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Database construction of organic polymorphs and new methods to create novel polymorphs

Research Project

Project/Area Number 19206082
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

MATSUOKA Masakuni  Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 教授 (40016671)

Co-Investigator(Kenkyū-buntansha) TAKIYAMA Hiroshi  東京農工大学, 大学院・共生科学技術研究院, 准教授 (40251582)
HADA Maiko  東京農工大学, 大学院・共生科学技術研究院, 助教 (90365883)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2007: ¥36,920,000 (Direct Cost: ¥28,400,000、Indirect Cost: ¥8,520,000)
Keywords結晶多形 / 多形の発現 / 多形の転移 / 転移速度 / XRD-DSC 装置 / 多形のデータベース / XRD-DSC装置
Research Abstract

有機物結晶を中心とした多形および多形間の転移(多形転移)現象について文献調査と実験的な研究を行った。まず、約500の物質に関する文献データを収集し、データベースの掲載項目と書式を決定し公表した。新たに購入した雰囲気制御機能をもつXRD/DSC装置に有機結晶多形の固相転移について、水分の影響と添加物の作用を検討した。さらに、遊星ボールミルを用いたグリシンの固相多形転移速度、アミノ酸を中心とする化合物を対象とする多形発現、ハロゲン化アルカリ金属塩結晶のメカノケミカル効果を明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (35 results)

All 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (24 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Solid-state Recrystallization Behavior of Binary Inorganic Salt Systems in Mechanochemical Processing2009

    • Author(s)
      M. Matsuoka, K. Danzuka
    • Journal Title

      J. Chem. Eng., Japan (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics of Humidity Driven Solid-State Polymorphic Transition of Theophylline Anhydrates2007

    • Author(s)
      K. Matsuo, M. Matsuoka
    • Journal Title

      J. Chem. Eng. Japan 40

      Pages: 541-549

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics of Solid State Polymorphic Transition of Caffeine2007

    • Author(s)
      K. Matsuo, M. Matsuoka
    • Journal Title

      J. Chem. Eng. Japan 40

      Pages: 468-472

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Solid State Polymorphic Transition of Theophilline Anhydrate and Humidity Effect2007

    • Author(s)
      K. Matsuo, M. Matsuoka
    • Journal Title

      Crystal Growth and Design 7

      Pages: 411-415

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics of Humidity Driven Solid-State Polymorphic Transition of Theophylline Anhydrates2007

    • Author(s)
      K. Matsuo and M. Matsuoka
    • Journal Title

      J. Chem. Eng. Japan 40(7)

      Pages: 541-549

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics of Solid State Polymorphic Transition of Caffeine2007

    • Author(s)
      K. Matsuo and M. Matsuoka
    • Journal Title

      J. Chem. Eng. Japan 40(6)

      Pages: 468-472

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solid State Polymorphic Transition of Theophilline Anhydrate and Humidity Effect2007

    • Author(s)
      K. Matsuo and M. Matsuoka
    • Journal Title

      Crystal Growth and Design 7(2)

      Pages: 411-415

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solid-state Recrystallization Behavior of Binary Inorganic Salt Systems in Mechanochemical Processing

    • Author(s)
      M. Matsuoka, K. Danzuka
    • Journal Title

      J. Chem. Eng., Japan (印刷中)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] メカノケミカル法による有機結晶多形の発現と制御2009

    • Author(s)
      山田記央、羽田麻衣子、松岡正邦
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学、神奈川
    • Related Report
      2008 Final Research Report
  • [Presentation] メカノケミカル法によるアミノ酸の固溶体の形成2009

    • Author(s)
      阿部友昭、羽田麻衣子、松岡正邦
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学、神奈川
    • Related Report
      2008 Final Research Report
  • [Presentation] Theophyllineの固相多形転移における湿度の影響2009

    • Author(s)
      岸祥史、羽田麻衣子、松岡正邦
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学、神奈川
    • Related Report
      2008 Final Research Report
  • [Presentation] メカノケミカル法による有機結晶多形の発現と制御2009

    • Author(s)
      山田記央, 羽田麻衣子, 松岡正邦
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] メカノケミカル法によるアミノ酸の固溶体の形成2009

    • Author(s)
      阿部友昭, 羽田麻衣子, 松岡正邦
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] Theophyllineの固相多形転移における湿度の影響2009

    • Author(s)
      岸祥史, 羽田麻衣子, 松岡正邦
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of Humidity on Polymorphic Transition of Theophylline2008

    • Author(s)
      Y. Kishi and M. Matsuoka
    • Organizer
      8^<th> International Conference on Separation Science and Technology
    • Place of Presentation
      Karuizawa、Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Controlled Manufacturing of Polymorphic Mixtures of MPPO2008

    • Author(s)
      Y. Nakata, Y. Kiyosawa, K. Kagara and M. Matsuoka
    • Organizer
      8th International Conference on Separation Science and Technology
    • Place of Presentation
      Karuizawa、Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of Seeding on Solution-Mediated Transformation of DL-Methionine2008

    • Author(s)
      M. Yamanobe-Hada, K. Danzuka, and M. Matsuoka
    • Organizer
      8^<th> International Conference on Separation Science and Technology
    • Place of Presentation
      Karuizawa、Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] 結晶多形転移に及ぼすマイクロ波の影響2008

    • Author(s)
      赤松俊介、松岡正邦
    • Organizer
      化学工学会第40回秋季大会
    • Place of Presentation
      東北大学、宮城
    • Related Report
      2008 Final Research Report
  • [Presentation] 反応晶析によるDL-メチオニン結晶の形態, 結晶多形, 嵩密度2008

    • Author(s)
      餘舛拓哉、羽田麻衣子、松岡正邦、古泉善行
    • Organizer
      化学工学会第40回秋季大会
    • Place of Presentation
      東北大学、宮城
    • Related Report
      2008 Final Research Report
  • [Presentation] 結晶多形の転移速度に及ぼす添加物の影響2008

    • Author(s)
      岸祥史、羽田麻衣子、松岡正邦
    • Organizer
      化学工学会第40回秋季大会
    • Place of Presentation
      東北大学、宮城
    • Related Report
      2008 Final Research Report
  • [Presentation] Kinetics of Polymorphic Transition of Glycine in Mechano-Chemical Processing2008

    • Author(s)
      M. Matsuoka, J. Hirata, S. Yoshizawa
    • Organizer
      17^<th> International Symposium on Industrial Crystallization
    • Place of Presentation
      Maastricht、The Netherlands
    • Related Report
      2008 Final Research Report
  • [Presentation] Operation Design Strategy for Controlling Polymorphism in the Anti-Solvent Crystallization2008

    • Author(s)
      H. Takiyama, T. Minamisono, Y. Osada, M. Matsuoka
    • Organizer
      17^<th> International Symposium on Industrial Crystallization
    • Place of Presentation
      Maastricht、The Netherlands
    • Related Report
      2008 Final Research Report
  • [Presentation] メカノケミカル法による有機結晶の多形発現と転移速度2008

    • Author(s)
      平田隼也、羽田麻衣子、松岡正邦
    • Organizer
      分離技術会年会
    • Place of Presentation
      明治大学、神奈川
    • Related Report
      2008 Final Research Report
  • [Presentation] Kinetics of Polymorphic Transition of Glycine in Mechano-Chemical Processing2008

    • Author(s)
      M. Matsuoka, J. Hirata, S. Yoshizawa
    • Organizer
      17^<th>International Symposium on Industrial Crystallization
    • Place of Presentation
      Maastricht, The Netherlands
    • Related Report
      2008 Annual Research Report
  • [Presentation] Operation Design Strategy for Controlling Polymorphism in the Anti-Solvent Crystallization2008

    • Author(s)
      H, Takiyama, T. Minamisono, Y. Osada, M. Matsuoka
    • Organizer
      17^<th>International Symposium on Industrial Crystallization
    • Place of Presentation
      Maastricht, The Netherlands
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of Humidity on Polymorphic Transition of Theophylline2008

    • Author(s)
      Y. Kishi, M. Matsuoka
    • Organizer
      8^<th>International Conference on Separation Science and Technology
    • Place of Presentation
      Karuizawa, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Controlled Manufacturing of Polymorphic Mixtures of MPPO2008

    • Author(s)
      Y. Nakata, Y. Kiyosawa, K. Kagara, M. Matsuoka
    • Organizer
      8^<th>International Conference on Separation Science. and Technology
    • Place of Presentation
      Karuizawa, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of Seeding on Solution-Mediated Transformation of DL-Methionine2008

    • Author(s)
      M. Yamanobe-Hada, K. Danzuka, M. Matsuoka
    • Organizer
      8^<ty> International Conference on Separation Science and Technology
    • Place of Presentation
      Karuizawa, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] メカノケミカル法による有機結晶の多形発現と転移速度2008

    • Author(s)
      平田隼也, 羽田麻衣子, 松岡正邦
    • Organizer
      分離技術会年会
    • Place of Presentation
      明治大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] 結晶多形転移に及ぼすマイクロ波の影響2008

    • Author(s)
      赤松俊介, 松岡正邦
    • Organizer
      化学工学会第40回秋季大会
    • Place of Presentation
      東北大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] 反応晶析によるDL-メチオニン結晶の形態, 結晶多形, 嵩密度2008

    • Author(s)
      餘舛拓哉, 羽田麻衣子, 松岡正邦, 古泉善行
    • Organizer
      化学工学会第40回秋季大会
    • Place of Presentation
      東北大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] 結晶多形の転移速度に及ぼす添加物の影響2008

    • Author(s)
      岸祥史, 羽田麻衣子, 松岡正邦
    • Organizer
      化学工学会第40回秋季大会
    • Place of Presentation
      東北大学
    • Related Report
      2008 Annual Research Report
  • [Book] 分かりやすい結晶多形2008

    • Author(s)
      松岡正邦
    • Total Pages
      100
    • Publisher
      分離技術会
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Remarks] 結晶多形のデータベースの構築

    • URL

      http://www.tuat.ac.jp/~indcryst/polymorphDB/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks] 申請中

    • URL

      http://www.tuat.ac.jp/~indcryst/polymorphDB/index.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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