| Budget Amount *help |
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2009: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2008: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2007: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Research Abstract |
Kaitocephalin has attracted much attention due to its potent antagonist activity to glutamate receptors in mammalian CNS, and is expected to be a potent candidate as a tool to investigate the function of glutamate receptors as well as a leadto develop neuroprotecting agent. In this study, we have achieved the highly efficient total synthesis of kaitocephalin which was accompanied by the development of new synthetic methods. We also performed the synthesis of its derivatives, structurally simplifiedanalogs, and other neuroactive amino acids, whose SAR studies revealed that kaitocephalin and some of its derivatives exhibited potent binding activities to NMDA receptors.
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