Research on production of a primate model for schizophrenia and development of transplant therapy by neural stem cell grafts

• Project/Area Number: 19209039
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: MORI Norio Hamamatsu University School of Medicine, 医学部, 教授 (00174376)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Kazuhiko 浜松医科大学, 医学部, 准教授 (80263911) ; KATAYAMA Taiichi 大阪大学, 連合小児発達学研究科, 教授 (80333459) ; INUBUSHI Toshiro 滋賀医科大学, MR医学総合研究センター, 教授 (20213142) ; TOOYAMA Ikuo 滋賀医科大学, 分子神経科学研究センター, 教授 (20207533) ; IWATA Yasuhide 浜松医科大学, 医学部附属病院, 講師 (10285025) ; SUZUKI Katsuaki 浜松医科大, 子どものこころの発達研究センター, 准教授 (00285040)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000); Fiscal Year 2009: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2008: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2007: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
• Keywords: 精神生理学 / 統合失調症 / 動物モデル / 神経幹細胞 / 神経画像 / 再生医療 / 総合失調症

Research Abstract

統合失調症の「神経幹細胞機能異常仮説」に基づき、サルの統合失調症モデルの作出と統合失調症に対する神経幹細胞脳内移植療法の開発を目的に、我々の開発したラットX線照射モデル脳内への神経幹細胞移植の効果を検討するとともに、頭部へのX線照射が成熟カニクイザルに及ぼす影響を検討した。その結果、X線照射モデルへ神経幹細胞を移植してもきわめて生着しにくいこと、サル脳へのX線照射は用量依存的に脳内組織幹細胞の分化を促すことが明らかになった。

Research Products

• [Journal Article] Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population. (2010)
  • Author(s): Kushima I, Aleksic B, Ito Y, Nakamura Y, Nakamura K, Mori N以下10名省略.
  • Journal Title: J Hum Genet 55(3) Pages: 133-6
  • NAID: 10030733833
  • Peer Reviewed
• [Journal Article] Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats: reversal by fluoxetine. (2010)
  • Author(s): Suzuki K, Okada K, Wakuda T, et. al.
  • Journal Title: PLoS One 5(2)
  • NAID: 120005314217
  • Peer Reviewed
• [Journal Article] Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. (2010)
  • Author(s): Maekawa M, Iwayama Y, Arai R, Nakamura K, et. al.
  • Journal Title: J Hum Genet 55(2) Pages: 127-30
  • NAID: 10030733813
  • Peer Reviewed
• [Journal Article] Brain serotonin and dopamine transporter bindings in adults with high-functioning autism. (2010)
  • Author(s): Nakamura K, Sekine Y, Ouchi Y, et. al.
  • Journal Title: Arch Gen Psychiatry 67(1) Pages: 59-68
  • Peer Reviewed
• [Journal Article] Serum levels of platelet derived growth factor BB homodimers are increased in male children with autism. (2010)
  • Author(s): Kajizuka M, Miyachi T, Matsuzaki H, Suzuki K, et. al.
  • Journal Title: Prog Neuropsycho pharmacol Biol Psychiatry 34(1) Pages: 154-8
  • Peer Reviewed
• [Journal Article] rain serotonin and dopamine transporter bindings in adults with high-functioning autism (2010)
  • Author(s): Nakamura K, Sekine Y, Ouchi Y, Tsujii M, Yoshikawa E, Futatsubashi M, Tsuchiya KJ, Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, Suda S, Sugiyama T, Takei N, Mori N.
  • Journal Title: Arch Gen Psychiatry 67(1) Pages: 59-68
  • Peer Reviewed
• [Journal Article] Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population (2010)
  • Author(s): Kushima I, Aleksic B, Ito Y, Nakamura Y, Nakamura K, Mori N, Kikuchi M, Inada T, Kunugi H, Nanko S, Kato T, Yoshikawa T, Ujike H, Suzuki M, Iwata N, Ozaki N.
  • Journal Title: J Hum Genet. 55(3) Pages: 133-136
  • NAID: 10030733833
  • Peer Reviewed
• [Journal Article] Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects (2010)
  • Author(s): Maekawa M, Iwayama Y, Arai R, Nakamura K, Ohnishi T, Toyota T, Tsujii M, Okazaki Y, Osumi N, Owada Y, Mori N, Yoshikawa T.
  • Journal Title: J Hum Genet. 55(2) Pages: 127-130
  • NAID: 10030733813
  • Peer Reviewed
• [Journal Article] Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats : reversal by fluoxetine (2010)
  • Author(s): Suzuki K, Okada K, Wakuda T, Shinmura C, Kameno Y, Iwata K, Takahashi T, Suda S, Matsuzaki H, Iwata Y, Hashimoto K, Mori N.
  • Journal Title: PLoS One 5(2)
  • NAID: 120005314217
  • Peer Reviewed
• [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism (2010)
  • Author(s): Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 34(1) Pages: 154-158
  • Peer Reviewed
• [Journal Article] A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient. (2009)
  • Author(s): Maekawa M, Iwayama Y, Nakamura K, et. al.
  • Journal Title: Neurosci Lett 462(3) Pages: 267-71
  • Peer Reviewed
• [Journal Article] An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis. (2009)
  • Author(s): Nakamura K, Sekine Y, Takei N, et. al.
  • Journal Title: Neurosci Lett 455(2) Pages: 120-3
  • Peer Reviewed
• [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population. (2009)
  • Author(s): Hattori E, (9名省略) Nakamura K, Iwata Y, Takei N, Mori N, et. al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet 150B(8) Pages: 1110-7
  • Peer Reviewed
• [Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder. (2009)
  • Author(s): Anitha A, Nakamura K, Yamada K, et. al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet 150B(7) Pages: 967-76
  • Peer Reviewed
• [Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using 19F magnetic resonance imaging. (2009)
  • Author(s): Amatsubo T, Morikawa S, Inubushi T, et. al.
  • Journal Title: Neurosci Res 63(1) Pages: 76-81
  • Peer Reviewed
• [Journal Article] Mitochondrial DNA haplogroup analysis in patients with bipolar disorder. (2009)
  • Author(s): Kazuno AA, (4名省略) Nakamura K, Mori N, et. al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet 150B(2) Pages: 243-7
  • Peer Reviewed
• [Journal Article] Assessment of Japanese stimulant control law offenders using the Addiction Severity Index --Japanese version : comparison with patients in treatment settings (2009)
  • Author(s): Watanabe T, Ogai Y, Koga T, Senoo E, Nakamura K, Mori N, Ikeda K.
  • Journal Title: Int J Environ Res Public Health 6(12) Pages: 3056-3069
  • Peer Reviewed
• [Journal Article] A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient (2009)
  • Author(s): Maekawa M, Iwayama Y, Nakamura K, Sato M, Toyota T, Ohnishi T, Yamada K, Miyachi T, Tsujii M, Hattori E, Maekawa N, Osumi N, Mori N, Yoshikawa T.
  • Journal Title: Neurosci Lett. 462(3) Pages: 267-271
  • Peer Reviewed
• [Journal Article] An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis (2009)
  • Author(s): Nakamura K, Sekine Y, Takei N, Iwata Y, Suzuki K, Anitha A, Inada T, Harano M, Komiyama T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Mori N.
  • Journal Title: Neurosci Lett. 455(2) Pages: 267-271
  • Peer Reviewed
• [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population (2009)
  • Author(s): Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, et al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. 150B(8) Pages: 1110-1117
  • Peer Reviewed
• [Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder (2009)
  • Author(s): Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. 150B(7) Pages: 967-976
  • Peer Reviewed
• [Journal Article] Mitochondrial DNA haplogroup analysis in patients with bipolar disorder (2009)
  • Author(s): Kazuno AA, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, Mori N, Yamada K, Yoshikawa T, Kato N, Kato T.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. 150B(2) Pages: 243-247
  • Peer Reviewed
• [Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging. (2009)
  • Author(s): Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I.
  • Journal Title: Neurosci Res 63 Pages: 76-81
  • Peer Reviewed
• [Journal Article] Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia. (2008)
  • Author(s): Yoshihara Y, (8名省略) Suzuki K, Sakahara H, Nakamura K, Mori N, Takei N.
  • Journal Title: Ann Gen Psychiatry 7 Pages: 25-25
  • NAID: 120005314220
  • Peer Reviewed
• [Journal Article] Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese meth-amphetamine abusers. (2008)
  • Author(s): Ezaki N, Nakamura K, Sekine Y, et. al.
  • Journal Title: Ann N Y Acad Sci 1139 Pages: 49-56
  • Peer Reviewed
• [Journal Article] Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood. (2008)
  • Author(s): Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, et. al.
  • Journal Title: PLoS One 3(11)
  • Peer Reviewed
• [Journal Article] Serum levels of P-selectin in men with high-functioning autism. (2008)
  • Author(s): Iwata Y, Tsuchiya KJ, Mikawa S, et. al.
  • Journal Title: Br J Psychiatry 193(4) Pages: 338-9
  • Peer Reviewed
• [Journal Article] Paternal age at birth and high functioning autistic spectrum disorder in (2008)
  • Author(s): Tsuchiya KJ, (3名省略) Nakamura K, et. al.
  • Journal Title: Br J Psychiatry 193(4) Pages: 316-21
  • Peer Reviewed
• [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism. (2008)
  • Author(s): Nakamura K, Anitha A, Yamada K, et. al.
  • Journal Title: Int J Neuropsycho pharmacol 11(8) Pages: 1073-84
  • Peer Reviewed
• [Journal Article] Distribution of natriuretic peptide receptor-C immunoreactivity in the rat brainstem and its relationship to cholinergic and catecholaminergic neurons. (2008)
  • Author(s): Abdelalim EM, (4名省略) Mori N, Tooyama I.
  • Journal Title: Neuroscience 155(1) Pages: 192-202
  • Peer Reviewed
• [Journal Article] Irradiation in adulthood as a new model of schizophrenia. (2008)
  • Author(s): Iwata Y, Suzuki K, Wakuda T, et. al.
  • Journal Title: PLoS One 3(5)
  • NAID: 120005313164
  • Peer Reviewed
• [Journal Article] Methamphetamine causes microglial activation in the brains of human abusers. (2008)
  • Author(s): Sekine Y, (4名省略) Nakamura K, Iwata Y, et. al.
  • Journal Title: J Neurosci 28(22) Pages: 5756-61
  • Peer Reviewed
• [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. (2008)
  • Author(s): Anitha A, Nakamura K, Yamada K, et. al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet 147B(7) Pages: 1019-27
  • Peer Reviewed
• [Journal Article] Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. (2008)
  • Author(s): Suzuki K, Nakamura K, Iwata Y, et. al.
  • Journal Title: Schizophr Res 98(1-3) Pages: 148-56
  • Peer Reviewed
• [Journal Article] Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder. (2008)
  • Author(s): Anitha A, Nakamura K, Yamada K, et. al.
  • Journal Title: Biol Psychiatry 63(7) Pages: 678-85
  • Peer Reviewed
• [Journal Article] 精神科領域疾患に対する脳深部刺激療法 (2008)
  • Author(s): 森則夫
  • Journal Title: 臨床評価 36(1) Pages: 55-59
• [Journal Article] MRIによる分子イメージングMRI分子プローブ (2008)
  • Author(s): 犬伏俊郎
  • Journal Title: 遺伝子医学MOOK 9 Pages: 88-93
• [Journal Article] 高次機能心の障害を科学する (2008)
  • Author(s): 遠山正彌, 森則夫
  • Journal Title: 脳21 11(1) Pages: 65-71
• [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. (2008)
  • Author(s): Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N, Yoshikawa T, Mori N.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet 147 Pages: 1019-27
  • Peer Reviewed
• [Journal Article] Irradiation in adulthood as a new model of schizophrenia. (2008)
  • Author(s): Iwata Y, Suzuki K, Wakuda T, Seki N, Thanseem I, Matsuzaki H, Mamiya T, Ueki T, Mikawa S, Sasaki T, Suda S, Yamamoto S, Tsuchiya KJ, Sugihara G, Nakamura K, Sato K, Takei N, Hashimoto K, Mori N.
  • Journal Title: PLoS ONE 3
  • NAID: 120005313164
  • Peer Reviewed
• [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism. (2008)
  • Author(s): Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota T, Suda S, Takei N, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya KJ, Sugihara G, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N.
  • Journal Title: Int J Neuropsychopharmacol 11 Pages: 1073-84
  • Peer Reviewed
• [Journal Article] Paternal age at birth and high-functioning autistic-spectrum disorder in offspring. (2008)
  • Author(s): Tsuchiya KJ, Matsumoto K, Miyachi T, Tsujii M, Nakamura K, Takagai S, Kawai M, Yagi A, Iwaki K, Suda S, Sugihara G, Iwata Y, Matsuzaki H, Sekine Y, Suzuki K, Sugiyama T, Mori N, Takei N.
  • Journal Title: Br J Psychiatry 193 Pages: 316-21
  • Peer Reviewed
• [Journal Article] Serum levels of P-selectin in men with high-functioning autism. (2008)
  • Author(s): Iwata Y, Tsuchiya KJ, Mikawa S, Nakamura K, Takai Y, Suda S, Sekine Y, Suzuki K, Kawai M, Sugihara G, Matsuzaki H, Hashimoto K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Br J Psychiatry 193 Pages: 338-9
  • Peer Reviewed
• [Journal Article] Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood. (2008)
  • Author(s): Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda S, Iwata K, Yamamoto S, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takei N, Mori N.
  • Journal Title: PLoS ONE 3
  • Peer Reviewed
• [Journal Article] Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers. (2008)
  • Author(s): Ezaki N, Nakamura K, Sekine Y, Thanseem I, Anitha A, Iwata Y, Kawai M, Takebayashi K, Suzuki K, Takei N, Iyo M, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N.
  • Journal Title: Ann N Y Acad Sci 1139 Pages: 49-56
  • Peer Reviewed
• [Journal Article] Correlation between high field MR images and histopathological findings of rat transplanted cancer immediately after partial microwave coagulation (2008)
  • Author(s): Murakami K, Morikawa S, Naka S, Demura K, Sato K, Shiomi H, Kurumi Y, Inubushi T, Tani T.
  • Journal Title: Magn Reson Med Sci 7 Pages: 105-12
  • NAID: 10024835746
  • Peer Reviewed
• [Journal Article] Maturational changes in diffusion anisotropy in the rat corpus callosum : comparison with quantitative histological evaluation. (2008)
  • Author(s): Jito J, Nakasu S, Ito R, Fukami T, Morikawa S, Inubushi T.
  • Journal Title: J Magn Reson Imaging 28 Pages: 847-54
  • Peer Reviewed
• [Journal Article] Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization (2008)
  • Author(s): Kubota K, Kumamoto N, Matsuzaki S. Hashimoto R, Hattori T, Okuda H, Takam H, Taked M, Katayama T, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun 379 Pages: 191-5
  • Peer Reviewed
• [Journal Article] Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptoralpha. (2008)
  • Author(s): Tachibana K, Anzai N, Ueda C, Katayama T, Yamasaki D, Kirino T, Takahashi R, Ishimoto K, Komori H, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J. Kodama T, Doi T.
  • Journal Title: FEBS Lett 582 Pages: 3884-8
  • Peer Reviewed
• [Journal Article] Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients (2008)
  • Author(s): Suzuki K, Nakamura K, Iwata Y, Sekine Y, Kawai M, Sugihara G, Tsuchiya KJ, Suda S, Matsuzaki H, Takei N, Hashimoto K, Mori N.
  • Journal Title: Schizophrenia Research 98(1-3) Pages: 148-56
  • Peer Reviewed
• [Journal Article] Gene and expression analyses reveal enhanced expression of pericentrin 2(PCNT2) in bipolar disorder (2008)
  • Author(s): Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Tohyama M, Yoshikawa T, Mori N.
  • Journal Title: Biol Psychiatry 63(7) Pages: 678-85
  • Peer Reviewed
• [Journal Article] Genetic analyses of Roundabout(ROBO) axon guidance receptors in autism (2008)
  • Author(s): Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara GI, Ouchi Y, Sugiyama T, Takei N, Koizumi K, Higashida H, Yoshikawa T, Mori N.
  • Journal Title: American Journal of Medical Genetics(B) 98(1-3) Pages: 148-56
  • Peer Reviewed
• [Journal Article] 【21世紀の脳科学をみすえて】高次機能心の障害を科学する (2008)
  • Author(s): 遠山 正彌, 森 則夫
  • Journal Title: 脳21 11巻1号 Pages: 65-71
• [Journal Article] 【ますます広がる分子イメージング技術】技術編MRIによる分子イメージングMRI分子プローブ (2008)
  • Author(s): 太伏 俊郎
  • Journal Title: 遺伝子医学MOOK 9巻 Pages: 88-93
• [Journal Article] Fluorine-19 fast recovery fast spin echo imaging for mapping 5-fluorouracil. (2007)
  • Author(s): Morikawa S, Inubushi T, Morita M, et. al.
  • Journal Title: Magn Reson Med Sci 6(4) Pages: 235-40
  • NAID: 10020158662
  • Peer Reviewed
• [Journal Article] Association analysis of HSP90B1 with bipolar disorder. (2007)
  • Author(s): Kakiuchi C, (4名省略) Nakamura K, Mori N, et. al.
  • Journal Title: J Hum Genet 52(10) Pages: 794-803
  • NAID: 10019776191
  • Peer Reviewed
• [Journal Article] SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism. (2007)
  • Author(s): Toyoda T, Nakamura K, Yamada K, et. al.
  • Journal Title: Biochem Biophys Res Commun 360(4) Pages: 715-20
  • Peer Reviewed
• [Journal Article] Disruption of reelin signaling attenuates methamphetamine induced hyperlocomotion. (2007)
  • Author(s): Matsuzaki H, Minabe Y, Nakamura K, Suzuki K, Iwata Y, et. al.
  • Journal Title: Eur J Neurosci 25(11) Pages: 3376-84
  • Peer Reviewed
• [Journal Article] Decreased serum levels of platelet endothelial adhesion molecule (PECAM-1) in subjects with high-functioning autism: a negative correlation with head circumference at birth. (2007)
  • Author(s): Tsuchiya KJ, Hashimoto K, Iwata Y, et. al.
  • Journal Title: Biol Psychiatry 62(9) Pages: 1056-8
  • Peer Reviewed
• [Journal Article] Autisticlike phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. (2007)
  • Author(s): Sadakata T, (9名省略) Nakamura K, Iwata Y, Tsuchiya KJ, Mori N, et. al.
  • Journal Title: J Clin Invest 117(4) Pages: 931-43
  • Peer Reviewed
• [Journal Article] Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism. (2007)
  • Author(s): Nishimura K, Nakamura K, Anitha A, et. al.
  • Journal Title: Biochem Biophys Res Commun 356(1) Pages: 200-6
  • Peer Reviewed
• [Journal Article] Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder. (2007)
  • Author(s): Kakiuchi C, (4名省略) Nakamura K, Mori N, et. al.
  • Journal Title: Neurosci Lett 417(3) Pages: 316-21
  • Peer Reviewed
• [Journal Article] Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism. (2007)
  • Author(s): Sugihara G, Hashimoto K, Iwata Y, Nakamura K, et. al.
  • Journal Title: Prog Neuropsycho pharmacol Biol Psychiatry 31(2) Pages: 412-5
  • Peer Reviewed
• [Journal Article] Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism. (2007)
  • Author(s): Suzuki K, Hashimoto K, Iwata Y, Nakamura K, et. al.
  • Journal Title: Biol Psychiatry 62(3) Pages: 267-9
  • Peer Reviewed
• [Journal Article] ミクログリア研究の新しい展開アルツハイマー病の細胞治療法の可能性. (2007)
  • Author(s): 遠山育夫.
  • Journal Title: Dementia Japan 21(3) Pages: 261-269
• [Journal Article] 統合失調症と神経幹細胞. (2007)
  • Author(s): 松崎秀夫, 岩田泰秀, 鈴木勝昭, 森則夫
  • Journal Title: 分子精神医学 7(2) Pages: 105-110
• [Journal Article] 細胞のトラッキング (2007)
  • Author(s): 犬伏俊郎
  • Journal Title: 映像情報Medical 39(4) Pages: 380-384
• [Journal Article] Disrution of reelin signaling attenuates methamphetamine-induced hyperlocomotion (2007)
  • Author(s): Matsuzaki H, Minabe Y, Nakamura K, Suzuki K, Iwata Y, Sekine Y, Tsuchiya KJ, Sugihara G, Suda S, Takei N, Nakahara D, Hashimoto K, Nairn AC, Mori N, Sato K.
  • Journal Title: European Journal of Neuroscience 25(11) Pages: 3376-84
  • Peer Reviewed
• [Journal Article] Decreased serum levels of epidermal growth factor inadult subjects with high-functioning autism (2007)
  • Author(s): Suzuki K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N.
  • Journal Title: Biological Psychiatry 62(3) Pages: 267-269
  • Peer Reviewed
• [Journal Article] Fluorine-19 fast recovery fast spin echo imaging for mapping 5-fluorouracil (2007)
  • Author(s): Morikawa S, Inubushi T, Morita M, Murakami K, Masuda C, Maki J, Tooyama I.
  • Journal Title: Magnetic Resonance Medical Science 6(4) Pages: 235-40
  • NAID: 10020158662
  • Peer Reviewed
• [Journal Article] SNP analyses of growth factor genes EGF,TGFbeta-1,and HGF reveal haplotypic association of EGF with autism (2007)
  • Author(s): Toyoda T, Nakamura K, Yamada K, Thanseem I, Anitha A, Suda S, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Takei N, Yoshikawa T, Mori N.
  • Journal Title: Biochem Biophys Res Commun 360(4) Pages: 715-20
  • Peer Reviewed
• [Journal Article] Decreased serum levels of platelet-endothelial adhesion molecule (PECAM-1) in subjects with high-functioning autism: a negative correlation with head circumference at birth (2007)
  • Author(s): Tsuchiya KJ, Hashimoto K, Iwata Y, Tsujii M, Sekine Y, Sugihara G, Matsuzaki H, Suda S, Kawai M, Minabe Y, Nakamura K, Yagi A, Iyo M, Takei N, Mori N.
  • Journal Title: Biological Psychiatry 62(9) Pages: 1056-8
  • Peer Reviewed
• [Journal Article] Genetic analyses of the brain-derived neurotrophic factor(BDNF)gene in autism (2007)
  • Author(s): Nishimura K, Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota T, Takei N, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Suda S, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N.
  • Journal Title: Biochem Biophys Res Common 356(1) Pages: 200-6
  • Peer Reviewed
• [Journal Article] 【神経幹細胞から何がわかるか】統合失調症と神経幹細胞 (2007)
  • Author(s): 松崎 秀夫, 岩田 泰秀, 鈴木 勝昭, 森 則夫
  • Journal Title: 分子精神医学 7巻2号 Pages: 105-110
• [Journal Article] 動物モデルを使った高磁場MRIによる認知症診断の可能性.
  • Author(s): 遠山育夫, 田口弘康, 雨坪知音, 森川茂廣
  • Journal Title: Cognition and Dementia 8(2) Pages: 121-125
• [Presentation] Dyslipidemia in male patients with high-functioning autism (2009)
  • Author(s): Matsuzaki H, Iwata K, Suda S, Miyachi T, Suzuki K, Nakamura K, Tsujii M, Takei N, Mori N.
  • Organizer: Society for Neuroscience 39th Annual Meeting
  • Place of Presentation: シカゴ (米国)
  • Year and Date: 2009-10-19
• [Presentation] Serotonin related gene expression changes in subjects with autism : A postmortem brain study (2009)
  • Author(s): Suda S, Iwata K, Anitha A, Thanseem I, Matsuzaki H, Kameno Y, Nakamura K, Mori N, Takei N.
  • Organizer: Society for Neuroscience 39th Annual Meeting
  • Place of Presentation: シカゴ (米国)
  • Year and Date: 2009-10-19
• [Presentation] Relationship between muscarinic receptor occupancy by scopolamine and cognitive impairment: A PET study with [11C]3-MPB in conscious monkeys. (2009)
  • Author(s): Yamamoto S, (4名省略) Mori N, Tsukada H.
  • Organizer: Society for Neuroscience 39th Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-18
• [Presentation] Dyslipidemia in male patients with highfunctioning autism. (2009)
  • Author(s): Matsuzaki H, (3名省略) Suzuki K, Nakamura K, Tsujii M, Takei N, Mori N.
  • Organizer: Society for Neuroscience 39th Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-18
• [Presentation] Tsujii M, Takei N, Mori N. Dyslipidemia in male patients with highfunctioning autism. (2009)
  • Author(s): Suda S, (5名省略) Nakamura K, Mori N, Takei N.
  • Organizer: Society for Neuroscience 39th Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-18
• [Presentation] Relationship between muscarinic receptor occupancy by scopolamine and cognitive impairment : A PET study with [<11>^C]3-MPB in conscious monkeys (2009)
  • Author(s): Yamamoto S, Kawamata M, Nishiyama S, Wakuda T, Takei N, Mori N, Tsukada H.
  • Organizer: Society for Neuroscience 39th Annual Meeting
  • Place of Presentation: シカゴ (米国)
  • Year and Date: 2009-10-18
• [Presentation] 広汎性発達障害者における血清アディポネクチン濃度の低下 (2009)
  • Author(s): 藤田梓, 松崎秀夫, 鈴木勝昭, 宮地泰士, 辻井正次, 中村和彦, 森則夫
  • Organizer: 日本児童青年精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-01
• [Presentation] PARSとADI-Rの試みについて (2009)
  • Author(s): 加茂麻優子, 中村和彦, 辻井正次, 宮地泰士, 土屋賢治, 鈴木勝昭, 森則夫
  • Organizer: 日本児童青年精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-01
• [Presentation] 自閉症者血清中の血管内皮増殖因子および血小板由来増殖因子濃度の変化 (2009)
  • Author(s): 梶塚正誠, 松崎秀夫, 宮地泰士, 鈴木勝昭, 中村和彦, 辻井正次, 森則夫
  • Organizer: 日本児童青年精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-01
• [Presentation] 成人自閉症者における脳内コリン系機能-PETによる検討. (2008)
  • Author(s): 鈴木勝昭, 杉原玄一, 吉原雄二郎, 横倉正倫, 中村和彦, 尾内康臣, 武井教使, 亀野陽亮, 森則夫
  • Organizer: 日本脳科学会第35回総会
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-06-13
• [Presentation] Reelin signalに着目した自閉症メカニズム解明の試み. (2008)
  • Author(s): 松崎秀夫, 岩田圭子, 竹林淳和, 杉原玄一, 鈴木勝昭, 中村和彦, 河合正好, 辻井正次, 武井教使, 森則夫
  • Organizer: 日本脳科学会第35回総会
  • Place of Presentation: 東京都新宿
  • Year and Date: 2008-06-13
• [Presentation] 成人自閉症者における脳内コリン系機能〜PETによる検討〜 (2008)
  • Author(s): 鈴木勝昭, 杉原玄一, 吉原雄二郎, 横倉正倫, 中村和彦, 尾内康臣, 武井教使, 亀野陽亮, 森則夫
  • Organizer: 日本脳科学会第35回総会
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-06-13
• [Presentation] Reelin signal に着目した自閉症メカニズム解明の試み (2008)
  • Author(s): 松崎秀夫, 岩田圭子, 竹林淳和, 杉原玄一, 鈴木勝昭, 中村和彦, 河合正好, 辻井正次, 武井教使, 森則夫
  • Organizer: 日本脳科学会第35回総会
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-06-13
• [Presentation] Genetic analysis of serotonergic factors in autism. (2008)
  • Author(s): K. Nakamura, A. Ayyappan, K. Yamada, S. Suda, M. Tsujii, Y. Iwayama, T. Miyachi, H. Matsuzaki, K. J. Tsuchiya, G. Sugihara, K. Suzuki, T. Sugiyama, N. Takei, T. Yoshiwaka, N. Mori
  • Organizer: 7^<th> Annual International Meeting For Autism Research
  • Place of Presentation: 英国, London
  • Year and Date: 2008-05-16
• [Presentation] Decreased serum levels of growth factors in male adults with high- functioning autism. (2008)
  • Author(s): Matsuzaki H, Iwata Y, Tsuchiya KJ, et. al.
  • Organizer: 7th Annual International Meeting For Autism Research
  • Place of Presentation: London, UK
  • Year and Date: 2008-05-15
• [Presentation] Genetic analysis of serotonergic factors in autism. (2008)
  • Author(s): Nakamura K, Anitha A, Yamada K, et. al.
  • Organizer: 7th Annual International Meeting For Autism Research
  • Place of Presentation: London, UK
  • Year and Date: 2008-05-15
• [Presentation] Decreased serum levels of growth factors in male adults with high-functioning autism. (2008)
  • Author(s): H. Matsuzaki, Y. Iwata, K. J. Tsuchiya, G., Sugihara, S. Suda, K. Suzuki, K. Miyachi, K. Matsumoto, K. Nakamura, M. Kawai, M. Tsujii, T. Sugiyama, N. Takei, N. Mori
  • Organizer: 7^<th> Annual International Meeting For Autism Research
  • Place of Presentation: 英国, London
  • Year and Date: 2008-05-15
• [Presentation] 脳内神経再生の修飾による統合失調症の新しい治療法開発の試み. (2007)
  • Author(s): 松崎秀夫, 和久田智靖, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
  • Organizer: 日本脳科学会第34回総会
  • Place of Presentation: 島根県出雲市
  • Year and Date: 2007-06-08
• [Presentation] 統合失調症病態モデルとしての子宮内仮死経験ラットの検討. (2007)
  • Author(s): 和久田智靖, 松崎秀夫, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
  • Organizer: 日本脳科学会第34回総会
  • Place of Presentation: 島根県出雲市
  • Year and Date: 2007-06-08
• [Presentation] 自閉症患者における血清トランスフォーミング増殖因子β1濃度の低下. (2007)
  • Author(s): 岡田京子, 橋本謙二, 岩田泰秀, ほか
  • Organizer: 日本脳科学会第34回総会
  • Place of Presentation: 島根県出雲市
  • Year and Date: 2007-06-08
• [Presentation] 成人自閉症患者における血清グルタミン酸レベルの増加. (2007)
  • Author(s): 四戸敦子, 橋本謙二, 中村和彦, ほか
  • Organizer: 日本脳科学会第34回総会
  • Place of Presentation: 島根県出雲市
  • Year and Date: 2007-06-08
• [Presentation] アルツハイマー病の細胞治療法とMR画像法による投与細胞のin vivo追跡法. (2007)
  • Author(s): 遠山育夫
  • Organizer: 日本脳科学会第34回総会
  • Place of Presentation: 島根県出雲市
  • Year and Date: 2007-06-08
• [Presentation] 脳内神経再生の修飾による統合失調症の新しい治療法開発の試み (2007)
  • Author(s): 松崎 秀夫, 和久田 智靖, 土手 基慶, 岩田 泰秀, 鈴木 勝昭, 遠山 正彌, 森 則夫
  • Organizer: 日本脳科学会第34回総会
  • Place of Presentation: 島根県出雲市
  • Year and Date: 2007-06-08
• [Presentation] 統合失調症病態モデルとしての子宮内仮死経験ラットの検討 (2007)
  • Author(s): 和久田 智靖, 松崎 秀夫, 土手 基慶, 岩田 泰秀, 鈴木 勝昭, 遠山 正彌, 森 則夫
  • Organizer: 日本脳科学会第34回総会
  • Place of Presentation: 島根県出雲市
  • Year and Date: 2007-06-08
• [Presentation] 自閉症患者における血清トランスフォーミング増殖因子β1濃度の低下 (2007)
  • Author(s): 岡田 京子, 橋本 謙二, 岩田 泰秀, 和久田 智靖, 土手 慶義, 横倉 正, 土屋 賢治, 中村 和彦, 武井 教使, 辻井 正次, 杉山 登志郎, 森 則夫
  • Organizer: 日本脳科学会第34回総会
  • Place of Presentation: 島根県出雲市
  • Year and Date: 2007-06-08
• [Presentation] 成人自閉症患者における血清グルタミン酸レベルの増加 (2007)
  • Author(s): 四戸 敦子, 橋本 謙二, 中村 和彦, 辻井 正次, 岩田 泰秀, 松崎 秀夫, 杉山 登志郎, 伊豫 雅臣, 武井 教使, 森 則夫
  • Organizer: 日本脳科学会第34回総会
  • Place of Presentation: 島根県出雲市
  • Year and Date: 2007-06-08
• [Remarks]
  • URL: http://www2.hama-med.ac.jp/w1b/psy/research/index.html