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Identification of a transcription factor complex which promotes nerve regeneration

Research Project

Project/Area Number 19209005
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionOsaka City University

Principal Investigator

KIYAMA Hiroshi  Osaka City University, 大学院・医学研究科, 教授 (00192021)

Co-Investigator(Kenkyū-buntansha) KONISHI Hiroyuki  大阪市立大学, 大学院・医学研究科, 助教 (90448746)
NAKAGOMI Saya  大阪市立大学, 大学院・医学研究科, 助教 (60423894)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2009: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2008: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2007: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Keywords解剖学 / 脳神経 / 再生医学 / 転写因子 / 神経再生 / DINE / ATF3 / STAT3 / 組織再生
Research Abstract

Nerve injury requires the expression of large ensembles of genes. The key molecular mechanism for this gene transcription regulation in injured neurons was poorly understood. We hypothesized an existence of transcription factor complex, which promoted expressions of multiple nerve injury associated molecules. In this study we have identified a promoter complex consisting of 4 transcription factors, ATF3, c-Jun, STAT3 and Sp1. This complex substantially promoted expression of nerve injury associated proteins such as DINE and SOD. This could be one of potent transcription factor complexes especially for nerve regeneration.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (29 results)

All 2010 2009 2008 2007 Other

All Journal Article (15 results) (of which Peer Reviewed: 6 results) Presentation (12 results) Remarks (2 results)

  • [Journal Article] Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuro-muscular junctions.2010

    • Author(s)
      Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T, Kiyama H
    • Journal Title

      J Neurosci 30(20)

      Pages: 6954-6962

    • Related Report
      2009 Final Research Report
  • [Journal Article] Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family.2010

    • Author(s)
      Jeong YH, Ishikawa K, Someya Y, Hosoda A, Yoshimi T, Yokoyama C, Kiryu-Seo S, Kang MJ, Tachibana T, Kiyama H, Fukumura T, Kim DH, Saeki S
    • Journal Title

      Biochem Biophys Res Commun 391(1)

      Pages: 1110-1115

    • Related Report
      2009 Final Research Report
  • [Journal Article] Simultaneous expression of glutathione, thioredoxin-1, and their reductases in nerve transected hypoglossal motor neurons of rat.2010

    • Author(s)
      Hama I, Nakagomi S, Konishi H, Kiyama H
    • Journal Title

      Brain Res 1306

      Pages: 1-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuro-muscular junctions.2010

    • Author(s)
      Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T, Kiyama H
    • Journal Title

      J Neurosci (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of pancreatitis-associated protein (PAP) family members in neurons following traumatic brain injury2009

    • Author(s)
      Ampo K, Suzuki A, Konishi H, Kiyama H
    • Journal Title

      J Neurotrauma 26(10)

      Pages: 1683-1693

    • Related Report
      2009 Final Research Report
  • [Journal Article] Induction of pancreatitis-associated protein (PAP) family members in neurons following traumatic brain injury2009

    • Author(s)
      Ampo K, Suzuki A, Konishi H, Kivama H
    • Journal Title

      J Neurotrauma 26(10)

      Pages: 1683-1693

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous expression of glutathione, thioredoxin-1, and their reductases in nerve transected hypoglossal motor neurons of rat2009

    • Author(s)
      Hama I, Nakagomi S, Konishi H, Kiyama H
    • Journal Title

      Brain Res 1306

      Pages: 1-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal injury-inducible gene is synergistically regulated by ATF3, cJun and STAT3 through the interaction with Sp1 in damaged neurons2008

    • Author(s)
      Kiryu-Seo S, Kato R, Ogawa T, Nakagomi S, Nagata K, Kiyama H
    • Journal Title

      J Biol Chem 283(11)

      Pages: 6988-6996

    • Related Report
      2009 Final Research Report 2008 Annual Research Report 2007 Annual Research Report
  • [Journal Article] G protein coupled receptor screen reveals a role for chemokine receptor CCR5 in suppressing microglial neurotoxicity2008

    • Author(s)
      Gamo K, Kiryu-Seo S, Konishi H, Aoki S, Matsushima K, Wada K, Kiyama H
    • Journal Title

      J Neurosci 28(46)

      Pages: 11980-11988

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Journal Article] Expression of pancreatitis-associated proteins in urothelium and urinary afferent neurons following cyclophosphamide-induced cystitis2008

    • Author(s)
      Takahara Y, Suzuki A, Maeda M, Kawashima H, Nakatani T, Kiyama H
    • Journal Title

      J Urol 179(4)

      Pages: 1603-1609

    • Related Report
      2009 Final Research Report
  • [Journal Article] Alteration of glial cell line-derived neurotrophic factor family receptor alpha-2 mRNA expression and its co-expression with neuronal nitric oxide synthase in pelvic ganglia following unilateral cavernous nerve injury2008

    • Author(s)
      Hisasue S, Kato R, Kobayashi K, Suetomi T, Kiyama H, Tsukamoto T
    • Journal Title

      Int J Urol 15(1)

      Pages: 82-86

    • NAID

      10020180181

    • Related Report
      2009 Final Research Report
  • [Journal Article] Expression of pancreatitis-associated proteins in urothelium and urinary afferent neurons following cyclophosphamide-induced cystitis2008

    • Author(s)
      Takahara Y, Suzuki A, Maeda M, Kawashima H, Nakatani T, Kiyama H
    • Journal Title

      J Urol 15(1)

      Pages: 1603-1609

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of peripherin as a Akt substrate in neurons2007

    • Author(s)
      Konishi H, Namikawa K, Shikata K, Kobatake Y, Tachibana T, Kiyama H
    • Journal Title

      J Biol Chem 282(32)

      Pages: 23491-23499

    • Related Report
      2009 Final Research Report
  • [Journal Article] Melanocortin receptor 4 is induced in nerve-injured motor and sensory neurons of mouse2007

    • Author(s)
      Tanabe K, Gamo K, Aoki S, Wada K, Kiyama H
    • Journal Title

      J Neurochem. 101(4):

      Pages: 1145-1152

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of peripherin as a novel Akt substrate in neurons2007

    • Author(s)
      Konishi H, Namikawa K, Shikata K, Kobatake Y, Tachibana T, Kiyama H
    • Journal Title

      J Biol Chem 282(32)

      Pages: 23491-23499

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝子導入による損傷神経の温存再生促進―その治療標的の多様性―2009

    • Author(s)
      木山博資
    • Organizer
      第50回日本神経学会、シンポジウム「中枢神経系の再生・次なる半世紀」
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2009-05-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 遺伝子導入による損傷神経の温存再生促進-その治療標的の多様性-2009

    • Author(s)
      木山博資
    • Organizer
      第50回日本神経学会 (招聘シンポジウム)
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経修復を誘導する分子メカニズム2009

    • Author(s)
      木山博資
    • Organizer
      大阪大学蛋白研セミナー「神経回路の形成と修復を司る分子機構」
    • Place of Presentation
      蛋白研、大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経修復を誘導する分子メカニズム2009

    • Author(s)
      木山博資
    • Organizer
      大阪大学蛋白研セミナー (招聘講演)
    • Place of Presentation
      大阪大学蛋白研、大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 末梢神経温存再生への戦略2008

    • Author(s)
      木山博資
    • Organizer
      第26回頭頸部自律神経研究会
    • Place of Presentation
      ホテルグランヴィア大阪、大阪
    • Year and Date
      2008-08-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経損傷後における遺伝子発現制御機構の解析中込咲綾2008

    • Author(s)
      濱五十鈴、木山博資
    • Organizer
      第23回神経組織の成長・再生・移植研究会
    • Place of Presentation
      ホテルスプリングス、千葉
    • Year and Date
      2008-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷神経再生時における抗酸化分子及びその還元酵素の遺伝子発現変動2008

    • Author(s)
      濱五十鈴、中込咲綾、木山博資
    • Organizer
      第23回神経組織の成長・再生・移植研究会
    • Place of Presentation
      ホテルスプリングス、千葉
    • Year and Date
      2008-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経損傷後における遺伝子発現制御機構の解析2008

    • Author(s)
      中込咲綾, 濱五十鈴, 木山博資
    • Organizer
      神経組織の成長・再生・移植研究会、第23回学術集会
    • Place of Presentation
      ホテルスプリングス幕張、幕張、千葉
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳外傷後におけるPAP/Regファミリー分子の発現解析2008

    • Author(s)
      安保 恵一、鈴木 了暢、小西 博之、木山 博資
    • Organizer
      日本解剖学会、第113回総会全国学術集会
    • Place of Presentation
      大分大学・医学部構内
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脳外傷後におけるPAP/Regファミリー分子の発現解析2008

    • Author(s)
      安保恵一、鈴木了暢、小西博之、木山博資
    • Organizer
      第113回日本解剖学会
    • Place of Presentation
      大分医科大学、大分
    • Related Report
      2009 Final Research Report
  • [Presentation] Damage-induced neuronal endopeptidase欠損動物の解析2007

    • Author(s)
      永田 健一、木山 博資
    • Organizer
      第9回ORIGIN神経科学研究会夏のワークショップ
    • Place of Presentation
      舘山寺サゴーロイヤルホテル
    • Year and Date
      2007-09-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Korean Physiological Society2007

    • Author(s)
      Kiyama H
    • Organizer
      59th annual meeting
    • Place of Presentation
      Grand hotel, Busan Korea
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-cu.ac.jp/anatomy1/

    • Related Report
      2009 Final Research Report
  • [Remarks] なし

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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