, L.W., Horimoto, K
  • Organizer: The Second International Symposium on Optimization and Systems Biology (OSB'08)
  • Place of Presentation: China
  • Year and Date: 2008-10-18
• [Presentation] Network Inference and Evaluation Based on Graphical Model (2008)
  • Author(s): Horimoto, K.
  • Organizer: Seminar on Computational Systems Biology
  • Place of Presentation: Shanghai University
  • Year and Date: 2008-08-13
• [Presentation] An Algebraic-Numeric Algorithm for the Model Selection in Kinetic Networks. (2007)
  • Author(s): Yoshida, H., Nakagawa, K., Anai, H., Horimoto, K
  • Organizer: 10th CASC
  • Place of Presentation: Germany
  • Year and Date: 2007-09-16
• [Presentation] Inference of Protein-Protein Interactions by Using Co-evolutionary Information (2007)
  • Author(s): Sato, T., Yamanishi, Y., Horimoto, K., Kanehisa, M., Toh, H
  • Organizer: Algebraic Biology 2007
  • Place of Presentation: Austria
  • Year and Date: 2007-07-02
• [Presentation] Exact parameter determination for Parkinson's disease diagnosis with PET using an algebraic approach (2007)
  • Author(s): Yoshida, H., Nakagawa, K., Anai, H., Horimoto, K
  • Organizer: Algebraic Biology 2007
  • Place of Presentation: Austria
  • Year and Date: 2007-07-02
• [Presentation] 創薬・副作用予測にむけた生命分子ネットワーク解析法の開発 (2007)
  • Author(s): 堀本 勝久
  • Organizer: 日本バイオインフォマティクス学会, JSBi合同研究会
  • Place of Presentation: 東京大学医科学研究所
• [Presentation] Design of Analysis Tools for Network Inference and Evaluation (2007)
  • Author(s): Horimoto, K.
  • Organizer: Systems Biology Workshop
  • Place of Presentation: 英国大使館
• [Presentation] 代数生物学-記号計算による生命現象解析 (2007)
  • Author(s): 堀本 勝久
  • Organizer: Innovative Mathematical Approaches for Systems Biology:System Identification, Analysis, Control and Design
  • Place of Presentation: 九州大学産業技術数理研究センター
• [Presentation] Dynamical analysis of biological networks by using reporter gene expressions in transfected cell microarray (2007)
  • Author(s): Horimoto, K.
  • Organizer: DMHF2007
  • Place of Presentation: 九州大学
• [Presentation] Consistency of causal graph with measured data (2007)
  • Author(s): Horimoto, K.
  • Organizer: International Conference on Multiple Decision Theory, Statistical Inference and Applications
  • Place of Presentation: Taiwan Science Academy
• [Book] Bioinformatics for Systems Biology: Second Edition, Introduction to Informatics(In Krawetz, S. (ed)) (2009)
  • Author(s): Aburatani, S., Saito, S., Horimoto, K
  • Publisher: Humana Press
• [Book] Symbolic Computation in Biology, Math. Comput. Sci (2009)
  • Author(s): Anai, H., Horimoto, K. (eds)
• [Book] Algebraic Biology, Lecture Notes in Computer Science (2008)
  • Author(s): Horimoto, K., Regensburger, G., Rosenkranz, M., Yoshida, H. (eds)
  • Publisher: Springer
• [Book] Algebraic Biology, Lecture Notes in Computer Science (2007)
  • Author(s): Anai, H., Horimoto, K., Kutsia, T. (eds)
  • Publisher: Springer
• [Book] Algebraic Biology, Lecture Notes in Computer Science 4545 (2007)
  • Author(s): Anai, H.
  • Total Pages: 377
  • Publisher: Springer
• [Book] Applied statistics for Network Biology: Methods in Systems Biology(F., Dehmer, M., Salvador, A. and Graber, A. (eds))
  • Author(s): Saito, S., Horimoto, K. : Network Screening
  • Publisher: Wiley(in press)
• [Remarks] ネットワーク推定サーバ"ASIAN"
  • URL: http://eureka.cbrc.jp/asian/
• [Remarks] 研究会「生体モデリングの新展開-分子からネットワークへ」開催(産業技術総合研究所臨海別館11F第三会議室、2009年11月26日)発表者:岡本正宏(九大院農学研究科)、Francois Lemaire、Alexandre Sedoglavic (Computer Science Lab., Lille Univ.)、阿久津達也(京大化学研究所)、今田友樹、永持仁(京大院情報学研究科)、堀本勝久(産総研CBRC)
• [Remarks] 本課題により開催した国際会議、Algebraic Biology 2007のwebページ