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Spatio-temporal analysis of small GTPases involved in vesicular trafficking by fluorescence imaging

Research Project

Project/Area Number 19209008
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionKyoto University

Principal Investigator

MATSUDA Michiyuki  京都大学, 生命科学研究科, 教授 (10199812)

Co-Investigator(Kenkyū-buntansha) TAKESHI Nakamura  東京理科大学, 教授 (60362604)
KIYOKAWA Etsuko  金沢医科大学, 医学部, 教授 (80300929)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2007: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
KeywordsFRET / G蛋白 / R-Ras / Rab5 / Rac / Ral / アポトーシス / 小胞輸送 / バイオセンサー / Rac1 / SH3BP1 / Exocyst
Research Abstract

Vesicular traffic regulates not only the process essential for cell survival but also intercellular and intracellular signaling. To elucidate the regulatory mechanism of vesicular traffic, we developed biosensors based on the principle of fluorescent resonance energy transfer, and succeeded for the first time to visualize the activity change of low-molecular weight GTPases on the vesicles. Furthermore, we identified molecules that regulate the activity of such low-molecular weight GTPases.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (62 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (33 results) (of which Peer Reviewed: 27 results) Presentation (26 results) Remarks (3 results)

  • [Journal Article] Stable expression of FRET biosensors : a new light in cancer research2011

    • Author(s)
      Aoki K, Komatsu N, Hirata E, Kamioka Y, Matsuda M
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 614-619

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells2011

    • Author(s)
      Goto A, Hoshino M, Matsuda M, Nakamura T
    • Journal Title

      Mol. Biol Cell

      Volume: 22 Pages: 1780-1790

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility2011

    • Author(s)
      Parrini MC, Sadou-Dubourgnoux A, Aoki K, Kunida K, Biondini M, Hatzoglou A, Poullet P, Formstecher E, Yeaman C, Matsuda M, Rosse C, Camonis J
    • Journal Title

      Mol. Cell

      Volume: 42 Pages: 650-661

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of an optimized backbone of FRET biosensors for kinases and GTPases2011

    • Author(s)
      N.Komatsu, K.Aoki, M.Yamada, H.Yukinaga, Y.Fujita, Y.Kamioka, M.Matsuda
    • Journal Title

      Mol.Biol.Cell

      Volume: 22(23) Pages: 4647-4656

    • NAID

      120003644367

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility2011

    • Author(s)
      M.C.Parrini, A.Sadou-Dubourgnoux, K.Aoki, K.Kunida, M.Biondini, A.Hatzoglou, P.Poullet, E.Formstecher, C.Yeaman, M.Matsuda, C.Rosse, J.Camonis
    • Journal Title

      Mol.Cell

      Volume: 42(5) Pages: 650-661

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of Foerster resonance energy transfer(FRET): Implications for signaling and pharmacology2010

    • Author(s)
      Kiyokawa E, Aoki K, Nakamura T, Matsuda M
    • Journal Title

      Annu. Rev. Pharmacol. Toxicol

      Volume: 51 Pages: 337-358

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors2009

    • Author(s)
      Aoki K, Matsuda M
    • Journal Title

      Nature Protocol

      Volume: 4 Pages: 1623-1631

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of RhoG activity is mediated by a syndecan 42009

    • Author(s)
      Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M
    • Journal Title

      J. Cell Biol

      Volume: 186 Pages: 75-83

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes2009

    • Author(s)
      Lu A, Tebar F, Alvarez-Moya B, Lopez-Alcala C, Calvo M, Enrich C, Agell N, Nakamura T, Matsuda M, Bachs O
    • Journal Title

      J. Cell Biol

      Volume: 184 Pages: 863-879

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging of signal transduction cascades with probes based on Forster Resonance Energy Transfer(FRET)2009

    • Author(s)
      Nakamura T, Matsuda M
    • Journal Title

      Curr. Protoc. Cell Biol

      Volume: 14 Pages: 14-10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ankyrin repeat domain 28(ANKRD28)2009

    • Author(s)
      Tachibana M, Kiyokawa E, Hara S, Iemura SI, Natsume T, Manabe T, Matsuda M
    • Journal Title

      Exp. Cell Res

      Volume: 315 Pages: 863-876

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes2009

    • Author(s)
      Lu, A., Tebar, F., Alvarez-Moya, B., Lopez-Alcala, C., Calvo, M., Enrich, C., Agell, N., Nakamura, T., Matsuda, M., Bachs, O.
    • Journal Title

      J. Cell Biol. 184

      Pages: 863-879

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation2009

    • Author(s)
      Tachibana, M., Kiyokawa, E., Hara, S., Iemura, S. I., Natsume, T., Manabe, T., Matsuda, M.
    • Journal Title

      Exp. Cell Res. 315

      Pages: 863-876

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK 180, promotes cell migration by regulating focal adhesion formation2009

    • Author(s)
      Tachibana, M., Kiyokawa, E., Hara, S., Iemura, S.I., Natsume, T., Manabe, T., Matsuda, M.
    • Journal Title

      Exp. Cell Res. 315

      Pages: 863-876

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissecting activation of the PAK1 kinase at protrusions in living cells2009

    • Author(s)
      Parrinim, M.C., Camonis, J.,
    • Journal Title

      J. Biol. Chem. 284

      Pages: 24133-24143

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging of signal transduction cascades with probes based on Forster Resonance Energy Transfer (FRET)2009

    • Author(s)
      Nakamura, T., Matsuda, M.
    • Journal Title

      Curr. Protoc. Cell Biol.

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A clathrin-dependent pathway leads to KRas signaling on late endosomes enroute to lysosomes2009

    • Author(s)
      Lu, A., Tebar, F., Alvarez-Moya, B., Lopez-Alcala, C., Calvo, M., Enrich, C., Agell, N., Nakamura, T., Matsuda, M., Bachs, O.
    • Journal Title

      J. Cell Biol. 184

      Pages: 863-879

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Forster resonance energy transfer2008

    • Author(s)
      Aoki K, Kiyokawa E, Nakamura T, Matsuda M
    • Journal Title

      Philos. Trans. R. Soc. Lond B Biol. Sci

      Volume: 363 Pages: 2143-2151

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport2008

    • Author(s)
      Hara S, Kiyokawa E, Iemura SI, Natsume T, Wassmer T, Cullen PJ, Hiai H, Matsuda M
    • Journal Title

      Mol. Biol. Cell

      Volume: 19 Pages: 3823-3835

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF2008

    • Author(s)
      Itoh RE, Kiyokawa E, Aoki K, Nishioka T, Akiyama T, Matsuda M
    • Journal Title

      J. Cell Sci

      Volume: 121 Pages: 2635-2642

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of Rab 5 activity identifies essential regulators for phagosome maturation2008

    • Author(s)
      Kitano M, Nakaya M, Nakamura T, Nagata S, Matsuda M
    • Journal Title

      Nature

      Volume: 453 Pages: 241-245

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] FRET imaging and in silico simulation : analysis of the signaling network of nerve growth factor-induced neuritogenesis2008

    • Author(s)
      Nakamura T, Aoki K, Matsuda M
    • Journal Title

      Brain Cell Biol

      Volume: 36 Pages: 19-30

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal regulation of Rac1 for engulfment of apoptotic cellsA1-Nakaya, M. Proc Natl. Acad2008

    • Author(s)
      Nakaya M, Kitano M, Matsuda M, Nagata S
    • Journal Title

      Sci. USA

      Volume: 105 Pages: 9198-9203

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells2008

    • Author(s)
      Nishioka T, Aoki K, Hikake K, Yoshizaki H, Kiyokawa E, Matsuda M
    • Journal Title

      Mol. Biol. Cell

      Volume: 19 Pages: 4213-4223

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport2008

    • Author(s)
      Hara, S., Kiyokawa, E., Iemura, S. I., Natsume, T., Wassmer, T., Cullen, P. J., Hiai, H., Matsuda, M.
    • Journal Title

      Mol. Biol. Cell 19

      Pages: 3823-3835

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Imaging of Rab5 activity identifies essential regulators for phagosome maturation2008

    • Author(s)
      Kitano, M., Nakaya, M., Nakamura, T., Nagata, S., Matsuda, M.
    • Journal Title

      Nature 453

      Pages: 241-245

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Spatiotemporal regulation of Racl for engulfinent ofapoptotic cells2008

    • Author(s)
      Nakaya, M., Kitano, M., Matsuda, M., Nagata, S.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A. 105

      Pages: 9198-9203

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Imaging of Rab5 activity identifies essential regulators for phagosome maturation.2008

    • Author(s)
      M. Kitano, M. Nakaya, T. Nakamura, S. Nagata, M. Matsuda.
    • Journal Title

      Nature 453

      Pages: 241-245

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal regulation of Racl for engulfment of apoptotic cells.2008

    • Author(s)
      M. Nakaya, M. Kitano, M. Matsuda, S. Nagata
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 105

      Pages: 9198-9203

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes2007

    • Author(s)
      Takaya A, Kamio A, Masuda M, Mochizuki N, Sawa H, Sato M, Nagashima K, Mizutani A, Matsuno A, Kiyokawa E, Matsuda M
    • Journal Title

      Mol. Biol. Cell

      Volume: 18 Pages: 1850-1860

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt-PDK1 complex mediates EGF-induced membrane protrusion through Ral activation2007

    • Author(s)
      Yoshizaki H, Mochizuki N, Gotoh Y, Matsuda M
    • Journal Title

      Mol. Biol. Cell

      Volume: 18 Pages: 119-128

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] R-Ras regulates exocytosis by Rg12/Rlf-mediated activation of RaIA on endosomes2007

    • Author(s)
      Takaya, A., Kamio, A., Masuda, M., Mochizuki, N., Sawa, H., Sato, M., Nagashima, K., Mizutani, A., Matsuno, A., Kiyokawa, E., Matsuda, M.
    • Journal Title

      Mol. Biol. Cell 18

      Pages: 1850-1860

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes.2007

    • Author(s)
      A. Takaya, A. Kamio, M. Masuda, N. Mochizuki, H. Sawa, M. Sato, K. Nagashima, A. Mizutani, A. Matsuno, E. Kiyokawa, and M. Matsuda
    • Journal Title

      Mol. Biol. Cell 18

      Pages: 1850-1860

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] PC12D細胞における、dbcAMP及びNGFによって誘導される神経突起生成のシグナル伝達経路のFRETを用いた解析Neuro2012

    • Author(s)
      後藤明弘、中村岳史、星野幹雄、松田道行
    • Organizer
      第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2012-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] FRETイメージングと統計的信号解析に基づく自発的な細胞遊走を制御する分子ネットワークの解析2010

    • Author(s)
      国田勝行、青木一洋、松田道行
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 管腔構造形成過程における信号伝達分子のFRETによる可視化2010

    • Author(s)
      八木俊輔, 松田道行, 清川悦子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of FRET probes for two-photon excitation microscopy2010

    • Author(s)
      熊谷悠香、清川悦子、松田道行
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Quantitative kinetic analysis revealed processive phosphorylation of ERK MAP kinase in mammalian cells2010

    • Author(s)
      Kazuhiro Aoki, and Michiyuki Matsuda
    • Organizer
      第33回日本分子生物学会年会・第82回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Monitoring of phosphatidic acid distribution in the living cells by FRET probes Monitoring of phosphatidic acid distribution in the living cells by FRET probes2010

    • Author(s)
      西岡照子、Michael A. Frohman、清川悦子、松田道行
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] FRETプローブを用いたホスファチジン酸のモニタリング2009

    • Author(s)
      西岡照子、清川悦子、松田道行
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Rasとカルシウムのシグナルは、Raf1においてShoc2を介して合流する2009

    • Author(s)
      吉木さや香、青木一洋、清川悦子、松田道行
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 二光子レーザー顕微鏡用のフォスファチジルイノシトールリン脂質に対するFRETバイオセンサーの開発2009

    • Author(s)
      熊谷悠香、清川悦子、松田道行
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 管腔構造形成過程における信号伝達分子のFRETによる可視化2009

    • Author(s)
      八木俊輔、清川悦子、松田道行
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] MDCK細胞の管腔形成におけるRhoファミリーG蛋白質のFRETイメージング2009

    • Author(s)
      八木俊輔、清川悦子、松田道行
    • Organizer
      第61回細胞生物学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] dbcAMP及びNGFによって誘導される神経突起生成のPC12D細胞におけるシグナル伝達と形態変化の違い2009

    • Author(s)
      後藤明弘, 中村岳史, 松田道行
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] dbcAMP及びNGFによって誘導される神経突起生成のPC12D細胞におけるシグナル伝達と形態変化の違い2009

    • Author(s)
      後藤明弘、中村岳史、松田道行
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] The DHR-1 domain of DOCK180 Binds to SNX5 and Regulates Cationindependent Mannose 6-phosphatate Receptor transport.2008

    • Author(s)
      S. Hara, E. Kiyokawa, S. Lemura, T. Natsume, T. Wassmer, P. Cullen, H. Hiai, M. Matsuda
    • Organizer
      The American Society for Cell Biology 48th Annual Meeting
    • Place of Presentation
      Moscone Center, San Francisco
    • Year and Date
      2008-12-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphatate receptor transport2008

    • Author(s)
      原 重雄, 清川悦子, 松田道行
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Spatiotemporal regulation of Rac1 and Rab5 during phagocytosis of apoptoticcells.2008

    • Author(s)
      M, Matsuda
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      University of New England
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 管腔形成過程におけるRhoファミリーG蛋白質のFRETイメージング2008

    • Author(s)
      八木俊輔、清川悦子、松田道行
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] FRET Imaging of Rho family GTP ase activity during cyst and tubule formation2008

    • Author(s)
      Syunsuke Yagi, Etsuko Kiyokawa, Michiyuki Matsuda
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of the FRET-Based Prove for Monitoring Rab5 Activity in Living Cells : The first iCeMS International Symposium-2008

    • Author(s)
      Masahiro Kitano, Michio Nakaya, Takeshi Nakamura, Shigekazu Nagata and Michiyuki Matsuda
    • Organizer
      The 11th International Membrane Research Forum
    • Place of Presentation
      Hotel Fujita Kyoto, Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] cAMP刺激によるPC12D細胞の神経突起伸展過程におけるシグナル分子のFRETを用いた解析2008

    • Author(s)
      後藤明弘, 中村岳史, 松田道行
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] R-Rasは、 Rgl2/Rlfを介してRalAをエンドソーム上で活性化し、エクソサイトーシスを制御する2007

    • Author(s)
      高谷昭行、神尾恭弘、増田道隆、望月直樹、澤洋文、佐藤まみ、長嶋和郎、水谷あきこ、松野あきら、清川悦子、松田道行
    • Organizer
      第40回日本発生生物学会、第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] アンキリンリピートドメイン28(ANKRD28)[新規DOCK180結合因子]は細胞遊走を制御する2007

    • Author(s)
      橘充弘、清川悦子、真鍋俊明、松田道行
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] DOCK180 regulates cation-independent mannose-6-phosphate receptor transport through SNX5 interaction2007

    • Author(s)
      原重雄、清川悦子、橘充弘、松田道行
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] R-Rasは、Rgl2/Rlfを介してRalAをエンドソーム上で活性化し、エクソサイトーシスを制御する2007

    • Author(s)
      高谷昭行、神尾恭弘、増田道隆、望月直樹、澤洋文、佐藤まみ、長嶋和郎、水谷あきこ、松野あきら、清川悦子、松田道行
    • Organizer
      第40回日本発生生物学会、第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of the FRET-Based Probe for Monitoring Rab5 Activity in Living Cells2007

    • Author(s)
      Masahiro Kitano, Takeshi Nakamura, Michiyuki Matsuda
    • Organizer
      The 10th Membrane Research Forum
    • Place of Presentation
      Hotel Fujita Kyoto, Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] NGF-PI3K-Rac1情報伝達経路の in vivo と in silico 解析 : SHIP2とPTENは神経突起形成を負に制御する2007

    • Author(s)
      青木一洋, 中村岳史, 松田道行
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Related Report
      2009 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.lif.kyoto-u.ac.jp/labs/fret/phogemon/index.htm

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.path1.med.kyoto-u.ac.jp/mm/publist.thm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://iisi.path1.med.kyoto-u.ac.jp/mm/index.htm

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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