Regenerative response to insults : a novel strategy based on endothelial regeneration

• Project/Area Number: 19209055
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Osaka University
• Principal Investigator: OGURA Hiroshi Osaka University, 医学系研究科, 講師 (70301265)
• Co-Investigator(Kenkyū-buntansha): SUGIMOTO Hisashi 大阪大学, 名誉教授 (90127241) ; KUWAGATA Yasuyuki 大阪大学, 医学系研究科, 准教授 (50273678) ; MATSUMOTO Naoya 大阪大学, 医学部附属病院, 助教 (50359808) ; 田中 裕 順天堂大学, 医学研究科, 教授 (90252676) ; 嶋津 岳士 近畿大学, 医学部附属病院, 教授 (50196474)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000); Fiscal Year 2009: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2008: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2007: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
• Keywords: 侵襲 / 再生 / 血管内皮 / 骨髄間質細胞 / 移植 / 前駆細胞 / 治療 / 多臓器障害 / 細胞移植 / 骨髄機能 / 血管内皮前駆細胞 / 細胞機能

Research Abstract

The objectives of this study were to evaluate the regenerative response of endothelium in patients with systemic inflammatory response syndrome and to examine the effects of mesenchymal stem cells in a rat model with multiple organ dysfunction syndrome (MODS). In patients with sepsis, long-term endothelial activation was observed with increased endothelial progenitor cells in blood and enhanced VEGF receptors on these cells. Transplantation of mesenchymal stem cells inhibit the production of inflammatory cytokines, protect against endothelial damage and improve survival in a rat model with MODS. Transplantation of mesenchymal stem cells may be a novel strategy to attenuate MODS.

Research Products

• [Journal Article] The effect of antithrombin on pulmonary endothelial damage induced by crush injury. (2009)
  • Author(s): Sonoi H, 松本直也, 小倉裕司, Hosotsubo H, Noguchi K, Kuwagata Y, 杉本壽, ら
  • Journal Title: Shock Vol32 Pages: 593-600
  • Peer Reviewed
• [Journal Article] Synbiotics decrease the incidence of septic complications in patients with severe SIRS : A preliminary report. (2009)
  • Author(s): Shimizu K, Ogura H, et al.
  • Journal Title: Digestive Diseases and Sciences 54 Pages: 1071-1078
  • Peer Reviewed
• [Journal Article] The effect of antithrombin on pulmonary endothelial damage indused by crush injury (2009)
  • Author(s): Sonoi H, Matsumoto, Ogura H, et al.
  • Journal Title: Shock 32 Pages: 593-600
  • Peer Reviewed
• [Journal Article] SIRS-Associated Coagulopathy (SAC)の病態と予後 (2009)
  • Author(s): 小倉裕司、中森靖、杉本壽
  • Journal Title: Coagulation & Inflamation 3 Pages: 19-23
• [Journal Article] Synbiotics decrease the incidence of septic complications in patients with severe SIRS : A preliminary report. (2009)
  • Author(s): Shimizu K, Ogura H, et al.
  • Journal Title: Digestive Diseases and Sciences (In press)
  • Peer Reviewed
• [Journal Article] The effect of antithrombin on pulmonary endothelial damage induced by crush injury (2009)
  • Author(s): Sonoi H, Matsumoto, Ogura H, et al.
  • Journal Title: Shock In press
  • Peer Reviewed
• [Journal Article] Sepsis患者における血管内皮前駆細胞の動向 (2007)
  • Author(s): 松嶋麻子、小倉裕司、康泰珍、松本直也、鍬方安行、田中裕、嶋津岳士、杉本壽, ら
  • Journal Title: shock誌 Vol22 Pages: 100-105
  • NAID: 10024300595
  • Peer Reviewed
• [Journal Article] Sepsis患者における血管内皮前駆細胞の動向 (2007)
  • Author(s): 松嶋麻子、小倉裕司、康泰珍, ら
  • Journal Title: Shock 22 Pages: 100-105
  • NAID: 10024300420
  • Peer Reviewed
• [Presentation] ラット敗血症・多臓器不全モデルにおける骨髄間質細胞移植による抗炎症効果の評価 (2010)
  • Author(s): 松本直也, ら
  • Organizer: 第38回日本救急医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-09
• [Presentation] 急性期DIC病態 (2009)
  • Author(s): 小倉裕司, ら
  • Organizer: 第37回日本救急医学会
  • Place of Presentation: 盛岡
  • Year and Date: 2009-10-30
• [Presentation] 急性期DIC病態の性差 (2009)
  • Author(s): 小倉裕司, ら
  • Organizer: 第37回日本救急医学学会総会・学術集会
  • Place of Presentation: 盛岡市民文化ホール
  • Year and Date: 2009-10-30
• [Presentation] SIRS、sepsis患者の腸管内治療 (2009)
  • Author(s): 清水健太郎、小倉裕司, ら
  • Organizer: 第37回日本救急医学学会総会・学術集会
  • Place of Presentation: 盛岡市民文化ホール
  • Year and Date: 2009-10-30
• [Presentation] SIRSからDIC/MODSへ (2009)
  • Author(s): 小倉裕司
  • Organizer: 第3回鹿児島DICSIRS/MOFセミナー
  • Place of Presentation: 鹿児島大学医学部鶴陵会館
  • Year and Date: 2009-09-11
• [Presentation] The effect of antithrombin on pulmonary endothelial damage induced by crush injury (2008)
  • Author(s): Sonoi H, Matsumoto, Ogura H, et al.
  • Organizer: 67^<th> meeting of American Association for the Surgery of Trauma
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2008-09-27
• [Presentation] The pattern of gram stained fecal flora was related with septic mortality in patients with severe sepsis (2008)
  • Author(s): Shimizu K, Ogura H, et al.
  • Organizer: 67^<th> meeting of American Association for the Surgery of Trauma
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2008-09-25
• [Presentation] Sepsis患者における血管内皮前駆細胞の動向 (2007)
  • Author(s): 松嶋麻子、小倉裕司、康泰珍, ら
  • Organizer: 日本ショック学会
  • Place of Presentation: 大津市ロイヤルパークホテル
  • Year and Date: 2007-05-11