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Development of new methods to prevent the progression or recover the vision in eyes of retinitis pigmentosa

Research Project

Project/Area Number 19209053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

FUJIKADO Takashi (2008-2009)  Osaka University, 医学系研究科, 教授 (50243233)

田野 保雄 (2007)  Osaka University, 医学系研究科, 教授 (80093433)

Co-Investigator(Kenkyū-buntansha) OHTA Jun  奈良先端科学技術大学院大学, 物質創成科学研究所, 教授 (80304161)
OHJI Masahito  滋賀医科大学, 医学部, 教授 (90252650)
KAMEI Motohiro  大阪大学, 医学系研究科, 准教授 (40281125)
IKUNO Yasushi  大阪大学, 医学系研究科, 講師 (50294096)
THUJIKAWA Motokazu  大阪大学, 医学系研究科, 助教 (70419472)
SAKAGUCHI Hirokazu  大阪大学, 医学系研究科, 助教 (80379172)
SAWAI Hajime  大阪大学, 医学系研究科, 准教授 (20202103)
不二門 尚  大阪大学, 医学系研究科, 教授 (50243233)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥50,310,000 (Direct Cost: ¥38,700,000、Indirect Cost: ¥11,610,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2008: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2007: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
Keywords網膜色素変性症 / 人工視覚 / 細胞死抑制 / 網膜色素変性 / 視神経刺激型 / 臨床試験 / 視細胞死抑制 / フォトトランスダクション / ロドプシン / メダカトランスポゾン / ヒト変異ロドプシン / 変異ロドプシントランスジェニック体
Research Abstract

1) We made constructs of 14 kinds of human rhodopsin mutants and injected 10 of the 14 into zebrafish embryos to establish transgenic lines for each mutation. We also performed phenotype analyses and found that the numbers of rod photoreceptors decreased in K296E, R135W, Q344X, and S334X transgenic lines. These transgenic lines are useful as a model of human retinitis pigmentosa.
2) We developed a unique and novel electrode device. The device was handled easily using a vitreoretinal forceps in the vitreous cavity and was easily implanted into the optic disc with one action. The patient perceived phosphenes with electrical stimulation through each of the electrodes.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (97 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (44 results) (of which Peer Reviewed: 44 results) Presentation (50 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Efficacy of suprachoroidal-transretinal stimulation in a rabbit model of retinal degeneration.2010

    • Author(s)
      Nishida K, Kamei M, Kondo M, Sakaguchi H, Suzuki M, Fujikado T, Tano Y.
    • Journal Title

      Invest Ophthalmol Vis Sci 51(4)

      Pages: 2263-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-year visual results for older Asian women treated with photodynamic therapy or bevacizumab for myopic choroidal neovascularization.2010

    • Author(s)
      Ikuno Y, Nagai Y, et al.
    • Journal Title

      Am J Ophthalmol 49

      Pages: 140-146

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light-controlled retinal stimulation on rabbit using CMOS-based flexible multi-chip stimulator.2009

    • Author(s)
      Tokuda T, Takeuchi Y, Noda T, Sasagawa K, Nishida K, Kitaguchi Y, Fujikado T, Tano Y, Ohta J
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc. 2009

      Pages: 646-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Artificial vision by direct optic nerve electrode (AV-DONE) implantation in a blind patient with retinitis pigmentosa.2009

    • Author(s)
      Sakaguchi H, Kamei M, Fujikado T, Yonezawa E, Ozawa M, Cecilia-Gonzalez C, Ustariz-Gonzalez O, Quiroz-Mercado H, Tano Y.
    • Journal Title

      J Artif Organs 12(3)

      Pages: 206-9

    • NAID

      10025351490

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 人工視覚システムの臨床応用を目指して2009

    • Author(s)
      田野保雄, 瓶井資弘, 生野恭司, 辻川元一, 坂口裕和, 西田健太郎, 方肖雲, 杜兆江, 謝平, 不二門尚, 日下俊次, 森本壮, 中内一揚, 別所建一郎, 下條裕史, 大川賀孝, 北口善之, 福田淳, 澤井元, 三好智満, 八木哲也, 小山内実, 宋文杰, 三宅養三, 近藤峰生, 子安俊行, 坂井隆夫, 栗本幸英, 平形明人, Quiroz-MercadoHugo, Ustariz-GonzalezOrlando, Cecilia-GonzalezCarmen, 太田淳, 徳田崇, 小澤素生田野保雄, 瓶井資弘, 生野恭司, 辻川元一, 坂口裕和, 西田健太郎, 方肖雲, 杜兆江, 謝平, 不二門尚, 日下俊次, 森本壮, 中内一揚, 別所建一郎, 下條裕史, 大川賀孝, 北口善之, 福田淳, 澤井元, 三好智満, 八木哲
    • Journal Title

      日本眼科学会雑誌 113巻

      Pages: 315-343

    • NAID

      10024805575

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of a transgenic rabbit model of retinal degeneration.2009

    • Author(s)
      Kondo M, Sakai T, Komeima K, Kurimoto Y, Ueno S, Nishizawa Y, Usukura J, Fujikado T, Tano Y, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci. 50(3)

      Pages: 1371-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optimal parameters of transcorneal electrical stimulation (TES) to be neuroprotective of axotomized RGCs in adult rats.2009

    • Author(s)
      Morimoto T, Miyoshi T, Sawai H, Fujikado T.
    • Journal Title

      Exp Eye Res. (E-Pub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitreous Levels of Erythropoietin and Vascular Endothelial Growth Fator in Eyes with Retinopathy of Prematurity.2009

    • Author(s)
      Sato T, Kusaka S, Shimojo H, Fujikado T.
    • Journal Title

      Ophthalmology. 116

      Pages: 1599-1603

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lens-sparing vitrectomy effective for reattachment of newly developed falciform retinal detachment in a patient with Norrie disease.2009

    • Author(s)
      Shima C, Kusaka S, Kondo H, Hasebe H, Fujikado T, Tano Y.
    • Journal Title

      Arch Ophthalmol 127

      Pages: 579-580

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of Titanium : Sapphire Laser Retinal Injury by Adaptive Optics Fundus Imaging and Fourier-Domain Optical Coherence Tomography.2009

    • Author(s)
      Kitaguchi Y, Fujikado T, Kusaka S, Yamaguchi T, Mihashi T, Tano Y.
    • Journal Title

      Am J Ophtnalmol 93

      Pages: 96-103

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene-expression profile in murine oxygen-induced retin opathy.2009

    • Author(s)
      Sato T, Kusaka S, Hashida N, Saishin Y, Fujikado T, Tano Y.
    • Journal Title

      Br J Ophthalmol 93

      Pages: 96-103

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of surgical treatments for central retinal vein occlusion ; RON vs cannulation of tPA into the retinal vein.2009

    • Author(s)
      Yamamoto T, Kamei M, Sakaguchi H, et al
    • Journal Title

      RETINA 29

      Pages: 1167-1174

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab for chroidal neovascularization attributable to pathological myopia : one-year results2009

    • Author(s)
      Ikuno Y, Sayanagi K, et al
    • Journal Title

      Am J Ophthalmol 147

      Pages: 94-100

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography.2009

    • Author(s)
      Ikuno y, Tano Y
    • Journal Title

      Invest Ophthalmol Vis Sci 50

      Pages: 3876-80

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab vs sub-tenon triamcinolone acetonide for choroidal neovascularization attributable to pathologic myopia.2009

    • Author(s)
      Wakabayashi T, Ikuno Y, Gomi F, Hamasaki T, Tano Y.
    • Journal Title

      Am J Ophthalmol 148

      Pages: 591-596

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Choroidal vascular hypofluorescence in indocyanine green angiography of high myopia.2009

    • Author(s)
      Sayanagi K, Ikuno Y, et al.
    • Journal Title

      Br J Ophthalmol 93

      Pages: 1687-90

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiographic changes after bevacizumab.2009

    • Author(s)
      Ikuno Y, Soga K, et al.
    • Journal Title

      Ophthalmology 116

      Pages: 2263-2263

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term results of intravitreal bevacizumab injection for chor oidal neovascularization secondary to angioid streaks.2009

    • Author(s)
      Sawa M, Gomi F, Tsujikawa M, et al
    • Journal Title

      Am J Ophthalmol 4

      Pages: 584-590

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] one-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial datachment secondary to age-related macular degeneration.2009

    • Author(s)
      Shima C, Gomi F, Sakaguchi H, Tsujikawa M, et al
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 7

      Pages: 899-906

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular autofluorescence in eyes with cystoid macula edema, detected with 488 nm-excitation but not with 580 nm-excitation.2009

    • Author(s)
      Besso K, Gomi F, Tsujikawa M, et al
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 6

      Pages: 729-34

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Artificial Vision by Direct Optic Nerve Electrode (AV_DONE) implantation in a blind patient with retinitis pigmentosa.2009

    • Author(s)
      Sakaguchi H, Kamei M, et al
    • Journal Title

      J Artif Organs 12

      Pages: 206-209

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of a Transgenic Rabbit Model of Retinal Degeneration2009

    • Author(s)
      Kondo M, Sakai T, ...., Tano Y, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-finger structure and pulsed-powering operation scheme for CMOS LSI-based flexible stimulator for retinal prosthesis.2008

    • Author(s)
      Tokuda T, Asano R, Hiyama K, Terasawa Y, Nishida K, Kitaguchi Y, Fujikado T, Tano Y, Ohta J.
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc. 2008

      Pages: 4212-5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of electrical stimulation on IGF-1 transcription by L-type calcium channels in cultured retinal Muller cells.2008

    • Author(s)
      Sato T, Fujikado T, Morimoto T, Matsushita K, Harada T, Tano Y.
    • Journal Title

      Jpn J Ophthalmol 52(3)

      Pages: 217-23

    • NAID

      10024154139

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct effect of electrical stimulation on induction of brain-derived neurotrophic factor from cultured retinal Muller cells.2008

    • Author(s)
      Sato T, Fujikado T, Lee TS, Tano Y.
    • Journal Title

      Invest Ophthalmol Vis Sci 49(10)

      Pages: 4641-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive optics fundus camera to examine localized changes in the photoreceptor layer of the fovea.2008

    • Author(s)
      Kitaguchi Y, Fujikado T, Bessho K, Sakaguchi H, Gomi F, Yamaguchi T, Nakazawa N, Mihashi T, Tano Y.
    • Journal Title

      Ophthalmology 115(10)

      Pages: 1771-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age at onset curves of retinitis pigmentosa.2008

    • Author(s)
      Tsujikawa M, Wada Y, Sukegawa M, Sawa M, Gomi F, Nishida K, Tano Y.
    • Journal Title

      Arch Ophthalmol 126(3)

      Pages: 337-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multi-finger structure and pulsed-powering operation scheme for CMOS LSI-based flexible stimulator for retinal prosthesis2008

    • Author(s)
      Tokuda T, Asano R, ...., Tano Y, Ohta J
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Pages: 4212-4215

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of electrical stimulation on IGF-1 transcription by L-type calcium channels in cultured retinal Muller cells2008

    • Author(s)
      Sato T, Fujikado T, ........ Tano Y.
    • Journal Title

      Jpn J Ophthalmol 52

      Pages: 217-223

    • NAID

      10024154139

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct effect of electrical stimulation on induction of brain-derived neurotrophic factor from cultured retinal Muller cells2008

    • Author(s)
      Sato T, Fujikado T, Lee TS, Tano Y
    • Journal Title

      Invest Ophthalmol Vis Sci. 49

      Pages: 4641-4646

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo stimulation on rabbit retina using CMOS LSI-based multi-chip flexible stimulator for retinal prosthesis.2007

    • Author(s)
      Tokuda T, Asano R, Sugitani S, Terasawa Y, Nunoshita M, Nakauchi K, Fujikado T, Tano Y, Ohta J.
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc 2007

      Pages: 5791-4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical imaging to evaluate retinal activation by electrical currents using suprachoroidal-transretinal stimulation.2007

    • Author(s)
      Okawa Y, Fujikado T, Miyoshi T, Sawai H, Kusaka S, Mihashi T, Hirohara Y, Tano Y.
    • Journal Title

      Invest Ophthalmol Vis Sci 48(10)

      Pages: 4777-84

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college of surgeons rats.2007

    • Author(s)
      Morimoto T, Fujikado T, Choi JS, Kanda H, Miyoshi T, Fukuda Y, Tano Y.
    • Journal Title

      Invest Ophthalmol Vis Sci 48(10)

      Pages: 4725-32

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of phosphenes elicited by extraocular stimulation in normals and by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa.2007

    • Author(s)
      Fujikado T, Morimoto T, Kanda H, Kusaka S, Nakauchi K, Ozawa M, Matsushita K, Sakaguchi H, Ikuno Y, Kamei M, Tano Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 245(10)

      Pages: 1411-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laboratory investigation of microelectronics-based stimulators for large-scale suprachoroidal transretinal stimulation (STS).2007

    • Author(s)
      Ohta J, Tokuda T, Kagawa K, Sugitani S, Taniyama M, Uehara A, Terasawa Y, Nakauchi K, Fujikado T, Tano Y
    • Journal Title

      J Neural Eng 4(1)

      Pages: 85-91

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Threshold suprachoroidal-transretinal stimulation current resulting in retinal damage in rabbits.2007

    • Author(s)
      Nakauchi K, Fujikado T, Kanda H, Kusaka S, Ozawa M, Sakaguchi H, Ikuno Y, Kamei M, Tano Y
    • Journal Title

      J Neural Eng 4(1)

      Pages: 50-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of phosphenes elicited by extraocular stimulation in normals and by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa.2007

    • Author(s)
      Fujikado T, Morimoto T, .Tano Y
    • Journal Title

      Graefes Archives of Clinical and Experimental Ophthalmology. 245

      Pages: 1411-1419

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Threshold suprachoroidal-transretinal stimulation current resulting in retinal damage in rabbits2007

    • Author(s)
      Nakauchi K, Fujikado T, .Tano Y
    • Journal Title

      Journal of Neural Engineering 4

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo Stimulation on Rabbit Retina using CMOS LSI-based Multi-Chip Flexible Stimulator for Retinal Prosthesis.2007

    • Author(s)
      Tokuda T, Asano R, .Tano Y, Ohta J
    • Journal Title

      Conference Proceedings IEEE Engineering in Medical and Biological Society. 1

      Pages: 5790-5793

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college of surgeons rats.2007

    • Author(s)
      Morimoto T, Fujikado T, .Tano Y
    • Journal Title

      Investigative Ophthalmology Visual Science. 48

      Pages: 4725-4732

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laboratory investigation of microelectronics-based stimulators for large-scale suprachoroidal transretinal stimulation (STS).2007

    • Author(s)
      Ohta J, Tokuda T, .Tano Y
    • Journal Title

      Journal of Neural Engineering 4

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical imaging to evaluate retinal activation by electrical currents using suprachoroidal-transretinal stimulation.2007

    • Author(s)
      Okawa Y, Fujikado T, .Tano Y
    • Journal Title

      Investigative Ophthalmology Visual Science. 48

      Pages: 4777-4784

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K) pathways differently regulate retinal pigment epithelial cell-mediated collagen gel contraction.2006

    • Author(s)
      Bando H, Ikuno Y, Hori Y, Sayanagi K, Tano Y
    • Journal Title

      Exp Eye Res 82

      Pages: 529-37

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Suprachoroida-Transretinal Stimulation in Rabbit Model of Rentinal Degeneration.

    • Author(s)
      Nishida K, Kamei M, et al
    • Journal Title

      Invest Ophtalmol Vis Sci (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Transcorneal electrical stimulation, for diagnosis and treatment of retina or optic nerve diseases.2009

    • Author(s)
      Fujikado T
    • Organizer
      第50回台湾眼科学会
    • Place of Presentation
      台北、中華民国
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Punctate Inner Choroidopathy and the Visual Outcome After Avastin for Secondary CNV2009

    • Author(s)
      Jo Y, Ikuno Y, et al.
    • Organizer
      American Academy of Ophthalmology Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 近視性脈絡膜新生血管に対するbevacizumab硝子体内投与後の脈絡膜厚の変化2009

    • Author(s)
      城友香理、生野恭司
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加齢黄斑変性におけるリン脂質酸化の関与2009

    • Author(s)
      鈴木三保子、瓶井資弘
    • Organizer
      日本眼炎症学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 網膜リン脂質の加齢変化2009

    • Author(s)
      瓶井資弘
    • Organizer
      第48回日本白内障学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] スペクトラルドメイン光干渉断層計を用いた強度近視眼の後眼部生体計測2009

    • Author(s)
      生野恭司、田野保雄
    • Organizer
      第113回日本眼学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 網膜色素変性モデルゼブラフィッシュにおける視細胞死の検討2009

    • Author(s)
      中尾武史、松村永和、辻川元一、田野保雄
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Photoreceptor Changes at One-Year Follow-Up of Titanium:Sapphire Laser Retinal Injury Observed With Flood-Illumination Adaptive Optics Fundus Camera.2009

    • Author(s)
      Kitaguchi Y., Fujikado T., Kusaka S., Yamaguchi T., Hirohara Y., Mihashi T., Maeda N., Tano Y.
    • Organizer
      2009 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of Transcorneal Electrical Stimulation(tes) in Patients With Traumatic Optic Neuropathy(ton)2009

    • Author(s)
      Shimojyo H., Fujikado T., Morimoto T., Okawa Y., Matsushita K., Kitaguti Y., Tano Y.
    • Organizer
      2009 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] 脈絡膜上経網膜刺激において大脳皮質誘発電位に影響を与える因子.2009

    • Author(s)
      西田健太郎、瓶井資弘、坂口裕和、北口善之、不二門尚、田野保雄
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Experimental Models of Retinitis Pigmentosa in Zebrafish2008

    • Author(s)
      M. Tsujikawa
    • Organizer
      2008 World Ophthalmology Congress
    • Place of Presentation
      Hong Kong
    • Year and Date
      2008-07-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Artificial Vision with Direct Optic Nerve Electrode (AV-DONE)2008

    • Author(s)
      H. Sakaguchi
    • Organizer
      2008 World Ophthalmology Congress
    • Place of Presentation
      Hong Kong
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Suppression of cyclic GMP-phosphodiestarase beta subunit has an insignificant effect on photoreceptor cell death in a zebrafish model2008

    • Author(s)
      T. Nakao, M. Tsujikawa, Y. Tano
    • Organizer
      2008 World Ophthalmology Congress
    • Place of Presentation
      Hong Kong
    • Year and Date
      2008-06-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Artificial Vision by Direct Optic Nerve Electrode (AV-DONE) for a Blind Patient With Retinitis Pigmentosa2008

    • Author(s)
      H. Sakaguchi, M. Kamei, ....... H. Quiroz-Mercado, Y. Tano.
    • Organizer
      2008 AEVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2008-04-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Phototransduction and Photoreceptor Cell Death Are Closely Related in a Zebrafish Model2008

    • Author(s)
      T. Nakao, M. Tsujikawa, Y. Tano.
    • Organizer
      2008 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2008-04-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Large-Surface-Area Electrodes Based on Bulk Micromachining2008

    • Author(s)
      Y. Terasawal, K. Osawa, ...... Y. Tano.
    • Organizer
      2008 AEVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2008-04-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Suprachoridal-Transretinal Stimulation (STS) Generates EEP in a Middle-Sized Animal Model of Retinal Degeneration2008

    • Author(s)
      K. Nishida, M. Kamei, M. ....... Y. Tano.
    • Organizer
      2008 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2008-04-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] A Microelectronics-Based Flexible Retinal Stimulator for Retinal Prosthesis With an Improved Safety and Fault Tolerance2008

    • Author(s)
      T. Tokuda, R. Asano, K. Hiyama, Y. Terasawa, Y. Tano, J. Ohta
    • Organizer
      2008 AEVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2008-04-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Contribution of Retinal Ganglion Cells to Intrinsic Signals in Retinal Optical Imaging by Trans-Corneal Electrical Stimulation or by Light Stimulation2008

    • Author(s)
      T. Fujikado, Y. Okawa, ............Y. Tano
    • Organizer
      2008 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2008-04-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Generation and Characteristics of Transgenic Rabbit Model of Retinal Degeneration2008

    • Author(s)
      M. Kondo, T. ....... Y. Tano, H. Terasaki.
    • Organizer
      2008 AEVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2008-04-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 人工視覚システムの臨床応用を目指して2008

    • Author(s)
      田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] ゼブラフィッシュ変異体ov1における視細胞死とフォトトランスダクシヨン2008

    • Author(s)
      中尾武史, 辻川元一, 田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] ゼブラフイシュ視細胞における強制発現系の開発2008

    • Author(s)
      辻川元一, 中尾武史, 田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中型動物における視細胞傷害モデルの作成2008

    • Author(s)
      西田健太郎, .....田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Contribution of Retinal Ganglion Cells to Intrinsic Signals in Retinal Optical Imaging by Trans-Corneal Electrical Stimulation or by Light Stimulation.2008

    • Author(s)
      Fujikado T., Okawa Y., Miyoshi T., Hirohara Y., Mihashi T., Tano Y.
    • Organizer
      2008 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] Reduced Photoreceptor Thickness Causes Blur of Photoreceptor Mosaic in the Image by Flood-illumination Adaptive Optics Fundus Camera.2008

    • Author(s)
      Kitaguchi Y., Fujikado T., Bessho K., Yamaguchi T., Nakazawa N., Hirohara Y., Mihashi T., Maeda N., Tano Y.
    • Organizer
      2008 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] Repeatability of Intrinsic Optical Imaging of the Retina's Response to Optical and Electric Stimuli.2008

    • Author(s)
      Mihashi T., Hirohara Y., Okawa Y., Miyoshi T., Fujikado T.
    • Organizer
      2008 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] Suprachoridal-Transretinal Stimulation (STS) Generates EEP in a Middle-Sized Animal Model of Retinal Degeneration.2008

    • Author(s)
      Nishida K., Kamei M., Kondo M., Sakai T., Z. Du Y., Kitaguchi Y., Nakauchi K., Sakaguchi H., Fujikado T., Tano Y.
    • Organizer
      2008 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] Artificial Vision by Direct Optic Nerve Electrode (AV-DONE) for a Blind Patient With Retinitis Pigmentosa.2008

    • Author(s)
      Sakaguchi H., Kamei M., Fujikado T., Yonezawa E., Ozawa M., Cecilia-Gonzalez C., Ustariz-Gonzalez O., Quiroz-Mercado H., Tano Y.
    • Organizer
      2008 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] 補償光学眼底カメラの画像に残存収差および網膜形態が及ぼす影響2008

    • Author(s)
      北口善之、不二門尚、別所建一郎、山口達夫、中澤直樹、広原陽子、三橋俊文、前田直之、田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] ロドプシントランスジェニックウサギ作成の試み2008

    • Author(s)
      近藤峰生、坂井隆夫、米今敬一、栗本幸英、子安俊行、宮田健太郎、西沢祐治、臼倉治郎、不二門尚、田野保雄、寺崎浩子
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 外傷性視神経症(TON)に対する経角膜電気刺激を用いた神経保護治療の検討.2008

    • Author(s)
      下條裕史、不二門尚、森本壮、松下賢治、大川賀孝、北口善之、田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 中型動物における視細胞障害モデルの作成2008

    • Author(s)
      西田健太郎、瓶井資弘、坂口裕和、近藤峰生、不二門尚、田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional Imaging2008

    • Author(s)
      不二門尚
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Artificial Vision by Direct Optic Nerve Electrode (AV-DONE) for Patients with Retinitis Pigmentosa2007

    • Author(s)
      H. Sakaguchi
    • Organizer
      Joint Congress of The 45th Annual Meeting of the Japanese Society for Artificial Organs and The 2nd Meeting of the International Federation for Artificial Organs
    • Place of Presentation
      Osaka
    • Year and Date
      2007-10-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] Middle-Sized Animal Model of Retinal Degeneration2007

    • Author(s)
      K. Nishida, M. Kamei, M. Suzuki, K. Nakauchi, T. Yamamoto, H. Sakaguchi, T. Fujikado, Y. Tano.
    • Organizer
      2007 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2007-05-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Artificial Vision by Direct Optic Nerve Electrode (AV-DONE) for a Patient with Retinitis Pigmentosa2007

    • Author(s)
      H. Sakaguchi, E. Yonezawa, H. Kanda, M. Ozawa, M. Kamei, T. Fujikado, O. Ustariz-Gonzalez, A. Solis-Vivanco, H. Quiroz-Mercado, Y.Tano
    • Organizer
      2007 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2007-05-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Improvement of Reproducibility and Durability in a Microelectronics-Based Stimulator for Suprachoroidal Transretinal Stimulation (STS)2007

    • Author(s)
      J. Ohta, T. Tokuda, S. Sugitani, M. Taniyama, R. Asano, Y. Terasawa, A. Uehara, K. Nakauchi, T. Fujikado, Y. Tano
    • Organizer
      2007 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2007-05-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phototransduction Accelerates Photoreceptor Cell Death in a Zebrafish Model2007

    • Author(s)
      T. Nakao, M. Tsujikawa, Y. Tano.
    • Organizer
      2007 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2007-05-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pulse Parameters Affecting Rat Collicular Evoked Potentials to Suprachoroidal-Transretinal Electrical Stimulation for Retinal Prosthesis2007

    • Author(s)
      H. Sawai, M. Kuroda, T.Fujikado, Y. Tano
    • Organizer
      2007 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2007-05-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Adaptive Optics Retinal Imaging in Rabbit Eyes2007

    • Author(s)
      Kitaguchi Y., Fujikado T., Bessho K., Yamaguchi T., Nakazawa N, Hirohara Y., Mihashi T., Maeda N., Tano Y.
    • Organizer
      2007 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] Contribution of Retinal Ganglion Cell Activity to Intrinsic Signals2007

    • Author(s)
      Okawa Y., Fujikado T., Miyoshi T., Hirohara Y., Mihashi T., Tano Y.
    • Organizer
      2007 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] Artificial Vision by Direct Optic Nerve Electrode (AV-DONE) for a Patient with Retinitis Pigmentosa.2007

    • Author(s)
      Sakaguchi H., Yonezawa E., Kanda H., Ozawa M., Kamei M., Fujikado T., Ustariz-Gonzalez O., Solis-Vivanco A., Quiroz-Mercado H., Tano Y.
    • Organizer
      2007 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] The Effect of Electrical Stimulation on Cultured Retinal Muller Cells.2007

    • Author(s)
      Sato T., Fujikado T., Matsushita K., Morimoto T., Kanda H., Harada T., Kusaka S., Tano Y.
    • Organizer
      2007 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] Artificial Vision by Direct Optic Nerve Electrode for Patients with Retinitis Pigmentosa.2007

    • Author(s)
      Sakaguchi H., Yonezawa E., Kanda H., Ozawa M., Kamei M., Fujikado T., Ustariz-Gonzalez O., Solis-Vivanco A., Quiroz-Mercado H., Tano Y.
    • Organizer
      2007 ARVO Annual meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] 網膜神経節細胞に起因する内因性信号2007

    • Author(s)
      大川賀孝, 不二門尚, 三好智満, 広原陽子, 三橋俊文, 田野保雄
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 有色家兎を用いた、補償光学眼底カメラの機能解析.2007

    • Author(s)
      北口善之, 不二門尚, 別所健一郎, 山口達夫, 中澤直樹, 広原陽子, 三橋俊文, 前田直之, 田野保雄
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 培養Muller細胞に対する電気刺激の生理的、機能的影響2007

    • Author(s)
      佐藤達彦, 不二門尚, 松下賢治, 森本壮, 神田寛行, 田野保雄
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 瞳孔反応によるTON患者に対する経角膜電気刺激治療の効果判定2007

    • Author(s)
      松下賢治, 不二門尚, 下條裕史, 森本壮, 北口善之, 大川賀孝, 田野保雄
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 経角膜電気刺激の損傷網膜神経節細胞に対する生存促進効果の刺激条件による変化.2007

    • Author(s)
      森本壮, 不二門尚, 三好智満, 田野保雄
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Book] 眼科プラクディス : 生体計測「Bruch膜厚」2009

    • Author(s)
      鈴木三保子、瓶井資弘
    • Publisher
      文光堂
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 特許権2011

    • Inventor(s)
      瓶井資弘、坂口裕和
    • Industrial Property Rights Holder
      (株)ニデック
    • Filing Date
      2011-02-16
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 特許権2008

    • Inventor(s)
      田野保雄, 不二門尚
    • Industrial Property Rights Holder
      田野保雄 (株)ニデック
    • Filing Date
      2008-10-24
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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