| Budget Amount *help |
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2010: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2009: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2008: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2007: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
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| Research Abstract |
This research project aims to develop a new class of HPLC packing materials with high selectivity. To accomplish this purpose, we proposed two goals :(1) Physical control of surface morphology and (2) chemical modification by graft polymerization on supporting materials and HPLC applications.
1. We established a new method for creation of core-shell particles with silica particles-layer shells. This method has several advantages that can be emphasized as follows :(a) the core-shell particles can be readily prepared by one-pot suspension polymerization.(b) The resultant shell is stably immobilized by covalent bonding.(c) By proper choosing the diameter and combination of silica particles, the shell structures can be adjusted from single-to multi-layers.(d) By using porous silica particles and removal of silica particles, the dimple structural surface can be created.
2. For chemical functionalization of silica surface, a polymer-grafting method has been investigated. Vinyl monomers with heterocyclic structures such as carbazole and oxazole were used. The resultant hybrids showed excellent separation ability in HPLC especially for polyaromatic hydrocarbons. It has also been established that the selectivity can be tuned by not only choosing a monomer but also polymerization method. The most successful results were observed in the base-line separation of tocopheroles containing β- and γisomers.
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