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Development of functional anti-cancer molecules based on precise control of excitation and relaxation pathways

Research Project

Project/Area Number 19205021
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemistry related to living body
Research InstitutionThe University of Tokyo

Principal Investigator

URANO Yasuteru  The University of Tokyo, 大学院・医学系研究科, 教授 (20292956)

Co-Investigator(Kenkyū-buntansha) OKUNO Hiroyuki  東京大学, 大学院・医学系研究科, 助教 (80272417)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥50,830,000 (Direct Cost: ¥39,100,000、Indirect Cost: ¥11,730,000)
Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2008: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2007: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Keywords蛍光プローブ / 分子イメージング / がん / 光誘起電子移動 / エンドサイトーシス / リソソーム / ペプチダーゼ / 光線力学的治療 / SNAP / アミノペプチダーゼ / スピロ環化 / 光線力学療法 / 分子内閉環 / ローダミン / ヒドロキシメチル基 / エタノール注入療法 / ロドール / ライソゾーム / 抗体医薬 / BODIPY / スペクトルイメージング / HER2
Research Abstract

It is a long-term goal of cancer diagnosis to develop tumor-imaging techniques that have sufficient specificity and sensitivity. To achieve this goal, minimizing the background signal originating from non-target tissues is critical. Here, we achieve highly specific in vivo cancer visualization by employing a newly-designed targeted "activatable" fluorescent imaging probe. This agent is activated after cellular internalization by sensing the pH change in the lysosome. Novel acidic pH-activatable probes based on the BODIPY fluorophore were synthesized, and then conjugated to a cancer-targeting monoclonal antibody. As proof of concept, ex and in vivo imaging of HER2-positive lung cancer cells in mice were performed. The probe was highly specific for tumors with minimal background signal.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (126 results)

All 2011 2010 2009 2008 2007

All Journal Article (25 results) (of which Peer Reviewed: 24 results) Presentation (93 results) Book (5 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling (FAPL) method.2011

    • Author(s)
      Komatsu T, Johnsson K, Okuno H, Bito H, Inoue T, Nagano T, Urano Y.
    • Journal Title

      J.Am.Chem.Soc. 133

      Pages: 6745-6751

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling(FAPL)method.2011

    • Author(s)
      Toru Komatsu
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ evaluation of kinetic resolution catalysts for nitroaldol by using a rationally designed fluorescence probe.2011

    • Author(s)
      Takuya Matsumoto
    • Journal Title

      J.Org.Chem.

      Volume: 76 印刷中(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolution of group 14 rhodamines as platforms for near-infrared fluorescence probes utilizing photoinduced electron transfer.2011

    • Author(s)
      Yuichiro Koide
    • Journal Title

      ACS Chem.Biol.

      Volume: 6 印刷中(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an Si-rhodamine-based far-red to near-infrared fluorescence probe selective for hypochlorous acid and applications for biological imaging.2011

    • Author(s)
      Yuichiro Koide
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133 Pages: 5680-5682

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of enzyme-activated photosensitizer based on intramolecular electron transfer.2010

    • Author(s)
      Takatoshi Yogo
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 4320-4323

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes.2009

    • Author(s)
      Urano Y, Asanuma D, Hama Y, Koyama Y, Barrett T, Kamiya M, Nagano T, Watanabe T, Hasegawa A, Choyke PL, Kobayashi H
    • Journal Title

      Nat.Med. 15

      Pages: 104-109

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes2009

    • Author(s)
      Urano Y, Asanuma D, Hama Y, Koyama Y, Barrett T, Kamiya M, Nagano T, Watanabe T, Hasegawa A, Choyke PL, Kobayashi H
    • Journal Title

      Nat.Med. 15

      Pages: 104-109

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Development of 2,6-carboxy-substituted boron dipyrromethene(BODIPY)as a novel scaffold of ratiometric fluorescent probes for live cell imaging2009

    • Author(s)
      Toru Komatsu
    • Journal Title

      Chem.Commun. 45

      Pages: 7015-7017

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and development of enzymatically activatable photosensitizer based on unique characteristics of thiazole orange2009

    • Author(s)
      Yuichiro Koide
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 6058-6059

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      浦野泰照
    • Journal Title

      蛋白質核酸酵素(共立出版)

      Pages: 1344-1355

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes2009

    • Author(s)
      Yasuteru Urano
    • Journal Title

      Nature Medicine 15

      Pages: 104-109

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive and selective tumor imaging with novel and highly activatable fluorescence probes.2008

    • Author(s)
      Urano Y
    • Journal Title

      Anal.Sci. 24

      Pages: 51-53

    • NAID

      10020143316

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and Synthesis of Highly Sensitive Fluorogenic Substrates for Glutahione s-transferase (GST) and Application for Activity Imaging in Living Cells2008

    • Author(s)
      Yuuta Fujikawa
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 14533-14543

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive and Selective Tumor Imaging with Novel and Highly Activatable Fluorescence Probes2008

    • Author(s)
      Yasuteru Urano
    • Journal Title

      Anal. Sci 24

      Pages: 5-8

    • NAID

      10020143316

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selcctive Photoinactivation of Protein Function through Environment-sensitive Switching of Singlet Oxygen Generation by Photosensitizer2008

    • Author(s)
      Takatoshi Yogo
    • Journal Title

      Proc. Natl. Acad. Sci 105

      Pages: 28-32

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An enzymatically activated fluorescence probe for targeted tumor imaging.2007

    • Author(s)
      Kamiya M, Kobayashi H, Hama Y, Koyama Y, Bernardo M, Nagano T, Choyke PL, Urano Y
    • Journal Title

      J.Am.Chem.Soc. 129

      Pages: 3918-3929

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An enzymatically activated fluorescence probe for targeted tumor imaging2007

    • Author(s)
      Kamiya M, Kobayashi H, Hama Y, Koyama Y, Bernardo M, Nagano T, Choyke PL, Urano Y
    • Journal Title

      J.Am.Chem.Soc. 129

      Pages: 3918-3929

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Design and Synthesis of a Library of BODIPY-Based Environmental Polarity Sensors Utilizing Photoinduced Electron Transfer-Controlled Fluorescence ON/0FF Switching2007

    • Author(s)
      Hisato Sunahara
    • Journal Title

      J. Am. Chem. Soc 129

      Pages: 5597-5604

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Highly Spccific, Rhodamine-Based Fluoresccnce Probe for Hypochlorous Acid and Its Application to Rea1-Time Imaglng of Phagocytosis2007

    • Author(s)
      Suguru Kenmoku
    • Journal Title

      J. Am. Chem. Soc 129

      Pages: 7313-7318

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and Synthesis of Fluorescent Probes for Selective Detection of Highly Reactive Oxygen Species in Mitochondria of Living Cells2007

    • Author(s)
      Yuichiro Koide
    • Journal Title

      J. Am. Chem. Soc 129

      Pages: 10324-10325

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Enzymatically Activated Fluorescence Probe for Targeted Tumor Imaging2007

    • Author(s)
      Mako Kamiya
    • Journal Title

      J. Am. Chcm. Soc 129

      Pages: 3918-3929

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly Activatable and Rapidly Releasable Caged Fluorescein Derivatives2007

    • Author(s)
      Tomonori Kobayashi
    • Journal Title

      J. Am. Chem. Soc 129

      Pages: 6696-6697

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Devclopment of an Iminocoumarin-Based Zinc Sensor Suitable for Ratiometric Fluorescence Imaging of Ncuronal Zinc2007

    • Author(s)
      Kensuke Komatsu
    • Journal Title

      J. Am. Chem. Soc 129

      Pages: 13447-13454

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Thiol-Reactive Fluorescence Probe Based on Donor-Excited Photoinduced Electron Transfer: Key Role of Ortho Substution2007

    • Author(s)
      Takuya Matsumoto
    • Journal Title

      Org. Lett 9

      Pages: 3375-3377

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Acti_vatable蛍光プローブの開発に基づく高感度迅速術中がん診断の実現2011

    • Author(s)
      浦野泰照
    • Organizer
      日本薬学会第131年会特別シンポジウム「生体反応・細胞挙動のセンシング-光を使って何ができるのか?-」
    • Place of Presentation
      グランシップ、静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル化学プローブの開発による、新たな生細胞観測、in vivoがんイメージングの実現2011

    • Author(s)
      浦野泰照
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学、神奈川
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel chemical fluorescence sensors for visualization of various ROS in living cells and animals2011

    • Author(s)
      浦野泰照
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナルプローブの精密設計による、術中迅速がん蛍光イメージングの実現2011

    • Author(s)
      浦野泰照
    • Organizer
      第7回ナノバイオ国際シンポジウム
    • Place of Presentation
      東京ビッグサイト、東京
    • Year and Date
      2011-02-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの開発による、細胞応答観測・in vivoがんイメージングの最前線2011

    • Author(s)
      浦野泰照
    • Organizer
      第40回日本心脈管作動物質学会
    • Place of Presentation
      香川国際会議場、香川
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 有機小分子蛍光プローブの開発による、細胞応答観測・in vivoがんイメージングの新展開2011

    • Author(s)
      浦野泰照
    • Organizer
      第38回千葉ベイシティカンファレンス
    • Place of Presentation
      オリエンタルホテル東京ベイ、千葉
    • Year and Date
      2011-02-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光機能性分子プローブの開発に基づく新しいin vivoがんイメージング2011

    • Author(s)
      浦野泰照
    • Organizer
      レーザー学会第31回年次大会
    • Place of Presentation
      電気通信大学、東京
    • Year and Date
      2011-01-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo cancer imaging with rationally designed fluorescence probes2010

    • Author(s)
      浦野泰照
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies, Fluorescent Sensors by Design (#181) (Invited)
    • Place of Presentation
      Honolulu (USA).
    • Year and Date
      2010-12-19
    • Related Report
      2010 Final Research Report
  • [Presentation] In vivo cancer imaging with rationally designed fluorescence probes2010

    • Author(s)
      Yasuteru Urano
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies, Fluorescent Sensors by Design (#181)
    • Place of Presentation
      Honolulu,USA
    • Year and Date
      2010-12-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo Tumor Imaging with Rationally Designed Fluorescence Probes2010

    • Author(s)
      浦野泰照
    • Organizer
      The 16th Takeda Science Foundation Symposium on Bioscience (Invited)
    • Place of Presentation
      Sheraton Miyako Hotel(東京都)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] In vivo Tumor Imaging with Rationally Designed Fluorescence Probes2010

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 16th Takeda Science Foundation Symposium on Bioscience
    • Place of Presentation
      The Miyako hotel in Tokyo,Tokyo
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの論理的開発に基づく術中がん診断の実現2010

    • Author(s)
      浦野泰照
    • Organizer
      GlycoTOKYOシンポジウム2010
    • Place of Presentation
      東京大学薬学部講堂、東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの開発に基づく、生細胞応答・in vivoがんイメージングの新展開2010

    • Author(s)
      浦野泰照
    • Organizer
      第4回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      東京大学武田先端知ビル、東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの論理的開発による新しい細胞応答観測・in vivaがんイメージングの実現2010

    • Author(s)
      浦野泰照
    • Organizer
      視る生物学5
    • Place of Presentation
      奈良先端科学技術大学院大学ミレニアムホール、奈良
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計によるin aivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第56回秋期特別総会病理学会
    • Place of Presentation
      北九州西日本総合展示場、福岡
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル化学プローブの開発による、新たな生細胞観測、in vivoがんイメージングの実現2010

    • Author(s)
      浦野泰照
    • Organizer
      第35回日本薬学会関東支部学術講演会
    • Place of Presentation
      日本薬学会長井記念ホール、東京
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電子移動の精密制御による新たな生体応答観測・先進医療の実現2010

    • Author(s)
      浦野泰照
    • Organizer
      第43回酸化反応討論会
    • Place of Presentation
      東京大学医学部鉄門講堂、東京
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル化学プローブの開発による新しい生体分子イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第6回「学際領域における分子イメージングフォーラム」
    • Place of Presentation
      宇宙航空研究開発機構調布航空宇宙センター、東京
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光ブローブの精密設計に基づく先進的がんイメージング技術の創製2010

    • Author(s)
      浦野泰照
    • Organizer
      創剤フォーラム第16回シンポジウム
    • Place of Presentation
      アルカディア市ヶ谷、東京
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Selective Molecular Imaging of Viable Cancer Cells with Rationally Designed"Activatable" Fluorescence Probes2010

    • Author(s)
      Yasuteru Urano
    • Organizer
      SPACC 17
    • Place of Presentation
      Kagoshima University,Kagoshima
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計による抗がん先進医療技術の創出2010

    • Author(s)
      浦野泰照
    • Organizer
      バィオジャパン2010
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル化学プローブの開発による新しい生体分子イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      生化学夏の学校2010
    • Place of Presentation
      箱根高原ホテル、神奈川
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光機能性プローブの精密設計によるがん医療の新展開2010

    • Author(s)
      浦野泰照
    • Organizer
      第32回日本光医学・光生物学会年会
    • Place of Presentation
      東京慈恵会医科大学、東京
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計に基づく、新たな生細胞応答観測・in vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第21回日本生体防御学会シンポジウム「活性酸素の生体防御シグナルとバイオイメージング」
    • Place of Presentation
      仙台市戦災復興記念館、宮城
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プロープ開発による新しい生体分子イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第23回バイオメディカル分析科学シンポジウムシンポジウム「in vivOイメージングと分析科学」
    • Place of Presentation
      ホテル松島大観荘、宮城
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 有機小分子蛍光プロープの精密設計に基づく、新たな生細胞応答観測・in vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第22回生体機能関連若手の会サマースクール
    • Place of Presentation
      国民宿舎「関ロッジ」、三重
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Real-time imaging of various ROS, RNS and related enzymatic activities in living cells by using precisely designed novel fluorescence probes2010

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto International Conference Center,Kyoto
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 化学蛍光プローブの精密設計による、新たな標的分子イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      レーザ顕微鏡研究会第36回講演会
    • Place of Presentation
      理化学研究和光本所鈴木梅太郎ホール、埼玉
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計による生細胞・生体内計測の実現2010

    • Author(s)
      浦野泰照
    • Organizer
      岡山大&理研ジョイントシンポジウム「最先端計測のトレンド2010」
    • Place of Presentation
      岡山大学創立50周年記念館、岡山
    • Year and Date
      2010-06-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プロープの開発による、生細胞応答・in vivOがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第21回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      東京大学小柴ホール、東京
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計による、新たな生細胞イメージング・in vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      日本顕微鏡学会第66回学術講演会シンポジウム
    • Place of Presentation
      名古屋国際会議場、愛知
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Selective and Sensitive in vivo Tumor Imaging with Rationally Doveloped Novel Fluorescence Probes2010

    • Author(s)
      浦野泰照
    • Organizer
      日本血栓止血学会第33回学術集会シンポジウム「Tnnovation of Technology」
    • Place of Presentation
      鹿児島城山観光ホテル、鹿児島
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの開発に基づくin vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      日本薬学会第130年会シンポジウム「有機化学を駆使した新しい分子イメージ」
    • Place of Presentation
      岡山大学津島キャンパス50周年記念館、岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Selective Molecular Imaging of Viable Cancer cells with Rationally Designed "Activatable" Fluorescence Probes2010

    • Author(s)
      浦野泰照
    • Organizer
      東北大学世界トップレベル研究拠点国際シンポジウム
    • Place of Presentation
      仙台国際センター、宮城
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rational design of novel fluorescence probes for visualizing various cellular responses and in vivo tumor imaging2010

    • Author(s)
      浦野泰照
    • Organizer
      The 2nd International Symposium of Global 5-5-10 Yonsei Systems Biology Initiative
    • Place of Presentation
      Yonsei University, Seoul, Korea
    • Year and Date
      2010-02-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計に基づくin vivo微小がんイメージングの実現2010

    • Author(s)
      浦野泰照
    • Organizer
      第2回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      沖縄コンベンションセンター、那覇
    • Year and Date
      2010-01-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Intraoperative Detection of Tiny Tumors in Living Mice with Novel, Fast-responding, and Highly Activatable Fluorescence Probes, SPIE BiOS2010 (Invited)2010

    • Author(s)
      浦野泰照
    • Place of Presentation
      San Francisco (USA).
    • Year and Date
      2010-01-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Intraoperative Detection of Tiny Tumors in Living Mice with Novel, Fast-responding, and Highly Activatable Fluorescence Probes2010

    • Author(s)
      浦野泰照
    • Organizer
      SPIE BiOS2010
    • Place of Presentation
      Moscone Convention Center, San Francisco, CA USA
    • Year and Date
      2010-01-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛍光プローブの開発による新たな医療の実現2010

    • Author(s)
      浦野泰照
    • Organizer
      日本応用物理学会関西支部 平成21年度第2回支部講演会
    • Place of Presentation
      大阪大学中之島センター 佐治敬三メモリアルホール、大阪
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計による、新たな生細胞イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      日本顕微鏡学会バイオメディカルニューマイクロスコープ分科会平成21年度シンポジウム講演会
    • Place of Presentation
      帝京大学医学臨床大講堂、東京
    • Year and Date
      2010-01-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機小分子蛍光プローブの精密設計に基づく、生細胞応答観測・in vivoがんイメージング2009

    • Author(s)
      浦野泰照
    • Organizer
      第13回日本内分泌病理学会学術総会
    • Place of Presentation
      山梨大学医学部、甲府
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Novel Fluorescence Probes Based on Rational Design Strategies : Real-time Visualization of Various Cellular Responses and in vivo Tumor Imaging2009

    • Author(s)
      浦野泰照
    • Organizer
      ISBIE-2009 (Invited)
    • Place of Presentation
      Taipei (Taiwan).
    • Year and Date
      2009-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of Novel Fluorescence Probes Based on Rational Design Strategies : Real-time Visualization of Various Cellular Responses and in vivo Tumor Imaging2009

    • Author(s)
      浦野泰照
    • Organizer
      ISBIE-2009
    • Place of Presentation
      Academia Sinica, Taipei, Taiwan
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rational design of novel fluorescence probes for visualizing various cellular responses and in vivo tumor imaging2009

    • Author(s)
      浦野泰照
    • Organizer
      4th Cell Stress Society International Congress on Stress Responses
    • Place of Presentation
      ガトーキングダムサッポロ北海道
    • Year and Date
      2009-10-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vivo cancer optical imaging with rationally and precisely designed fluorescence probes2009

    • Author(s)
      浦野泰照
    • Organizer
      第68回日本癌学会学術集会International Session(招待講演)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] In vivo cancer optical imaging with rationally and precisely designed fluorescence probes2009

    • Author(s)
      浦野泰照
    • Organizer
      第68回日本癌学会学術集会 International Session
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2009-10-02
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] In vivo cancer optical imaging with rationally and precisely designed fluorescence probes2009

    • Author(s)
      浦野泰照
    • Organizer
      JCA 2009 International Session
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機小分子蛍光プローブの精密設計に基づく、細胞応答・がんイメージングの新展開2009

    • Author(s)
      浦野泰照
    • Organizer
      創薬・薬理フォーラム 第17回シンポジウム
    • Place of Presentation
      日本薬学会長井ホール、東京
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rational design of novel fluorescence probes for visualizing various cellular responses and in vivo tumor imaging2009

    • Author(s)
      浦野泰照
    • Organizer
      European Conference on Chemistry for Life Sciences 2009 (Invited)
    • Place of Presentation
      Frankfurt (Germany).
    • Year and Date
      2009-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Rational design of novel fluorescence probes for visualizing various cellular responses and in vivo tumor imaging2009

    • Author(s)
      浦野泰照
    • Organizer
      European Conference on Chemistry for Life Sciences 2009
    • Place of Presentation
      Frankfurt am Main, Germany
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Selective Molecular Imaging of Viable Cancer Cells with Rationally Designed "Activatable" Fluorescence Probes2009

    • Author(s)
      Yasuteru Urano
    • Organizer
      International Conference on Biomaterials at the interface of chemistry, physics, and biology
    • Place of Presentation
      京都大学百周年時計台記念館ホール、京都
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Selective Molecular Imaging of Viable Cancer Cells With Rationally Dsigned pH-Activatable Fluorescence Probes2009

    • Author(s)
      浦野泰照
    • Organizer
      International Conference on Photochemistry
    • Place of Presentation
      Toredo, Spain
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機小分子蛍光プローブの精密設計に基づく、生細胞・in vivoがんイメージング2009

    • Author(s)
      浦野泰照
    • Organizer
      ーザー顕微鏡研究会第35回講演会
    • Place of Presentation
      理化学研究所鈴木梅太郎記念ホール、埼玉
    • Year and Date
      2009-07-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Novel Fluorescence Probes Based on Rational Design Strategies for Visualizing Cellular Responses and Targeted Tumor Imaging2009

    • Author(s)
      浦野泰照
    • Organizer
      Engineering Conference International, Advances in Optics for Biotechnology, Medicine and Surgery XI
    • Place of Presentation
      Burlington, Vermont, USA
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計に基づく、生命現象・病態イメージング2009

    • Author(s)
      浦野泰照
    • Organizer
      第34回日本香粧品学会
    • Place of Presentation
      ヤクルトホール、東京
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規蛍光プローブの精密設計による生細胞酵素活性イメージング2009

    • Author(s)
      浦野泰照
    • Organizer
      日本薬物動態学会第2回ビジョンシンポジウム
    • Place of Presentation
      東京大学小柴ホール、東京
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛍光プローブの論理的精密設計による、生細胞応答・in vivoがんイメージング2009

    • Author(s)
      浦野泰照
    • Organizer
      第2回稲盛フロンティア研究講演会
    • Place of Presentation
      九州大学伊都キャンパス、福岡
    • Year and Date
      2009-05-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛍光プローブの精密開発に基づく、生細胞応答・in vivoがんイメージングの新展開2009

    • Author(s)
      浦野泰照
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      大宮ソニックシティ、埼玉
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計に基づくin vivo光がんイメージング2009

    • Author(s)
      浦野泰照
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機小分子蛍光プローブの論理的開発に塞づく新たな細胞応答・in vivoがんイメージングの実現2009

    • Author(s)
      浦野 泰照
    • Organizer
      第1回同志社大学ナノサイエンス研究センター シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2009-03-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光プローブの精密開発に基づく、生細胞応答・in vivoがんイメージングの新展開2009

    • Author(s)
      浦野 泰照
    • Organizer
      第2回創薬とイメージングに関するシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rational Development of Small Molecular-based Fluorescence Probes for Visualizing Various Cellular Responses and in vivo Tiny Tumors2009

    • Author(s)
      Yasuteru Urano
    • Organizer
      BiOS 2009
    • Place of Presentation
      San Jose, CA USA
    • Year and Date
      2009-01-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生物・医学領域研究の進展に大きく貢献する分子イメージングプローブを化学を駆使して精密に開発する2008

    • Author(s)
      浦野 泰照
    • Organizer
      京都府立大学ケミカルバイオロジーシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-12-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rational Development of Novel Fluorescence Probes for Visualizing Cellular Responses and Targeted Tumor Imaging2008

    • Author(s)
      Yasuteru Urano
    • Organizer
      BMB2008 Symposium 3S23 New Trends in Chemical Biology
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rational Development of Various Small Molecule-based Fluorescence Probes and Their Application to Opical Tumor Imaging2008

    • Author(s)
      Yasuteru Urano
    • Organizer
      2008 JAFoE Symposium
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rational Development of Novel Fluorescence Probes for Visualizing Cellular Responses and Targeted Tumor Imaging2008

    • Author(s)
      Yasuteru Urano
    • Organizer
      2008 Riken Conference on Chemical Biology
    • Place of Presentation
      成田
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光プローブの精密分子設計に基づく細胞応答・in vivoがんイメージング2008

    • Author(s)
      浦野 泰照
    • Organizer
      東京大学工学部 第1回ChemBioハイブリッドレクチャー
    • Place of Presentation
      東京
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞応答イメージングを指向した蛍光プローブの精密分子設計2008

    • Author(s)
      浦野 泰照
    • Organizer
      日本薬学会関東支部学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計に基づく活性酸素・がんの高選択的光イメージング2008

    • Author(s)
      浦野 泰照
    • Organizer
      日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of specific fluorescence probes for various ROS and their application to real-time imaging of ROS production in living cells2008

    • Author(s)
      Yasuteru Urano
    • Organizer
      Lipid Peroxidation 2008
    • Place of Presentation
      軽井沢
    • Year and Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Selective Molecular Imaging of Viable Cancer Cells With pH Activatable Fluorescence Probes2008

    • Author(s)
      Yasuteru Urano
    • Organizer
      EMBL Conference on Chemical Biology
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Highly Selective Live Cancer Cell Imaging with Novel pH Activatable Fluorescence Probes2008

    • Author(s)
      浦野泰照
    • Organizer
      Gordon Research Conference, Lasers in Medicine & Biology (Invited)
    • Place of Presentation
      New Hampshire (USA).
    • Year and Date
      2008-07-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Highly Selective Live Cancer Cell Imaging with Novel pH Activatable Fluorescence Probes2008

    • Author(s)
      Yasuteru Urano
    • Organizer
      Gordon Research Conference, Lasers in Medicine & Biology (Invited)
    • Place of Presentation
      Holderness School, Plymouth, NH, USA
    • Year and Date
      2008-07-24
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Highly Selective Live Cancer Cell Imaging with Novel pH Activatable Fluorescence Probes2008

    • Author(s)
      Yasuteru Urano
    • Organizer
      Gordon Research Conference, Lasers in Medicine & Biology
    • Place of Presentation
      New Hampshire, USA
    • Year and Date
      2008-07-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] "化学"の力を駆使し、生きている試料の中で今起きていることを詳らかにする2008

    • Author(s)
      浦野 泰照
    • Organizer
      平成20年度有機合成セミナー
    • Place of Presentation
      岐阜
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rational Development of Novel Fluorescence Pobes for Visualizing Cellular Responses and Targeted Tumor Imaging2008

    • Author(s)
      Yasuteru Urano
    • Organizer
      the 60th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 種選択的・オルガネラ選択的ROS検出蛍光プローブの開発とその応用2008

    • Author(s)
      浦野 泰照
    • Organizer
      第61回日本酸化ストレス学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光プローブの精密開発に基づく、生細胞応答・in vivoがんイメージングの新展開2008

    • Author(s)
      浦野 泰照
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 「化学」を駆使した「医療」への新たな貢献-スマート蛍光プローブの精密設計に基づくin vivoがんイメージング-2008

    • Author(s)
      浦野 泰照
    • Organizer
      第88春季化学会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光プローブの精密分子設計・開発と、その細胞応答・がんイメージング今の適用2008

    • Author(s)
      浦野 泰照
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計に基づく、各種生命現象・疾患蛍光イメージング2008

    • Author(s)
      浦野 泰照
    • Organizer
      日本顕微鏡学会バイオメデカルニューマイクロスコープ分科会平成19年度シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-03-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Sensitive and Selective Tumor Imaging with Novel and Highly Activatable Fluorescence Strategies2008

    • Author(s)
      Yasuferu Urano
    • Organizer
      BiOS 2008, SPIE Photonic West
    • Place of Presentation
      SanJose
    • Year and Date
      2008-01-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Sensitive and Highly Selective Tumor Imaging with Novel"Smart"Fluorescence Probes2007

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 4th Takeda Science Foundation Symposium on Pharma Sciences"On the Frontiers of Chemical Biology"
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of highly specific fluorescence probes for various reactive oxygen specibs and their application to realtime imaging of ROS production in liVing cells2007

    • Author(s)
      Yasuteru Urhno
    • Organizer
      Fourth Joint Meeting of the Society for Free Radical Research Australasia and Japan 2007
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-12-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of a Highly Specofic Rhodamine-based Fluorescence Probe for Hypochlorous Acid and its Application to Real-time Imagin of Pha2007

    • Author(s)
      Yasuteru Urano
    • Organizer
      SFRBM 14th Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      2007-11-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] スマートプローブの精密設計に基づく高S/Nがん蛍光イメージング2007

    • Author(s)
      浦野 泰照
    • Organizer
      第66回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of fluorescence probe for diagnosis of cancersin earl sta2007

    • Author(s)
      Yuta Fujikawa
    • Organizer
      Joint Molecular Imaging Conference
    • Place of Presentation
      Rhode Island
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Highly selective fluorescence imaging of tumor by using preCisely designed fluorescence probe2007

    • Author(s)
      浦野 泰照
    • Organizer
      Gordon Research Conference/Chemical Sensors and Interfacial Design
    • Place of Presentation
      Salve Regina University
    • Year and Date
      2007-07-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Sensitive and Highly Selective Tumor Imagipg with Novel Activatable Fluorescence Strategies2007

    • Author(s)
      Yasuteru Urano
    • Organizer
      Ist Japanese'Swiss Symposium on Chemical Biolo
    • Place of Presentation
      Lausanne
    • Year and Date
      2007-06-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Developm、ent of a Highly Specific Fluorescence Probe for Hypochlorous Acid Based on the Regulation of Unique Spirocyclization and Its Apphcation to Real・Time Imaging of Phagocytosis2007

    • Author(s)
      Yasuteru Urano
    • Organizer
      Gordon Research Conference/Bioorganic Chemistry
    • Place of Presentation
      Andover
    • Year and Date
      2007-06-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計に基づく活性酸素・がんの高選択的光イメージング2007

    • Author(s)
      浦野 泰照
    • Organizer
      第26回分子病理学研究会湘南シンポジウム
    • Place of Presentation
      葉山
    • Year and Date
      2007-06-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 各種活性酸素種・窒素種の選択的可視化を実現する蛍光プローブの開発2007

    • Author(s)
      浦野 泰照
    • Organizer
      第50回日本腎臓学会学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 次亜塩素酸特異的蛍光プローブHySOxを用いたファゴサイトーシスイメージング2007

    • Author(s)
      浦野 泰照
    • Organizer
      第2回日本ケミカルバイオロジ-研究会年会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-09
    • Related Report
      2007 Annual Research Report
  • [Book] 化学フロンティア22生命現象を理解する分子ツール2010

    • Author(s)
      浦野泰照
    • Total Pages
      174
    • Publisher
      化学同人
    • Related Report
      2010 Annual Research Report
  • [Book] 蛋白質 核酸 酵素 542009

    • Author(s)
      浦野泰照
    • Publisher
      蛍光プローブの精密設計による生細胞応答の観測とin vivoがんイメージングの実現
    • Related Report
      2010 Final Research Report
  • [Book] 実験医学別冊 生命現象の動的理解を目指すライブイメージング2008

    • Author(s)
      浦野 泰照
    • Total Pages
      9
    • Publisher
      羊土社
    • Related Report
      2008 Annual Research Report
  • [Book] 化学工業2007

    • Author(s)
      浦野 泰照
    • Total Pages
      6
    • Publisher
      化学工業社
    • Related Report
      2007 Annual Research Report
  • [Book] Medical Bio2007

    • Author(s)
      浦野 泰照
    • Total Pages
      5
    • Publisher
      オーム社
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] がん診断薬2010

    • Inventor(s)
      浦野泰照、長野哲雄、坂部雅世
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Filing Date
      2010-01-13
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] がん診断薬2010

    • Inventor(s)
      浦野泰照, 長野哲雄, 坂部雅世
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Filing Date
      2010-01-13
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] がん診断薬2010

    • Inventor(s)
      浦野泰照、長野哲雄、坂部雅世
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2010-004794
    • Filing Date
      2010-01-13
    • Related Report
      2009 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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