• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Moleculo-pathological Study on Vascular Remodeling in Japanese

Research Project

Project/Area Number 19209012
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKyushu University

Principal Investigator

SUEISHI Katsuo  Kyushu University, 大学院・医学研究院, 教授 (70108710)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Kazunori  九州大学, 大学院・医学研究院, 講師 (50217668)
KOGA Takaomi  九州大学, 大学病院, 講師 (70380615)
ONIMARU Mitsuho  九州大学, 大学院・医学研究院, 助教 (00380626)
OKANO Shinji  九州大学, 大学病院, 医員 (10380429)
飯田 三雄  九州大学, 大学院・医学研究院, 教授 (00127961)
Co-Investigator(Renkei-kenkyūsha) IIDA Mitsuo  九州大学, 大学院・医学研究院, 教授 (00127961)
KIYOHARA Yutaka  九州大学, 大学院・医学研究院, 教授 (80161602)
KUBO Mitsuaki  独立行政法人理化学研究所, 遺伝子多型タイピング研究所・支援チーム, グループディレクター (30442958)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000)
Fiscal Year 2008: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2007: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Keywords動脈硬化 / 血管新生 / 川崎病 / 可溶型Tie-2 / 色素上皮細胞由来因子(PEDF) / PKC アイソフォーム / podoplanin / 遺伝子治療 / PKCアイソフォーム / 久山町コホート研究 / Ang-1 / 可溶型Tie-2連関 / 糖尿病 / PKCη / heme oxvgenase-1(HO-1)
Research Abstract

久山町コホート研究の対象症例を含めた日本人剖検例を用いて、我国の動脈硬化症を中心にした血管病の病理学的特徴を検討し、虚血臓器の転帰を決定する要因として側副血管再生が重要であるが、動脈硬化は局所の病的新生血管形成により促進されることを明らかにした。また欧米の動脈硬化とは質的な相対的相違があることが示唆された。現在、動脈硬化による下肢虚血に対して新規の遺伝子治療を九州大学病院で実施、継続している。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (102 results)

All 2009 2008 2007 Other

All Journal Article (46 results) (of which Peer Reviewed: 46 results) Presentation (53 results) Book (3 results)

  • [Journal Article] Soluble Flt-1 gene transfer ameliorates neointima formation after wire injury in flt-1 tyrosine kinase deficient mice2009

    • Author(s)
      Koga J, Matoba T, Egashira K, Kubo M, Miyagawa M, Iwata E, Sueishi K, Shibuya M, Sunagawa K
    • Journal Title

      Arterioscler Thromb Vasc Biol 29(in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complete elimination of established neuroblastoma by synergistic action of γ-irradiation and DCs treated with rSeV expressing interferon-β gene2009

    • Author(s)
      Tatsuta K, Tanaka S, Tajiri T, Shibata S, Komaru A, Ueda Y, Inoue M, Hasegawa M, Suita S, Sueishi K, Taguchi T, Yonemitsu Y
    • Journal Title

      Gene Ther 16

      Pages: 240-251

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese. Autopsied with diabetes Mellitus: Hisayama Study2009

    • Author(s)
      Song J, Sumiyoshi S, Nakashima Y, Doi Y, Iida M, Kiyohara Y, Sueishi K
    • Journal Title

      Atherosclerosis 202

      Pages: 573-581

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soluble Flt-1 gene transfer ameliorates neointima formation after wire injury in flt-1 tyrosine kinase deficient mice2009

    • Author(s)
      Koga J
    • Journal Title

      Arterioscler Thromb Vasc Biol 29(in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology2009

    • Author(s)
      Nakano K
    • Journal Title

      J Am Coll Cardiol Intv 2

      Pages: 277-283

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete elimination of established neuroblastoma by synergisticaction of γ-irradiation and DCs treated with rSeV expressing interferon-β gene2009

    • Author(s)
      Tatsuta K
    • Journal Title

      Gene Ther 16

      Pages: 240-251

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese autopsies with diabetes mellitus : Hisayama study2009

    • Author(s)
      Song J
    • Journal Title

      Atherosclerosis 202

      Pages: 573-581

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration2008

    • Author(s)
      Murakami Y, Ikeda Y, Yonemitsu Y, Onimaru M, Nakagawa K, Kohno R, Miyazaki M, Hisatomi T, Nakamura M, Yabe T, Hasegawa M, Ishibashi T, Sueishi K
    • Journal Title

      Am J Pathol 173

      Pages: 1326-1338

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression2008

    • Author(s)
      Fujii T, Onimaru M, Yonemitsu Y, Kuwano H, Sueishi K
    • Journal Title

      Am J Physiol Heart Circ Physiol 294

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] role of diffuse intimal thickening and extracellular matrix proteoglycans2008

    • Author(s)
      Nakashima Y, Wight TN, Sueishi K: Early atherosclerosis humans
    • Journal Title

      Cardiovasc Res 79

      Pages: 14-23

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CHFR expression is preferentially impaired in smoking-related squamous cell carcinoma of the lung, and the diminished expression significantly harms outcomes2008

    • Author(s)
      Takeshita M, Koga T, Takayama K, Kouso H, Nishimura-Ikeda Y, Yoshino I, Maehara Y, Nakanishi Y, Sueishi K
    • Journal Title

      Int J Cancer 123

      Pages: 1623-1630

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] VEGF funetion for upregulation of endogeneous P1GF expression during FGF-2-mediated therapeutic angiogenesis2008

    • Author(s)
      Fujii T, Yonemitsu Y, Onimaru M, Inoue M, Hasegawa M, Kuwano H, Sueishi K
    • Journal Title

      Atherosclerosis 200(1)

      Pages: 51-57

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Newly developed Sendai virus vector for retinal gene transfer: reduction of innate immune response via deletion of all envelope-related genes2008

    • Author(s)
      Murakami Y, Ikeda Y, Yonemitsu Y, Tanaka S, Kondo H, Okano S, Kohno R, Miyazaki M, Inoue M, Hasegawa M, Ishibashi T, Sueishi K
    • Journal Title

      J Gene Med 10

      Pages: 165-176

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secular trends in the incidence of and risk factors for ischemic stroke and its subtypes in Japanese population2008

    • Author(s)
      Kubo M, Hata J, Doi Y, Tanizaki Y, Iida M, Kiyohara Y
    • Journal Title

      Circulation 118

      Pages: 2672-2678

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations2008

    • Author(s)
      Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jorgensen T, Sandbak A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose H, Hayashi M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S
    • Journal Title

      Nat Genet 40

      Pages: 1098-1102

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-sensitive C-reactive protein and coronary heart disease in a general polpulation of Japanese: the Hisayama study2008

    • Author(s)
      Arima H, Kubo M, Yonemoto K, Doi, Nimomiya T, Tanizaki Y,Hata J, Matsumura K, Iida M, Kiyohara Y
    • Journal Title

      Arterioscler Thromb Vasc Biol 28

      Pages: 1385-1391

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of metabolic syndrome on the development of cardiovascular disease in general Japanes population: the Hisayama study2008

    • Author(s)
      Ninomiya T, Kubo M, Doi Y, Yonemoto K, Tanizaki Y, Rahman M, Arima H, Tsuruya K, Iida M, Kiyohara Y
    • Journal Title

      Stroke 38

      Pages: 2063-2069

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of kidney disease and blood pressure on the development of cardiovascular disease: an overview from the Japan Arteriosclerosis Longitudinal Study2008

    • Author(s)
      Ninomiya T, Kiyohara Y, Tokuda Y, Doi Y, Arima H, Harada A, Ohashi Y, Ueshima H
    • Journal Title

      Circulation 118

      Pages: 2694-2701

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population2008

    • Author(s)
      Doi Y, Kubo M, Yonemoto K, Ninomiya T, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y
    • Journal Title

      J Clin Endocrinol Metab 93

      Pages: 3425-3429

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration2008

    • Author(s)
      Murakami Y
    • Journal Title

      Am J Pathol 173

      Pages: 1326-1338

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Statins restore ischemic limb blood flow in diabetic microangiopathyvia eNOS/NO upregulation but not via PDGF-BB expression2008

    • Author(s)
      Fujii T
    • Journal Title

      Am J Physiol Heart Circ Physiol 294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early atherosclerosis humans : role of diffuse intimal thickening and extracellular matrix proteoglycans2008

    • Author(s)
      Nakashima Y
    • Journal Title

      Cardiovasc Res 79

      Pages: 14-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CHFR expression is preferentially impaired in smoking-related squamous cell carcinoma of the lung, and the diminished expression significantly harms outcomes2008

    • Author(s)
      Takeshita M
    • Journal Title

      Int J Cancer 123

      Pages: 1623-1630

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actions of two main metabolites of propiverine (M-1 and M-2) on voltage-dependent L-type Ca^<2+> currents and Ca^<2+> transients in murine urinary bladder myocytes2008

    • Author(s)
      Zhu HL
    • Journal Title

      J Pharmacol Exp Ther 324

      Pages: 118-127

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and biophysical properties of voltage-gated Na^+ channels in murine vas deferens2008

    • Author(s)
      Zhu HL
    • Journal Title

      Biophys J 94

      Pages: 3340-3351

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VEGF funetion for upregulation of endogeneous PIGF expression during FGF-2-mediated therapeutic angiogenesis2008

    • Author(s)
      Fujii T
    • Journal Title

      Atherosclerosis 200

      Pages: 51-57

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newly developed Sendai virus vector for retinal gene transfer : reduction of innate immune response via deletion of all envelope-related genes2008

    • Author(s)
      Murakami Y
    • Journal Title

      J Gene Med 10

      Pages: 165-176

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early human atherosclerosis:Role of diffuse intimal thickening and extracellular matrix proteoglycans2008

    • Author(s)
      Nakashima Y
    • Journal Title

      Cardiovasc Res (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newly developed Sendai virus vector for retinal gene transfer:reduction of innate immune response via deletion of all envelope-related genes2008

    • Author(s)
      Murakami Y
    • Journal Title

      J Gene Med 10

      Pages: 165-176

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction2007

    • Author(s)
      Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M
    • Journal Title

      Hum Mol Genet 16

      Pages: 630-639

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo repopulation of cytoplasmically gene transferred hematopoietic cells by temperature-sensitive mutant of recombinant Sendai viral vector2007

    • Author(s)
      Yoshida K, Yonemitsu Y, Tanaka S, Yoshida S, Shibata S, Kondo H, Okano S, Ishikawa F, Akashi K, Inoue M, Hasegawa M, Sueishi K
    • Journal Title

      Biochem Biophys Res Commun 361

      Pages: 811-816

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An autopsy case report of annuloaortic ectasia with cardiac tamponade ruptured from an aneurysm of the right Valsalva sinus2007

    • Author(s)
      Fujii T, Sumiyoshi S, Koga T, Nishizaka M, Matsukawa R, Kuwano H, Sueishi K
    • Journal Title

      Pathol Res Pract 203

      Pages: 671-675

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prehypertension increases the risk for renal arteriosclerosis in autopsies : The Hisayama Study2007

    • Author(s)
      Ninomiya T, Kubo M, Doi Y, Yomemoto K, Tanizaki Y, Tsuruya K, Sueishi K, Tsuneyoshi M, Iida M, Kiyohara Y
    • Journal Title

      J Am Soc Nephrol 18

      Pages: 2135-2142

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of deletion of envelope-related genes of recombinant Sendai viruses on immune responses following pulmonary gene transfer of neonatal mice2007

    • Author(s)
      Tanaka S, Yonemitsu Y, Yoshida K, Okano S, Kondo H, Inoue M, Hasegawa M, Masumoto K, Suita S, Taguchi T, Sueishi K
    • Journal Title

      Gene Ther 14

      Pages: 1017-1028

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early human atherosclerosis : Accumulation of lipid and proteoglycans in intimal thickening followed by macrophage infiltration2007

    • Author(s)
      Nakashima Y, Fujii H, Sumiyoshi S, Wight TN, Sueishi K
    • Journal Title

      Arterioscler Thromb Vasc Biol 27(5)

      Pages: 1159-1165

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of immunostimulatory virotherapy using non-transmissible Sendai virus -activated dendritic cells2007

    • Author(s)
      Yoneyama Y, Ueda Y, Akutsu Y, Matunaga A, Shimada H, Kato T, Kubota-Akizawa M, Okano S, Shibata S, Sueishi K, Hasegawa M, Ochiai T, Yonemitsu Y
    • Journal Title

      Biochem Biophys Res Commun 355(1)

      Pages: 129-135

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A nonsynonymous SNP in PRKCH (proteinkinase C η) increases the risk of cerebral infarction2007

    • Author(s)
      Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y
    • Journal Title

      Nature Genetics 39(2)

      Pages: 212-217

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo repopulation of cytoplasmically gene transferred hematopoietic cells by temperature-sensitive mutant of recombinant Sendai viral vector2007

    • Author(s)
      Yoshida K
    • Journal Title

      Biochem Biophys Res Commun 361

      Pages: 811-816

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Animal models for steroid-induced osteonecrosis2007

    • Author(s)
      Yamamoto T
    • Journal Title

      Clin Calcium 17

      Pages: 879-886

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An autopsy case report of annuloaortic ectasia with cardiac tamponade ruptured from an aneurysm of the right Valsalva sinus2007

    • Author(s)
      Fujii T
    • Journal Title

      Pathol Res Pract 203

      Pages: 671-675

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prehypertension increases the risk for renal arteriosclerosis (in autopsies:The Hisayama Study2007

    • Author(s)
      Ninomiya T
    • Journal Title

      J Am Soc Nephrol 18

      Pages: 2135-2142

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of deletion of envelope-related genes of recombinant Sendai viruses on immune responses following pulmonary gene transfer of neonatal mice2007

    • Author(s)
      Tanaka S
    • Journal Title

      Gene Ther 14

      Pages: 1017-1028

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early human atherosclerosis:Accumulation of lipid and proteoglycans in intimal thickening followed by macrophage infiltration2007

    • Author(s)
      Nakashima Y
    • Journal Title

      Arterioscler Thromb Vasc Biol 27

      Pages: 1159-1165

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of immunostimulatory virotherapy using non-transmissible Sendai virus-activated dendritic cells2007

    • Author(s)
      Yoneyama Y
    • Journal Title

      Biochem Biophys Res Commun 355

      Pages: 129-135

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A nonsynonymous SNP in PRKCH(protein kinase Cη)increases the risk of cerebral infarction2007

    • Author(s)
      Kubo M
    • Journal Title

      Nature Genetics 39

      Pages: 212-217

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for coronary atherosclerosis in a general Japapnese population

    • Author(s)
      Nakashima Y, Kiyohara Y, Doi Y, Kubo M, Iida M, Sueishi K
    • Journal Title

      The Hisayama study. Pathol Res Pract (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] PKC-MMP-14 axis regulates endothelial soluble Tie-2(sTie-2)production : involvement of sTie-2 in diabetes mellitus-associated vascular complications2008

    • Author(s)
      Onimaru M, Murakami Y, Ikeda Y, Niizato H, Ishibashi T, Sueishi K
    • Organizer
      第16回日本血管生物医学会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-12-04
    • Related Report
      2008 Final Research Report
  • [Presentation] PKC-MMP-14 axis regulates endothelial soluble Tie-2 (STie-2) production : involvement of sTie-2 in diabetes mellitus-associated vascular complications2008

    • Author(s)
      Onimaru M
    • Organizer
      第16回日本血管生物医学会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腫瘍内活性化樹状細胞投与療法はT 細胞依存性腫瘍血管新生抑制効果を惹起する2008

    • Author(s)
      Okano S, Kondo H, Sueishi K
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 腫瘍内活性化樹状細胞投与療法はT細胞依存性腫瘍血管新生抑制効果を惹起する2008

    • Author(s)
      Okano S
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 可溶型Tie-2(sTie-2)の産生機構と病態学的意義-PKC/MMP-14連関の重要性と糖尿病関連病態への関与-2008

    • Author(s)
      鬼丸満穂
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 血管再生の分子機構 : 内因性血管新生関連因子の時・空間的協調性2008

    • Author(s)
      鬼丸満穂、米満吉和、居石克夫
    • Organizer
      第54 回日本病理学会秋期特別総会
    • Place of Presentation
      松山市
    • Year and Date
      2008-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 血管再生の分子機構 : 内因性血管新生関連因子の時・空間的協調性-2008

    • Author(s)
      鬼丸満穂
    • Organizer
      第54回日本病理学会秋期特別総会
    • Place of Presentation
      松山市
    • Year and Date
      2008-11-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺癌におけるCHFR発現の抗癌剤感受性マーカーとしての有用性2008

    • Author(s)
      竹下正文
    • Organizer
      第49回日本肺癌学会総会
    • Place of Presentation
      北九州市
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Assessment of antitumor immune response using allogeneic dendritic cells2008

    • Author(s)
      Kondo H, Okano S, Sueishi K
    • Organizer
      第67 回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] A pivotal role of CD4 T-cells(CD4) for long-lived memory CD8 T-cells(mCD8) in tumor immunotherapy2008

    • Author(s)
      Okano S, Kondo H, Sueishi K
    • Organizer
      第67 回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Assessment of antitumor immune response using allogeneic dendritic cells2008

    • Author(s)
      Kondo H
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] A pivotal role of CD4 T-cells(CD4) for long-lived memory CD8 T-cells(mCD8) in tumor immunotherapy2008

    • Author(s)
      Okano S
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 可溶型Tie-2(sTie-2)の産生機構と病態学的意義-PKC/MMP-14連関の重要性と糖尿病関連病態への関与-2008

    • Author(s)
      鬼丸満穂、村上祐介、池田康博、新里晴子、石橋達朗、居石克夫
    • Organizer
      第49回日本脈管学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 扁平上皮癌におけるPodoplaninの発現と癌リンパ管新生に関する病理学的検討2008

    • Author(s)
      鈴木華子、鬼丸満穂、中川和憲、中村誠司、居石克夫
    • Organizer
      第49回日本脈管学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 樹状細胞(CD)療法における腫瘍血管新生抑制効果とT細胞の役割に関する病理学的検討2008

    • Author(s)
      岡野慎士、近藤晴彦、有松千絵、居石克夫
    • Organizer
      第49回日本脈管学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 可溶型Tie-2(sTie-2)の産生機構と病態学的意義-PKC/MMP-14連関の重要性と糖尿病微小血管障害への関与-2008

    • Author(s)
      鬼丸満穂、村上祐介、池田康博、石橋達朗、居石克夫
    • Organizer
      第13回血管病理研究会
    • Place of Presentation
      東京都
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 蛋白漏出性胃腸症を伴ったAIDS関連カポジ肉腫の1剖検例2008

    • Author(s)
      近藤晴彦
    • Organizer
      第13回血管病理研究会
    • Place of Presentation
      東京都
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Metalloproteinase-mediated ectodomain shedding of Tie-2 modulates angiopoietin-1-dependent Tie-2 signaling in endothelial cells2008

    • Author(s)
      Onimaru M, Sueishi K
    • Organizer
      15th International Vascular Biology Meeting
    • Place of Presentation
      Australia
    • Year and Date
      2008-06-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Metalloproteinase-mediated ectodomain shedding of Tie-2 modulates angiopoietin-1-dependent Tie-2 signaling in endothelial cells2008

    • Author(s)
      Onimaru M
    • Organizer
      15th International Vascular Biology Meeting
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tie-2 の可溶型変換機構とそれに伴うTie-2 関連シグナル修飾に関する分子病理学的検討2008

    • Author(s)
      鬼丸満穂、居石克夫
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Tie-2の可溶型変換機構とそれに伴うTie-2関連シグナル修飾に関する分子病理学的検討2008

    • Author(s)
      鬼丸満穂
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腫瘍内活性化樹状細胞(DC)投与療法(ITADT)における腫瘍血管新生抑制効果とT細胞の役割に関する病理学的検討2008

    • Author(s)
      岡野慎士、近藤晴彦、居石克夫
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 扁平上皮癌におけるPodoplaninの発現と癌リンパ管新生に関する病理学的検討2008

    • Author(s)
      鈴木華子、鬼丸満穂、中川和憲、中村誠司、居石克夫
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 網膜変性モデル動物におけるpigment epithelium-derived factor (PEDF)の作用に関する病態学的検討2008

    • Author(s)
      村上祐介、鬼丸満穂、米満吉和、中川和憲、池田康博、中村誠、矢部武士、長谷川護、石橋達朗、居石克夫
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Fas欠損アロ樹状細胞を用いた抗腫瘍効果の病態学的検討2008

    • Author(s)
      近藤晴彦
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスCAWS 誘発冠動脈炎の発生におけるVEGF-A, TNFα病理学的意義に関する検討2008

    • Author(s)
      西尾壽乘、鬼丸満穂、藤井浩、三浦典子、大野尚仁、高橋啓、鈴木和男、原寿郎、居石克夫
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-15
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスCAWS誘発冠動脈炎の発生におけるVEGF-A, TNFα病理学的意義に関する検討2008

    • Author(s)
      西尾壽乗
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 非小細胞肺癌における細胞周期制御分子Aurora-A及びCHFR発現の臨床病理学的検討2008

    • Author(s)
      竹下正文
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation of mitochondrial release of apoptosis-inducing factor is a mechanism for neuroprotective activity of pigment epithelium-derived factor in retinal degeneration2008

    • Author(s)
      Murakamia Y, Ikeda Y, Yonemitsu Y, Onimaru M, Nakagawa K, Kohno R, Miyazaki M, Nakamura M, Yabe T, Inoue M, Hasegawa M, Ishibashi T, Sueishi K
    • Organizer
      ARVO 2008 Annual Meeting(78回)
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Year and Date
      2008-04-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of mitochondrial release of apoptosis-inducing factor is a mechanism for neuroprotective activity of pigment epithelium-derived factor in retinal degneration2008

    • Author(s)
      Murakamia Y
    • Organizer
      ARVO 2008 Annual Meeting
    • Place of Presentation
      Fort Lauderdale, U. S. A.
    • Year and Date
      2008-04-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Atherosclerosis and angiogenesis:double face of neovascularization in atherosclerotic intima vs collateral vessels in isschemic organs2008

    • Author(s)
      Sueishi K
    • Organizer
      Program of the JSPS Hematology Workshop "Thrombosis and Thalassemia in Asia"
    • Place of Presentation
      福岡市
    • Year and Date
      2008-02-23
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Tie-2 の可溶型変換機構とそれに伴うTie-2関連シグナル修飾に関する分子病理学的検討2007

    • Author(s)
      鬼丸満穂、居石克夫
    • Organizer
      第15回日本血管生物医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2007-11-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Tie-2の可溶型変換機構とそれに伴うTie-2関連シグナル修飾に関する分子病理学的検討2007

    • Author(s)
      鬼丸 満穂
    • Organizer
      第15回日本血管生物医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2007-11-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Fas欠損樹状細胞を用いた抗腫瘍効果の検討2007

    • Author(s)
      近藤 晴彦
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 樹状細胞を用いた腫瘍免疫療法における機能的に異なるメモリーCD8T細胞産生のためのCD4T細胞の重要な役割2007

    • Author(s)
      Okano S, Kondo H, Sueishi K
    • Organizer
      第37 回日本免疫学会総会・学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 樹状細胞を用いた腫瘍免疫療法における機能的に異なるメモリーCD8T細胞産生のためのCD4T細胞の重要な役割2007

    • Author(s)
      Okano S
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tie-2の可溶型変換機構とそれに伴うTie-2 関連シグナル修飾に関する分子病理学的検討2007

    • Author(s)
      鬼丸満穂、居石克夫
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      志摩市
    • Year and Date
      2007-11-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Tie-2の可溶型変換機構とそれに伴うTie-2関連シグナル修飾に関する分子病理学的検討2007

    • Author(s)
      鬼丸 満穂
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      志摩市
    • Year and Date
      2007-11-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tie-2 の可溶型変換機構とそれに伴うTie-2関連シグナル修飾に関する分子病理学的検討2007

    • Author(s)
      鬼丸満穂、居石克夫
    • Organizer
      第48回日本脈管学会総会
    • Place of Presentation
      松本市
    • Year and Date
      2007-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Tie-2の可溶型変換機構とそれに伴うTie-2関連シグナル修飾に関する分子病理学的検討2007

    • Author(s)
      鬼丸 満穂
    • Organizer
      第48回日本脈管学会総会
    • Place of Presentation
      松本市
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗VEGF-A抗体、抗TNFα抗体投与によるマウスCAWS 惹起冠動脈炎の発症抑制効果に関する病理検討2007

    • Author(s)
      西尾壽乘、鬼丸満穂、三浦典子、大野尚仁、高橋啓、鈴木和男、原寿郎、居石克夫
    • Organizer
      第48回日本脈管学会総会
    • Place of Presentation
      松本市
    • Year and Date
      2007-10-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗VEGF-A抗体、抗TNFα抗体投与によるマウスCAWS惹起冠動脈炎の発症抑制効果に関する病理検討2007

    • Author(s)
      西尾 壽乗
    • Organizer
      第48回日本脈管学会総会
    • Place of Presentation
      松本市
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト早期粥状硬化の発生 : 肥厚内膜におけるプロテオグリカンとリポ蛋白の局在の関連、ならびにマクロファージの浸潤の機序に関する免疫組織化学的検討2007

    • Author(s)
      中島豊、住吉真治、トーマス ワイト、居石克夫
    • Organizer
      第39回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-07-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 久山町健診剖検例における冠状動脈動脈硬化の病理組織学的研究 : 糖尿病および高血圧の病態学的意義2007

    • Author(s)
      住吉真治、中島豊、土井康文、清原裕、飯田三雄、居石克夫
    • Organizer
      第39回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-07-13
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト早期粥状硬化の発生:肥厚内膜におけるプロテオグリカンとリボ蛋白の局在の関連、ならびにマクロファージの浸潤の機序に関する免疫組織化学的検討2007

    • Author(s)
      中島 豊
    • Organizer
      第39回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 久山町健診剖検例における冠状動脈動脈硬化の病理組織学的研究:糖尿病および高血圧の病態学的意義2007

    • Author(s)
      住吉 真治
    • Organizer
      第39回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] VEGF function for upregulation of endogenous PLGF expression during FGF-2-mediated therapeutic angiogenesis2007

    • Author(s)
      Fujii T, Yonemitsu Y, Onimaru M, Sueishi K
    • Organizer
      XXIst Congress of the International Society on Thrombosis and Haemostasis第21回国際血栓止血学会
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2007-07-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of angiopoietin(ANG)-1/Tie-2 signaling pathway for ANG-2 expression in vascular endothelial cells angiogenesis2007

    • Author(s)
      Onimaru M, Yonemitsu Y, Fujii T, Sueishi K
    • Organizer
      XXIst Congress of the International Society on Thrombosis nd Haemostasis第21回国際血栓止血学会
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2007-07-08
    • Related Report
      2008 Final Research Report
  • [Presentation] VEGF function for upregulation of endogenous PLGF expression during FGF-2-mediated therapeutic angiogenesis2007

    • Author(s)
      Fujii T
    • Organizer
      第21回国際血栓止血学会
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2007-07-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of angiopoietin(ANG)-1/Tie-2 signaling pathway for ANG-2 expression in vascular endothelial cells2007

    • Author(s)
      Onimaru M
    • Organizer
      第21回国際血栓止血学会
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2007-07-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 動脈硬化と血管新生2007

    • Author(s)
      居石克夫
    • Organizer
      第8回Pharmaco-Hematology シンポジウム
    • Place of Presentation
      金沢市
    • Year and Date
      2007-06-07
    • Related Report
      2008 Final Research Report
  • [Presentation] 動脈硬化と血管新生2007

    • Author(s)
      居石 克夫
    • Organizer
      第8回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      金沢市
    • Year and Date
      2007-06-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Newly developed Sendai virus vector for retinal gene transfer : Reduction of innate immune response due to delection of all envelop-related genes2007

    • Author(s)
      Murakami Y, Ikeda Y, Yonemitsu Y, Tanaka S, Okano S, Kohno R, Miyazaki M, Inoue M, Hasegawa M, Ishibashi T, Sueishi K
    • Organizer
      ARVO 2007 Annual Meeting(77回)
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Year and Date
      2007-05-07
    • Related Report
      2008 Final Research Report
  • [Book] Atherosclerosis and angiogenesis : double face of neovascularization in atherosclerotic intima and collateral vessels in ischemic organs. In : Recent advances in thrombosis and hemostasis,(eds: Tanaka K, Davie EW)2008

    • Author(s)
      Sueishi K, Onimaru M, Nakashima Y
    • Publisher
      Springer-Japan KK, Tokyo
    • Related Report
      2008 Final Research Report
  • [Book] Recent advances in thrombosis and hemostasis2008

    • Author(s)
      Sueishi K
    • Publisher
      Springer-Japan KK
    • Related Report
      2008 Annual Research Report
  • [Book] Recent advances in thrombosis and hemostasis2008

    • Author(s)
      Sueishi K
    • Publisher
      Springer Japan(in press)
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi