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Study concerning analysis of genes causing oral congenital anomalies

Research Project

Project/Area Number 19209062
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

NATSUME Nagato  Aichi Gakuin University, 歯学部, 教授 (90183532)

Co-Investigator(Kenkyū-buntansha) 平原 史樹  横浜市立大学, 大学院・医学研究科, 教授 (30201734)
高戸 毅  東京大学, 医学部附属病院, 教授 (90171454)
戸塚 靖則  北海道大学, 大学院・歯学研究科, 教授 (00109456)
野口 誠  富山大学, 大学院・医学薬学研究部, 教授 (50208328)
小村 健  東京医科歯科大学, 医歯学総合研究科, 教授 (10334434)
Co-Investigator(Renkei-kenkyūsha) KUBOTA Eiro  神奈川歯科大学, 医学部, 教授 (50170030)
FUKUSHIMA Yoshimitsu  信州大学, 医学部, 教授 (70273084)
YOSHIURA Koichiro  長崎大学, 医歯(薬)学総合研究科, 教授 (00304931)
NIIKAWA Norio  北海道医療大学, 個体差健康科学研究所, 教授 (00111170)
HIRAHARA Fumiki  横浜市立大学, 医学部, 教授 (30201734)
NOGUCHI Makoto  富山大学, 医学部, 教授 (50208328)
ENDO Toshiaki  札幌医科大学, 医学部, 准教授 (90213595)
TAKATO Tsuyoshi  東京大学, 医学部附属病院, 教授 (90171454)
TOTSUKA Yasunori  北海道大学, 歯学研究科(研究院), 教授 (00109456)
SUGIYAMA Yoshiki  岩手医科大学, 医学, 教授 (00162909)
FUKUSHIMA Akimune  岩手医科大学, 医学部, 准教授 (20208937)
ECHIGO Seishi  東北大学, 歯学研究科(研究院), 教授 (70005114)
FUKUDA Masayuki  秋田大学, 医学部, 准教授 (20272049)
UCHIYAMA Takeshi  東京歯科大学, 医学部, 教授 (40085874)
KOMURA Ken  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10334434)
ASANO Kazuhiro  獨協医科大学, 医学部, 講師 (70296135)
KURITA Kenichi  愛知学院大学, 歯学部, 教授 (40133483)
TAKAMATSU Kiyoshi  東京歯科大学, 歯学部, 教授 (30206875)
SAKASHITA Hideaki  明海大学, 歯学部, 教授 (10178551)
YAMAMOTO Masahiko  愛知学院大学, 心身科学部, 教授 (40378039)
古郷 幹彦  大阪大学, 歯学研究科(研究院), 教授 (20205371)
NARIAI Yoshiki  島根大学, 医学部, 講師 (60333465)
MORI Yoshihide  九州大学, 歯学研究科(研究院), 教授 (00231639)
SUGIHARA Kazumasa  鹿児島大学, 医歯(薬)学総合研究科, 教授 (00117516)
NAKAMURA Norifumi  鹿児島大学, 医歯(薬)学総合研究科, 教授 (60217875)
GOTO Masaaki  佐賀大学, 医学部, 教授 (10145211)
IKENOUE Tsuyomu  宮崎大学, 医学部, 教授 (60232211)
OZEKI Satoru  福岡歯科大学, 歯学部, 教授 (80117077)
TAKAHASHI Tetsu  九州歯科大学, 歯学部, 教授 (60226850)
SUNAKAWA Hajime  琉球大学, 医学部, 教授 (30112452)
IIDA Seiji  岡山大学, 医歯薬学総合研究科, 教授 (40283791)
KOUTSUMA Shiro  東京大学, 医学部附属病院, 教授 (10272569)
KAMEYAMA Yoichiro  愛知学院大学, 歯学部, 名誉教授 (70113066)
INOUE Makoto  愛知学院大学, 薬学部, 教授 (50191888)
FURUKAWA Hiroo  愛知学院大学, 心身科学部, 准教授 (70291763)
MINAMI Katsuhiro  愛知学院大学, 歯学部, 講師 (70346162)
NIIMI Tetuyuki  愛知学院大学, 歯学部, 講師 (60291762)
Research Collaborator MAEDA Hatsuhiko  愛知学院大学, 歯学部, 教授 (30175591)
YOSHIDA Waka  愛知学院大学, 歯学部, 助教 (10513210)
SUZUKI Satoshi  愛知学院大学, 歯学部, 非常勤助教 (30468996)
FUJIWARA Kumiko  愛知学院大学, 歯学部, 講師 (60404737)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Keywords先天異常 / 口唇裂 / 口蓋裂 / 遺伝子解析 / バンキング
Research Abstract

The incidences of congenital oral anomalies are not so high that even the incidence of cleft lip/palate that is the highest among the congenital oral anomalies is only 0.015%, let alone the incidence of a syndrome of congenital oral anomalies. Therefore, it is difficult to collect samples of a syndrome of congenital oral anomalies from one country alone and genetically analyze them. This study developed a system to collect many genes relating to congenital oral anomalies from as many countries as possible and bank them to provide researchers with those samples.
The results are :
The number of samples collected from foreign people : 7057
(Vietnamese : 4290, Mongol : 1999, Myanmarese : 580, Mexican : 30, Laotian : 158)
The number of samples collected from Japanese : 1717

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2011 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 10 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Milk prevents cleft palate in A/J mice2011

    • Author(s)
      TOMOKI KATO
    • Journal Title

      The Cleft Palate-Craniofacial Journal

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口唇形成術述後に認められた類皮野嚢胞および類表皮嚢胞に関する検討2011

    • Author(s)
      加藤大貴
    • Journal Title

      日本口蓋裂学会雑誌

      Volume: 36(1)(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Milk prevents cleft palate in A/J mice2010

    • Author(s)
      加藤大貴, 夏目長門
    • Journal Title

      The Cleft Palate-Craniofacial journal (In press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口唇形成術述後に認められた類皮野嚢胞および類表皮嚢胞に関する検討2010

    • Author(s)
      加藤大貴,夏目長門
    • Journal Title

      日本口蓋裂学会雑誌 36(1)(Inpress)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study of folate pathway gene polymorphisms and nonsyndromic cleft lip with/without cleft palate in a Japanese population2009

    • Author(s)
      後藤尊広, 新垣敬一, 夏目長門, 砂川元
    • Journal Title

      Ryukyu Med.J. 28(3,4)

      Pages: 13-21

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ミャンマー人における口唇口蓋裂発症とMTHFR遺伝子C677T多型の関連に対する検討2009

    • Author(s)
      後藤尊広,新垣敬一,國仲梨香,石川拓,仲間錠嗣,夏目長門,大関悟,砂川元
    • Journal Title

      琉球医学会誌 28巻1-2

      Pages: 25-29

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A RELATIONSHIP BETWEEN NONSYNDROMIC CLEFT LIP OR CLEFT LIP AND PALATE AND METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) GENE A1298C POLYMORPHISMS IN MONGOLIAN2009

    • Author(s)
      Lkhagva-OchirErkhembaatar, Tserenkhand Tsooj, Yoshida Waka, Goto Takahiro, Niimi Teruyuki, Furukawa Hiroo, Fujiwara Kumiko, Tumendemberel Ochirbat, Minami Katsuhiro, Suzuki Satoshi, Koshiji Chikako, Ariuntuul Garidhuu, Erkhembaatar Tudevdorj, Natsume Nagato
    • Journal Title

      Aichi-Gakuin Dental Science 22

      Pages: 19-24

    • NAID

      10031126384

    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] MATERNAL A1298C POLYMORPHISM OF THE 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE IS ASSOCIATED TO OCCURRENCE OF CLEFT PALATE ONLY IN MONGOLIANS2009

    • Author(s)
      Tserenkhand Tsooj, Lkhagva-OchirErkhembaatar, Yoshida Waka, Ariuntuul Garidkhuu, Lkhagvasuren Tserenkhuu, Erkhembaatar Tudevdorj, Furukawa Hiroo, Fujiwara Kumiko, Niimi Teruyuki, Minami Katsuhiro, Suzuki Satoshi, Goto Takahiro, Koshiji Chikako, Maeda Hatsuhiko, Natsume Nagato
    • Journal Title

      Aichi-Gakuin Dental Science 22

      Pages: 25-33

    • NAID

      10031126385

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study of folate pathway gene polymorphisms and nonsyndromic cleft lip with/without cleft palate in a Japanese population2009

    • Author(s)
      akahiro Goto, Keiichi Arakaki, Nagato Natsume, Hajime Sunakawa
    • Journal Title

      Ryukyu Med. J. 28(3,4)

      Pages: 13-21

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] ミャンマー人における口唇口蓋裂発症とMTHFR 遺伝子C677T 多型の関連に対する検討2009

    • Author(s)
      後藤尊広, 新垣敬一, 國仲梨香, 石川拓, 仲間錠嗣, 夏目長門, 大関悟, 砂川元
    • Journal Title

      琉球医学会誌 28巻1-2

      Pages: 25-29

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] MATERNAL A1298C POLYMORPHIS M OF THE 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE IS ASSOCIATED TO OCCURRENCE OF CLEFT PALATE ONLY IN MONGOLIANS2009

    • Author(s)
      Tserenkhand Tsooj, Lkhagva-OchirErkhembaatar, Yoshida Waka, Ariuntuul Garidkhuu, Lkhagvasuren Tserenkhuu, Erkhembaatar Tudevdorj, Furukawa Hiroo, Fujiwara Kumiko, Niimi Teruyuki, Minami Katsuhiro, Suzuki Satoshi, Goto Takahiro, Koshiji Chikako, Maeda Hatsuhiko, Natsume Nagato
    • Journal Title

      Aichi-Gakuin Dental Science 22

      Pages: 25-33

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Association study of folate pathway gene polymorphisms and nonsyndromic cleft lip with/without cleft palate in a Japanese population2009

    • Author(s)
      後藤尊広
    • Journal Title

      Ryukyu Med.J. 28(3, 4)

      Pages: 13-21

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミャンマー人における口唇口蓋裂発症とMTHFR遺伝子C677T多型の関連に対する検討2009

    • Author(s)
      後藤尊広
    • Journal Title

      琉球医学会誌 28巻1-2

      Pages: 25-29

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本人非症候群性口唇口蓋裂の発症と葉酸代謝酵素遺伝子多型における関連解析2010

    • Author(s)
      後藤尊広,新垣敬一,仲間錠嗣,石川拓,天願俊泉,古川博雄,南克浩,新美照幸,鈴木聡,藤原久美子,吉田和加,越路千佳子,夏目長門、砂川元
    • Organizer
      第34回日本口蓋裂学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-27
    • Related Report
      2010 Final Research Report
  • [Presentation] CLEFT LIP AND PALATE SURVEILLANCE AT THE CENTER FOR MONITORING OF CONGENITAL ABNORMALITIES IN MONGOLIA2010

    • Author(s)
      Natsume N, Imai Y, Koshiji C, Senda A, Maeda H, Otsuka T, Numabe H, Yoshida W, Od B, Bulgan B, Azzaya U, Ariuntuul G, Erkhembaatar T
    • Organizer
      The 67th Annual Meeting of the American Cleft Palate-Craniofacial Association
    • Place of Presentation
      Fort Worth, USA
    • Year and Date
      2010-03-20
    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] 口唇口蓋裂患者とその家族に対する遺伝カウンセリングの現状第2報クライアントの特長について2010

    • Author(s)
      藤原久美子,山本正彦,種村道代,鈴木聡,古川博雄,夏目長門
    • Organizer
      第53回日本口腔科学会中部地方部会
    • Place of Presentation
      富山
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] CLEFT LIP AND/OR PALATE CONGENITAL ORAL DISEASE GENE BANK, 20092009

    • Author(s)
      Natsume N, Takato T, Noguchi M, Sugiyama Y, Echigo S, Uchiyama T, Omura K, Kubota E, Sakashita H, Imai Y, Kurita K, Yamamoto M, Kogo M, Mori Y, Sugihara K, Nakamura N, Ozeki S, Takahashi T, Yanagisawa S, Goto M, Ikenoue T, Yoshiura K, Sunakawa H, Suzuki S, Yoshida W, Hayakawa T
    • Organizer
      The 11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies
    • Place of Presentation
      Fortaleza, Brazil
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] CLEFT LIP AND/OR PALATE CONGENITAL ORAL DI SEASE GENE BANK, 20092009

    • Author(s)
      Nagato Natsume
    • Organizer
      The 11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies
    • Place of Presentation
      Fortaleza, Brazil
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔先天異常遺伝カウンセリング2008

    • Author(s)
      夏目長門,鈴木聡,古川博雄,新美照幸,南克浩,藤原久美子,山本正彦
    • Organizer
      第20回日本小児口腔外科学会
    • Place of Presentation
      川越
    • Year and Date
      2008-09-19
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report 2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.aichi-gakuin.ac.jp/~cong_ano/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.aichi-gakuin.ac.jp/~cong_ano/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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