Studies on digestive cancer metastasis using mouse models
| Project/Area Number |
19209010
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKETO Makoto Kyoto University, 医学研究科, 教授 (70281714)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Masahiro 京都大学, 医学研究科, 准教授 (60362464)
KITAMURA Takanori 京都大学, 医学研究科, 助教 (10378622)
SONOSHITA Masahiro 京都大学, 医学研究科, 助教 (80511857)
MIYOSHI Hiroyuki 京都大学, 医学研究科, 助教 (30362479)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000)
Fiscal Year 2008: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2007: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
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| Keywords | 分子腫瘍学 / 癌 / 転移 / 病理学 / 細胞・組織 / Notch / ケモカイン / マイクロアレイ / CXCR3 |
|---|
| Research Abstract |
Aes (amino-terminal enhancer of split)が大腸癌の血行性転移を抑制すること、その機序として、Aes がNotch シグナル抑制を介して癌細胞の血管内侵入を阻害することを、マウスモデルを用いて明らかにした.AES の発現消失はヒト大腸癌の肝転移とも相関していた.また、ケモカイン受容体CXCR3 の阻害薬はメラノーマのリンパ節転移を抑制し、CXCR3がリンパ節転移の治療標的となる可能性が示された.
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Report
(3 results)
Research Products
(86 results)
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[Journal Article] Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4 -deficient intestinal adenocarcinomas2009
Author(s)
Kitamura, T., Biyajima, K., Aoki, M., Oshima, M., Taketo, M. M.
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Journal Title
Lab Invest 89
Pages: 98-105
Related Report
Peer Reviewed
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[Journal Article] Activated macrophages promote Wnt signalling through tumour necrosis factor -alpha in gastric tumour cells2008
Author(s)
Oguma, K., Oshima, H., Aoki, M., Uchio, R., Naka, K., Nakamura, S., Hirao, A., Saya, H., Taketo, M.M., Oshima, M
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Journal Title
EMBO J 27
Pages: 1671-1681
NAID
Related Report
Peer Reviewed
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[Journal Article] Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes2007
Author(s)
Kawada, K., Hosogi, H., Sonoshita, M., Sakashita, H., Manabe, T., Shimahara, Y., Sakai, Y., Takabayashi, A., Oshima, M., Taketo, M.M
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Journal Title
Oncogene 26
Pages: 4679-4688
Related Report
Peer Reviewed
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