Development of Micro Fluidic Systems for Real Time Function Analysis of Single Biomolecules

• Project/Area Number: 19206046
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: Waseda University
• Principal Investigator: SHOJI Shuichi Waseda University, 理工学術院, 教授 (00171017)
• Co-Investigator(Kenkyū-buntansha): 関口 哲志 早稲田大学, ナノ理工学研究機構, 准教授 (70424819) ; 荒川 貴博 早稲田大学, 理工学術院, 助手 (50409637) ; 船津 高志 早稲田大学, 薬学研究科, 教授 (00190124)
• Co-Investigator(Renkei-kenkyūsha): 関口 哲志 早稲田大学, ナノテクノロジー研究所, 准教授 (70424819) ; 水野 潤 早稲田大学, ナノテクノロジー研究所, 准教授 (60386737)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000); Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000); Fiscal Year 2007: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
• Keywords: 計測システム / 微細プロセス技術 / バイオデバイス / MEMS / MicroTAS / マイクロ流体デバイス / 生体分子ソーティング / 細胞破砕 / PolymerMEMS / ナノインプリント / 3次元微細加工

Research Abstract

Micro fluidic Systems for real time function analysis of single biomolecules were proposed and demonstrated. By applying MEMS and μTAS technologies, functional particular cell trapping and culture micro flow systems, a damage free cell rapture device, high through-put bio molecules sorting systems and high performance biomolecules analysis chips have been developed. Multi sample treatment and handling system technologies are also proposed and demonstrated.

Research Products

• [Journal Article] High-Throughput Single-Cell Manipulation System for a Large Number of Target Cells (2011)
  • Author(s): T.Arakawa, M.Noguchi, K.Sumitomo, Y.Yamaguchi, S.Shoji
  • Journal Title: Biomicrofluidics Vol.5 No.1 Pages: 14114-14114
  • Peer Reviewed
• [Journal Article] Improvement of Filtration Performance Using Self-Turning of Flow Resistance (2011)
  • Author(s): D.H.Yoon, Y.K.Bahk, B.H.Kwon, S.S.Kim, Y.-D.Kim, T.Arakawa, J.S.Go, S.Shoji
  • Journal Title: Japanese Journal of Applied Physics 50 Pages: 17201-17201
  • Peer Reviewed
• [Journal Article] Improvement of Filtration Performance Using Self-Turning of Flow Resistance (2011)
  • Author(s): D.H.Yoon, Y.K.Bahk, Y.-D.Kim, T.Arakawa, J.S.Go, S.Shoji, et al.
  • Journal Title: Japanese Journal of Applied Physics Volume: 50 Pages: 17201-17201
  • Peer Reviewed
• [Journal Article] Studies on Low-Temperature Direct Bonding of VUV, YUV/O3 nd O2 Plasma Pretreated Cyclo-Olefin Polymer (2011)
  • Author(s): H.Shinohara, J.Mizuno, S.Shoji
  • Journal Title: Sensors and Actuators A Volume: 165 Pages: 124-131
  • Peer Reviewed
• [Journal Article] High-Throughput Single-Cell Manipulation System for a Large Number of Target Cells (2011)
  • Author(s): T.Arakawa, M.Noguchi, K.Sumitomo, Y.Yamaguchi, S.Shoji
  • Journal Title: Biomicrofluidics Volume: 5 Pages: 14114-14114
  • Peer Reviewed
• [Journal Article] Microfluidic Cell Sorter with Flow Switching Triggered by a Sol-Gel Transition of a Thermo-Reversible Gelation Polymer (2010)
  • Author(s): K.Ozaki, H.Sugino, Y.Shirasaki, T.Aoki, T.Arakawa, T.Funatsu, S.Shoji
  • Journal Title: Sensors and Actuators B 150 Pages: 449-455
  • Peer Reviewed
• [Journal Article] Integration in a Multilayer Microfluidic Chip of 8 Parallel Cell Sorters with Flow Control by Sol-Gel Transition of Thermoreversible Gelation Polymer (2010)
  • Author(s): H.Sugino, T.Arakawa, Y.Nara, Y.Shirasaki, K.Ozaki, S.Shoji, T.Funatsu
  • Journal Title: Lab on a Chip 2010,10 Pages: 2559-2565
  • Peer Reviewed
• [Journal Article] Au-Electrode-Embedded Cyclo-Olefin Polymer Microchip Using Low-Temperature Direct Bonding (2010)
  • Author(s): H.Shinohara, J.Mizuno, S.Shoji
  • Journal Title: IEEJ Transactions on Sensors and Micromachines Volume: 130 Pages: 347-350
  • NAID: 10026498119
  • Peer Reviewed
• [Journal Article] Integration in a Multilayer Microfluidic Chip of 8 Parallel Cell Sorters with Flow Control by Sol-Gel Transition of Thermoreversible Gelation Polymer (2010)
  • Author(s): H.Sugino, T.Arakawa, Y.Nara, K.Ozaki, S.Shoji, T.Funatsu, et al.
  • Journal Title: Lab on a Chip Volume: 2010.10 Pages: 2559-2565
  • Peer Reviewed
• [Journal Article] Microfluidic Cell Sorter with Flow Switching Triggered by a Sol-Gel Transition of a Thermo-Reversible Gelation Polymer (2010)
  • Author(s): K.Ozaki, H.Sugino, T.Aoki, T.Arakawa, T.Funatsu, S.Shoji, et al.
  • Journal Title: Sensors and Actuators B Volume: 150 Pages: 449-455
  • Peer Reviewed
• [Journal Article] 光を用いた高速微小領域流体制御–バイオ・MicroTAS分野への光応用 (2010)
  • Author(s): 庄子習一
  • Journal Title: 月刊オプトロニクス Volume: 29 Pages: 104-107
• [Journal Article] On-Chip Microfluidic Sorting with Fluorescence Spectrum Detection and Multiway Separation (2009)
  • Author(s): H Sugino, K.Ozaki, Y.Shirasaki, T.Arakawa, S.Shoji, T.Funatsu
  • Journal Title: Lab on a Chip 2009 Pages: 1254-1260
  • Peer Reviewed
• [Journal Article] Fabrication of Post-Hydrophilic Treatment-Free Plastic Biochip Using Polyurea Film (2009)
  • Author(s): H.Shinohara, Y.Takahashi, J.Mizuno, S.Shoji
  • Journal Title: Sensors & Actuators A Vol.154 Pages: 187-191
  • Peer Reviewed
• [Journal Article] On-Chip Microfluidic Sorting with Fluorescence Spectrum Detection and Multiway Separation (2009)
  • Author(s): H, Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, T. Funatsu
  • Journal Title: Lab on a Chip 2009 Pages: 1254-1260
  • Peer Reviewed
• [Journal Article] Fabrication of Post-Hydrophilic Treatment-Free Plastic Biochip Using Polyurea Film (2009)
  • Author(s): H. Shinohara, Y. Takahashi, J. Mizuno, S. Shoji
  • Journal Title: Sensors & Actuators A Vol. 154 Pages: 187-191
  • Peer Reviewed
• [Journal Article] Fabrication of Post-Hydrophilic Treatment-Free Plastic Biochip Using Polyurea Film (2009)
  • Author(s): H.Shinohara, Y.Takahashi, J.Mizuno, S.Shoji
  • Journal Title: Sensors & Actuators A 154 Pages: 187-191
  • Peer Reviewed
• [Journal Article] On-Chip Microfluidic Sorting with Fluorescence Spectrum Detection and Multiway Separation (2009)
  • Author(s): H, Sugino, K.Ozaki, Y.Shirasaki, T.Arakawa, S.Shoji, T.Funatsu
  • Journal Title: Lab on a Chip 2009 9 Pages: 1254-1260
  • Peer Reviewed
• [Journal Article] Polymer Microchip Integrated with Nano-Electrospray Tip for Electrophoresis-Mass Spectrometry (2008)
  • Author(s): H.Shinohara, T.Suzuki, F.Kitagawa, J.Mizuno, K.Otsuka, S.Shoji
  • Journal Title: Sensors and Actuators B 132 Pages: 368-373
  • Peer Reviewed
• [Journal Article] Parallel and Passive Distribution to Arrayed Microwells Using Self-Regulating Pinched Flow (2008)
  • Author(s): K.Kawai, M.Kanai, T.Munaka, H.Abe, A.Murakami, S.Shoji
  • Journal Title: Sensors and Materials Vol.20, No.6 Pages: 281-288
  • Peer Reviewed
• [Journal Article] Micro-Bubble Formation with Organic Membrane in a Multiphase Microfluidic System (2008)
  • Author(s): T.Arakawa, T.Yamamoto, S.Shoji
  • Journal Title: Sensors & Actuators A Vol.143 Pages: 58-63
  • Peer Reviewed
• [Journal Article] Polymer Microchip Integrated with Nano-Electrospray Tip for Electrophoresis-Mass Spectrometry (2008)
  • Author(s): H. Shinohara, T. Suzuki, F. Kitagawa, J. Mizuno, K. Otsuka, S. Shoji
  • Journal Title: Sensors and Actuators B132 Pages: 368-373
  • Peer Reviewed
• [Journal Article] Parallel and Passive Distribution to Arrayed Microwells Using Self-Regulating Pinched Flow (2008)
  • Author(s): K. Kawai, M. Kanai, T. Munaka, H. Abe, A. Murakami, S. Shoji
  • Journal Title: Sensors and Materials Vol. 20, No. 6 Pages: 281-288
  • Peer Reviewed
• [Journal Article] Micro-Bubble Formation with Organic Membrane in a Multiphase Microfluidio System (2008)
  • Author(s): T. Arakawa, T. Yamamoto, S. Shoii
  • Journal Title: Sensors & Actuators A 143 Pages: 58-63
  • Peer Reviewed
• [Journal Article] Polymer Microchip Integrated with Nano-Electrospray Tip for Electrophoresis-Mass Spectrometry (2008)
  • Author(s): H. Shinohara, T. Suzuki, F. Kitagawa, J. Mizuno, K. Otsuka, S. Shoii
  • Journal Title: Sensors and Actuators B 132 Pages: 368-373
  • Peer Reviewed
• [Journal Article] Parallel and Passive Distribution to Arrayed Microwells Using Self-Regulating Pinched Flow (2008)
  • Author(s): K. Kawai, M. Kanai, T. Munaka, H. Abe, A. Murakami, S. Shoji
  • Journal Title: Sensors and Materials 20 Pages: 281-288
  • Peer Reviewed
• [Journal Article] Rapid Multi-Reagents Exchange TIRFM Microfluidic System for Single Biomolecular Imaging (2007)
  • Author(s): T.Arakawa, T.Sameshima, Y.Sato, T.Ueno, Y.Shirasaki, T.Funatsu, S.Shoji
  • Journal Title: Sensors and Actuators B 128 Pages: 218-225
  • Peer Reviewed
• [Journal Article] Rapid Multi-Reagents Exchange TIRFM Microfluidic System for Single Biomolecular Imaging (2007)
  • Author(s): T. Arakawa, T. Sameshima, Y. Sato, T. Ueno, Y. Shirasaki, T. Funatsu, S. Shoji
  • Journal Title: Sensors and Actuators B128 Pages: 218-225
  • Peer Reviewed
• [Journal Article] 3D Sheath Flow Using Hydrodynamic Position Control of the Sample Flow (2007)
  • Author(s): H.Sato, Y.Sasamoto, D.Yagyu, T.Sekiguchi, S.Shoji
  • Journal Title: Journal of Micromechanics and Microengineering 17 Pages: 2211-2216
  • Peer Reviewed
• [Presentation] 化学・バイオ応用ナノ/マイクロ流体デバイス・システム (2011)
  • Author(s): 庄子習一
  • Organizer: MEMS Engineering Forum 2011
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-03-07
• [Presentation] NEXAFS and XPS Studies of VUV/O3 Treated Aromatic Polyurea for High-Speed Electrophoresis Microchips (2011)
  • Author(s): H.Shinohara, S.Shoji, J.Mizuno, K.Otsuka, O.Ohara, et al.
  • Organizer: The 6th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems : IEEE-NEMS 2011
  • Place of Presentation: Kaohsiung, Taiwan
  • Year and Date: 2011-02-21
• [Presentation] 集積化マイクロ・ナノ流体システムと環境技術への応用展望 (2011)
  • Author(s): 庄子習一
  • Organizer: 精密工学会 超精密加工専門委員会 第61回研究会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-01-28
• [Presentation] Volume Controlled High Throughput Picoliter Droplet Generation System Using Cascade Multi-Stage Separation Channel (2011)
  • Author(s): M.Fujii, K.Kawai, D.H.Yoon, S.Shoji
  • Organizer: The 24th International Conference on Micro Electro Mechanical Systems : MEMS 2011(1201-1204)
  • Place of Presentation: Cancun, Mexico
  • Year and Date: 2011-01-24
• [Presentation] Volume Controlled High Throughput Picoliter Droplet Generation System Using Cascade Multi-Stage Separation Channel (2011)
  • Author(s): M.Fujii, K.Kawai, D.H.Yoon, S.Shoji
  • Organizer: The 24th International Conference on Micro Electro Mechanical Systems : MEMS 2011
  • Place of Presentation: Cancun, Mexico
  • Year and Date: 2011-01-24
• [Presentation] Micro/Nanofluidic Devices for Chemical/Biochemical Micro Total Malysis Systems (2010)
  • Author(s): S.Shoji, D.H.Yoon, J.Mizuno, T.Sekiguchi, T.Funatsu, et al.
  • Organizer: The 2nd NIMS(MANA)-Waseda International Symposium
  • Place of Presentation: Tsukuba(招待講演)
  • Year and Date: 2010-12-01
• [Presentation] MEMS/ナノテクノロジーによるマイクロ/ナノ流体システム構築とバイオ・医療への応用 (2010)
  • Author(s): 庄子習一
  • Organizer: 第60回日本アレルギー学会秋季学術大会(Vol.59 No.9・10 1157)
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] MEMS/ナノテクノロジーによるマイクロ/ナノ流体システム構築とバイオ・医療への応用 (2010)
  • Author(s): 庄子習一
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-11-26
• [Presentation] Partly Disposable Lab-on-a-Chip System Using Electromagnetically-Drive Hydraulic Valves (2010)
  • Author(s): K.Miyamoto, K.Kawai, S.Shoji
  • Organizer: 23rd International Microproccesses and Nanotechnology Conference : MNC2010(12D-11-123)
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-11-12
• [Presentation] Partly Disposable Lab-on-a-Chip System Using Electromagnetically-Drive Hydraulic Valves (2010)
  • Author(s): K.Miyamoto, K.Kawai, S.Shoji
  • Organizer: 23rd International Microproccesses and Nanotechnology Conference : MNC2010
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-11-12
• [Presentation] High Speed Generation of Uniform Femtoliter Volume Droplets Using Cascade Multi-Stage Separation Microfluidic Device (2010)
  • Author(s): M.Fujii, K.Kawai, D.H.Yoon, S.Shoji
  • Organizer: 23rd International Microproccesses and Nanotechnology Conference : MNC2010
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-11-11
• [Presentation] A Microfluidic Mammalian Cell Sorter with Thermal Gelation Polymer Solution (2010)
  • Author(s): Y.Shirasaki, J.Mizuno, S.Shoji, T.Funatsu, O.Ohara, et al.
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-06
• [Presentation] Fabrication of Vertical and High-Aspect-Ratio Glass Microfluidic Device by Borosilicate Glass Molding to Silicon Structure (2010)
  • Author(s): K.Kawai, F.Yamaguchi, A.Nakahara, S.Shoji
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010(1193-1195)
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-05
• [Presentation] Size Controllable Polymeric Microlens Fabrication by Using a Multiphase Droplet Including Air Core (2010)
  • Author(s): D.H.Yoon, T.Arakawa, J.S.Go, S.Shoji
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010(1118-1120)
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-05
• [Presentation] Selective Droplet Sampling Flow System Using Minimum Number of Horizontal Pneumatic Valves Formed by Single Step PDMS Molding (2010)
  • Author(s): D.H.Yoon, D.Wakui, T.Sekiguchi, S.Shoji
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010(1085-1087)
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-05
• [Presentation] Selective Droplet Sampling Flow System Using Minimum Number of Horizontal Pneumatic Valves Formed by Single Step PDMS Molding (2010)
  • Author(s): D.H.Yoon, D.Wakui, T.Sekiguchi, S.Shoji
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-05
• [Presentation] Size Controllable Polymeric Microlens Fabrication by Using a Multiphase Droplet Including Air Core (2010)
  • Author(s): D.H.Yoon, T.Arakawa, J.S.Go, S.Shoji
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-05
• [Presentation] Fabrication of Vertical and High-Aspect-Ratio Glass Microfluidic Device by Borosilicate Glass Molding to Silicon Structure (2010)
  • Author(s): K.Kawai, F.Yamaguchi, A.Nakahara, S.Shoji
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-05
• [Presentation] On-Chip Gas Concentration Gradient Formation Using Poreflon^<TM> and Neoflon^<TM> for In Vitro Observation of Cancer Cell (2010)
  • Author(s): Y.Harada, K.Kawai, S.Shoji
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010(551-553)
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-04
• [Presentation] Ultimate Hydrogel Thermal-Transition Based Flow Control System for User-Friendly Particle and Cell Sorting (2010)
  • Author(s): H.Sugino, K.Ozaki, D.H.Yoon, S.Shoji, T.Funatsu, et al.
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-04
• [Presentation] On-Chip Gas Concentration Gradient Formation Using PoreflonTM and NeoflonTM for In Vitro Observation of Cancer Cell (2010)
  • Author(s): Y.Harada, K.Kawai, S.Shoji
  • Organizer: The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010
  • Place of Presentation: Groningen, The Netherlands
  • Year and Date: 2010-10-04
• [Presentation] MEMS/NT Based Biological Cell Function Malysis Micro Fluidic Devices/Systems (2010)
  • Author(s): S.Shoji
  • Organizer: 2010 Taiwan-Japan Bilateral Symposium-Nanotech and Health Care
  • Place of Presentation: Kaohsiung, Taiwan(招待講演)
  • Year and Date: 2010-09-23
• [Presentation] Fabrication of High-Aspect-Ratio Amorphous Perfluorinated Polymer Structure for Total Internal Reflection Fluorescence Microscopy (2010)
  • Author(s): A.Nakahara, Y.Shirasaki, K.Kawai, O.Ohara, J.Mizuno, S.Shoji
  • Organizer: The 36th International Conference on Micro & Nano Engineering : MNE 2010(P-LIFE-68)
  • Place of Presentation: Genoa, Italy
  • Year and Date: 2010-09-21
• [Presentation] Fabrication of High-Aspect-Ratio Amorphous Perfluorinated Polymer Structure for Total Internal Reflection Fluorescence Microscopy (2010)
  • Author(s): A.Nakahara, Y.Shirasaki, K.Kawai, O.Ohara, J.Mizuno, S.Shoji
  • Organizer: The 36th International Conference on Micro & Nano Engineering : MNE 2010
  • Place of Presentation: Genoa, Italy
  • Year and Date: 2010-09-21
• [Presentation] Integrated Hydrophilic Surface Treatment System of Vapor Deposition Polymerization and Vacuum Ultraviolet Irradiation for Biochemical Microchips (2010)
  • Author(s): H.Shinohara, T.Hori, S.Umeda, S.Shoji, O.Ohara, J.Mizuno, et al.
  • Organizer: The 36th International Conference on Micro & Nano Engineering : MNE 2010
  • Place of Presentation: Genoa, Italy
  • Year and Date: 2010-09-21
• [Presentation] Polymer MEMSとその化学・バイオ・医療への応用 (2010)
  • Author(s): 庄子習一
  • Organizer: 第34回センサ&アクチュエータ技術シンポジウム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-09-07
• [Presentation] Precise Structure Controlled Plastic Hot Embossing Method for Low-Temperature Direct Bonding (2010)
  • Author(s): H.Shinohara, J.Mizuno, S.Shoji
  • Organizer: International Conference on Electronics Packaging : ICEP2010
  • Place of Presentation: Sapporo
  • Year and Date: 2010-05-14
• [Presentation] Studies on Direct Bonding of PDMS with Plastic Materials Using Pretreatment of Atmospheric-Pressure Oxygen Plasma (2010)
  • Author(s): S.Matsui, H.Shinohara, J.Mizuno, S.Shoji
  • Organizer: International Conference on Electronics Packaging : ICEP2010
  • Place of Presentation: Sapporo
  • Year and Date: 2010-05-14
• [Presentation] ボストキュアを用いたレプリカモールドの理型性の向上 (2010)
  • Author(s): 李凌義, 川口泰秀, 角崎健太郎, 水野潤, 庄子習一
  • Organizer: 第57回応用物理学関係連合講演会
  • Place of Presentation: 平塚
  • Year and Date: 2010-03-20
• [Presentation] MEMS Fabricated Liquid Chromatography Microchip for Practical Uses (2010)
  • Author(s): M.Noguchi, M.Tsunoda, J.Mizuno, T.Funatsu, S.Shoji
  • Organizer: The 23rd IEEE International Conference on Micro Electro Mechanical Systems : MEMS 2010(911-914)
  • Place of Presentation: Hong Kong
  • Year and Date: 2010-01-27
• [Presentation] MEMS Fabricated Liquid Chromatography Microchip for Practical Uses (2010)
  • Author(s): M.Noguchi, M.Tsunoda, J.Mizuno, T.Funatsu, S.Shoji
  • Organizer: The 23rd IEEE International Conference on Micro Electro Mechanical Systems : MEMS 2010
  • Place of Presentation: Hong Kong
  • Year and Date: 2010-01-27
• [Presentation] Multi Channel Droplet Sorting Device with Horizontal Pneumatic Actuation Using Single Layer PDMS Flexible Parallel Walls (2010)
  • Author(s): D.Wakui, S.Takahashi, T.Sekiguchi, S.Shoji
  • Organizer: The 23rd IEEE International Conference on Micro Electro Mechanical Systems : MEMS 2010(144-147)
  • Place of Presentation: Hong Kong
  • Year and Date: 2010-01-26
• [Presentation] Multi Channel Droplet Sorting Device with Horizontal Pneumatic Actuation Using Single Layer POMS Flexible Parallel Walls (2010)
  • Author(s): D.Wakui, S.Takahashi, T.Sekiguchi, S.Shoji
  • Organizer: The 23rd IEEE International Conference on Micro Electro Mechanical Systems : MEMS 2010
  • Place of Presentation: Hong Kong
  • Year and Date: 2010-01-26
• [Presentation] High Speed Generation of Uniform Femtoliter Volume Droplets Using Cascade Multi-Stage Separation Microfluidic Device (2010)
  • Author(s): M.Fujii, K.Kawai, D.H.Yoon, S.Shoji
  • Organizer: 23rd International Microproccesses and Nanotechnology Conference : MNC2010(11C-4-2)
  • Place of Presentation: Fukuoka
• [Presentation] Filtration of a Fluid from Mixed Microparticles by Using Self-Tuning of Flow Resistance Microfilter (2009)
  • Author(s): D.H.Yoon, Y.K.Bahk, T.Arakawa, J.S.Go, S.Shoji
  • Organizer: Ninth International Symposium on Microchemistry and Microsystems : ISMM 2009
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 2009-11-07
• [Presentation] High Performance Multiple E. Coli Cell Sorting System Using Thermosensitive Hydrogel and Fluorescence Spectrum Detection (2009)
  • Author(s): K.Ozaki, H.Sugino, T.Arakawa, Y.Shirasaki, T.Funatsu, S.Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1856-1858)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] Microvalve Integrated All Neoflon Accurate Sample Injecter Fabricated by Low Temperature Embossing and Bonding (2009)
  • Author(s): K.Miyamoto, K.Kawai, T.Sato, M.Kanai, S.Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1590-1592)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] Precise Volume Controlled Multi Reagents Injective Microwell Array for Efficient Cell Function Analysis (2009)
  • Author(s): Y.Shibata, K.Kawai, M.Kanai, 庄子習一
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1488-1490)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] Generation of Polystyrene Microcapsules as Nanoliter Volume Gas Encapsulants by Using Gas-Organic-Water Multiphase Junction (2009)
  • Author(s): D.H.Yoon, T.Arakawa, J.S.Go, S.Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1422-1424)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] Multi Uniform Picoliter Volume Droplets Generation and Sorting Device for Digital Picoliter Dispenser (2009)
  • Author(s): M.Fujii, K.Kawai, S.Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1356-1358)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] High Performance Multiple E. Coli Cell Sorting System Using Thermosensitive Hydrogel and Fluorescence Spectrum Detection (2009)
  • Author(s): K. Ozaki, H. Sugino, T. Arakawa, Y. Shirasaki, T. Funatsu, S. Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] Multi Uniform Picoliter Volume Droplets Generation and Sorting Device for Digital Picoliter Dispenser (2009)
  • Author(s): M.Fujii, K.Kawai, S.Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2009
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] Generation of Polystyrene Microcapsules as Nanoliter Volume Gas Encapsulants by Using Gas-Organic-Mater Multiphase Junction (2009)
  • Author(s): D.H.Yoon, T.Arakawa, J.S.Go, S.Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2009
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] Precise Volume Controlled Multi Reagents Injective Microwell Array for Efficient Cell Function Analysis (2009)
  • Author(s): Y.Shibata, K.Kawai, M.Kanai, S.Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2009
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] Microvalve Integrated All Neoflon Accurate Sample Injecter Fabricated by Low Temperature Embossing and Bonding (2009)
  • Author(s): K.Miyamoto, K.Kawai, T.Sato, M.Kanai, S.Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2009
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] High Performance Multiple E.Coli Cell Sorting System Using Thermosensitive Hydrogel and Fluorescence Spectrum Detection (2009)
  • Author(s): K.Ozaki, H.Sugino, T.Arakawa, Y.Shirasaki, T.Funatsu, S.Shoji
  • Organizer: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2009
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-04
• [Presentation] MEMS Based Cell Function Analysis Micro Fluidic Devices and Systems (2009)
  • Author(s): 庄子習一
  • Organizer: The 3rd IEEE International Conference on Nano/Molecular Medicine and Engineering : IEEE-NANOMED 2009(16)
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2009-10-20
• [Presentation] MEMS Based Cell Function Analysis Micro Fluidic Devices and Systems (2009)
  • Author(s): S.Shoji
  • Organizer: The 3rd IEEE International Conference on Nano/Molecular Medicine and Engineering : IEEE-NANOMED 2009
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2009-10-20
• [Presentation] 100 Picoliter Droplet Handling Using 256 (2^8) Microvalve Array with 18 Multiplexed Control Lines (2009)
  • Author(s): K.Kawai, Y.Shibata, S.Shoji
  • Organizer: The 15th International Conference on Solid-State Sensors, Actuators and Microsystems : Transducers 2009(802-805)
  • Place of Presentation: Denver
  • Year and Date: 2009-06-23
• [Presentation] 100 Picoliter Droplet Handling Using 256(28)Microvalve Array with 18 Multiplexed Control Lines (2009)
  • Author(s): K.Kawai, Y.Shibata, S.Shoji
  • Organizer: The 15th International Conference on Solid-State Sensors, Actuators and Microsystems : Transducers 2009
  • Place of Presentation: Denver, USA
  • Year and Date: 2009-06-23
• [Presentation] Studies on Low-Temperature Bonding Mechanism of VUN and Plasma Pretreated Cyclo-Olefin Polymer (2009)
  • Author(s): H.Shinohara, T.Suzuki, J.Mizuno, S.Shoji
  • Organizer: The 15th International Conference on Solid-State Sensors, Actuators and Microsystems : Transducers 2009
  • Place of Presentation: Denver, USA
  • Year and Date: 2009-06-23
• [Presentation] Large Scale Micro Fluidic Systems for Sequential Trapping, Labeling and Content Extraction of Single Cells (2009)
  • Author(s): M.Noguchi, T.Arakawa, Y.Yamaguchi, S.Shoji
  • Organizer: The 15th International Conference on Solid-State Sensors, Actuators and Microsystems : Transducers 2009(628-631)
  • Place of Presentation: Denver, USA
  • Year and Date: 2009-06-22
• [Presentation] Large Scale Micro Fluidic Systems for Sequential Trapping, Labeling and Content Extraction of Single Cells (2009)
  • Author(s): M. Noguchi, T. Arakawa, Y. Yamaguchi, S. Shoji
  • Organizer: The 15th International Conference on Solid-State Sensors, Actuators and Microsystems : Transducers 2009
  • Place of Presentation: Denver, USA
  • Year and Date: 2009-06-22
• [Presentation] 温度感受性ハイドロゲルと蛍光検出を用いた細胞・生体分子の一括分離システム (2009)
  • Author(s): 尾崎和人, 杉野弘和, 荒川貴博、白崎善隆, 船津高志, 庄子習一
  • Organizer: 第19回化学とマイクロ・ナノシステム研究会(19th CHEMINAS)
  • Place of Presentation: 広島
  • Year and Date: 2009-05-28
• [Presentation] MEMS Based Cell Function Analysis Micro Fluidic Systems (2009)
  • Author(s): S.Shoji, K.Kawai, H.Shinohara, D.H.Yoon, T.Arakawa, T.Funatsu
  • Organizer: The 11th Korean MEMS Conference : KMEMS 2009(1-3)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-04-03
• [Presentation] Precise Titration Microfluidic System Using Sub-Picoliter Droplet Injection (2009)
  • Author(s): K.Kawai, M.Fujii, S.Shoji
  • Organizer: 22nd IEEE International Conference on Micro Electro Mechanical Systems : MEMS 2009(519-522)
  • Place of Presentation: Sorrento, Italy
  • Year and Date: 2009-01-27
• [Presentation] Precise Titration Microfluidic System Using Sub-Picoliter Droplet Injection (2009)
  • Author(s): K. Kawai, M. Fujii, S. Shoji
  • Organizer: 22nd IEEE International Conference on Micro Electro Mechanical Systems : MEMS 2009
  • Place of Presentation: Sorrento, Italy
  • Year and Date: 2009-01-27
• [Presentation] MEMS・ナノテクノロジーのバイオ・医療への応用 (2009)
  • Author(s): 庄子習一
  • Organizer: 平成21年度第1回ちばバイオテクノロジーセミナー
  • Place of Presentation: 千葉
  • Year and Date: 2009-01-13
• [Presentation] MEMS/NTを応用した細胞機能解析マイクロシステム (2008)
  • Author(s): 庄子習一、荒川貴博、川合健太郎、篠原秀敏、船津高志
  • Organizer: 第17回日本コンピュータ外科学会大会(213-214)
  • Place of Presentation: 東京女子医科大学、東京
  • Year and Date: 2008-11-01
• [Presentation] High Performance Parallel Bioparticle Sorter with 3-Dimensional PDMS Chip (2008)
  • Author(s): H. Sugino, Y. Nara, Y. Shirasaki, T. Arakawa, S. Shoji, T. Funatsu
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-10-14
• [Presentation] Cell Rupture Microfluidic Device Using Nano Needle Allay for Damage-Free Extraction of Organelles (2008)
  • Author(s): T. Arakawa, Y. Shirasaki, D. Yamazaki, T. Funatsu, S. Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-10-13
• [Presentation] High Performance Microfluidic Device for Sequential Trapping, Labeling and Content Extraction of Single Cells (2008)
  • Author(s): Y.Murakami, T.Arakawa, S.Nomura, Y.Yamaguchi, S.Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(1774-1776)
  • Place of Presentation: San Diego, USA
• [Presentation] Multiplexed Pneumatic Valve Control System for Large Scale Integrated Microfluidic Circuit (LSIMC) (2008)
  • Author(s): K.Kawai, Y.Shibata, M.Kanai, S.Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(683-685)
  • Place of Presentation: San Diego, USA
• [Presentation] High Performance Multiple Biomolecules Sorting System (2008)
  • Author(s): K.Ozaki, H.Sugino, T.Arakawa, Y.Shirasaki, T.Funatsu, S.Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(489-491)
  • Place of Presentation: San Diego, USA
• [Presentation] Dynamic Imaging of Single Biomolecular Interaction Using Flow Control and TIRFM (2008)
  • Author(s): T.Arakawa, T.Sameshima, Y.Sato, Y.Sumiyoshi, T.Ueno, Y.Shirasaki, T.Funatsu, S.Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(296-298)
  • Place of Presentation: San Diego, USA
• [Presentation] Cell Rupture Microfluidic Device Using Nano Needle Allay for Damage-Free Extraction of Organelles (2008)
  • Author(s): T.Arakawa, Y.Shirasaki, D.Yamazaki, T.Funatsu, S.Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(215-217)
  • Place of Presentation: San Diego, USA
• [Presentation] Post-Hydrophilic Treatment Free Plastic Biochip Fabrication Method Using Polyurea Film (2008)
  • Author(s): H.Shinohara, Y.Takahashi, J.Mizuno, S.Shoji
  • Organizer: 21st IEEE International Conference on Micro Electro Mechanical Systems : IEEE MEMS 2008(367-370)
  • Place of Presentation: Tucson
• [Presentation] Cell Function Analysis Tools Fabricated by MEMS and Nanotechnology (2008)
  • Author(s): S.Shoji, T.Arakawa, K.Kawai, T.Funatsu
  • Organizer: International Symposium on Surface Science and Nanotechnology : ISSS-5(407)
  • Place of Presentation: Tokyo
• [Presentation] Highly Stable and Reproducible Cyclo-Olefin PoIymer Nano-Electrospray Tip for EIectrophoresis-Mass Spectrometry (2008)
  • Author(s): H. Shinohara, F. Kitagawa, J. Mizuno, K. Otsuka, S. Shoji
  • Organizer: The 4th Asia Pacific Conference on Transducers and Micro/Nano Technologies : APCOT 2008
  • Place of Presentation: Taiwan
• [Presentation] Dynamic Imaging of Single Biomolecular Interaction Using Flow Control and TIRFM (2008)
  • Author(s): T. Arakawa, Y. Sato, Y. Sumiyoshi, Y. Shirasaki, T. Funatsu, S. Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008
  • Place of Presentation: San Diego, USA
• [Presentation] High Performance Multiple Biomolecules Sorting System (2008)
  • Author(s): K. Ozaki, H. Sugino, T. Arakawa, Y. Shirasaki, T. Funatsu, S. Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008
  • Place of Presentation: San Diego, USA
• [Presentation] Multiplexed Pneumatic Valve Control System for Large Scale Integrated Microfluidic Circuit (LSIMC) (2008)
  • Author(s): K. Kawai, Y. Shibata, M. Kanai, S. Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008
  • Place of Presentation: San Diego, USA
• [Presentation] High Performance Microfluidic Device for Sequential Trapping, Labeling and Content Extraction of Single Cells (2008)
  • Author(s): Y. Murakami, T. Arakawa, S. Nomura, Y. Yamaguchi, S. Shoji
  • Organizer: The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008
  • Place of Presentation: San Diego, USA
• [Presentation] All Fluoroplastic Nanoliter Sample Injector (2008)
  • Author(s): T. Sato, K. Kawai, M. Kanai, S. Shoji
  • Organizer: 21st International Microprocesses and Nanotechnology Conference : MNC2008
  • Place of Presentation: Fukuoka
• [Presentation] 3D Hydrodynamic Focusing Device Using Symmetrical Herringbone Grooves (2008)
  • Author(s): Y. Sasamoto, H. Sato, T. Sekiguchi, S. Shoji, T. Homma
  • Organizer: International Symposium on Microchemistry and Microsystems : ISMM 2008
  • Place of Presentation: Kyoto
• [Presentation] All Fluoroplastio (NEOFLON EFEP) Microfluidic Devices Fabricated by Low Temperature Molding and Bonding (2008)
  • Author(s): T. Sato, K. Kawai, M. Kanai, S. Shoji
  • Organizer: International Symposium on Microchemistry and Microsystems : ISMM 2008
  • Place of Presentation: Kyoto
• [Presentation] Cell Function Analysis Tools Fabricated by MEMS and Nanotechnology (2008)
  • Author(s): S. Shoji, T. Arakawa, K. Kawai, T. Funatsu
  • Organizer: International Symposium on Surface Science and Nanotechnology : ISSS-5
  • Place of Presentation: Tokyo
• [Presentation] Post-Hydrophilic Treatment Free Plastic Biochip Fabrication Method Using Polyurea Film (2008)
  • Author(s): H. Shinohara, Y. Takahashi, J. Mizuno, S. Shoji
  • Organizer: 21st IEEE International Conference on Micro Electro Mechanical Systems:IEEE MEALS 2008
  • Place of Presentation: Tucson
• [Presentation] Soft Cell Rupture Device Using Nano Needle Allay for Damage-free Extraction of Organelles (2008)
  • Author(s): D. Yamazaki, T. Arakawa, Y. Shirasaki, T. Funatsu, S. Shoji
  • Organizer: 2008 International Conference on Nanoscience and Nanotechnology:ICONN 2008
  • Place of Presentation: Melbourne
• [Presentation] High Speed Organelles Sorting Microsystem Driven by a Single Pressure Source (2007)
  • Author(s): T.Aoki, Y.Shirasaki, T.Arakawa, H.Sugino, T.Funatsu, S.Shoji
  • Organizer: The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2007(224-226)
  • Place of Presentation: Paris
• [Presentation] Efficient Addressable Fluid Control System Using Pneumatic Valve Array (2007)
  • Author(s): K.Kawai, M.Kanai, S.Shoji
  • Organizer: The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2007(32-34)
  • Place of Presentation: Paris
• [Presentation] High Speed Organelles Sorting Microsystem Driven by a Single Pressure Source (2007)
  • Author(s): T. Aoki, Y. Shirasaki, T. Arakawa, H. Sugino, T. Funatsu, S. Shoji
  • Organizer: The 11th International Confierence on Miniaturized Systems for Chemistry and Life Sciences:μTAS 2007
  • Place of Presentation: Paris
• [Presentation] Efficient Addressable Fluid Control System Using Pneumatic Valve Array (2007)
  • Author(s): K. Kawai, M. Kanai, S. Shoji
  • Organizer: The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences:μTAS 2007
  • Place of Presentation: Paris
• [Presentation] Parallel Bioparticle Sorting with TGP Solution in 3-Dimentional Microflow System (2007)
  • Author(s): H. Sugino, Y. Nara, Y. Shirasaki, T. Arakawa, S. Shoji, T. Funatsu
  • Organizer: The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences:uTA5 2007
  • Place of Presentation: Paris
• [Presentation] Fabrication of the functional 3-D Micromesh Structures Coated with Ti02 Particles and Biocatalyst (2007)
  • Author(s): S. Keino, H. Matsumura, M. Ishioka, H. Sato, S. Shoji
  • Organizer: 20th International Microprocesses and Nanotechnology Conference:MNC 2007
  • Place of Presentation: Kyoto
• [Book] BIO INDUSTRY(第27巻 第3号) (2010)
  • Author(s): 庄子習一、川合健太郎
  • Publisher: (株)シーエムシー出版
• [Book] BIO INDUSTRY (2010)
  • Author(s): 庄子習一, 川合健太郎
  • Total Pages: 7
  • Publisher: (株)シーエムシー出版
• [Book] BIO INDUSTRY 第27巻 第3号―大規模集積流体システム (2010)
  • Author(s): 庄子習一, 川合健太郎
  • Total Pages: 7
  • Publisher: (株)シーエムシー出版
• [Book] MEMS/NEMS工学全集(Fundamentals and Applications of MEMS/NEMS Engineering) (2009)
  • Author(s): 庄子習一
  • Publisher: (株)テクノシステム
• [Book] マイクロ・ナノ化学チップと医療・環境・バイオ分析 (2009)
  • Author(s): 庄子習一
  • Publisher: 技術教育出版社
• [Book] 「MEMS/NEMS工学全集 (Fundamentals and Applications of MEMS/NEMS Ehgineering) (2009)
  • Author(s): 庄子習一
  • Total Pages: 8
  • Publisher: (株)テクノシステム
• [Book] MEMS/NEMS工学全集(Fundamentals and Applications of MEMS/NEMS Engineering)第5章 第18節 バイオチッブ (2009)
  • Author(s): 庄子習一
  • Total Pages: 8
  • Publisher: (株)テクノシステム
• [Book] バイオテクノロジーシリーズ細胞分離・操作技術の最前線 (2008)
  • Author(s): 庄子習一、荒川貴博、川合健太郎
  • Total Pages: 9
  • Publisher: シーエムシー出版
• [Book] バイオテクノロジーシリーズ細胞分離・操作技術の最前線 (2008)
  • Author(s): 庄子習一, 荒川貴博, 川合健太郎
  • Total Pages: 9
  • Publisher: シーエムシー出版
• [Book] M41 Micropump : liquid (2007)
  • Author(s): S.Shoji, H.Sato, R.Zengerle
  • Publisher: Comprehensive Microsystems, Elsevier Science Ltd.
• [Book] Comprehensive Microsystems (2007)
  • Author(s): S. Shoji, H. Sato, R. Zengerle
  • Publisher: Elsevier Science Ltd.