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Whole genome association study of functional psychoses

Research Project

Project/Area Number 19209040
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

YOSHIKAWA Takeo  The Institute of Physical and Chemical Research, 分子精神科学研究チーム, チームリーダー (30249958)

Co-Investigator(Kenkyū-buntansha) YAMADA Kazuo  独立行政法人理化学研究所, 分子精神科学研究チーム, 副チームリーダー (10322695)
HATTORI Eiji  独立行政法人理化学研究所, 分子精神科学研究チーム, 研究員 (80399443)
TOYOTA Tomoko  独立行政法人理化学研究所, 分子精神科学研究チーム, 研究員 (20392045)
IWAYAMA Yoshimi  独立行政法人理化学研究所, 分子精神科学研究チーム, リサーチアソシエイト (60399441)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2009: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2008: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2007: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Keywordsゲノムワイド関連解析 / 統合失調症 / 躁うつ病 / アフィメトリックス100K SNPチップ / 階層化 / 主成分分析 / GABA / Affymetrix 100K SNPチップ / Principal Component Analysis / Affymetrix 100K SNP チップ / 全ゲノム関連解析 / イルミナビーズアレイ
Research Abstract

We performed whole genome association study of schizophrenia and bipolar disorder. For schizophrenia, we examined 100K SNPs (single nucleotide polymorphisms) using trio samples in the first stage, and in the second stage we used case-control samples. In the final stage, we examined Chinese quad samples. It is of note that in Japanese population, multiple GABAergic genes showed association with schizophrenia. For bipolar disorder, we examined 100K SNPs using case-control samples. We have published the data and made it open to public via an in house server.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Remarks (4 results)

  • [Journal Article] 統合失調症のミエリン仮説と軸索阻害因子についての考察.2010

    • Author(s)
      治徳大介、吉川武男
    • Journal Title

      鳥取臨床科学研究会誌 Vol.2,No.1

      Pages: 114-120

    • NAID

      40017084972

    • Related Report
      2009 Final Research Report
  • [Journal Article] 統合失調症の疾患脆弱性遺伝子およびシグナルパスウェイについての研究.2010

    • Author(s)
      山田和男
    • Journal Title

      神経化学 Vol.49(No.1)

      Pages: 11-24

    • NAID

      10026416367

    • Related Report
      2009 Final Research Report
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population.2009

    • Author(s)
      Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T
    • Journal Title

      Neuropsychiatr Gene 150B

      Pages: 1100-1117

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 精神疾患ゲノム研究「はじめに」.2009

    • Author(s)
      吉川武男
    • Journal Title

      医学のあゆみ Vol.229,No.3

      Pages: 175-175

    • Related Report
      2009 Final Research Report
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population2009

    • Author(s)
      Hattori E, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 150B(8)

      Pages: 1100-1117

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神疾患ゲノム研究「はじめに」2009

    • Author(s)
      吉川武男
    • Journal Title

      医学のあゆみ No.3

      Pages: 175-175

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 統合失調症のミエリン仮説と軸索阻害因子についての考察2009

    • Author(s)
      治徳大介
    • Journal Title

      鳥取臨床科学研究会誌 (in press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 統合失調症の疾患脆弱性遺伝子およびシグナルパスウェイについての研究2009

    • Author(s)
      山田和男
    • Journal Title

      神経化学 (in press)

    • NAID

      10026416367

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Preliminary Genome-wide Association Study of Bipolar Disorder in the Japanese Population

    • Author(s)
      Hattori E
    • Journal Title

      Neuropsychiatric Genetics (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 統合失調症グルタミン酸系の遺伝基盤と治療への応用2009

    • Author(s)
      吉川武男
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会シンポジウム「統合失調症グルタミン酸系治療薬の臨床開発と基礎研究」
    • Place of Presentation
      京都
    • Year and Date
      2009-11-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 統合失調症グルタミン酸系の遺伝基盤と治療への応用2009

    • Author(s)
      吉川武男
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学シンポジウム「統合失調症グルタミン酸系治療薬の臨床開発と基礎研究」
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetics of Bipolar disorder2008

    • Author(s)
      Eiji Hattori
    • Organizer
      2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetics of Bipolar disorder2008

    • Author(s)
      服部栄治
    • Organizer
      2^<nd> WFSBP Asia-Pacific Congress and 30^<th> Annual Meeting of JSBP
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.riken.jp/r-world/research/lab/nokagaku/age/molecular/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks] 双極性障害のゲノムワイドスキャンデーター

    • URL

      http://molpsych.brain.riken.jp/data.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://molpsych.brain.riken.jp/data.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://molpsych.brain.riken.jp/jgimd_wgas.zip

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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