| Project/Area Number |
19209019
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
KANG Dongchon Kyushu University, 大学院・医学研究院, 教授 (80214716)
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| Co-Investigator(Kenkyū-buntansha) |
KAYAMORI Yuzo 九州大学, 大学病院, 技師長 (90398066)
UCHIUMI Takeshi 九州大学, 大学院・医学研究院, 准教授 (80253798)
KANKI Tomotake 九州大学, 大学病院, 助教 (50398088)
FUKUOH Atsushi 九州大学, 大学病院, 助教 (80363365)
TAKAYANAGI Ryoichi 九州大学, 大学院・医学研究院, 教授 (30154917)
KONO Suminori 九州大学, 大学院・医学研究院, 教授 (70128015)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2008: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2007: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
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| Keywords | ミトコンドリアDNA / 遺伝子診断 / 活性酸素 / 糖尿病 / ミトコンドリア病 / 遺伝子多型 / 老化 |
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| Research Abstract |
The following three projects are integrated for further understanding of mitochondrial disease and for construction of its diagnostic system : (1) molecular mechanism of maintenance of mitochondrial DNA (mtDNA), (2) molecular diagnosis of mitochondrial disease, and (3) mtDNA analysis of somatic cells. Now we accept genetic tests of mitochondrial disease from all over Japan. During this period, we have shown that maintenance of mtDNA can delay natural aging process in TFAM-expressing transgenic mice. The mtDNA analysis of somatic cells is on going.
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