Analysis of factors implicated in pathogenicity of mononegaviruses and development of a vaccine candidate.
Project/Area Number |
19208025
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied veterinary science
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Research Institution | The University of Tokyo |
Principal Investigator |
KAI Chieko The University of Tokyo, 医科学研究所, 教授 (10167330)
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Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Hiroyuki 東京大学, 農学生命科学研究科, 教授 (40155891)
YONEDA Misako 東京大学, 医科学研究所, 准教授 (40361620)
SATOU Hiroki 東京大学, 医科学研究所, 助教 (50418654)
|
Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2009: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2008: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2007: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
|
Keywords | モノネガウイルス / モービリウイルス / 病原性 / 組換えウイルス / 宿主因子 / 麻疹ウイルス / 牛疫ウイルス / イヌジステンパーウイルス / アクセサリー蛋白 / 病原性発現 / 組換えウイルスワクチン |
Research Abstract |
We investigated the key factors in pathogenicity of morbilliviruses, and developed a vaccine for Nipah virus infection. For morbilliviruses, it was discovered that MV induced different cellular responses in a cell-type specific mannar, and viral nucleocapsid protein had inhibitory potency for IFN-α/β and γ signaling. For Nipah virus, we showed that accessory proteins play key roles in it's pathogenicity. We have also showed that our established recombinant measles virus expressing Nipah virus protein effectively protected hamsters from NiV infection.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] The nonstructural proteins of Nipah virus play a key role in pathogenicity in vivo.2010
Author(s)
Yoneda, M., Guillaume, V., Sato, H., Fujita, K., Georges-Courbot, M-C., Ikeda, F., Omi, M., Muto-Terao, Y., Wild, F., Kai, C.
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Journal Title
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Peer Reviewed
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[Journal Article] Phosphorylation of measles virus nucleoprotein upregulates the transcriptional activity of minigenomic RNA.2008
Author(s)
Hagiwara K., Sato H., Inoue Y., Watanabe A., Yoneda M., Ikeda F., Fujita K., Fukuda H., Takamura C., Kozuka-Hata H., Oyama M., Sugano S., Ohmi S., Kai C.
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Journal Title
Proteomics 8
Pages: 1871-1879
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[Journal Article] A novel monolayer cell line derived from human umbilical cord blood cells shows high sensitivity to measles virus.2007
Author(s)
Kobune F., Ami Y., Katayama M., Takahashi M., Tuul R., Korukluoglu G., Kiyohara T., Miura R., Sato H., Yoneda M., Kai C.
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Journal Title
J.Gen.Virol. 88
Pages: 1565-1567
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[Presentation] Analysis of phosphorylation residues on Nipah virus nucleoprotein.2009
Author(s)
Huang, M., Sato, H., Hagiwara, K., Watanabe, A., Kozuka-Hata, H., Oyama, M., Yoneda, M., Kai, C.
Organizer
The 9th Awaji International Forum
Place of Presentation
淡路夢舞台国際会議場
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