Efficient Synthesis of Natural Products Having Intriguing Biological Activities Useful for Drug Discovery
| Project/Area Number |
19209001
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
HATAKEYAMA SUSUMI (HATAKEYAMA Susumi) Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (20143000)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Jun 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (80250413)
TAKAHASHI Keisuke 長崎大学, 大学院・医歯薬学総合研究科, 助教 (60380854)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2008: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2007: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
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| Keywords | 有機合成化学 / 全合成 / 天然物 / 創薬リード / グルタミン酸受容体作用化合物 / カイトセファリン / PP2A阻害化合物 / ホストリエシン / ホスラクトマイシン / 抗腫瘍活性化合物 / オキサゾロマイシン / 医療開発リード / サリノスポラミドA / 医薬開発リード / ダイシハーベイン / ネオオキサゾロマイシン |
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| Research Abstract |
We have studied on the total synthesis of natural products having intriguing biological activities useful for drug discovery. As a result, we have developed efficient methodologies for the synthesis of dyshiherbaine, a glutamate receptor agonist, phoslactomycin B and fostriecin, PP2A inhibitors, and neooxazolomycin, an antitumor antibiotic. In addition, we have developed a new methodology for the construction of heterocycles which relies on an In(III)-catalyzed Conia-ene reaction, and achieved the total synthesis of salinosporamide A, a proteasome inhibitor.
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Report
(5 results)
Research Products
(39 results)
