| Budget Amount *help |
¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000)
Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2008: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2007: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
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| Research Abstract |
New neurons are generated in the dentate gyrus of the hippocampal formation from neural stem cells, and contribute to the maintenance of hippocampal plasticity. The number of new neurons decreases as age progresses, but neural stem cells are reserved even in aged animals and elderly people, suggesting the contribution of adult neruogenesis on the maintenance of hippocampal function. There is a hypothesis that donepezil can maintain hippocampal plasticity through the promotion of new neuron generation. Donepezil is a leading medication for Alzheimer disease, but its mechanism for treating Alzheimer disease has not been fully clarified yet. To know roles of donepezil in maintaining and/or enhancing hippocampal plasticity, we evaluated the effect of donepezil on regulation of adult hippocampal neurogenesis, and discovered that donepezil promotes the genesis of new neurons even in aged animals.
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