Pathogenesis-based therapy development for polyglutamine diseases

• Project/Area Number: 19209033
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: SOBUE Gen Nagoya University, 大学院・医学系研究科, 教授 (20148315)
• Co-Investigator(Kenkyū-buntansha): TANAKA Fumiaki 名古屋大学, 大学院・医学系研究科, 准教授 (30378012) ; ADACHI Hiroaki 名古屋大学, 大学院・医学系研究科, COE特任講師 (40432257) ; KATSUNO Masahisa 名古屋大学, 高等研究院, 高等研究院 (50402566) ; 道勇 学 愛知医科大学, 医学部, 特任教授 (90293703)
• Co-Investigator(Renkei-kenkyūsha): DOYU Manabu 愛知医科大学, 医学部, 教授 (90293703)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥50,960,000 (Direct Cost: ¥39,200,000、Indirect Cost: ¥11,760,000); Fiscal Year 2008: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2007: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
• Keywords: 神経分子病態学 / ポリグルタミン / 分子シャペロン / ユビキチンープロテアソーム / 球脊髄性筋萎縮症 / アンドロゲン受容体 / リュープロレリン / CAGリピート / ユビキチン・プロテアソーム / 熱ショック蛋白質

Research Abstract

遺伝性運動ニューロン疾患である球脊髄性筋萎縮症(SBMA)のマウスモデルにおいて、分子シャペロンやユビキチン-プロテアソーム系の機能を増強することにより神経変性の進行が抑えられることを明らかにした。また、すでにSBMAのマウスモデルにおいて病態抑止効果が明らかとなっているアンドロゲン低下療法について、患者を対象とした第II相臨床試験を実施し、本治療法が患者においても病態を抑えることを明らかにした。

Research Products

• [Journal Article] Pathogenesis-targeting Therapeutics for Spinal and Bulbar Muscular Atrophy (SBMA) (2009)
  • Author(s): Suzuki K, Katsuno M, Banno H, Sobue G
  • Journal Title: Neuropathology (in press)
  • NAID: 10028192075
  • Peer Reviewed
• [Journal Article] Neuropathology and therapeutic intervention in spinal and bulbar muscular atrophy (2009)
  • Author(s): Banno H, Katsuno M, Suzuki K, Tanaka F, Sobue G
  • Journal Title: Int. J. Mol. Sci (in press)
  • Peer Reviewed
• [Journal Article] Correlation between pyramidal tract degeneration and widespread white matter involvement in amyotrophic lateral sclerosis : A study with tractography and diffusion-tensor imaging (2009)
  • Author(s): Senda J, Ito M, Watanabe H, Atsuta N, Kawai Y, Katsuno M, Tanaka F, Naganawa S, Fukatsu H, Sobue G
  • Journal Title: Amyotroph. Lateral Scler (in press)
  • Peer Reviewed
• [Journal Article] Getting a handle on Huntington's disease : the case for cholesterol (2009)
  • Author(s): Katsuno M, Adachi H, Sobue G
  • Journal Title: Nat. Med 15 Pages: 253-254
  • Peer Reviewed
• [Journal Article] Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR. Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk (2009)
  • Author(s): Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC
  • Journal Title: J. Neurosci 29 Pages: 1987-1997
  • Peer Reviewed
• [Journal Article] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy (2009)
  • Author(s): Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G
  • Journal Title: Ann. Neurol 65 Pages: 140-150
  • Peer Reviewed
• [Journal Article] 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in a SBMA model mouse (2009)
  • Author(s): Tokui K, Adachi H, Waza M, Katsuno M, Minamiyama M, Doi H, Tanaka K, Hamazaki J, Murata S, Tanaka F, Sobue G
  • Journal Title: Hum. Mol. Genet 18 Pages: 898-910
  • Peer Reviewed
• [Journal Article] Pathogenesis-target ing Therapeutics for Spinal and Bulbar Muscular Atrophy (SBMA). (2009)
  • Author(s): Suzuki K, et al
  • Journal Title: Neuropathology (in press)
  • Peer Reviewed
• [Journal Article] Neuropathology and therapeutic intervention in spinal andbulbar muscular atrophy. (2009)
  • Author(s): Banno H, et al
  • Journal Title: Int. J. Mol. Sc (in press)
  • Peer Reviewed
• [Journal Article] Correlation between pyramidal tract degeneration and wide spread white matter involvement in amyotrophic lateral sclerosis : A study with tractography and diffusion-tensor imaging. (2009)
  • Author(s): Senda J, et al
  • Journal Title: Amyotroph. Lateral Scler (in press)
  • Peer Reviewed
• [Journal Article] Getting a handle on Huntington's disease : the case for cholesterol. (2009)
  • Author(s): Katsuno M, et al
  • Journal Title: Nat. Med 15 Pages: 253-254
  • Peer Reviewed
• [Journal Article] Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. (2009)
  • Author(s): Young JE, et al
  • Journal Title: J. Neurosci 29 Pages: 1987-1997
  • Peer Reviewed
• [Journal Article] Phase 2 trial of leuprorelin in patients with spinal andbulbar muscular atrophy. (2009)
  • Author(s): Bannon, et al
  • Journal Title: Ann. Neurol 65 Pages: 140-150
  • Peer Reviewed
• [Journal Article] 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function ina SBMA model mouse. (2009)
  • Author(s): Tokui K, et al
  • Journal Title: Hum. Mol. Genet 18 Pages: 898-910
  • Peer Reviewed
• [Journal Article] Walking capacity evaluated by the 6-minute walk test in spinal and bulbar muscular atrophy (2008)
  • Author(s): Takeuchi Y, Katsuno M, Banno H, Suzuki K, Kawashima M, Atsuta N, Ito M, Watanabe H, Tanaka F, Sobue G
  • Journal Title: Muscle Nerve 38 Pages: 946-971
  • Peer Reviewed
• [Journal Article] Molecular Genetics and Biomarkers of Polyglutamine Diseases (2008)
  • Author(s): Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, Adachi H, Tanaka F, Sobue G
  • Journal Title: Current Mol. Med. 8 Pages: 221-234
  • Peer Reviewed
• [Journal Article] Cognitive impairment in spinocerebellar ataxia type 6 (2008)
  • Author(s): Suenaga M, Kawai Y, Watanabe H, Atsuta N, Ito M, Tanaka F, Katsuno M, Fukatsu H, Naganawa S, Sobue G
  • Journal Title: J. Neurol .Neurosurg. Psychiatry 79 Pages: 496-499
  • Peer Reviewed
• [Journal Article] CAG repeat size correlates to electrophysiological motor and sensory phenotypes in SBMA (2008)
  • Author(s): Suzuki K, Katsuno M, Banno H, Takeuchi Y, Atsuta N, Ito M, Watanabe H, Yamashita F, Hori N, Nakamura T, Hirayama M, Tanaka F, Sobue G
  • Journal Title: Brain 131 Pages: 229-239
  • Peer Reviewed
• [Journal Article] Walking capacity evaluated by the 6-minute walk test in spinal and bulbar muscular atrophy. (2008)
  • Author(s): Takeuchi Y, et al
  • Journal Title: Muscle Nerve 38 Pages: 964-971
  • Peer Reviewed
• [Journal Article] Molecular Genetics and Biomarkers of Polyglutamine Diseases. (2008)
  • Author(s): Katsuno M, et al
  • Journal Title: Current Mol. Med. 8 Pages: 221-234
  • Peer Reviewed
• [Journal Article] Cognitive impairment in spinocerebellar ataxia type 6. (2008)
  • Author(s): Suenaga M, et al
  • Journal Title: J. Neurol. Neurosurg. Psychiatry 79 Pages: 496-499
  • Peer Reviewed
• [Journal Article] CAG repeat size correlates to electrophysiological motor and sensory phenotypes in SBMA. (2008)
  • Author(s): Suzuki K, et al
  • Journal Title: Brain 131 Pages: 229-239
  • Peer Reviewed
• [Journal Article] CAG repeat size correlates to electrophysiological motor and sensory phenotypes in SBMA (2008)
  • Author(s): Suzuki K, Katsuno M, Banno H, Yamashita F, Hori N, Nakamura T, Hirayama M, Tanaka F, Sobue G
  • Journal Title: Brain 131 Pages: 229-239
  • Peer Reviewed
• [Journal Article] Therapeutic strategies for spinal and bulbar muscular atrophy (SBMA) (2007)
  • Author(s): Katsuno M, Banno H, Suzuki K, Takeuchi Y, Minamiyama M, Waza M, Adachi H, Tanaka F, Sobue G
  • Journal Title: Drug Future 32 Pages: 907-917
  • Peer Reviewed
• [Journal Article] CHIP Overexpression Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model (2007)
  • Author(s): Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
  • Journal Title: J. Neurosci 27 Pages: 5115-5126
  • Peer Reviewed
• [Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (2007)
  • Author(s): Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G
  • Journal Title: Neuropathol. Appl. Neurobiol 33 Pages: 135-151
  • Peer Reviewed
• [Journal Article] ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor (2007)
  • Author(s): Yang Z, Chang YJ, Yu IC, Yeh S, Wu CC, Miyamoto H, Merry DE, Sobue G, Chen LM, Chang SS, Chang C
  • Journal Title: Nat. Med 13 Pages: 348-353
  • Peer Reviewed
• [Journal Article] ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor (2007)
  • Author(s): Yang, Z., Chang, Y. J., Yu, I. C., Yeh, S., Wu, C.C., Miyamoto, H., Merry, D. E., Sobue, G., Chen, L. M., Chang, S.S. & Chang, C
  • Journal Title: Nat. Med 13 Pages: 348-353
  • Peer Reviewed
• [Journal Article] Altered venous capacitanec as a cause of postprandial hypotension in multiple system atrophy (2007)
  • Author(s): Takamori M, Hirayama M, Kobayashi R, Ito H, Mabuchi N, Nakamura T, Hori N, Koike Y, Sobue G
  • Journal Title: Clin Auton Res 17 Pages: 20-25
  • Peer Reviewed
• [Journal Article] Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model (2007)
  • Author(s): Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanak F, Doyu M, Sobue G
  • Journal Title: J Neurosci 27 Pages: 5115-5126
  • Peer Reviewed
• [Journal Article] Congenial fibrosis of the extraocular muscles (CFEOM) sydrome associated with progressive cerebellar ataxia (2007)
  • Author(s): Yoshida K, Okano T, Hoshi K, Yahikozawa H, Suzuki K, Bannno H, Tamura T, Sobue G, Ikeda S
  • Journal Title: AM J Med Genet 143A Pages: 1494-1501
  • Peer Reviewed
• [Journal Article] Enhanced aquaporin-4 immunoreactivity in sporadic creutzfeldt-Jakob disease (2007)
  • Author(s): Iwasaki Y, Mimuro M, Yoshida M. Hashizume Y, Ito M, Kitamoto T, Wakayama Y, Sobue G
  • Journal Title: Neuropathology 27 Pages: 314-323
  • NAID: 10021235965
  • Peer Reviewed
• [Journal Article] Widespread Spinal cord invovement in progressive in supranuclear plasy (2007)
  • Author(s): Iwasaki Y, Yoshida M. Hashizume Y, Hattori M, Aiba I, Sobue G
  • Journal Title: Neuropathology 27 Pages: 331-340
  • Peer Reviewed
• [Journal Article] Gene expressions specifically detected in motor neurons (dynactin l, early growth response 3, Acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to athologic markers in sporadic amyotrophic lateral sclerosis (2007)
  • Author(s): Jiang Y, Yamamoto M, Tanaka F, Ishigaki S, Katsuno M, Adachi H, Niwia J, Doyu M, Yoshida M, Hashizume Y, Sobue G
  • Journal Title: Neuropathol Exp Neurol 66 Pages: 617-627
  • Peer Reviewed
• [Journal Article] Ataxic vs painful form of paraneoplastic neuropathy (2007)
  • Author(s): Oki Y, Koike H, Iijima M, Mori K, Hattori N, Katsuno M, Nakamura T, Hirayama M, Tanaka F, Shiraishi M, Yazaki S, Nokura K, Yamamoto H,Sobue G
  • Journal Title: Neurology 69 Pages: 564-572
  • Peer Reviewed
• [Journal Article] Genetic evidence for a protective role for heat shock factor l and heat shock protein 70 against colitis (2007)
  • Author(s): Tanaka K, Namba T, Arai Y, Fujimoto M, Adachi H, Sobue G, Takeuchi K, Nakai A, Mizushima T
  • Journal Title: J Biol Chem 282 Pages: 23240-23252
  • Peer Reviewed
• [Journal Article] Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1 (2007)
  • Author(s): Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, Sobue G
  • Journal Title: J Biol Chem 282 Pages: 28087-28095
  • Peer Reviewed
• [Journal Article] Recent progress in alcoholic and thiamine-deficiency neuropathy (2007)
  • Author(s): Koike H, Oki Y, Iijima M, katsuno M, Hattori N, Sobue G
  • Journal Title: Current trend in Neurology 2 Pages: 79-85
  • Peer Reviewed
• [Journal Article] Therapeutic strategies for spinal and bulbar musculara atrophy (SBMA) (2007)
  • Author(s): Katsuno M, Bannno H, Suzuki K, Takeuchi Y, Minamiyama M, Waza M, Adachi H, Tanaka F, Sobue G
  • Journal Title: Drugns of the Future 32 Pages: 907-917
  • Peer Reviewed
• [Journal Article] Nonmyelinating Schwann cell involvement with well-preserved unmyelinated axons in Charco-Matie-Tooth disease type 1A (2007)
  • Author(s): Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Katsuno M, Tanaka F, Watanabe H, Doyu M, Yoshikawa H, Sobue G
  • Journal Title: J Neuropathol Exp Neurol 66 Pages: 1027-1036
  • Peer Reviewed
• [Journal Article] Dobutamine stress test unmasks cardiac sympathetic denervation in Parkinson's disease (2007)
  • Author(s): Nakamura T, Hirayama M, Ito H, Takamori M, Hamada K, Takeuchi S, Watanabe H, Koike Y, Sobue G
  • Journal Title: J Neurol Sci 263 Pages: 133-138
  • Peer Reviewed
• [Journal Article] Pyramidal tract degeneration in sporadic Creutzfeldt-Jakob disease (2007)
  • Author(s): Iwasaki Y, Yoshida M, Hashizume Y, Kitamoto T, Sobue G
  • Journal Title: Neuropathology 27 Pages: 434-441
  • NAID: 10021236410
  • Peer Reviewed
• [Journal Article] Hypophosphataemic neuropathy in a patient who received intravenous hyperalimentation (2007)
  • Author(s): Iguchi Y, Mori K, Koike H, Mano K, Goto Y, Kato T, Nakano T, Furukawa D, Sobue G
  • Journal Title: Neurol Neurosurg Psychiatry 78 Pages: 1159-1160
  • Peer Reviewed
• [Journal Article] In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5'splice sites (2007)
  • Author(s): Sahashi K, Masuda A, Matsuura T, Shinmi J, Zhang Z, Takeshima Y, Matsuo M, Sobue G, Ohno K
  • Journal Title: Nucleic Acids Res 35 Pages: 5995-6003
  • Peer Reviewed
• [Journal Article] Intravenous immunoglobulin therapy markedly ameliorates muscle weakness and severe pain in proximal diabetic neuropathy (2007)
  • Author(s): Kawagashira Y, Watanabe H, Oki Y, Iijima M, Koike H, Hattori N, Katsuno M, Tanaka F, Sobue G
  • Journal Title: J Neurol Neurosurg Psychiatry 78 Pages: 899-901
  • Peer Reviewed
• [Journal Article] Scientific highlights. 17th International Symposium on ALS/MND Yokohama, Japan, November 30, 2006 through December 2, 2006 (2007)
  • Author(s): Sobue G
  • Journal Title: Amyotroph Lateral Scler (2) Pages: 121-123
  • Peer Reviewed
• [Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (2007)
  • Author(s): Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G
  • Journal Title: Neuropathol Appl Neurobiol 33 Pages: 135-151
  • Peer Reviewed
• [Journal Article] Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atropyh (2007)
  • Author(s): Ito M, Watanabe H, Kawai Y, Atsuta N, Tanaka F, Naganawa S, Fukatsu H, Sobue G
  • Journal Title: J Neurol Neurosurg Psychiatry 78 Pages: 722-728
  • Peer Reviewed
• [Journal Article] ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor (2007)
  • Author(s): Yang Z, Chang YJ, Yu IC, Yeh S, Wu CC, Miyamoto H, Merry DE, Sobue G, Chen LM, Chang SS, Chang C
  • Journal Title: Nat Med 13 Pages: 348-353
  • Peer Reviewed
• [Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SODI proteins and reduce their cellular toxicity (2007)
  • Author(s): Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
  • Journal Title: Neurobiol Dis 25 Pages: 331-241
  • Peer Reviewed
• [Presentation] 神経変性疾患の病態に基づく治療開発 (2008)
  • Author(s): 祖父江元
  • Organizer: 第四回神経内科の基礎と臨床
  • Place of Presentation: 京都
  • Year and Date: 2008-11-21
• [Presentation] 神経変性疾患の病態に基づく治療開発. (2008)
  • Author(s): 祖父江元
  • Organizer: 第四回神経内科の基礎と臨床
  • Place of Presentation: 京都
  • Year and Date: 2008-11-21
• [Presentation] 分子シャペロンによる神経変性疾患の治療への展望 (2008)
  • Author(s): 祖父江元
  • Organizer: 日本ハイパーサーミア学会第25回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-12
• [Presentation] 分子シャペロンによる神経変性疾患の治療への展望. (2008)
  • Author(s): 祖父江元
  • Organizer: 日本ハイパーサーミア学会第25回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-12
• [Presentation] 神経変性疾患の病態抑止治療 (2008)
  • Author(s): 祖父江元
  • Organizer: 第39回日本内科学会北海道支部生涯教育講演会
  • Place of Presentation: 北海道
  • Year and Date: 2008-06-16
• [Presentation] 神経変性疾患の分子標的治療 : 球脊髄性筋萎縮症を中心に (2008)
  • Author(s): 祖父江元
  • Organizer: 第49回日本神経病理学会総会学術集会シンポジウムI「末梢神経・筋疾患の臨床病理-病因解明と治療開発にはたす新たな役割-」
  • Place of Presentation: 東京
  • Year and Date: 2008-05-20
• [Presentation] 神経変性疾患の分子標的治療 : 球脊髄性筋萎縮症を中心に. (2008)
  • Author(s): 祖父江元
  • Organizer: 第49回日本神経病理学会総会学術集会シンポジウムI「末梢神経・筋疾患の臨床病理一病因解明と治療開発にはたす新たな役割-」
  • Place of Presentation: 東京
  • Year and Date: 2008-05-20
• [Presentation] 孤発性ALS病態関連分子の探索と疾患モデルの開発 (2008)
  • Author(s): 田中章景、和座雅浩、丹羽淳、祖父江元
  • Organizer: 第49回日本神経学会総会. シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] 孤発性ALS病態関連分子の探索と疾患モデルの開発. (2008)
  • Author(s): 田中章景, et al
  • Organizer: 第49回日本神経学会総会. シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] 神経変性疾患の分子標的治療への展望-SBMAを中心に- (2008)
  • Author(s): 祖父江元
  • Organizer: Academic Conference in Tokyo
  • Place of Presentation: 東京
  • Year and Date: 2008-02-07
• [Presentation] An oral Hsp90 inhibitor ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model (2008)
  • Author(s): Adachi H, Tokui K, Waza M, Katsuno M, Minamiyama M, Doi H, Tanaka F, Sobue G
  • Organizer: Neuroscience 2009
  • Place of Presentation: Washington DC, USA
• [Presentation] Skeletal muscle involvement in spinal and bulbar muscular atrophy (2008)
  • Author(s): Katsuno M, Kawashima M, Banno H, Suzuki K, Takeuchi Y, Suga N, Adachi H, Tanaka F, Sobue G
  • Organizer: The 19th International Symposium on ALS/MND
  • Place of Presentation: Birmingham, UK
• [Presentation] An oral Hsp90 inhibitor ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model. (2008)
  • Author(s): Adachi H, et al
  • Organizer: Neuroscience 2009.
  • Place of Presentation: washington DC, USA
• [Presentation] Skeletal muscle involvement in spinal and bulbar muscular atrophy. (2008)
  • Author(s): Katsuno M, et al
  • Organizer: The 19th International Symposium on ALS/MND
  • Place of Presentation: Birmingham, UK
• [Presentation] 分子シャペロンによる神経変性疾患の治療への展望 (2007)
  • Author(s): 祖父江元
  • Organizer: 第2回臨床ストレス応答学会大会ランチョンセミナー
  • Place of Presentation: 福岡
  • Year and Date: 2007-11-30
• [Presentation] 神経変性疾患の病態抑止治療 (2007)
  • Author(s): 祖父江元
  • Organizer: 第48回日本神経学会総会 シンポジウム「神経変性疾患の動物モデル」
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-16
• [Presentation] Myocardial involvement in spinal and bulbar muscular atrophy (2007)
  • Author(s): Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, Tanaka F, Sobue G
  • Organizer: 18th International symposium on ALS/MND
  • Place of Presentation: Toronto, Canada
• [Presentation] CHIP overexpression reduces the mutant AR protein and ameliorates phenotypes of the SBMA transgenic mouse model (2007)
  • Author(s): Adachi H, Waza M, Tokui K, Katsuno M, Tanaka F, Sobue G
  • Organizer: Neuroscience 2007
  • Place of Presentation: San Diego, USA
• [Presentation] Translational approaches for polyglutamine disease (2007)
  • Author(s): Sobue G
  • Organizer: 第4回21世紀COE国際シンポジウム(The 21st century center for excellence (COE) program 4th international symposium on functional molecules linked to neurodegeneration and oncogenesis-toward molecular targeted therapy-)
  • Place of Presentation: Nagoya, Japan
• [Presentation] Mutant SOD1 and protein aggregation/degradation in motoneuronal cells (2007)
  • Author(s): Sobue G
  • Organizer: Mutant SOD1 and familial ALS : from molecule to man
  • Place of Presentation: Milano, Italy
• [Presentation] Reversible dysfunction in polyglutamine disease (2007)
  • Author(s): Sobue G
  • Organizer: Neuro2007
  • Place of Presentation: Yokohama, Japan