| Budget Amount *help |
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2007: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Research Abstract |
We have conducted focused proteomics of phosphorylated proteins by using tautomycetin. Protein phosphatase 1 (PP1) was found to act as a kind of regulatory enzyme for signal transduction in mammalian cells. For example, it positively regulates TNFα/NF-κB pathway as well as Raf. In addition, we isolated ATM30, a substrate of both PP1 and ATM/ATR kinase. ATM30 was found to be a ribosomal protein RPS3A(a) by MALDI-TOF/MS analysis.
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