| Budget Amount *help |
¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2009: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2008: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2007: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
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| Research Abstract |
Streptococcus mutans is known to be a major cariogenic bacterial species that may also show virulence in blood. Serotype k strains, a minor serotype present in the oral cavity, may show higher levels of virulence in blood, because of a longer duration of bacteremia due to lower antigenicity derived from defects of major cell surface antigens. In addition, the higher rate of the organisms with collagen-binding properties identified in this strain may also be associated with virulence toward blood vessel endothelia with exposed internal collagen tissue.
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