Improvement of meat production by central regulation using a factor extracted from Shochu distillery by-product in fowls especially in native fowl

• Project/Area Number: 19208024
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Zootechnical science/Grassland science
• Research Institution: Kagoshima University
• Principal Investigator: HAYASHI Kunioki Kagoshima University, 農学部, 教授 (80041656)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Shin 神戸大学, 大学院・農学研究科, 教授 (60107985) ; KATO Kazo 東北大学, 大学院・農学研究科, 教授 (60091831) ; OHTSUKA AKIRA 鹿児島大学, 農学部, 准教授 (10233173) ; SUGAWARA KUNIO 宇都宮大学, 農学部, 教授 (50091947)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥49,400,000 (Direct Cost: ¥38,000,000、Indirect Cost: ¥11,400,000); Fiscal Year 2009: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2008: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000); Fiscal Year 2007: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
• Keywords: 飼料 / 生理活性物質 / 筋肉タンパク質分解 / 食欲制御 / 焼酎粕 / 成長促進物質 / ブトキシブチルアルコール / 焼酎粕因子 / 鶏 / 神経ペプチド / 視床下部 / 下垂体 / 摂食調節

Research Abstract

The present study showed that the growth promoter buthoxybuthyl alcohol (BBA) found from Shochu distillery by-product reduces muscle proteolysis. This effect of BBA was caused by decreases in genes expressions of factors relating to the skeletal muscle proteolysis such as calpain, ubiquitin, and proteasome.
Furthermore, the present study showed changes in secretions of growth hormone (GH), adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) due to BBA. BBA increased GH secretion and decreased secretions of ACTH and CRH. BBA increased feed intake because CRH is reduced followed by nerve peptides synthesis in the hypothalamus.

Research Products

• [Journal Article] Effects of Feeding Hexane-Extracts of a Schochu Distillery By-Product on Skeletal Muscle Protein Degradation in Broiler Chicken (2010)
  • Author(s): Kamizono T, Hayashi K
  • Journal Title: Bioscience Biotechnology Biochemistry 74 Pages: 92-95
• [Journal Article] Effect of dietary coenzyme Q10 on colesterol metabolism in chickens (2010)
  • Author(s): Honda K, Kamisoyama H, Motoori T, Saneyasu T, Hasegawa S
  • Journal Title: The Journal of Poultry Science 47 Pages: 41-47
• [Journal Article] Effects of Feeding Hexane-Extracts of a Schochu Distillery By-Product on Skeletal Muscle Protein Degradation in Broiler Chicken (2010)
  • Author(s): Kamizono T, Hayashi K
  • Journal Title: Bioscience Biotechnology Biochemistry Volume: 74 Pages: 92-95
  • Peer Reviewed
• [Journal Article] Effect of dietary coenzyme Q10 on colesterol metabolism in chickens (2010)
  • Author(s): Honda K, Kamisoyama H, Motoori T, Saneyas T, Hasegawa S
  • Journal Title: The Journal of Poultry Science Volume: 47 Pages: 41-47
  • Peer Reviewed
• [Journal Article] 焼酎粕濃縮液給与によるブロイラーの生産性および肉質の改善 (2009)
  • Author(s): 林國興、前田真希、北原和弥、田子山徹、大塚彰
  • Journal Title: 日本畜産学会報 80 Pages: 35-39
• [Journal Article] Corticotropin-releasing factor is a downstream mediator of the beta-melanocyte stimulating hormone-induced anorexigenic pthway in chicks (2009)
  • Author(s): Kamisoyama H, Honda K, Saneyasu T, Sugahara K, Hasegawa S
  • Journal Title: Neuroscience letters 458 Pages: 102-105
• [Journal Article] 焼酎粕上清濃縮液給与によるブロイラーの生産性および肉質の改善 (2009)
  • Author(s): 林, 他
  • Journal Title: 日本畜産学会報 80 Pages: 35-39
  • NAID: 10029739905
  • Peer Reviewed
• [Journal Article] Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats, Bioscience (2008)
  • Author(s): Kamisoyama H, Honda K, Tominaga Y, Yokota S, Hasegawa S
  • Journal Title: Biotechnology, and Biochemistry 72, 12 Pages: 3225-3231
• [Journal Article] Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats (2008)
  • Author(s): Kami soyama, et al.
  • Journal Title: Bioscience, Biotechnology, and Biochemistry 72 Pages: 3225-3231
  • Peer Reviewed
• [Journal Article] The functional roles of glucagon family in the central regulation of food intake in chicks (2008)
  • Author(s): Hasegawa, et al.
  • Journal Title: 1^<st> Mediterranean summit of WPSA Pages: 774-778
• [Journal Article] Central administration of glucagon suppresses food intake in chicks (2007)
  • Author(s): Honda K, Kamisoyama H, Saito N, Kurose Y, Sugahara K, Hasegawa S
  • Journal Title: Neuroscience Letters 416, 2 Pages: 198-201
  • NAID: 120000976618
• [Journal Article] Central administration of glucagon suppresses food intake in chicks (2007)
  • Author(s): Honda, et. al.
  • Journal Title: Neuroscience Letters 416 Pages: 198-201
  • Peer Reviewed
• [Presentation] ブロイラーの骨格筋成長に対する1,1-ジブトキシブタンの作用 (2010)
  • Author(s): 神園巴美、大塚彰、橋本文雄、林國興
  • Organizer: 日本家禽学会秋期大会
  • Place of Presentation: 長野
  • Year and Date: 2010-09-14
• [Presentation] ブロイラーの骨格筋成長に対する1, 1-ジブトキシブタンの作用 (2010)
  • Author(s): 神園巴美、大塚彰、橋本文雄、林國興
  • Organizer: 日本家禽学会秋期大会
  • Place of Presentation: 信州大学
  • Year and Date: 2010-09-14
• [Presentation] Development of functional feed ingredients using naturally occurring compounds (2010)
  • Author(s): S.Hasegawa, K.Honda, H.Kamisoyama, K.Hayashi
  • Organizer: XIIIth European Poultry Conference
  • Place of Presentation: Tours、France
• [Presentation] Effects of functional feed ingredients on the quantities and qualities of chicken meat and egg (2009)
  • Author(s): S.Hasegawa, K.Honda, H.Kamisoyama, K.Hayashi
  • Organizer: The XIX European Symposium on the Quality of Poultry Meat and XIII European Symposium on the Quality of Eggs and Egg Products
  • Place of Presentation: Turku、Finland
• [Presentation] An efficient and economical method to improve chicken meat quality using distillery by-product. (2009)
  • Author(s): T.Kamizono, T.Tagoyama, K.Kitahara, A.Ohtsuka, K.Hayashi
  • Organizer: The XIX European Symposium on the Quality of Poultry Meat and XIII European Symposium on the Quality of Eggs and Egg Products
  • Place of Presentation: Turku, Finland
• [Presentation] ブロイラーの筋肉タンパク質分解に対する焼酎粕ヘキサン抽出物給与の影響 (2009)
  • Author(s): 神園巴美、林國興
  • Organizer: 日本畜産学会第111回大会
  • Place of Presentation: 沖縄
• [Presentation] Influence biomass feed to meet quality on Japanese black cattle (2008)
  • Author(s): Kobashikawa, H., Kamata, Y., Astrid, A., Uehara, I., Hirayama, T., Hirakawa, M., Tamaki, H., Suzuki, K, Katoh, K.
  • Organizer: The 13^<th> AAAP
  • Place of Presentation: Hanoi, Vietnam
  • Year and Date: 2008-09-22
• [Presentation] ビール粕および泡盛粕由来発酵飼料を給与した場合の血中BUN、VFA、ホルモン濃度 (2008)
  • Author(s): 小橋川,寛、上原,薫、佐藤,勝祥、Ardiyant Astrid、平山,琢二、加藤,和雄
  • Organizer: 日本畜産学会第109回大会
  • Place of Presentation: 常盤大学
  • Year and Date: 2008-03-29
• [Presentation] Effect of shochu distillery by-product on skeletal muscle growth in broiler chickens (2008)
  • Author(s): T.Kamizono, T.Tagoyama, A.Ohtsuka, K.Hayashi
  • Organizer: Poultry Science Annual Meeting
  • Place of Presentation: Ontario, Canada
• [Presentation] ブロイラーにおける焼酎粕分離濃縮液給与の影響 (2008)
  • Author(s): 神園巴美、林國興
  • Organizer: 第59回西日本畜産学会大会
  • Place of Presentation: 佐賀
• [Presentation] The functional roles of glucagon family in the central regulation of food intake in chicks (2008)
  • Author(s): S.Hasegawa, K.Honda, H.Kamisoyama
  • Organizer: 1^<st> Mediterranean Summit of WPSA
  • Place of Presentation: Porto Carras、Chalkidiki、Greece
• [Presentation] Effect of shochu distillery by-product on skeletal musele growth in broiler chickens (2008)
  • Author(s): Kamizono, et al.
  • Organizer: 97^<th> Annual Meeting of Poultry Science Association
  • Place of Presentation: Canada
• [Presentation] Physiological function of butoxybutyl alcohol a novel compound in broiler (2007)
  • Author(s): S.Inada, A.Ohtsuka, K.Hayashi
  • Organizer: Poultry Science Annual Meeting
  • Place of Presentation: San Antonio, USA