| Project/Area Number |
19209038
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Keio University |
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Principal Investigator |
KUDOH Jun Keio University, 医学部, 教授 (80178003)
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| Co-Investigator(Kenkyū-buntansha) |
IKENO Masashi 慶應義塾大学, 医学部, 講師 (80298546)
SHIBUYA Kazunori 慶應義塾大学, 医学部, 助教 (90296723)
SAKAI Kosuke 慶應義塾大学, 医学部, 助教 (70245463)
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| Research Collaborator |
SHIMIZU Nobuyoshi 慶應義塾大学, 名誉教授
ASAKAWA Shuichi 東京大学, 農学部, 教授
OKAZAKI Tuneko 名古屋大学, 名誉教授
SUZUKI Nobutaka 慶應義塾大学, 医学部, 助教
MIYAMOTO Kenichi 慶應義塾大学, 医学部, 助教
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥49,400,000 (Direct Cost: ¥38,000,000、Indirect Cost: ¥11,400,000)
Fiscal Year 2009: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2008: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2007: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Keywords | ダウン症 / トリソミー21 / ヒト21番染色体 / 疾患モデルマウス / HAC / BAC / マウス16番染色体 / 顕微注入法 / マウス17番染色体 / マウス10番染色体 |
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| Research Abstract |
In this study, we attempted to produce novel Down syndrome model mice. We therefore took advantage of gene map of human chromosome 21 which we have brushed up over a decade, bacterial artificial chromosome (BAC) clones, and human artificial chromosome (HAC) which has been developed recently.
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