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Synthetic strategy for clinical application of personalized medicinefor gastrointestinal cancers

Research Project

Project/Area Number 19209042
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

MONDEN Morito  Osaka University, 医学系研究科, 教授 (00127309)

Co-Investigator(Kenkyū-buntansha) SEKIMOTO Mitugu  大阪大学, 医学系研究科, 准教授 (10273658)
DOKI Yuichiro  大阪大学, 医学系研究科, 教授 (20291445)
TAKEMASA Ichiro  大阪大学, 医学系研究科, 教授 (50379252)
NISHIMURA Osamu  大阪大学, 蛋白質研究所, 特任教授 (10374125)
DONO Keizo  大阪大学, 医学系研究科, 講師 (60283769)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2008: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2007: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Keywords消化器がん / 個別医療 / DNAチップ / プロテオミクス / 臨床応用 / バイオマーカー / 大規模症例登録 / 分子診断 / 個別化医療 / 基盤整備
Research Abstract

本研究は、臨床試験と分子生物学的情報解析のスパイラル的発展を主軸とし、大規模消化器癌症例を対象に、癌組織の遺伝子・タンパク発現プロファイルとネットワーク解析により、癌の転移・再発、治療応答性の予測診断やバイオマーカーを探索し、個別医療として数年のうちに臨床応用化を実現することを目的とした。本研究により、癌の分子メカニズムの総合的理解が進み、画一的な治療を脱却し患者に過不足の少ない最適な医療を提供することが期待される。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (42 results)

All 2008 2007 Other

All Journal Article (22 results) (of which Peer Reviewed: 13 results) Presentation (20 results)

  • [Journal Article] Gene expression of colorectal cancer : Preoperative genetic diagnosis using endoscopic biopsies2008

    • Author(s)
      Komori T.,Takemasa I., Yamasaki M., Motoori M., Kato T., Kikkawa N., Kawaguchi N., Ikeda M., Yamamoto H., Sekimoto M., Matsubara K., Matsuura N., Monden M.
    • Journal Title

      Int J Oncol 32(2)

      Pages: 367-375

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic data.2008

    • Author(s)
      Kittaka N.,Takemasa I., Takeda Y., Marubashi S., Nagano H., Umeshita K., Dono K., Matsubara K., Matsuura N., Monden M.
    • Journal Title

      Eur J Cancer 44

      Pages: 885-897

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changing Society, Evolving Surgery2008

    • Author(s)
      Monden M.
    • Journal Title

      Surgery Today. : 3 8

      Pages: 195-205

    • NAID

      10021283990

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis.2008

    • Author(s)
      Takeno A.,Takemasa I., Doki Y., Yamasaki M., Miyata H., Takiguchi S., Fujiwara Y., Matsubara K., Monden M.
    • Journal Title

      Br J Cancer 21(99)

      Pages: 1307-1315

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma : A novel approach for biomarker discovery.2008

    • Author(s)
      Watanabe M.,Takemasa I., Kawaguchi N., Miyake M., Nishimura N., Matsubara T., Matsuo E., Sekimoto M., Nagai K., Matsuura N., Monden M., Nishimura O.
    • Journal Title

      Proteomics Clin Appl.

      Pages: 925-935

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 転移因子を標的とした肝転移の治療戦略2008

    • Author(s)
      山本浩文、竹政伊知朗、池田正孝、関本貢嗣、門田守人
    • Journal Title

      癌の臨床 54(3)

      Pages: 169-174

    • Related Report
      2008 Final Research Report
  • [Journal Article] 大腸癌の個別化医療に向けて2008

    • Author(s)
      竹政伊知朗、池田正孝、山本浩文、関本貢嗣、森正樹、門田守人
    • Journal Title

      Frontiers in Gastroenterology 13(3)

      Pages: 224-231

    • Related Report
      2008 Final Research Report
  • [Journal Article] 腹膜播種-予測診断-日本臨床2008

    • Author(s)
      竹野淳、竹政伊知郎、土岐祐一郎、藤原義之、門田守人
    • Journal Title

      66(5)

      Pages: 581-585

    • Related Report
      2008 Final Research Report
  • [Journal Article] Gene expression of colorectal cancer : Preoperative genetic diagnosis using endoscopic biopsies.2008

    • Author(s)
      Komori T., Takemasa I., Yamasaki M., Motoori M., Kato T, Kikkawa N., Kawaguchi N., Ikeda M., Yamamoto H., Sekimoto M., Matsubara K., Matsuura N., Monden M.
    • Journal Title

      Int J Oncol 32(2)

      Pages: 367-375

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic data2008

    • Author(s)
      Kittaka N., Takemasa I., Takeda Y., Marubashi S., Nagano H., Umeshita K., Dono K., Matsubara K., Matsuura N., Monden M.
    • Journal Title

      Eur J Cancer 44

      Pages: 885-897

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changing Society, Evolving Surgery2008

    • Author(s)
      Monden M.
    • Journal Title

      Surgery Today 38

      Pages: 195-205

    • NAID

      10021283990

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis.2008

    • Author(s)
      Takeno A., Takemasa I., Doki Y., Yamasaki M., Miyata H., Takiguchi S., Fujiwara Y., Matsubara K., Monden M.
    • Journal Title

      Br J Cancer 21(99)

      Pages: 1307-1315

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma : A novel approach for biomarker discovery.2008

    • Author(s)
      Watanabe M., Takemasa I., Kawaguchi N., Miyake M., Nishimura N., Matsubara T., Matsuo E., Sekimoto M., Nagai K., Matsuura N., Monden M., Nishimura O.
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 925-935

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 転移因子を標的とした肝転移の治療戦略2008

    • Author(s)
      山本浩文, 竹政伊知朗, 池田正孝, 関本貢嗣, 門田守人
    • Journal Title

      Biotherapy 22(2)

      Pages: 96-104

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 大腸癌の個別化医療に向けて2008

    • Author(s)
      竹政伊知朗, 池田正孝, 山本浩文, 関本貢嗣, 森正樹, 門田守人
    • Journal Title

      Frontiers in Gastroenterology 13(3)

      Pages: 224-231

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 腹膜播種-予測診断-2008

    • Author(s)
      竹野淳, 竹政伊知郎, 土岐祐一郎, 藤原義之, 門田守人
    • Journal Title

      日本臨床 66(5)

      Pages: 581-585

    • Related Report
      2008 Annual Research Report
  • [Journal Article] An Application of the 2-Nitrobenzenesulfenyl(NBS) Method to Proteomic Profiling of Human Colorectal Carcinoma: A Novel Approach for Biomarker Discovery2008

    • Author(s)
      Watanabe M., Takemasa I. Kawaguchi N., Miyake M., Nishimura N., Matsubara T., Matsuo E., Sekimoto M., Nagai K., Matsuura N., Monden., Nishimura O.
    • Journal Title

      PROTEOMICS-Clinical Applications (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic date2008

    • Author(s)
      Kittaka N., Takemasa I., Takeda Y., Marubashi S., Nagano H., Umeshita K., Dono K., Matsubara K., Matsuura N., Monden M.
    • Journal Title

      European Journal of Cancer (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression of colorectal cancer: preoperative genetic diagnosis using endoscopic biopsies.2008

    • Author(s)
      Komori T, Takemasa I, Yamasaki M, Motoori M, Kato T, Kikkawa N, Kawaguchi N, Ikeda M, Yamamoto H, Sekimoto M, Matsubara K, Matsuura N, Monden M.
    • Journal Title

      Int J Oncol. 32(2)

      Pages: 367-75

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大腸癌術前3DPET-CT検査の有用性、方法、および画像解析法2007

    • Author(s)
      竹政伊知朗、岩本康男、濱田星紀、橋本博美、梅原宜之、藤井洋平、堀次元気、桃井理紗
    • Journal Title

      GE Today 23

      Pages: 37-42

    • Related Report
      2008 Final Research Report
  • [Journal Article] 大腸癌術前3D PET-CT検査の有用性、方法、および画像解析法2007

    • Author(s)
      竹政伊知朗、岩本康男、濱田星紀、橋本博美、梅原宜之、藤井洋平、堀次元気、桃井理紗
    • Journal Title

      GE Today 23

      Pages: 37-42

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 遺伝子発現プロファイルによる消化器癌転移推測の可能性を探る

    • Author(s)
      竹政伊知朗、池田正孝、山本浩文、関本貢嗣、門田守人
    • Journal Title

      分子消化器病 4(1)

      Pages: 35-40

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Prediction of response to neoadujvant chemotherapy in ESCC(esophageal squamous cell carcinoma) using endoscopic biopsies.2008

    • Author(s)
      Takeno A.,Motoori M., Takemasa I., Doki Y., Yamasaki M., Miyata H., Takiguchi S., Fujiwara Y., Matsubara K., Monden M.
    • Organizer
      11th world congress of the international society for diseases of the esophagus
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene Identification of Acute Cellular Rejection in Recipients with Recurrent Hepatitis C after Liver Transplantation.2008

    • Author(s)
      Asaoka T.,Marubashi S., Dono K., Hama N., Takahashi H., Kobayashi S., Takeda Y., Takemasa I., Nagano H., Umeshita K., Ruiz P., Matsubara K., Monden M., Doki Y., Mori M.
    • Organizer
      The Transplantation Society
    • Place of Presentation
      Sydney
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene Identification of Acute Cellular Rejection in Recipients with Recurrent. : Hepatitis C after Liver Transplantation.2008

    • Author(s)
      Asaoka T.,Marubashi S., Dono K., Hama N., Takahashi H., Kobayashi S., Takeda Y., Takemasa I., Nagano H., Umeshita K., Kato T., Ruiz P., Andreas GT., Monden M.
    • Organizer
      The 2008 Joint International Congress of ILTS, ELITA & LICAGE
    • Place of Presentation
      Paris
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular mapping of human hepatocellular carcinoma to gain deeper biological insights from genomic deta2008

    • Author(s)
      橘高信義、竹政伊知郎、武田裕、丸橋繁、永野浩昭、梅下浩司、堂野恵三、松原謙一、松浦成昭、門田守人、森正樹、土岐祐一郎
    • Organizer
      第67回日本癌学会学術総
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 胃癌原発巣の遺伝子発現プロファイルから見た転移再発形式の特徴とチロシンキナーゼの関連について2008

    • Author(s)
      竹野淳、土岐祐一郎、竹政伊知朗、山崎誠、宮田博志、瀧口修司、藤原義之、門田守人
    • Organizer
      第17回日本がん転移学会総会
    • Place of Presentation
      鹿児島
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] クリプトーム解析診断による肝細胞癌切除後早期再発予測2008

    • Author(s)
      村上昌裕、永野浩昭、竹政伊知朗、野田剛広、吉岡慎一、小林省吾、丸橋繁、武田裕、堂野恵三、梅下浩司、松原謙一、門田守人
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] NBS法による大腸癌組織を用いた新規転移関連蛋白の検討2008

    • Author(s)
      徳岡優佳、竹政伊知朗、渡辺真、三宅正和、人羅俊貴、野村昌哉、池田正孝、山本浩文、 関本貢嗣、西村紀、門田守人
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 大腸癌網羅的遺伝子解析を用いた新規マーカーを探索 : 高発現遺伝子とタンパク発現との比較2008

    • Author(s)
      徳岡優佳、三宅正和、竹政伊知朗、池田正孝、山本浩文、関本貢嗣、松原謙一、門田守人
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 臨床型custon-made microarrayを用いた大腸癌異時性再発予測に関する検討2008

    • Author(s)
      橘高信義、竹政伊知朗、三宅正和、竹野淳、池田正孝、山本浩文、関本貢嗣、松原謙一、門田守人
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 網羅的遺伝子発現解析に基づく胃癌根治切除後異時性腹膜播種の予測診断と臨床応用への可能性2008

    • Author(s)
      竹野淳、竹政伊知朗、土岐祐一郎、山崎誠、木村豊、三木宏文、高地耕、藤谷和正、今村博司、本告正明、藤田淳也、飯島正平、丸山憲太郎、宮田博志、瀧口修司、藤原義之、松原謙一、門田守人
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 胃癌におけるチロシンキナーゼ包括的解析と予後再発形式との関連についての検討2008

    • Author(s)
      土岐祐一郎、竹野淳、山崎誠、竹政伊知朗、藤原義之、瀧口修司、宮田博志、牧野知紀、西田俊朗、松原謙一、門田守人
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 網羅的遺伝子発現解析とネットワーク解析にもとづく新規胃癌関連分子の探索2008

    • Author(s)
      竹野淳、竹政伊知朗、土岐祐一郎、山崎誠、宮田博志、瀧口修司、藤原義之、松原謙一、門田守人
    • Organizer
      第80回日本胃癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Prediction of response to neoadujvant chemotherapy in ESCC(esophageal squamous cell carcinoma) using endoscopic biopsies2008

    • Author(s)
      Takeno A., Motoori M., Takemasa I., Doki Y., Yamasaki M., Miyata H., Takiguchi S., Fujiwara Y., Matsubara K., Monden M.
    • Organizer
      11th world congress of the international society for diseases of the esophagus
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gene Identification of Acute Cellular Rejection in Recipients with Recurrent Hepatitis C after Liver Transplantation2008

    • Author(s)
      Asaoka T., Marubashi S., Dono K., Hama N., Takahashi H., Kobayashi S., Takeda Y., Takemasa I., Nagano H., Umeshita K., Kato T., Ruiz P., Andreas GT., Monden M.
    • Organizer
      The 2008 Joint International Congress of ILTS, ELITA & LICAGE
    • Place of Presentation
      Paris
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gene Identification of Acute Cellular Rejection in Recipients with Recurrent Hepatitis C after Liver Transplantation2008

    • Author(s)
      Asaoka T., Marubashi S., Dono K., Hama N., Takahashi H., Kobayashi S., Takeda Y, Takemasa I., Nagano H., Umeshita K., Ruiz P., Matsubara K., Monden M., Doki Y, Mori M.
    • Organizer
      The Transplantation Society
    • Place of Presentation
      Sydney
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular mapping of human hepatocellular carcinoma to gain deeper biological insights from genomic deta2008

    • Author(s)
      橘高信義, 竹政伊知郎, 武田裕, 丸橋繁, 永野浩昭, 梅下浩司, 堂野恵三, 松原謙一, 松浦成昭, 門田守人, 森正樹, 土岐祐一郎
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] NBS法を用いた新規プロテーム解析-大腸癌のタンパクプロファイル解析-2007

    • Author(s)
      竹政伊知朗、渡辺真、三宅正和、徳岡優佳、人羅俊貴、池田正孝、山本浩文、関本貢嗣、松浦成昭、西村紀、永井克、門田守人
    • Organizer
      第18回日本消化器癌発生学会総会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 大腸癌肝転移形成過程における遺伝子発現プロファイル解析2007

    • Author(s)
      山崎誠、土岐祐一郎、竹政伊知朗、藤原義之、瀧口修司、宮田博志、関本貢嗣、松原謙一、門田守人
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 網羅的遺伝子発現解析による胃癌根治切除後の予後予測診断とその臨床応用2007

    • Author(s)
      竹野淳、竹政伊知朗, 本告正明, 山崎誠, 木村豊, 三木宏文, 青木太郎, 平尾素宏, 今村博司, 高地耕, 藤田淳也, 飯島正平, 丸山憲太郎, 飯島正平,丸山憲太郎、宮田博志、瀧口修司、藤原義之、土岐祐一郎、松原謙一、門田守人
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 肝移植後の急性拒絶に関する網羅的遺伝子発現解析2007

    • Author(s)
      浅岡忠史、丸橋繁、堂野恵三、濱直樹、吉岡慎一、後藤邦仁、高橋秀典、宮本敦史、武田裕、竹政伊知朗、永野浩昭、梅下浩司、加藤友朗、PhillipRuiz、AndreasTzakis、松原謙一、門田守人
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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