• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The study of functional polymorphism within the deoxyribonuclease I gene associated with disease.

Research Project

Project/Area Number 19209025
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionShimane University

Principal Investigator

TAKESHITA Haruo  Shimane University, 医学部, 教授 (90292599)

Co-Investigator(Kenkyū-buntansha) 安田 年博  福井大学, 医学部, 教授 (80175645)
高塚 尚和  島根大学, 医学部, 准教授 (40242490)
藤原 純子  島根大学, 医学部, 助教 (20346381)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2007: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
KeywordsDNase / 疾患感受性遺伝子 / DNase I / 心筋梗塞 / DNASE1*1 / DNASE1*2 / 遺伝的多型形質 / 多型 / DNASE1^*1 / DNASE1^*2 / DNASE1 / 癌 / 民族頻度分布 / Database / 遺伝的多型
Research Abstract

Using both the PCR-RFLP and multiplex single base extension techniques, genotyping of all the non-synonymous SNPs was performed in healthy subjects (n=1,559) of three ethnic groups including 15 populations. Among them, only four SNPs, R-21S, Y95S, G105R, and Q222R, together with the synonymous SNP L186L, were polymorphic in all or some populations. The Asian group showed a relatively low genetic diversity of these SNPs, whereas the African group had the highest diversity. The distribution pattern of the common SNP Q222R was classified into three ethnic groups. Activity levels of the amino acid-substituted DNase I forms derived from SNPs R-21S, G105R, P132A, and P197S were significantly high compared with that of the wild type; the polymorphic SNPs R-21S (Africans and Mexicans) and G105R (Africans) gave rise to a high activity-harboring DNase I isoform. On the other hand, activity levels from Q35H, R85G, V89M, C209Y, Q222R, and A224P were significantly low, but these SNPs, except Q222R, were not distributed in any of the populations examined. However, since these SNPs may produce potentially low levels of in vivo DNase I activity, a minor allele in each SNP will be served as a genetic risk factor for autoimmune diseases. Therefore, information on the worldwide distribution of non-synonymous SNPs in DNASE1 and the effects of the corresponding amino acid substitution on the activity levels will provide a genetic basis for the clarification of a possible relationship between DNase I and diseases.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (133 results)

All 2010 2009 2008 2007 Other

All Journal Article (66 results) (of which Peer Reviewed: 37 results) Presentation (66 results) Remarks (1 results)

  • [Journal Article] Exposure, metabolism, and health effects of arsenic in residents from arsenic-contaminated groundwater areas of Vietnam and Cambodia : a review.2010

    • Author(s)
      Agusa T, Kunito T, Kubota R, Inoue S, Fujihara J, Minh TB, Ha NN, Tu NP, Trang PT, Chamnan C, Takeshita H, Iwata H, Tuyen BC, Viet PH, Tana TS, Tanabe S.
    • Journal Title

      Rev Environ Health. 25

      Pages: 193-220

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genetic and expression analysis of all non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease I-like 1 and 2 genes.2010

    • Author(s)
      Ueki M, Fujihara J, Takeshita H, Kimura-Kataoka K, Iida R, Nakajima T, Kominato Y, Yuasa I, Yasuda T.
    • Journal Title

      Electrophoresis. 31

      Pages: 2063-2069

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genetic polymorphisms in glutathione S-transferase (GST) superfamily and arsenic metabolism in residents of the Red River Delta, Vietnam.2010

    • Author(s)
      Agusa T, Iwata H, Fujihara J, Kunito T, Takeshita H, Minh TB, Trang PT, Viet PH, Tanabe S.
    • Journal Title

      Toxicol Appl Pharmacol. 242

      Pages: 352-362

    • Related Report
      2010 Final Research Report
  • [Journal Article] Global analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes.2010

    • Author(s)
      Fujihara J, Yasuda T, Iida R, Kimura-Kataoka K, Soejima M, Koda Y, Kato H, Panduro A, Yuasa I, Takeshita H.
    • Journal Title

      Electrophoresis. 31

      Pages: 3552-3557

    • Related Report
      2010 Final Research Report
  • [Journal Article] A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity.2010

    • Author(s)
      Yasuda T, Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Tsubota E, Soejima M, Koda Y, Kato H, Panduro A.
    • Journal Title

      Int J Biochem Cell Biol. 42

      Pages: 1216-1225

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genetic and expression analysis of all 7 non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease II gene, with potential relevance to autoimmunity.2010

    • Author(s)
      Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Yuasa Y, Nakajima T, Kominato Y, Yasuda T.
    • Journal Title

      Clin Chim Acta. 411

      Pages: 92-98

    • Related Report
      2010 Final Research Report
  • [Journal Article] Global analysis of genetic variation in human arsenic (+ 3 oxidation state) methyltransferase (AS3MT).2010

    • Author(s)
      Fujihara J, Soejima M, Yasuda T, Koda Y, Agusa T, Kunito T, Tongu M, Yamada T, Takeshita H.
    • Journal Title

      Toxicol Appl Pharmacol. 243

      Pages: 292-299

    • Related Report
      2010 Final Research Report
  • [Journal Article] Global analysis of genetic variation in human arsenic (+3 oxidation state) methyltransferase (AS3MT).2010

    • Author(s)
      Fujihara J, Soejima M, Yasuda T, Koda Y, Agusa T, Kunito T, Tongu M, Yamada T, Takeshita H.
    • Journal Title

      Toxicol Appl Pharmacol.

      Volume: 243 Pages: 292-299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and expression analysis of all 7 non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease II gene, with potential relevance to autoimmunity.2010

    • Author(s)
      Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Yuasa Y, Nakajima T, Kominato Y, Yasuda T.
    • Journal Title

      Clin Chim Acta

      Volume: 411 Pages: 92-98

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity.2010

    • Author(s)
      Yasuda T, Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Tsubota E, Soejima M, Koda Y, Kato H, Panduro A.
    • Journal Title

      Int J Biochem Cell Biol.

      Volume: 42 Pages: 1216-1225

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes.2010

    • Author(s)
      Fujihara J, Yasuda T, Iida R, Kimura-Kataoka K, Soejima M, Koda Y, Kato H, Panduro A, Yuasa I, Takeshita H.
    • Journal Title

      Electrophoresis

      Volume: 31 Pages: 3552-3557

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms in glutathione S-transferase (GST) superfamily and arsenic metabolism in residents of the Red River Delta, Vietnam.2010

    • Author(s)
      Agusa T, Iwata H, Fujihara J, Kunito T, Takeshita H, Minh TB, Trang PT, Viet PH, Tanabe S.
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 242 Pages: 352-362

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and expression analysis of all non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease I-like 1 and 2 genes.2010

    • Author(s)
      Ueki M, Fujihara J, Takeshita H, Kimura-Kataoka K, Iida R, Nakajima T, Kominato Y, Yuasa I, Yasuda T.
    • Journal Title

      Electrophoresis

      Volume: 31 Pages: 2063-2069

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exposure, metabolism, and health effects of arsenic in residents from arsenic-contaminated groundwater areas of Vietnam and Cambodia : a review.2010

    • Author(s)
      Agusa T, Kunito T, Kubota R, Inoue S, Fujihara J, Minh TB, Ha NN, Tu NP, Trang PT, Chamnan C, Takeshita H, Iwata H, Tuyen BC, Viet PH, Tana TS, Tanabe S.
    • Journal Title

      Rev Environ Health

      Volume: 25 Pages: 193-220

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNase Il3遺伝子の非同義置換型SNPにおけるコーカソイド特異的アレルは不活性な酵素を産生する2010

    • Author(s)
      藤原純子, 中島たみ子, 小湊慶彦, 湯浅勲, 加藤秀章, 飯田礼子, 植木美鈴, 安田年博, 竹下治男
    • Journal Title

      DNA多型

      Volume: 17 Pages: 259-263

    • NAID

      10029668413

    • Related Report
      2010 Annual Research Report
  • [Journal Article] mtDNA配列による迅速簡便なヤマトシジミの同定および産地判別の検討2010

    • Author(s)
      藤原純子, 竹下治男, 阿草哲郎, 藤田恭久, 中村幹雄, 鴛海智佳, 細澤豪志, 植木美鈴, 飯田礼子
    • Journal Title

      DNA多型

      Volume: 17 Pages: 109-112

    • NAID

      10029668113

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Ethnic variation in genotype frequencies of δ -aminolevulinic acid dehydratase (ALAD).2009

    • Author(s)
      Fujihara J, Agusa T, Yasuda T, Soejima M, Kato H, Panduro A, Koda Y, Kimura K, Takeshita H.
    • Journal Title

      Toxicol Lett. 191

      Pages: 236-239

    • Related Report
      2010 Final Research Report
  • [Journal Article] Allele frequencies and haplotypes for five Y-STRs (DYS441, DYS442, DYS443, DYS444, and DYS445) in Ovambo and Turks populations using mutiplex PCR system.2009

    • Author(s)
      Fujihara J, Tsubota E, Iida R, Takeshita H.
    • Journal Title

      Forensic Sci Int Genetics. 3

      Pages: 268-269

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme.2009

    • Author(s)
      Ueki M, Takeshita H, Fujihara J, Iida R, Yuasa I, Kato H, Panduro A, Nakajima T, Kominato Y, Yasuda T.
    • Journal Title

      Clin Chim Acta. 407

      Pages: 20-24

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Serum deoxyribonuclease I can be used as a useful marker for diagnosis of death due to ischemic heart disease.2009

    • Author(s)
      Yasuda T, Iida R, Kawai Y, Nakajima T, Kominato Y, Fujihara J, Takeshita H.
    • Journal Title

      Legal Med. 11

    • NAID

      10027262728

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Cytochrome P450 1A1, glutathione S-transferases M1 and T1 polymorphisms in Ovambos and Mongolians.2009

    • Author(s)
      Fujihara J, Yasuda T, Iida R, Takatsuka H, Fujii Y, Takeshita H.
    • Journal Title

      Legal Med. 22

    • NAID

      10027263340

    • Related Report
      2010 Final Research Report
  • [Journal Article] Development of a sensitive enzyme-linked immunosorbent assay for measurement of DNase I in human serum.2009

    • Author(s)
      Nakajima T, Takagi R, Tajima Y, Makita C, Kominato Y, Kuribara J, Ohshima S, Tada H, Tsurugaya H, Kobayashi Y, Takeshita H, Kawai Y, Yasuda T.
    • Journal Title

      Clin Chim Acta. 403

      Pages: 219-222

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Genotyping of five single nucleotide polymorphisms in the OCA2 and HERC2 genes associated with blue-brown eye color in the Japanese population.2009

    • Author(s)
      Iida R, Ueki M, Takeshita H, Fujihara J, Nakajima T, Kominato Y, Nagao M, Yasuda T.
    • Journal Title

      Cell Biochem Funct. 27

      Pages: 323-327

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Allele frequencies and haplotypes for 28 Y-STRs in Ovambo population.2009

    • Author(s)
      Fujihara J, Yuasa I, Muro T, Iida R, Tsubota E, Nakamura H, Imamura S, Yasuda T, Takeshita H.
    • Journal Title

      Legal Med. 11

      Pages: 205-208

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Genetic polymorphisms in AS3MT and arsenic metabolism in residents of the Red River Delta, Vietnam.2009

    • Author(s)
      Agusa T, Iwata H, Fujihara J, Kunito T, Takeshita H, Minh TB, Trang PTK, Viet PH, Tanabe S.
    • Journal Title

      Toxicol Appl Pharmacol. 236

      Pages: 131-141

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] The diversity of the glutathione S-transferase omega 1 (A140D) and 2 (N142D) gene polymorphisms in worldwide populations.2009

    • Author(s)
      Takeshita H , Fujihara J, Takatsuka H, Agusa T, Yasuda T, Kunito T.
    • Journal Title

      Clin Exp Pharmacol Physiol. 36

      Pages: 283-286

    • Related Report
      2010 Final Research Report
  • [Journal Article] HPLC determination of chlorhexidine (CHX) in whole blood by solid phase extraction and kinetics following an intravenous infusion in rats.2009

    • Author(s)
      Xue Y, Tang M, Hieda Y, Fujihara J, Takayama K, Takatsuka H, Takeshita H.
    • Journal Title

      J Anal Toxicol. 33

      Pages: 85-91

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Simultaneous genotyping of eleven non-synonymous SNPs in the four glutathione peroxidase genes using the multiplex single base extension method.2009

    • Author(s)
      Iida R, Tsubota E, Yuasa I, Takeshita H, Yasuda T.
    • Journal Title

      Clinica Chimica Acta. 402

      Pages: 79-82

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a possible marker of arsenic poisoning : a clinical case study on the relationship between concentrations of 8-OHdG and each arsenic compound in urine of an acute promyelocytic leukemia patient being treated with arsenic trioxide.2009

    • Author(s)
      Fujihara J, Agusa T, Tanaka J, Fujii Y, Moritani T, Hasegawa M, Iwata H, Tanabe S, Takeshita H.
    • Journal Title

      Forensic Toxicol. 27

      Pages: 41-44

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Gln222Arg (A2317G) polymorphism in the deoxyribonuclease I gene exhibits ethnic and functional differences.2009

    • Author(s)
      Takeshita H , Soejima M, Koda Y, Yasuda T, Takatsuka H, Fujihara J.
    • Journal Title

      Clin Chem Lab Med. 47

      Pages: 51-55

    • Related Report
      2010 Final Research Report
  • [Journal Article] Multiplex single base extension method for simultaneous genotyping of non-synonymous SNPs in the three human SOD genes.2009

    • Author(s)
      Iida R, Tsubota E, Takeshita H, Yasuda T.
    • Journal Title

      Electrophoresis. 29

      Pages: 4788-4794

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Ethnic differences in five intronic polymorphisms associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene.2009

    • Author(s)
      Fujihara J, Fujii Y, Agusa T, Kunito T, Yasuda T, Moritani T, Takeshita H.
    • Journal Title

      Toxicol Appl Pharmacol. 234

      Pages: 41-46

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Gln222Arg (A2317G) polymorphism in the deoxyribonuclease I gene exhibits ethnic and functional differences2009

    • Author(s)
      Takeshita H, Soejima M, Koda Y, Yasuda T, Takatsuka H, Fujihara J.
    • Journal Title

      Clin Chem Lab Med. 47

      Pages: 51-55

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Development of a sensitive enzyme-linked immunosorbent assay for measurement of DNase I in human serum2009

    • Author(s)
      Nakajima T, Takagi R, Tajima Y, Makita C, Kominato Y, Kuribara J, Ohshima S, Tada H, Tsurugaya H, Kobayashi Y, Takeshita H, Kawai Y, Yasuda T.
    • Journal Title

      Clin Chim Acta. 403

      Pages: 219-222

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Serum deoxyribonuclease I can be used as a useful marker for diagnosis of death due to ischemic heart disease2009

    • Author(s)
      Yasuda T, Iida R, Kawai Y, Nakajima T, Kominato Y, Fujihara J, Takeshita H.
    • Journal Title

      Legal Med. 11

    • NAID

      10027262728

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Two N-linked Glycosylation Sites (Asn18 and Asn106) are Both Required for full enzymatic activity, thermal stability and resistance to proteolysis in the mammalian Deoxyribonuclease I2009

    • Author(s)
      Fujihara J, Yasuda T, Kunito T, Fujii Y, Takatsuka H, Moritani T, Takeshita H
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry 72

      Pages: 3197-3205

    • NAID

      10027535084

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Gln222Arg (A2317G) polymorphism in the deoxyribonuclease I gene exhibits ethnic and functional differences.2009

    • Author(s)
      Takeshita H, Soejima M, Koda Y, Yasuda T, Takatsuka H, Fujihara J.
    • Journal Title

      Clin Chem Lab Med. 47

      Pages: 51-55

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The diversity of the glutathione S-transferase omega 1 (A140D) and 2 (N142D) gene polymorphisms in worldwide populations.2009

    • Author(s)
      Takeshita H, Fujihara J, Takatsuka H, Agusa T, Yasuda T, Kunito T.
    • Journal Title

      Clin Exp Pharmacol Physiol. 36

      Pages: 283-286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 1A1, glutathione S-transferases M1 and T1 polymorphisms in Ovambos and Mongolians.2009

    • Author(s)
      Fujihara J, Yasuda T, Iida R, Takatsuka H, Fujii Y, Takeshita H.
    • Journal Title

      Legal Med. 11

    • NAID

      10027263340

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒ素代謝に関与するAS3MT M287T多型はアジア人特異的低変異性を示す2009

    • Author(s)
      藤原純子, 阿草哲郎, 副島美貴子, 中島たみ子, 岩田久人, 田辺信介, 竹下治男.
    • Journal Title

      DNA多型 17

      Pages: 169-172

    • NAID

      10025754390

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 核酸分解酵素DNase I 遺伝子の転写調節機構の解明2009

    • Author(s)
      高木利恵, 中島たみ子, 小湊慶彦, 加藤恵理子, 高士祐一, 新田みなみ, 山根庸弘, 藤原純子, 竹下治男, 植木美鈴, 安田年博.
    • Journal Title

      DNA多型 17

      Pages: 177-179

    • NAID

      10025754406

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リアルタイムPCRを用いたABO遺伝子型検査法の開発2009

    • Author(s)
      室友紀, 今村真二, 中村博明, 藤原純子, 高塚尚和, 竹下治男.
    • Journal Title

      DNA多型 17

      Pages: 210-212

    • NAID

      10025754467

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトRNase superfamily遺伝子における非同義置換型SNP解析2009

    • Author(s)
      藤原純子, 竹下治男, 中島たみ子, 小湊慶彦, 飯田礼子, 湯浅勲, 植木美鈴, 安田年博.
    • Journal Title

      DNA多型 17

      Pages: 260-264

    • NAID

      10025754566

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allele frequencies for 15 STR loci in Ovambo population using AmpFlSTR^R Identifiler Kit.2008

    • Author(s)
      Muro T, Fujihara J, Nakamura H, Imamura s, Yasuda T, Takeshita H.
    • Journal Title

      Legal Med. 10

      Pages: 157-159

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secl-FUT2-Seel hybrid allele generated by interlocus gene conversion.2008

    • Author(s)
      Soejima M, Fujihara J, Takeshita H, Koda Y.
    • Journal Title

      Transfusion. 48

      Pages: 488-492

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of genotyping methods for single nucleotide polymorphism in the human pancreatic ribonuclease gene(RNASE1) and their application to population studies.2008

    • Author(s)
      Ueki M, Iida R, Fujihara J, Takeshita H, Yuasa I, Kominato Y, Yasuda T.
    • Journal Title

      Biochem genet. 48

      Pages: 145-153

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extremely high prevalence of DNASE1^*1 allele in African populations.2008

    • Author(s)
      Takeshita H, Fujihara J, Soejima M, Koda Y, Yasuda T, Nakajima T.
    • Journal Title

      Cell Biochem Funct. 26

      Pages: 151-153

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variation of FUT2 in Ovambos, Turks, and Mongolians.2008

    • Author(s)
      Soejima M, Nakajima T, Fujihara J, Takeshita H, Koda Y.
    • Journal Title

      Transfusion. 48

      Pages: 1423-1431

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of sudden death after gingival injection of a therapeutic dose of lidocaine : distribution of lidocaine in whole blood and various tissues.2008

    • Author(s)
      Hasegawa M, Fujihara J, Takatsuka H, Chung HC, Takeshita H.
    • Journal Title

      Forensic Toxicol. 26

      Pages: 41-44

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asian specific low mutation frequencies of the M287T polymorphism in the human arsenic (+3 oxidation state)methvltransferase (AS3MT) gene.2008

    • Author(s)
      Fujihara J, Soeiima M, Koda Y, Kunito T, Takeshita H.
    • Journal Title

      Mutat Res. 654

      Pages: 158-161

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three single polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly lessgenetic heterogeneity in six populations.2008

    • Author(s)
      Ueki M, Takeshita H, Fujihara J, Takatsuka H, Yuasa I, Iida R, Yasuda T.
    • Journal Title

      Cell Biochem Funct. 26

      Pages: 718-722

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 2J2^*7 polymorphisms in Japanese, Mongolians and Ovambos.2008

    • Author(s)
      Takeshita H, Tsubota E, . Takatsuka H, Kunito T, Fujihara J.
    • Journal Title

      Cell Biochem Funct. 26

      Pages: 813-816

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two N-linked glycosylation sites (Asn18 and Asnl06) are both required tor full enzymatic activity, thermal stability and resistance to proteolysis in the mammalian deoxvribonuclease I.2008

    • Author(s)
      Takeshita H, Tsubota E, Takatsuka H, Kunito T, Fujihara J.
    • Journal Title

      Biosci Biotech Biochem. 72

      Pages: 3197-3205

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between genetic polymorphism of arsenic(+3oxidation state) methyltransferasa (AS3MT) and profiles of urinary arsenic commpounds in Vietnamese. 2008 ; 19 : 265-2672008

    • Author(s)
      Agusa T, Fujihara J Takeshita H, Iwata H, Minh TB, TRANG PTK, Viet PH, Tanabe S.
    • Journal Title

      Biomed Res Trace Elem. 19

      Pages: 265-267

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms influencing arsenic metabolism in human : evidence from Vietnam. In : Murakami Y, Nakayama K, Kitamura s, Iwata H, Tanabe S(Eds. ), Tokyo2008

    • Author(s)
      Agusa T, Fujihara J, Minh TB, Trang PTK, Takeshita H, Iwata H, Viet PH, Tanabe S.
    • Journal Title

      Biological Response to Chemical Pollutants (Interdisciplinary Studies on Environmental Chemistry, Vol. 1). 2008 ; TERRAPUB 1

      Pages: 179-185

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved purification and characterization of equine DNaseI.2008

    • Author(s)
      Fuiihara J, Moritani T, Tongu M, Yamada T, Takeshita H, Tabuchi M.
    • Journal Title

      Shimane J Med Sci. 25

      Pages: 1-5

    • NAID

      120005585234

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トリカブトを用いて自殺した一剖検例2008

    • Author(s)
      高塚尚和, 松村繁樹, 飯田礼子, 坪田悦子, 竹下治男, 松木孝澄
    • Journal Title

      法医学の実際と研究 51

      Pages: 51-55

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variation of Interleukin 8-251 A>T polymorphism in world-wide populations and intra-ethnic differences in Japanese populations.2007

    • Author(s)
      Fujihara J, et. al.
    • Journal Title

      Clinica Chimica Acta 377

      Pages: 79-82

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CYP1A2 polymorphism(C>A at position-163)in Ovambos, Koreans and Mongolians.2007

    • Author(s)
      Fujihara J, et. al.
    • Journal Title

      Cell Biochem Funct 25

      Pages: 491-494

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two deoxyribonuclease I gene polymorphisms and correlation between genotype and its activity in Japanese population.2007

    • Author(s)
      Fujihara J, et. al.
    • Journal Title

      Legal Med 9

      Pages: 233-236

    • NAID

      10024172712

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allele frequencies for nine STR loci in Ovambo population using AmpF/STR [○!R] Profiler Kit.2007

    • Author(s)
      Fujihara J, et. al.
    • Journal Title

      Forensic Sci Int 169

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility of mammalian deoxyribonucleases I(DNases I)to proteolysis by proteases and its relationships to tissue distribution: biochemical and molecular analysis of equine DNase I.2007

    • Author(s)
      Ueki M, et. al.
    • Journal Title

      Comp Biochem Physiol B Biochem Mol Biol 148

      Pages: 93-102

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum deoxyribonuclease I activity can be used as a novel maker of transient myocardial ischemia: results on vasospastic angina pectoris induced by the provocation test.2007

    • Author(s)
      Morikawa N, et. al.
    • Journal Title

      Eur HeartJ 28

      Pages: 2992-2997

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Population differences in the human arsenic(+3 oxidation state)methyltransferase(AS3MT)gene polymorphism detected by using genotyping method.2007

    • Author(s)
      Fujihara J, et. al.
    • Journal Title

      Toxicol Appl Pharmacol 225

      Pages: 251-254

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of Two Deoxyribonuclease I Gene Polymorphisms.2007

    • Author(s)
      Takeshita H, et. al.
    • Journal Title

      Shimane J Med Sci 24

      Pages: 15-20

    • NAID

      110008755224

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extremely high prevalence of DNASE1^*1 allele in African populations.2007

    • Author(s)
      Takeshita H, et. al.
    • Journal Title

      Cell Biochem Funct 26

      Pages: 151-153

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 法医学的個人識別を応用したしじみ等食品技術開発2010

    • Author(s)
      藤原純子, 藤田恭久, 竹下治男
    • Organizer
      起源分析技術研究懇談会第4回講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNase Iの動物種別臓器分布からの分子進化的考察2010

    • Author(s)
      大野怜一朗, 藤原純子, 植木美鈴, 安田年博, 木村かおり, 大塚洋輔, 頓宮美樹, 山田高也, 飯田礼子, 竹下治男
    • Organizer
      第27回日本法医学会中四国地方会
    • Place of Presentation
      徳島
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] メタロチオネインMT2A(-209A/G)多型の頻度分布とアルカリフォスファターゼ(ALP)活性との相関解析2010

    • Author(s)
      大塚洋輔, 藤原純子, 大野怜一朗, 木村かおり, 頓宮美樹, 山田高也, 福井裕, 藤田恭久, 竹下治男
    • Organizer
      第27回日本法医学会中四国地方会
    • Place of Presentation
      徳島
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 法医学的個人識別を応用したしじみ等食品判別技術開発2010

    • Author(s)
      藤原純子, 竹下治男, 藤田恭久
    • Organizer
      日本分析化学会表示・第4回起源分析技術研究懇談会 抄録集
    • Place of Presentation
      東京(p.77)
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトSOD1、SOD2およびSOD2遺伝子内の非同義置換型SNPの同時解析-血清SOD活性と多型性SNPとの相関について2010

    • Author(s)
      安田年博, 植木美鈴, 飯田礼子, 竹下治男
    • Organizer
      日本DNA多型学会 抄録集
    • Place of Presentation
      三島(p.91)
    • Related Report
      2010 Final Research Report
  • [Presentation] DNase II遺伝子に座位する非同義置換型SNPには不活性な酵素を産生するmonor alleleが分布する2010

    • Author(s)
      藤原純子, 木村かおり, 竹下治男, 中島たみ子, 小湊慶彦, 湯浅勲, 飯田礼子, 植木美鈴, 安田年博
    • Organizer
      日本DNA多型学会 抄録集
    • Place of Presentation
      三島(p.77)
    • Related Report
      2010 Final Research Report
  • [Presentation] 動物種特異的臓器分布から明らかにされたDNase Iの分子進化2010

    • Author(s)
      藤原純子, 竹下治男, 安田年博, 植木美鈴, 飯田礼子, 中島たみ子, 小湊慶彦
    • Organizer
      日本DNA多型学会 抄録集
    • Place of Presentation
      三島(p.44)
    • Related Report
      2010 Final Research Report
  • [Presentation] メタロチオネインMT2A(-209A/G)多型の頻度分布とアルカリフォスファターゼ(ALP)活性との相関解析2010

    • Author(s)
      大塚洋輔, 藤原純子, 大野怜一朗, 木村かおり, 頓宮美樹2, 山田高也2, 福井裕, 藤田恭久, 竹下治男
    • Organizer
      第27回日本法医学会中四国地方会.講演要旨集
    • Place of Presentation
      徳島(p.9-11)
    • Related Report
      2010 Final Research Report
  • [Presentation] DNase Iの動物種別臓器分布からの分子進化的考察2010

    • Author(s)
      大野怜一朗, 藤原純子, 植木美鈴, 安田年博, 木村かおり, 大塚洋輔, 頓宮美樹, 山田高也, 飯田礼子, 竹下治男
    • Organizer
      第27回日本法医学会中四国地方会.講演要旨集
    • Place of Presentation
      徳島(p.8-9)
    • Related Report
      2010 Final Research Report
  • [Presentation] 酸化亜鉛ナノ粒子によるエチジウムブロマイド発光強度上昇の検討2010

    • Author(s)
      藤原純子, 竹下治男, 藤田恭久
    • Organizer
      ナノ学会第8回大会.ナノ学会講演予稿集
    • Place of Presentation
      岡崎(p212)
    • Related Report
      2010 Final Research Report
  • [Presentation] サンドイッチELISA法による血清DNase I蛋白量の測定2010

    • Author(s)
      中島たみ子, 佐野利恵, 藤原純子, 竹下治男, 安田年博, 小湊慶彦
    • Organizer
      第94次日本法医学会総会.日法医誌64(補冊)
    • Place of Presentation
      東京(p.56)
    • Related Report
      2010 Final Research Report
  • [Presentation] DNase I及びDNase II遺伝子exon内SNP検索:集団調査及び酵素活性に及ぼす変異の影響2010

    • Author(s)
      木村かおり, 藤原純子, 竹下治男, 飯田礼子, 安田年博, 副島美貴子, 神田芳郎, 加藤秀章
    • Organizer
      第94次日本法医学会総会.日法医誌64(補冊)
    • Place of Presentation
      東京(p.54)
    • Related Report
      2010 Final Research Report
  • [Presentation] 哺乳類DNase IにおけるN-グリコシド型糖鎖解析2010

    • Author(s)
      藤原純子, 木村かおり, 竹下治男, 安田年博, 飯田礼子, 小湊慶彦, 佐野利恵, 中島たみ子
    • Organizer
      第94次日本法医学会総会.日法医誌64(補冊)
    • Place of Presentation
      東京(p.93)
    • Related Report
      2010 Final Research Report
  • [Presentation] 哺乳類DNase IにおけるN-グリコシド型糖鎖解析2010

    • Author(s)
      藤原純子, 木村かおり, 竹下治男, 安田年博, 飯田礼子, 小湊慶彦, 佐野利恵, 中島たみ子
    • Organizer
      第94次日本法医学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNase I及びDNase II遺伝子exon内SNP検索:集団調査及び酵素活性に及ぼす変異の影響2010

    • Author(s)
      木村かおり, 藤原純子, 竹下治男, 飯田礼子, 安田年博, 副島美貴子, 神田芳郎, 加藤秀章
    • Organizer
      第94次日本法医学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] サンドイッチELISA法による血清DNase I蛋白量の測定2010

    • Author(s)
      中島たみ子, 佐野利恵, 藤原純子, 竹下治男, 安田年博, 小湊慶彦
    • Organizer
      第94次日本法医学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸化亜鉛ナノ粒子によるエチジウムブロマイド発光強度上昇の検討2010

    • Author(s)
      藤原純子, 竹下治男, 藤田恭久
    • Organizer
      ナノ学会第8回大会
    • Place of Presentation
      岡崎
    • Related Report
      2010 Annual Research Report
  • [Presentation] 亜ヒ酸製剤を投与された急性前骨髄球性白血病(APL)患者の血清および尿中ヒ素化合物濃度と尿中8-OHdG分析2010

    • Author(s)
      藤原純子, 阿草哲郎, 金井理恵, 長谷川正紀, 山口清次, 竹下治男
    • Organizer
      日本法中毒学会第29年会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Deoxyribonuclease II (DNase II)遺伝子に座位する非同義置換型SNPには不活性な酵素を産生するminor alleleが分布する2010

    • Author(s)
      藤原純子, 木村かおり, 竹下治男, 中島たみ子, 小湊慶彦, 湯浅勲, 飯田礼子, 植木美鈴, 安田年博
    • Organizer
      日本DNA多型学会第19回学術集会
    • Place of Presentation
      三島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動物種特異的臓器分布から明らかにされたDNase Iの分子進化2010

    • Author(s)
      藤原純子, 竹下治男, 安田年博, 植木美鈴, 飯田礼子, 中島たみ子, 小湊慶彦
    • Organizer
      日本DNA多型学会第19回学術集会
    • Place of Presentation
      三島
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNase I exon内非同義置換SNP検索 : 酵素性状に及ぼす置換の影響2009

    • Author(s)
      藤原純子, 安田年博, 植木美鈴, 飯田礼子, 木村かおり, 高塚尚和, 神田芳郎, 副島美貴子, 加藤秀章, 竹下治男
    • Organizer
      第26回日本法医学会中四国地方会
    • Place of Presentation
      山口
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNase II遺伝子exon内SNP検索 : 酵素活性に及ぼす変異の影響2009

    • Author(s)
      木村かおり, 藤原純子, 高塚尚和, 栂とも子, 植木美鈴, 飯田礼子, 安田年博, 竹下治男
    • Organizer
      第26回日本法医学会中四国地方会
    • Place of Presentation
      山口
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] MIB算出のための免疫染色手法と画像解析半自動カウント法2009

    • Author(s)
      栂とも子, 丸山理留敬, 仁尾義則, 高橋節典, 高山公子, 木村かおり, 藤原純子, 高塚尚和, 竹下治男
    • Organizer
      第26回日本法医学会中四国地方会
    • Place of Presentation
      山口
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNASE1 exon 内SNP検索 : アジア人においてDNase I Gln222Argのみが多型性を有する2009

    • Author(s)
      藤原純子, 高塚尚和, 竹下治男, 神田芳郎, 副島美貴子, 小湊慶彦, 田島裕, 中島たみ子, 飯田礼子, 安田年博
    • Organizer
      日本法医学雑誌
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-16
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] ベトナムのヒ素汚染地域住民におけるAS3MT遺伝子多型とヒ素代謝の関係2009

    • Author(s)
      阿草哲郎, 岩田久人, 藤原純子, 國頭恭, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 竹下治男, 田辺信介
    • Organizer
      第15回ヒ素シンポジウム.プログラム・抄録集
    • Place of Presentation
      大阪(p52)
    • Related Report
      2010 Final Research Report
  • [Presentation] ベトナム人におけるAS3MT遺伝子多型とヒ素代謝能の関係2009

    • Author(s)
      阿草哲郎, 岩田久人, 藤原純子, 國頭恭, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 竹下治男, 田辺信介
    • Organizer
      日本DNA多型学会第18回学術集会.抄録集
    • Place of Presentation
      久留米(p29)
    • Related Report
      2010 Final Research Report
  • [Presentation] ベトナム人におけるGSTスーパーファミリーの遺伝子多型と尿中ヒ素化合物プロファイルの関係2009

    • Author(s)
      阿草哲郎, 岩田久人, 藤原純子, 國頭恭, 竹下治男, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 田辺信介
    • Organizer
      第20回日本微量元素学会.プログラム・抄録集
    • Place of Presentation
      東京(p163)
    • Related Report
      2010 Final Research Report
  • [Presentation] ベトナム人のヒ素曝露とその代謝遺伝子多型2009

    • Author(s)
      阿草哲郎, 岩田久人, 藤原純子, 國頭恭, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 竹下治男, 田辺信介
    • Organizer
      第18回環境化学討論会.講演要旨集
    • Place of Presentation
      つくば(p222-223)
    • Related Report
      2010 Final Research Report
  • [Presentation] mtDNA配列による迅速簡便なヤマトシジミの同定および産地判別の検討2009

    • Author(s)
      藤原純子, 竹下治男, 阿草哲郎, 藤田恭久, 中村幹雄, 鴛海智佳, 細澤豪志, 植木美鈴, 飯田礼子
    • Organizer
      日本DNA多型学会第18回学術集会
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] MIB算出のための免疫染色手法と画像解析半自動カウント法2009

    • Author(s)
      栂とも子, 丸山理留敬, 仁尾義則, 高橋節典, 高山公子, 木村かおり, 藤原純子, 高塚尚和, 竹下治男
    • Organizer
      第26回日本法医学会中四国地方会.講演要旨集
    • Place of Presentation
      山口(p12-13)
    • Related Report
      2010 Final Research Report
  • [Presentation] DNase II遺伝子exon内SNP検索:酵素活性に及ぼす変異の影響2009

    • Author(s)
      木村かおり, 藤原純子, 高塚尚和, 栂とも子, 植木美鈴, 飯田礼子, 安田年博, 竹下治男
    • Organizer
      第26回日本法医学会中四国地方会.講演要旨集
    • Place of Presentation
      山口(p10-11)
    • Related Report
      2010 Final Research Report
  • [Presentation] DNase I exon内非同義置換SNP検索:酵素性状に及ぼす置換の影響2009

    • Author(s)
      藤原純子, 安田年博, 植木美鈴, 飯田礼子, 木村かおり, 高塚尚和, 神田芳郎, 副島美貴子, 加藤秀章, 竹下治男
    • Organizer
      第26回日本法医学会中四国地方会.講演要旨集
    • Place of Presentation
      山口(p8-9)
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒ素中毒の指標としての尿中8-OhdGの有用性:亜ヒ酸製剤を投与されたAPL患者における検討2009

    • Author(s)
      藤原純子, 阿草哲郎, 田中順子, 長谷川正紀, 守谷珠美, 岩田久人, 田辺信介, 竹下治男
    • Organizer
      日本法中毒学会第28年会講演要旨集
    • Place of Presentation
      金沢(p50-51)
    • Related Report
      2010 Final Research Report
  • [Presentation] DNASE1 exon内SNP検索:アジア人においてDNase I Gln222Argのみが多型性を有する2009

    • Author(s)
      藤原純子, 高塚尚和, 竹下治男, 神田芳郎, 副島美貴子, 小湊慶彦, 田島裕, 中島たみ子, 飯田礼子, 安田年博
    • Organizer
      日本法医学雑誌.63
    • Place of Presentation
      金沢(p91)
    • Related Report
      2010 Final Research Report
  • [Presentation] RNase I superfamily遺伝子における分子多様性:非同義置換型SNPs解析2009

    • Author(s)
      安田年博, 飯田礼子, 藤原純子, 竹下治男, 中島たみ子, 小湊慶彦, 湯浅勲
    • Organizer
      日本法医学雑誌.63
    • Place of Presentation
      大阪(p89)
    • Related Report
      2010 Final Research Report
  • [Presentation] DNA修復酵素(hOGGおよびXRCC1)多型における酸化ストレスとの相関2009

    • Author(s)
      竹下治男, 守谷珠美, 藤原純子, 阿草哲郎, 藤井由己, 高塚尚和
    • Organizer
      第93次日本法医学会総会.日本法医学雑誌.63
    • Place of Presentation
      大阪(p73)
    • Related Report
      2010 Final Research Report
  • [Presentation] DNA修復酵素(hOGGおよびXRCC1)多型における酸化ストレスとの相関2009

    • Author(s)
      竹下治男, 守谷珠美, 藤原純子, 阿草哲郎, 藤井由己, 高塚尚和.
    • Organizer
      第93次日本法医学会総会.
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] RNase I superfamily遺伝子における分子多様性:非同義置換型SNPs解析2009

    • Author(s)
      安田年博, 飯田礼子, 藤原純子, 竹下治男, 中島たみ子, 小湊慶彦, 湯浅勲.
    • Organizer
      第93次日本法医学会総会.
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNASE 1 exon内SNP検索 : アジア人においてDNase I Gln222Argのみが多型性を有する2009

    • Author(s)
      藤原純子, 高塚尚和, 竹下治男, 神田芳郎, 副島美貴子, 小湊慶彦, 田島裕, 中島たみ子, 飯田礼子, 安田年博
    • Organizer
      第93次日本法医学会総会.
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒ素中毒の指標としての尿中8-OhdGの有用性 : 亜ヒ酸製剤を投与されたAPL患者における検討2009

    • Author(s)
      藤原純子, 阿草哲郎, 田中順子, 長谷川正紀, 守谷珠美, 岩田久人, 田辺信介, 竹下治男
    • Organizer
      日本法中毒学会第28年会
    • Place of Presentation
      金沢
    • Related Report
      2009 Annual Research Report
  • [Presentation] ベトナム人におけるGSTスーパーファミリーの遺伝子多型と尿中ヒ素化合物プロファイルの関係2009

    • Author(s)
      阿草哲郎, 岩田久人, 藤原純子, 國頭恭, 竹下治男, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 田辺信介
    • Organizer
      第20回日本微量元素学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] ベトナム人におけるAS3MT遺伝子多型とヒ素代謝能の関係2009

    • Author(s)
      阿草哲郎, 岩田久人, 藤原純子, 國頭恭, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 竹下治男, 田辺信介
    • Organizer
      日本DNA多型学会第18回学術集会
    • Place of Presentation
      久留米
    • Related Report
      2009 Annual Research Report
  • [Presentation] ベトナムのヒ素汚染地域住民におけるAS3MT遺伝子多型とヒ素代謝の関係2009

    • Author(s)
      阿草哲郎, 岩田久人, 藤原純子, 國頭恭, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 竹下治男, 田辺信介
    • Organizer
      第15回ヒ素シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 亜ヒ酸製剤を投与された急性前骨髄性白血病(APL)患者の尿中ヒ素化合物および8-OHdG分析による毒性影響評価2008

    • Author(s)
      藤原純子, 阿草哲郎, 田中順子, 藤井由己, 守谷珠美, 竹下治男
    • Organizer
      第20回日本中毒学会中国四国地方会
    • Place of Presentation
      出雲
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 魚船内における死亡事例2008

    • Author(s)
      長谷川正紀, 加藤貴雄, 香川昌人, 間瀬田千香暁, 藤原純子, 高塚尚和, 高山公子, 竹下治男
    • Organizer
      第20回日本中毒学会中国四国地方会
    • Place of Presentation
      出雲
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ベトナム人におけるヒ素代謝遺伝子多型と尿中ヒ素化合物の関係2008

    • Author(s)
      阿草哲郎, 藤原純子, 竹下治男, 國頭恭, Minh TB, Trang PTK, Viet PH, 田辺信介, 岩田久人
    • Organizer
      第14回ヒ素シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNA修復酵素(hOGG1)多型における酸化ストレスとの相関および集団特異的頻度分布の発見2008

    • Author(s)
      守谷珠美, 藤原純子, 阿草哲郎, 藤井由己, 高塚尚和, 草刈いづみ, 竹下治男
    • Organizer
      第25回日本法医学会中四国地方会
    • Place of Presentation
      米子
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨の形状から女性と考えたが、DNA検査により男性と判明した一例2008

    • Author(s)
      高塚尚和, 飯田礼子, 藤原純子, 竹下治男, 松木孝澄
    • Organizer
      第25回日本法医学会中四国地方会
    • Place of Presentation
      米子
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Determination of skin and blood levels of benzalkonium chloride (BAC)topically applied in rat skin.2008

    • Author(s)
      Tsujino Y, Hieda Y, Xue Y, Takeshita H, Morita E
    • Organizer
      International Investigative Dermatology2008
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cytochrome P450 1A1, glutathione S-transferases M1 and T1 polymorphisms in Ovambos and Mongolians.2008

    • Author(s)
      Fujihara J, Yasuda T, Iida R, Takatsuka H, Fujii Y, Takeshita H.
    • Organizer
      7th International Symposium ADVANCESIN LEGAL MEDICINE (ISALM).
    • Place of Presentation
      Osaka
    • Related Report
      2008 Annual Research Report
  • [Presentation] Serum deoxyribonuclease l can be used as a useful marker for diagnosis of death due to ischemic heart disease.2008

    • Author(s)
      Yasuda T, Iida R, Kawai Y, Nakajima T, Kominato Y, Fujihara J, Takeshita H
    • Organizer
      7th International Symposium ADVANCESIN LEGAL MEDICINE (ISALM).
    • Place of Presentation
      Osaka
    • Related Report
      2008 Annual Research Report
  • [Presentation] Determination of white petrolatum in skin and blood following topical application of ointment using gas chromatography-mass spectrometry2008

    • Author(s)
      Tsujino Y, Hieda Y, Takeshita H, Morita E
    • Organizer
      The 10th China-Japan Joint Meeting of Dermatology
    • Place of Presentation
      China
    • Related Report
      2008 Annual Research Report
  • [Presentation] アジア人に見出されたAS3MT (M287T)多型の低変異性.2008

    • Author(s)
      藤原純子, 安田年博, 藤井由己, 高塚尚和, 竹下治男
    • Organizer
      第92次日本法医学会総会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNase I多型Databaseの構築 : 民族特異的頻度分布の発見2008

    • Author(s)
      竹下治男, 藤原純子, 安田年博, 副島美貴子, 神田芳郎, 高塚尚和, 鍾被瑛, 藤井由己, 小湊慶彦, 中島たみ子
    • Organizer
      第92次日本法医学会総会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] 有鉤義歯誤嚥が見落とされ窒息により死亡した症例2008

    • Author(s)
      高塚尚和, 鍾筱〓, 高山公子, 片岡かおり, 藤原純子, 竹下治男
    • Organizer
      第92次日本法医学会総会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] 尿中ヒ素化合物の化学形態別分析とヒ素代謝における個人差に関与する遺伝的多型の解析2008

    • Author(s)
      藤原純子, 阿草哲郎, 岩田久人, 田辺信介, 安田年博, 長谷川正紀, 竹下治男
    • Organizer
      日本法中毒学会第27年会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ベトナム人におけるAS3MT遺伝子多型と尿中ヒ素化合物プロファイルの関係2008

    • Author(s)
      阿草哲郎, 藤原純子, 竹下治男, 岩田久人, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 田辺信介
    • Organizer
      第19回日本微量元素学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトRNase superfamily遺伝子における非同義置換型SNP解析2008

    • Author(s)
      藤原純子, 竹下治男, 中島たみ子, 小湊慶彦, 湯浅勲, 植木美鈴, 飯田礼子, 安田年博
    • Organizer
      日本DNA多型学会第17回学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒ素代謝に関与するAS3MT (M287T)多型はアジア人特異的低変異性を示す2008

    • Author(s)
      藤原純子, 阿草哲郎, 副島美貴子, 中島たみ子, 竹下治男
    • Organizer
      日本DNA多型学会第17回学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gln222Arg (A2317G) polymorphism in the deoxyribonuclease l gene exhibits ethnic and functional differences2008

    • Author(s)
      藤原純子, 安田年博, 飯m礼子, 竹下治男
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] N-linked lycos lation at Asnl8 and Asnl06 are both required for full enzymatic activity, thermal stability and resistance to roteolysis in the mammalian deoxyribonuclease I2008

    • Author(s)
      竹下治男, 藤原純子, 安田年博, 飯田礼子
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 心筋梗塞の新規な疾患感受性遺伝子としてのDNase I遺伝子2007

    • Author(s)
      藤原純子, 他
    • Organizer
      日本DNA多型学会第16回学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 微小穿刺法を用いた尿中DNase Iの起源の検討2007

    • Author(s)
      藤原純子, 他
    • Organizer
      第91次日本法医学会総会
    • Place of Presentation
      秋田
    • Related Report
      2007 Annual Research Report
  • [Presentation] Actin-inhibition and folding of vertebrate deoxyribonuclease I are affected by mutations at residues 67 and 114.2007

    • Author(s)
      Fujihara J, et. al.
    • Organizer
      第80回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 亜ヒ酸製剤を投与された急性前骨髄球性白血病(APL)患者の血清および尿中ヒ素化合物濃度と尿中8-OHdG分析

    • Author(s)
      藤原純子, 阿草哲郎, 金井理恵, 長谷川正紀, 山口清次, 竹下治男
    • Organizer
      日本法中毒学会第29年会講演要旨集
    • Place of Presentation
      東京(p126-127)
    • Related Report
      2010 Final Research Report
  • [Presentation] ベトナム人のヒ素曝露とその代謝遺伝子多型

    • Author(s)
      阿草哲郎, 岩田久人, 藤原純子, 國頭恭, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 竹下治男, 田辺信介
    • Organizer
      第18回環境化学討論会
    • Place of Presentation
      筑波
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.med.shimane-u.ac.jp/legal_med/Legal%20Med%20index.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi