Synthetic strategy for clinical application of personalized medicinefor gastrointestinal cancers
Project/Area Number |
19209042
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
|
Research Institution | Osaka University |
Principal Investigator |
MONDEN Morito Osaka University, 医学系研究科, 教授 (00127309)
|
Co-Investigator(Kenkyū-buntansha) |
SEKIMOTO Mitugu 大阪大学, 医学系研究科, 准教授 (10273658)
DOKI Yuichiro 大阪大学, 医学系研究科, 教授 (20291445)
TAKEMASA Ichiro 大阪大学, 医学系研究科, 教授 (50379252)
NISHIMURA Osamu 大阪大学, 蛋白質研究所, 特任教授 (10374125)
DONO Keizo 大阪大学, 医学系研究科, 講師 (60283769)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2008: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2007: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
|
Keywords | 消化器がん / 個別医療 / DNAチップ / プロテオミクス / 臨床応用 / バイオマーカー / 大規模症例登録 / 分子診断 / 個別化医療 / 基盤整備 |
Research Abstract |
本研究は、臨床試験と分子生物学的情報解析のスパイラル的発展を主軸とし、大規模消化器癌症例を対象に、癌組織の遺伝子・タンパク発現プロファイルとネットワーク解析により、癌の転移・再発、治療応答性の予測診断やバイオマーカーを探索し、個別医療として数年のうちに臨床応用化を実現することを目的とした。本研究により、癌の分子メカニズムの総合的理解が進み、画一的な治療を脱却し患者に過不足の少ない最適な医療を提供することが期待される。
|
Report
(3 results)
Research Products
(42 results)
-
[Journal Article] Gene expression of colorectal cancer : Preoperative genetic diagnosis using endoscopic biopsies2008
Author(s)
Komori T.,Takemasa I., Yamasaki M., Motoori M., Kato T., Kikkawa N., Kawaguchi N., Ikeda M., Yamamoto H., Sekimoto M., Matsubara K., Matsuura N., Monden M.
-
Journal Title
Int J Oncol 32(2)
Pages: 367-375
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma : A novel approach for biomarker discovery.2008
Author(s)
Watanabe M.,Takemasa I., Kawaguchi N., Miyake M., Nishimura N., Matsubara T., Matsuo E., Sekimoto M., Nagai K., Matsuura N., Monden M., Nishimura O.
-
Journal Title
Proteomics Clin Appl.
Pages: 925-935
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Gene expression of colorectal cancer : Preoperative genetic diagnosis using endoscopic biopsies.2008
Author(s)
Komori T., Takemasa I., Yamasaki M., Motoori M., Kato T, Kikkawa N., Kawaguchi N., Ikeda M., Yamamoto H., Sekimoto M., Matsubara K., Matsuura N., Monden M.
-
Journal Title
Int J Oncol 32(2)
Pages: 367-375
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma : A novel approach for biomarker discovery.2008
Author(s)
Watanabe M., Takemasa I., Kawaguchi N., Miyake M., Nishimura N., Matsubara T., Matsuo E., Sekimoto M., Nagai K., Matsuura N., Monden M., Nishimura O.
-
Journal Title
Proteomics Clin Appl 2
Pages: 925-935
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] An Application of the 2-Nitrobenzenesulfenyl(NBS) Method to Proteomic Profiling of Human Colorectal Carcinoma: A Novel Approach for Biomarker Discovery2008
Author(s)
Watanabe M., Takemasa I. Kawaguchi N., Miyake M., Nishimura N., Matsubara T., Matsuo E., Sekimoto M., Nagai K., Matsuura N., Monden., Nishimura O.
-
Journal Title
PROTEOMICS-Clinical Applications (In press)
Related Report
Peer Reviewed
-
-
[Journal Article] Gene expression of colorectal cancer: preoperative genetic diagnosis using endoscopic biopsies.2008
Author(s)
Komori T, Takemasa I, Yamasaki M, Motoori M, Kato T, Kikkawa N, Kawaguchi N, Ikeda M, Yamamoto H, Sekimoto M, Matsubara K, Matsuura N, Monden M.
-
Journal Title
Int J Oncol. 32(2)
Pages: 367-75
Related Report
Peer Reviewed
-
-
-
-
-
[Presentation] Molecular mapping of human hepatocellular carcinoma to gain deeper biological insights from genomic deta2008
Author(s)
橘高信義, 竹政伊知郎, 武田裕, 丸橋繁, 永野浩昭, 梅下浩司, 堂野恵三, 松原謙一, 松浦成昭, 門田守人, 森正樹, 土岐祐一郎
Organizer
第67回日本癌学会学術総会
Place of Presentation
名古屋
Year and Date
20081028-20081030
Related Report
-
[Presentation] Prediction of response to neoadujvant chemotherapy in ESCC(esophageal squamous cell carcinoma) using endoscopic biopsies2008
Author(s)
Takeno A., Motoori M., Takemasa I., Doki Y., Yamasaki M., Miyata H., Takiguchi S., Fujiwara Y., Matsubara K., Monden M.
Organizer
11th world congress of the international society for diseases of the esophagus
Place of Presentation
Budapest, Hungary
Year and Date
20080910-20080913
Related Report
-
[Presentation] Prediction of response to neoadujvant chemotherapy in ESCC(esophageal squamous cell carcinoma) using endoscopic biopsies.2008
Author(s)
Takeno A.,Motoori M., Takemasa I., Doki Y., Yamasaki M., Miyata H., Takiguchi S., Fujiwara Y., Matsubara K., Monden M.
Organizer
11th world congress of the international society for diseases of the esophagus
Place of Presentation
Budapest, Hungary
Year and Date
20080910-13
Related Report
-
[Presentation] Gene Identification of Acute Cellular Rejection in Recipients with Recurrent Hepatitis C after Liver Transplantation2008
Author(s)
Asaoka T., Marubashi S., Dono K., Hama N., Takahashi H., Kobayashi S., Takeda Y, Takemasa I., Nagano H., Umeshita K., Ruiz P., Matsubara K., Monden M., Doki Y, Mori M.
Organizer
The Transplantation Society
Place of Presentation
Sydney
Year and Date
20080810-20080816
Related Report
-
[Presentation] Gene Identification of Acute Cellular Rejection in Recipients with Recurrent Hepatitis C after Liver Transplantation.2008
Author(s)
Asaoka T.,Marubashi S., Dono K., Hama N., Takahashi H., Kobayashi S., Takeda Y., Takemasa I., Nagano H., Umeshita K., Ruiz P., Matsubara K., Monden M., Doki Y., Mori M.
Organizer
The Transplantation Society
Place of Presentation
Sydney
Year and Date
20080810-16
Related Report
-
-
[Presentation] Gene Identification of Acute Cellular Rejection in Recipients with Recurrent Hepatitis C after Liver Transplantation2008
Author(s)
Asaoka T., Marubashi S., Dono K., Hama N., Takahashi H., Kobayashi S., Takeda Y., Takemasa I., Nagano H., Umeshita K., Kato T., Ruiz P., Andreas GT., Monden M.
Organizer
The 2008 Joint International Congress of ILTS, ELITA & LICAGE
Place of Presentation
Paris
Year and Date
20080709-20080712
Related Report
-
[Presentation] Gene Identification of Acute Cellular Rejection in Recipients with Recurrent. : Hepatitis C after Liver Transplantation.2008
Author(s)
Asaoka T.,Marubashi S., Dono K., Hama N., Takahashi H., Kobayashi S., Takeda Y., Takemasa I., Nagano H., Umeshita K., Kato T., Ruiz P., Andreas GT., Monden M.
Organizer
The 2008 Joint International Congress of ILTS, ELITA & LICAGE
Place of Presentation
Paris
Year and Date
20080709-12
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] 網羅的遺伝子発現解析による胃癌根治切除後の予後予測診断とその臨床応用2007
Author(s)
竹野淳、竹政伊知朗, 本告正明, 山崎誠, 木村豊, 三木宏文, 青木太郎, 平尾素宏, 今村博司, 高地耕, 藤田淳也, 飯島正平, 丸山憲太郎, 飯島正平,丸山憲太郎、宮田博志、瀧口修司、藤原義之、土岐祐一郎、松原謙一、門田守人
Organizer
第107回日本外科学会定期学術集会
Place of Presentation
大阪
Year and Date
20070411-14
Related Report
-