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Pancreatic β cell impairment and adaptation of type 2 diabetes mellitus in overnutrition era

Research Project

Project/Area Number 19209034
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionTohoku University

Principal Investigator

OKA Yoshitomo  Tohoku University, 大学院・医学系研究科, 教授 (70175256)

Co-Investigator(Kenkyū-buntansha) 石原 寿光  東北大学, 病院, 講師 (60361086)
石垣 泰  東北大学, 病院, 助教 (50375002)
山田 哲也  東北大学, 病院, 助教 (90400374)
Co-Investigator(Renkei-kenkyūsha) ISHIHARA Hisamitsu  日本大学, 医学部・内科学系, 教授 (60361086)
YAMADA Tetsuya  東北大学, 大学院・医学系研究科, 准教授 (90400374)
ISHIGAKI Yasusi  東方大学, 病院, 講師 (50375002)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2009: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2008: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2007: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Keywordsインスリン分泌 / 膵β細胞 / 小胞体ストレス / 再生治療 / 増殖
Research Abstract

Pancreatic β cell mass contributes to the development of diabetes. We show that induction of 4E-BP1 promotes β cell survival under ER stress. The Eif4ebp1 gene encoding 4E-BP1 was revealed to be a direct target of the transcription factor ATF4. We also found that hepatic activation of extracellular regulated kinase signaling induced pancreatic β cell proliferation through a neuronal-mediated relay of metabolic signals. Thus, inter-organ metabolic relay systems may serve as valuable targets in regenerative treatments for diabetes.

Report

(4 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (55 results)

All 2009 2008 2007

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (26 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice2009

    • Author(s)
      Akiyama M, Hatanaka M, Ohta Y, Ueda K, Yanai A, Uehara Y, Tanabe K, Tsuru M, Miyazaki M, Saeki S, Saito T, Shinoda K, Oka Y, Tanizawa Y.
    • Journal Title

      Diabetologia 52(4)

      Pages: 653-663

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carotid arterial elasticity is a sensitive atherosclerosis value reflecting visceral fat accumulation in obese subjects2009

    • Author(s)
      Tokita A, Ishigaki Y, Okimoto H, Hasegawa H, Koiwa Y, Kato M, Ishihara H, Hinokio Y, Katagiri H, Kanai H, Oka Y.
    • Journal Title

      Atherosclerosis 206

      Pages: 168-172

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating oxidized LDL-a biomarker and a pathogenic factor2009

    • Author(s)
      Ishigaki Y, Oka Y, Katagiri H.
    • Journal Title

      Current Opinion in Lipidology 20

      Pages: 363-369

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eradication of insulin resistance2009

    • Author(s)
      Imai J, Yamada T, Saito T, Ishigaki Y, Hinokio Y, Kotake H, Oka Y, Katagiri H.
    • Journal Title

      Lancet 374

      Pages: 264-264

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel mechanism regulating βcell mass : Neuronal relay from the liver to pancreatic βcells2009

    • Author(s)
      Imai J, Oka Y, Katagiri H.
    • Journal Title

      Islet 1

      Pages: 75-77

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice2009

    • Author(s)
      Akiyama M, Hatanaka M, Ohta Y, Ueda K, Yanai A, Uehara Y, Tanabe K, Tsuru M, Miyazaki M, Saeki S, Saito T, Shinoda K, Oka Y, Tanizawa Y.
    • Journal Title

      Diabetologia 52

      Pages: 653-663

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Obesity Alters Circadian Expressions of Molecular Clock Genes in the Brainstem2009

    • Author(s)
      Kaneko K, Yamada T, Tsukita S, Takahashi K, Ishigaki Y, Oka Y, Katagiri H.
    • Journal Title

      Brain Res 1263

      Pages: 58-68

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peginterferon (PEG-IFN) plus ribavirin combination therapy, but neither interferon nor PGE-IFN alone, induced type 1 diabetes in a patient with chronic hepatitis C.2009

    • Author(s)
      Ogihara T, Katagiri H, Yamada T, Kudo H, Imai J, Ishigaki Y, Hinokio Y, Yamagiwa Y, Ueno Y, Shimosegawa T, Oka Y.
    • Journal Title

      Internal Medicine 48

      Pages: 1387-1390

    • NAID

      130000122019

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carotid arterial elasticity is a sensitive atherosclerosis value reflecting visceral fat accumulation in obese subjects.2009

    • Author(s)
      Tokita A, Ishigaki Y, Okimoto H, Hasegawa H, Koiwa Y, Kato M, Ishihara H, Hinokio Y, Katagiri H, Kanai H, Oka Y.
    • Journal Title

      Atherosclerosis 206

      Pages: 168-172

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating oxidized LDL-a biomarker and a pathogenic factor.2009

    • Author(s)
      Ishigaki Y, Oka Y, Katagiri H
    • Journal Title

      Current Opinion in Lipidology 20

      Pages: 363-369

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eradication of insulin resistance2009

    • Author(s)
      Imai J, Yamada T, Saito T, Ishigaki Y, Hinokio Y, Kotake H, Oka Y, Katagiri H
    • Journal Title

      Lancet 374

      Pages: 264-264

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel mechanism regulating sscell mass : Neuronal relay from the liver to pancreatic sscells.2009

    • Author(s)
      Imai J, Oka Y, Katagiri H
    • Journal Title

      Islet 1

      Pages: 75-77

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice.2009

    • Author(s)
      Akiyama M, Hatanaka M, Ohta Y, Ueda K, Yanai A, Uehara Y, Tanabe K, Tsuru M, Miyazaki M, Saeki S, Saito T, Shinoda K, Oka Y, Tanizawa Y
    • Journal Title

      Diabetologia 52

      Pages: 653-663

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Obesity Alters Circadian Expressions of Molecular Clock Genes in the Brainstem.2009

    • Author(s)
      Kaneko K, Yamada T, Tsukita S, Takahashi K, Ishigaki Y, Oka Y, Katagiri H
    • Journal Title

      Brain Res 1263

      Pages: 58-68

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peginterferon(PEG-IFN)plus ribavirin combination therapy, but neither interferon nor PGE-IFN alone, induced type 1 diabetes in a patient with chronic hepatitis C.2009

    • Author(s)
      Ogihara T, Katagiri H, Yamada T, Kudo H, Imai J, Ishigaki Y, Hinokio Y, Yamagiwa Y, Ueno Y, Shimosegawa T, Oka Y.
    • Journal Title

      Internal Medicine 48

      Pages: 1387-1390

    • NAID

      130000122019

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfsl knockout mice2009

    • Author(s)
      Akiyama M, Hatanaka M, Ohta Y, Ueda K, Yanai A, Uehara Y, Tanabe K, Tsuru M, Miyazaki M, Saeki S, Saito T, Shinoda K, Oka Y, Tanizawa Y.
    • Journal Title

      Diabetologia (Epub ahead of print)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATF4-mediated induction of 4E-BP1 contributes to pancreatic β cell survival under endoplasmic reticulum stress2008

    • Author(s)
      Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y.
    • Journal Title

      Cell Metabolism 7

      Pages: 269-276

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral and gene expression analyses of WFS1 knockout mice as apossible animal model of mood disorder2008

    • Author(s)
      Kato T, Ishiwata M, Yamada K, Kasahara T, Kakiuchi C, Iwamoto K, Kawamura K, Ishihara H, Oka Y.
    • Journal Title

      Neuroscience Research 61

      Pages: 143-158

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis2008

    • Author(s)
      Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y.
    • Journal Title

      Circulation 118

      Pages: 75-83

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of pancreatic β cell mass by neuronal signals from the liver2008

    • Author(s)
      Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y.
    • Journal Title

      Science 322

      Pages: 1250-1254

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATF4-mediated induction of 4E-BP1 contributes to pancreatic β cell survivalunder endoplasmic reticulum stress2008

    • Author(s)
      Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tasbiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y.
    • Journal Title

      Cell Metabolism 7

      Pages: 269-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inter-organ metabolic communication involved in energy homeostasis : potential therapeutic targets for obesity and metabolic syndrome2008

    • Author(s)
      Yamada T, Oka Y, Katagiri H
    • Journal Title

      Pharmacol Ther 117

      Pages: 188-98

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of pancreatic β cell mass by neuronal signals from the liver2008

    • Author(s)
      Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T Minokoshi Y, Oka Y.
    • Journal Title

      Science 322

      Pages: 1250-1254

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors2007

    • Author(s)
      Takahashi R, Ishihara H, Takahashi K, Tamura A, Yamaguchi S, Yamada T, Katagiri H, Oka Y.
    • Journal Title

      J Mol Endocrinol 38

      Pages: 127-136

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance2007

    • Author(s)
      Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Kanzaki M, Yamamoto T, Ishibashi S, Oka Y.
    • Journal Title

      Diabetes 56

      Pages: 24-33

    • NAID

      10027299912

    • Related Report
      2010 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow (BM) transplantation promotes {beta} cell regeneration after acute injury through BM cell mobilization2007

    • Author(s)
      Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H.
    • Journal Title

      Endocrinology 148

      Pages: 2006-2015

    • Related Report
      2010 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors2007

    • Author(s)
      Takahashi R, Ishihara H, Takahashi K, Tamura A, Yamaguchi S. Yamada T, Katagiri H, Oka Y.
    • Journal Title

      J Mol Endocrinol 38

      Pages: 127-136

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] (若手研究奨励賞審査講演) 肝臓におけるERK経路活性化は膵島再生を促進する2009

    • Author(s)
      今井淳太, 片桐秀樹, 岡芳知
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Related Report
      2010 Final Research Report
  • [Presentation] 肝からの神経を介した, 肥満に伴う高血圧の発症機序2009

    • Author(s)
      宇野健司, 片桐秀樹, 山田哲也, 石垣泰, 今井淳太, 長谷川豊, 高俊弘, 金子慶三, 齋藤徳郎, 鈴木俊伸, 荻原健英, 岡芳知
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥満による延髄孤束核における概日リズムの変調2009

    • Author(s)
      金子慶三, 片桐秀樹, 山田哲也, 荻原健英, 石垣泰, 今井淳太, 宇野健司, 長谷川豊, 澤田正二郎, 高俊弘, 鈴木俊伸, 齋藤徳郎, 突田壮平, 高橋圭, 檜尾好徳, 岡芳知
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 自律神経を介した肝臓-膵β細胞連関による膵β細胞増殖機構2009

    • Author(s)
      今井淳太, 片桐秀樹, 荻原健英, 石垣泰, 山田哲也, 宇野健司, 長谷川豊, 高俊弘, 金子慶三, 鈴木俊伸, 齋藤徳郎, 突田壮平, 高橋圭, 檜尾好徳, 岡芳知
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 膵β細胞におけるATF6α欠損マウスを用いた検討2009

    • Author(s)
      薄井正寛, 石原寿光, 鈴木千登世, 近藤敬一, 丹治泰裕, 冨永竜, 佐竹千尋, 山口賢, 石垣泰, 檜尾好徳, 片桐秀樹, 森和俊, 岡芳知
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Obesity and Insulin Resistance Alter Circadian Expressions of Molecular Clock Genes in the Brainstem2009

    • Author(s)
      Keizo Kaneko, Tetsuya Yamada, Yoshitomo Oka, Hideki Katagiri
    • Organizer
      第69回米国糖尿病学会
    • Place of Presentation
      ニューオーリンズ(アメリカ)
    • Related Report
      2010 Final Research Report
  • [Presentation] 超音波測定による頸動脈血管弾性は内臓肥満に伴う早期動脈硬化を評価できる2009

    • Author(s)
      石垣泰, 鴇田藍, 片桐秀樹, 岡芳知
    • Organizer
      第2回日本肥満症治療学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] (若手研究奨励賞審査講演)肝臓におけるERK経路活性化は膵島再生を促進する2009

    • Author(s)
      今井淳太, 片桐秀樹, 岡芳知
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝からの神経を介した、肥満に伴う高血圧の発症機序2009

    • Author(s)
      宇野健司, 片桐秀樹, 山田哲也, 石垣泰, 今井淳太, 長谷川豊, 高俊弘, 金子慶三, 齋藤徳郎, 鈴木俊伸, 荻原健英, 岡芳知
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Obesity and Insulin Resistance Alter Circadian Expressions of Molecular Clock Genes in the Brainstem.2009

    • Author(s)
      Keizo Kaneko, Tetsuya Yamada, Yoshitomo Oka, Hideki Katagiri
    • Organizer
      第69回米国糖尿病学会
    • Place of Presentation
      ニューオーリンズ(アメリカ)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Arterial elasticity is a new parameter for evaluating atherosclerosis in subjects with visceral adiposity.2009

    • Author(s)
      Yasushi Ishigaki, Ai Tokita, Hisashi Okimoto, Hideyuki Hasegawa, Makoto Kato, Yoshinori Hinokio, Hideki Katagiri, Hiroshi Kanai, Yoshitomo Oka
    • Organizer
      第41回日本動脈硬化学会総会
    • Place of Presentation
      下関
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of CHOP in oxidative stress and vascular inflammation.2009

    • Author(s)
      Junhong Gao, Hideki Katagiri, Yasushi Ishigaki, Tetsuya Yamada, Shojiro Sawada, Hisamitsu Ishihara, Junta Imai, Kenji Uno, Yutaka Hasegawa, Suguru Yamaguchi, Yoshinori Hinokio, Masataka Mori, Yoshitomo Oka
    • Organizer
      第41回日本動脈硬化学会総会
    • Place of Presentation
      下関
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膵β細胞量の調節におけるmRNA翻訳制御の役割2008

    • Author(s)
      石原寿光, 山口賢, 岡芳知
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 肝からの神経を介した臓器間ネットワークとメタボリックシンドローム2008

    • Author(s)
      宇野健司, 山田哲也, 岡芳知, 片桐秀樹
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 動脈硬化発症・進展における小胞体ストレス応答の役割2008

    • Author(s)
      高俊弘, 片桐秀樹, 岡芳知, 他14名
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 膵β細胞における小胞体ストレス応答と酸化ストレス応答の特徴2008

    • Author(s)
      冨永竜, 石原寿光, 岡芳知, 他6名
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 翻訳抑制因子4E-BP1は小胞体ストレス応答転写因子ATF4の直接ターゲットである2008

    • Author(s)
      佐竹千尋, 石原寿光, 岡芳知, 他6名
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 翻訳抑制因子4E-BP1は、慢性的な小胞体ストレス下の膵β細胞において、翻訳抑制を介して細胞を保護する2008

    • Author(s)
      山口賢, 石原寿光, 岡芳知, 他7名
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] インスリン抵抗性におけるCHOPの役割の検討2008

    • Author(s)
      石垣泰, 片桐秀樹, 岡芳知, 他14名
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] IL-6の持つ糖反応性インスリン分泌促進作用とそのメカニズムについて2008

    • Author(s)
      鈴木俊伸, 今井淳太, 片桐秀樹, 荻原健英, 石垣泰, 山田哲也, 宇野健司, 長谷川豊, 澤田正二郎, 高俊弘, 金子慶三, 齋藤徳郎, 突田壮平, 高橋圭, 檜尾好徳, 岡芳知
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 肥満による血圧上昇・インスリン抵抗性における血管内皮細胞でのNF-κβシグナルの役割2008

    • Author(s)
      長谷川豊、片桐秀樹、岡芳知, 他13名
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] インスリン需要増大時の膵β細胞小胞体ストレスと細胞死-wfs1欠損マウスをモデルとした検討-2007

    • Author(s)
      谷澤幸生, 秋山優, 幡中雅行, 植田浩平, 宮崎睦子, 岡芳知
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] 翻訳抑制因子4E-BP1の欠損は、小胞体ストレスによる細胞障害を悪化させる2007

    • Author(s)
      山口賢, 石原寿光, 田村明, 山田高弘, 佐竹千尋, 薄井正寛, 冨永竜, 檜尾好徳, 荻原健英, 鈴木進, 片桐秀樹, 岡芳知
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] 膵β細胞における小胞体ストレスによる翻訳抑制因子4E-BP1発現誘導機構2007

    • Author(s)
      薄井正寛, 佐竹千尋, 石原寿光, 田村明, 山田高弘, 山口賢, 冨永竜, 宗像佑一郎, 檜尾好徳, 荻原健英, 鈴木進, 片桐秀樹, 岡芳知
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] 膵β細胞特異的小胞体ストレス応答の検討2007

    • Author(s)
      宗像佑一郎, 石原寿光, 田村明, 山田高弘, 山口賢, 佐竹千尋, 薄井正寛, 冨永竜, 檜尾好徳, 荻原健英, 鈴木進, 片桐秀樹, 岡芳知
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Translational Suppressor 4E-BP1 is a Critical Component of the ER Stress Response Involved in Component of the ER Stress Response Involved in Pancreatic b Cell Survival2007

    • Author(s)
      Hisamitsu Ishihara, Suguru Yamaguchi, Yoshitomo Oka
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] Methood For Enhancing Pancreatic Beta Cell Proliferation, Increasing Serum Insulin Concentration, Decreasing Blood Glucose Concentration And Treating And/Or Preventing Diabetes2008

    • Inventor(s)
      片桐秀樹, 岡芳知, 今井淳太
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-07-01
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] Methood For Enhancing Pancreatic Beta Cell Proliferation, Increasing Serum Insulin Concentration, Decreasing Blood Glucose Concentration And Treating And/Or Preventing Diabetes2008

    • Inventor(s)
      片桐秀樹、岡芳知、今井淳太
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-07-01
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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