| Project/Area Number |
19209064
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
SHIZUKUISHI Satoshi Osaka University, 大学院・歯学研究科, 教授 (00028789)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKI Michio 大阪大学, 医学系研究科, 助教 (00403056)
TANAKA Muneo 大阪大学, 歯学部附属病院, 講師 (90263300)
KUBONIWA Masae 大阪大学, 大学院・歯学研究科, 助教 (00303983)
SEKINE Shinichi 大阪大学, 大学院・歯学研究科, 助教 (70506344)
片岡 宏介 大阪大学, 歯学研究科, 助教 (50283792)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2007: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
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| Keywords | メタボリックシンドローム / 歯周病 / 疫学 / 分子生物学 / 歯周病原性細菌歯肉上皮細胞 / バイオフィルム / Porphyromonas gingivalis / Fusobacterium nucleatum / 免疫 / 糖尿病 / 血清脂質異常 / 炎症性サイトカイン / 動脈硬化性疾患 / 動物モデル / 歯周病細菌 / 肥満 / 血圧高値 / 空腹時血糖 / 循環器疾患 / バイオマーカー |
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| Research Abstract |
The purpose of this investigation was to examine the association of periodontal disease and various components of metabolic syndrome. In epidemiological studies, high blood pressure and periodontitis were significantly associated with macrovascular disease(s) as risk indicators. Levels of the inflammatory biomarkers including ICAM in the subjects with periodontitis increased meaningfully in comparison with the subjects without periodontitis. In apolipoprotein E-deficient mice, high-cholesterol diet and infection with Porphyromonas gingivalis accelerated inflammatory cytokines and atherosclerosis. Furthermore, a series of in vitro infection studies revealed that a periodontal pathogen caused cell cycle dysregulation in gingival epithelial cells.
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