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Cellular responses to inhibition of DNA replication fork progression at DNA lesions

Research Project

Project/Area Number 19209003
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionGakushuin University (2008-2009)
Osaka University (2007)

Principal Investigator

HANAOKA Fumio  Gakushuin University, 理学部, 教授 (50012670)

Co-Investigator(Kenkyū-buntansha) MASUTANI Chikahide  大阪大学, 生命機能研究科, 准教授 (40241252)
OHKUMO Tuyoshi  大阪大学, 生命機能研究科, 助教 (50432505)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000)
Fiscal Year 2009: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2008: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2007: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Keywords遺伝子 / 癌 / DNA複製 / 放射線 / ゲノム / クロマチン / 細胞周期 / がん
Research Abstract

We studied how eukaryotic cells respond to various DNA damages that prevent the progression of DNA replication fork. We found that one of the translesion DNA synthesis polymerase, DNA polymerase η, interacts with several other repair proteins such as mismatch repair proteins, is phosphorylated and ubiquitinated at certain amino acid residues, and changes the intracellular localization upon UV irradiation. We demonstrated that the template-switching mechanism is operating not only in prokaryotes but also in higher eukaryotes.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report

Research Products

(67 results)

All 2010 2009 2008 2007 Other

All Journal Article (47 results) (of which Peer Reviewed: 46 results) Presentation (19 results) Remarks (1 results)

  • [Journal Article] Structure and mechanism of human DNA polymeraseη2010

    • Author(s)
      Biertumpfel, C., Zhao, Y., Kondo, Y., Ramon-Maiques, S., Gregory, M., Lee, J.Y., Masutani, C., Lehmann, A.R., Hanaoka, F., Yang, W
    • Journal Title

      Nature 465

      Pages: 44-1049

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.2010

    • Author(s)
      Jee, J., Mizuno, T., Kamada, K., Tochio, H., Chiba, Y., Yanagi, K.I., Yasuda, G., Hiroaki, H., Hanaoka, F., Shirakawa, M.
    • Journal Title

      J. Biol. Chem 285

      Pages: 15931-15940

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymerization by DNA polymerase eta is blocked by cisdiamminedichloroplatinum( II) 1, 3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells.2010

    • Author(s)
      Chijiwa, S., Masutani, C., Hanaoka, F., Iwai, S., Kuraoka, I
    • Journal Title

      Carcinogenesis 31

      Pages: 388-393

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells.2010

    • Author(s)
      Sekimoto, T., Oda, T., Pozo, F.M., Murakumo, Y., Masutani, C., Hanaoka, F., Yamashita, T
    • Journal Title

      Mol. Cell 37

      Pages: 79-89

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides.2010

    • Author(s)
      Katafuchi, A., Sassa, A., Niimi, N., Gruz, P. Fujimoto, H., Masutani, C., Hanaoka, F., Ohta, T., Nohmi, T.
    • Journal Title

      Nucleic Acids Res 38

      Pages: 859-867

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells.2010

    • Author(s)
      Sekimoto, T., et al.
    • Journal Title

      Mol.Cell 37

      Pages: 79-89

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The chromosomal association of condensin II is required by a noncatalytic function of PP2A.2009

    • Author(s)
      Takemoto, A., Maeshima, K., Ikehara, T., Yamaguchi, K., Murayama, A., Imamura, S., Imamoto, N., Yokoyama, S., Hirano, T., Watanabe, Y., Hanaoka, F., Yanagisawa, J., Kimura, K
    • Journal Title

      Nat. Struct. Mol. Biol 16

      Pages: 1302-1308

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning.2009

    • Author(s)
      Sugasawa, K., Akagi, J., Nishi, R., Iwai, S., Hanaoka, F.
    • Journal Title

      Mol. Cell 36

      Pages: 642-653

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A nobel interaction between human DNA polymerase eta and MutL alpha. Biochem. Biophys.2009

    • Author(s)
      Kanao, R., Hanaoka, F., Masutani, C.
    • Journal Title

      Biochem. Biophys. Res. Commun 389

      Pages: 40-45

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eukaryotic DNA polymerases alpha, beta and epsilon incorporate guanine opposite 2, 2, 4-triamino-5(2H)-oxazolone.2009

    • Author(s)
      Kino, K., Sugasawa, K., Mizuno, T., Bando, T., Sugiyama, H., Akita, M., Miyazawa, H., Hanaoka, F.
    • Journal Title

      Chembiochem 10

      Pages: 2613-2616

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) in vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus.2009

    • Author(s)
      Fukuda, H., Takamura-Enya, T., Masuda, Y., Nohmi, T., Seki, C., Kamiya, K., Sugimura, T., Masutani, C., Hanaoka, F., Nakagama, H.
    • Journal Title

      J. Biol. Chem 284

      Pages: 25585-25592

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells.2009

    • Author(s)
      Nishi, R., Alekseev, S., Dinant, C., Hoogstraten, D., Houtsmuller, A.B., Hoeijmakers, J.H., Vermeulen, W., Hanaoka, F., Sugasawa, K.
    • Journal Title

      DNA Repair 8

      Pages: 767-776

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.2009

    • Author(s)
      Akagi, J., Masutani, C., Kataoka, Y., Kan, T., Ohashi, E., Mori, T., Ohmori, H., Hanaoka, F.
    • Journal Title

      DNA Repair 8

      Pages: 585-599

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases.2009

    • Author(s)
      Kimura, T., Takeuchi, T., Kumamoto-Yonezawa, Y., Ohashi, E., Ohmori, H., Masutani, C., Hanaoka, F., Sugawara, F., Yoshida, H., Mizushina, Y.
    • Journal Title

      Bioorg. Med. Chem 17

      Pages: 1811-1816

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin A-Cdk1 regulates the origin firing program in mammalian cells.2009

    • Author(s)
      Katsuno, Y., Suzuki, A., Sugimura, K., Okumura, K., Zineldeen, D.H., Shimada, M., Niida, H., Mizuno, T., Hanaoka, F., Nakanishi, M.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106

      Pages: 3184-3189

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central forkhead domain of human TFIIE beta plays a primary role in binding double-stranded DNA at transcription initiation.2009

    • Author(s)
      Tanaka, A., Watanabe, T., Iida, Y., Hanaoka, F., Ohkuma Y.
    • Journal Title

      Genes Cells 14

      Pages: 395-405

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.2009

    • Author(s)
      Akagi, J., et al.
    • Journal Title

      DNA Repair 8

      Pages: 585-599

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel interaction between human DNA polymerase eta and MutLalpha.2009

    • Author(s)
      Kanao, R., et al.
    • Journal Title

      Biochem. Biophys.Res.Commun. 389

      Pages: 40-45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin A-Cdk1 regulates the origin firing program in mammalian cells.2009

    • Author(s)
      Katsuno, Y., et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106

      Pages: 3184-3189

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA polymerase eta is a limiting factor for A:T mutations in Ig genes and contributes to antibody affinity maturation.2008

    • Author(s)
      Masuda, K., Ouchida, R., Yokoi, M., Hanaoka, F., Azuma, T., Wang, J.Y.
    • Journal Title

      Eur. J. Immunol 38

      Pages: 796-2805

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.2008

    • Author(s)
      Fukumoto, Y., Dohmae, N., Hanaoka, F.
    • Journal Title

      Mol. Cell. Biol 28

      Pages: 6746-6756

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel DNA microarray system for analysis of nascent mRNAs.2008

    • Author(s)
      Ohtsu, M., Kawate, M., Fukuoka, M., Gunji, W., Hanaoka, F., Utsugi, T., Onoda, F., Murakami, Y.
    • Journal Title

      DNA Res 15

      Pages: 241-251

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations.2008

    • Author(s)
      Ouchida, R., Ukai, A., Mori, H., Kawamura, K., Dolle, M.E.T., Tagawa, M., Sakamoto, A., Tokuhisa, T., Yokosuka, T., Saito, T., Yokoi, M., Hanaoka, F., Vijg, J., Wang, J.Y.
    • Journal Title

      DNA Repair 7

      Pages: 1392-1398

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.2008

    • Author(s)
      Martomo, S.A., Saribasak, H., Yokoi, M., Hanaoka, F., Gearhart, P.J.
    • Journal Title

      DNA Repair 7

      Pages: 1603-1608

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.2008

    • Author(s)
      Tsuji, Y., Watanabe, K., Araki, K., Shinohara, M., Yamagata, Y., Tsurimoto, T., Hanaoka, F., Yamamura, K., Yamaizumi, M., Tateishi, S.
    • Journal Title

      Genes Cells 13

      Pages: 343-354

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA adduct, during translesion synthesis catalyzed by human DNA polymerases.2008

    • Author(s)
      Yasui, M., Suenaga, E., Koyama, N., Masutani, C., Hanaoka, F., Gruz, P., Shibutani, S., Nohmi, T., Hayashi, M., Honma, M.
    • Journal Title

      J. Mol. Biol 377

      Pages: 1015-1023

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta.2008

    • Author(s)
      Hidaka, K., Yamada, M., Kamiya, H., Masutani, C., Harashima, H., Hanaoka, F., Nohmi, T.
    • Journal Title

      DNA Repair 7

      Pages: 497-506

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutagenic radioadaptation in a human lymphoblastoid cell line.2008

    • Author(s)
      Yatagai, F., Umebayashi, Y., Homma, M., Sugasawa, K., Takayama, Y., Hanaoka, F.
    • Journal Title

      Mutat. Res 638

      Pages: 48-55

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel class of temperature-sensitive mutants generated by RNAi-r. Biochem.2008

    • Author(s)
      Inaki, M., Utsugi, T., Onoda, F., Hanaoka, F., Murakami, Y.
    • Journal Title

      Biophys. Res. Commun 365

      Pages: 472-477

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.2008

    • Author(s)
      Tsuji, Y., et al.
    • Journal Title

      Genes Cells 13

      Pages: 343-354

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.2008

    • Author(s)
      Fukumoto, Y., et al.
    • Journal Title

      Mol. Cell. Biol. 28

      Pages: 6746-6756

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation.2007

    • Author(s)
      Yasuda, G., Nishi, R., Watanabe, E., Mori, T., Iwai, S., Orioli, D., Stefanini, M., Hanaoka, F., Sugasawa, K.
    • Journal Title

      Mol. Cell. Biol 27

      Pages: 6606-6614

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dicer-related drh-3 gene functions in germ-line development by maintenance of chromosomal integrity in Caenorhabditis elegans.2007

    • Author(s)
      Nakamura, M., Ando, R., Nakazawa, T., Yudazono, T., Tsutsumi, N., Hatanaka, N., Ohgake, T., Hanaoka, F., Eki, T.
    • Journal Title

      Genes Cells 12

      Pages: 997-1010

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide survey and systematic RNAi-based characterization of helicase-like genes in Caenorhabditis elegans.2007

    • Author(s)
      Eki, T., Ishihara, T., Katsura, I., Hanaoka, F.
    • Journal Title

      DNA Res 14

      Pages: 183-199

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rad54 dissociates homologous recombination intermediates by branch migration.2007

    • Author(s)
      Bugreev, D.V., Hanaoka, F., Mazin, A.V.
    • Journal Title

      Nat. Struct. Mol. Biol 14

      Pages: 746-753

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A second PCNA loader complex, Ctf18-RFC, stimulates DNA polymeraseηactivity.2007

    • Author(s)
      Shiomi, Y., Masutani, C., Hanaoka, F., Kimura, H., Tsurimoto, T.
    • Journal Title

      J. Biol. Chem 282

      Pages: 20906-20914

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA polymeraseηand・function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.2007

    • Author(s)
      Masuda, K., Ouchida, R., Hikida, M., Kurosaki, T., Yokoi, M., Masutani, C., Seki, M., Wood, R.D., Hanaoka, F., O-Wang, J.
    • Journal Title

      J. Biol. Chem 282

      Pages: 17387-17394

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 2-Hydroxy-dATP enhances A:T→C:G mutations caused by 8-hydroxy-dGTP by suppressing its degradation upon replication in a HeLa extract.2007

    • Author(s)
      Satou, K., Kasai, H., Masutani, C., Hanaoka, F., Harashima, H., Kamiya, H.
    • Journal Title

      Biochemistry 46

      Pages: 6639-6646

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymeraseη.2007

    • Author(s)
      Shimizu, M., Gruz, P., Kamiya, H., Masutani, C., Xu, Y., Usui, Y., Sugiyama, H., Harashima, H., Hanaoka, F., Nohmi, T.
    • Journal Title

      Biochemistry 46

      Pages: 5515-5522

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the human GINS complex and its assembly and functional interface in replication initiation. Nature Struct.2007

    • Author(s)
      Kamada, K., Kubota, Y., Arata, T., Shindo, Y., Hanaoka, F.
    • Journal Title

      Nature Struct. Mol. Biol 14

      Pages: 388-396

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the role of Aurora B on the chromosomal targeting of condensin I.2007

    • Author(s)
      Takemoto, A., Murayama, A., Katano, M., Urano, T., Furukawa, K., Yokoyama, S., Yanagisawa, J., Hanaoka, F., Kimura, K.
    • Journal Title

      Nucleic Acids Res 35

      Pages: 2403-2412

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analyses of a single-stranded telomeric DNA binding domain of fission yeast pot1: conflict with x-ray crystallographic structure.2007

    • Author(s)
      Torigoe, H., Dohmae, N., Hanaoka, F., Furukawa, A.
    • Journal Title

      Biosci. Biotechnol. Biochem 71

      Pages: 481-490

    • NAID

      10027511703

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation.2007

    • Author(s)
      Furumoto, T., Tanaka, A., Ito, M., Malik, S., Hirose, Y., Hanaoka, F., Ohkuma, Y.
    • Journal Title

      Genes Cells 12

      Pages: 119-132

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensing of DNA damage by XPC/Rad4: 0ne protein for many lesions.2007

    • Author(s)
      Sugasawa, K.&Hanaoka, F.
    • Journal Title

      Nat. Struct. Mol. Biol. 14

      Pages: 887-888

    • Related Report
      2007 Annual Research Report
  • [Journal Article] In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation.2007

    • Author(s)
      Yasuda, G. et. al.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 6606-6614

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the human GINS complex and its assembly and functional interface in replication initiation.2007

    • Author(s)
      Kamada, K. et. al.
    • Journal Title

      Nat. Struct. Mol. Biol. 14

      Pages: 388-396

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus.

    • Author(s)
      Eichinger, C.S., Mizuno, T., Mizuno, K., Miyake, Y., Yanagi, K., Imamoto, N., Hanaoka, F.
    • Journal Title

      J. Biol. Chem 284

      Pages: 30604-30614

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] UV-induced mutations in the epidermal genome of DNA polymerase eta- and iota-deficient mice occurring in vivo.2009

    • Author(s)
      Fumio Hanaoka
    • Organizer
      Seeberg Symposium 2009
    • Place of Presentation
      Aalesund, Norway
    • Year and Date
      2009-06-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 損傷を乗り越えるポリメラーゼの機能と発癌の制御2009

    • Author(s)
      花岡文雄
    • Organizer
      東北大学・加齢医学研究所・シンポジウム平成20年度・ゲノムリサーチセンター・ワークショップ「癌と老化を乗り越えるDNA修復の科学」
    • Place of Presentation
      仙台
    • Year and Date
      2009-03-13
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA研究の将来(財)ライフサイエンス振興財団2009

    • Author(s)
      花岡文雄
    • Organizer
      25周年記念シンポジウム-ライフサイエンスの輝かしい未来-
    • Place of Presentation
      東京
    • Year and Date
      2009-03-04
    • Related Report
      2009 Final Research Report
  • [Presentation] UV-induced mutations in the epidermal genome of TLS polymerase-deficient mice2009

    • Author(s)
      Hanaoka, F
    • Organizer
      The 40th International Symposium of the Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] UV-induced mutations in the epidermal genome of DNA polymeraseη- andι-deficient mice occurring in vivo2009

    • Author(s)
      Hanaoka, F
    • Organizer
      Second Erling Seeberg Symposium on DNA Repair, Keynote Address
    • Place of Presentation
      Alesund and Geiranger, Norway
    • Related Report
      2009 Final Research Report
  • [Presentation] ゲノム情報維持の分子機構に関する研究2009

    • Author(s)
      花岡文雄
    • Organizer
      日本薬学会第129年会日本薬学会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え複製研究の最前線2008

    • Author(s)
      花岡文雄
    • Organizer
      東京都臨床医学総合研究所
    • Place of Presentation
      東京
    • Year and Date
      2008-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え型DNAポリメラーゼ・イータおよびイオタ欠損マウスの皮膚における紫外線誘発発がんと突然変異2008

    • Author(s)
      花岡文雄
    • Organizer
      日本放射線影響学会第51回大会、シンポジウム「放射線発がんの基盤を形成する遺伝子・細胞・組織の応答」
    • Place of Presentation
      北九州
    • Year and Date
      2008-11-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え複製とがん2008

    • Author(s)
      花岡文雄
    • Organizer
      第67回日本癌学会学術総会、モーニング・レクチャー
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Translesion synthesis and cancer2008

    • Author(s)
      Hanaoka, F
    • Organizer
      Clare Hall Laboratories, Cancer Research UK
    • Place of Presentation
      South Mimms, UK
    • Year and Date
      2008-07-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box2008

    • Author(s)
      Fukumoto, Y., Dohmae, N., Hanaoka, F.
    • Organizer
      The 6th 3R Symposium (3R Symposium 2008
    • Place of Presentation
      掛川
    • Related Report
      2009 Final Research Report
  • [Presentation] In vivo and in vitro studies on DNA polymerase eta2008

    • Author(s)
      Hanaoka, F
    • Organizer
      Gordon Research Conference on Mutagenesis
    • Place of Presentation
      Oxford, UK
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え複製の分子機構-DNAポリメラーゼ・イータを中心に-2007

    • Author(s)
      花岡文雄, ほか
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Recent studies on mammalian DNA polymerase eta, the product of XP variant responsible gene2007

    • Author(s)
      Hanaoka, F
    • Organizer
      Mayo Clinic
    • Place of Presentation
      Rochester, Minnesota, USA
    • Year and Date
      2007-05-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Defective translesion DNA synthesis and links to human disease.2007

    • Author(s)
      Hanaoka, F.
    • Organizer
      9th Annual Midwest DNA Repair Symposium, Keynote Lecture
    • Place of Presentation
      Columbus, Ohio
    • Year and Date
      2007-05-20
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA repair and ubiquitin.2007

    • Author(s)
      Hanaoka, F.
    • Place of Presentation
      Ohio State University Medical Center, Columbus, Ohio, USA(招待講演)
    • Year and Date
      2007-05-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え複製の分子機構-DNAポリメラーゼ・イータを中心に-2007

    • Author(s)
      花岡文雄、横井雅幸、大雲剛志、金尾梨絵、赤木純一、益谷央豪
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)、シンポジウム「DNA修復研究の最前線」
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え複製とがん2007

    • Author(s)
      花岡文雄、益谷央豪、塚本徹哉、立松正衛
    • Organizer
      第66回日本癌学会学術総会、シンポジウム「ゲノム不安定性」
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] TLS polymerase deficiencies and cancer2007

    • Author(s)
      Hanaoka, F
    • Organizer
      The 3rd Japan-US DNA Repair Meeting
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.gakushuin.ac.jp/univ/sci/bio/laboratory/detail_hanaoka/theme.html

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-03-31   Modified: 2016-04-21  

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