Epidemiology of human visceral leishmaniasis (Kala-azar) in Old World

• Project/Area Number: 19256001
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: The University of Tokyo
• Principal Investigator: MATSUMOTO Yoshitsugu The University of Tokyo, 大学院・農学生命科学研究科, 教授 (00173922)
• Co-Investigator(Kenkyū-buntansha): 松本 安喜 東京大学, 大学院・農学生命科学研究科, 准教授 (90251420) ; 吾妻 健 高知大学, 医学部, 教授 (40117031) ; 細川 篤 琉球大学, 医学部, 講師 (10181497)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000); Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000); Fiscal Year 2009: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000); Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000); Fiscal Year 2007: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
• Keywords: 感染症 / 人獣共通感染症 / 原虫 / 免疫学 / リーシュマニア症 / Leishmania donovani / マウスモデル / カラアザール / PKDL / バングラデシュ / 遺伝子解析 / モンゴル / オオスナネズミ / 内臓型リーシュマニア症

Research Abstract

The comparative studies of Leishmania parasites from different foci ; visceral leishmaniasis patients, post kala-azar dermal leishmaniasis patients, cutaneous leishmaniasis patients, were attempted to understand the polymorphism of leishmaniasis as caused by L. donovani s.l. in Old world. Our study emphasizes the unreliability of the identification of Leishmania species solely on the basis of clinical presentation.

Research Products

• [Journal Article] Recent collections of Sergentomyia squamirostris (Newstead) (Diptera : Psychodidae) in Japan, with descriptions and illustrations (2011)
  • Author(s): Sanjoba C, Ozbel Y, Asada M, Osada Y, Gantuya S, Matsumoto Y.
  • Journal Title: Med.Entomol.Zool. 62(1) Pages: 71-77
  • Peer Reviewed
• [Journal Article] Distribution and ecological aspects of sand fly (Diptera : Psychodidae) species in Sri Lanka. (2011)
  • Author(s): Ozbel Y, Sanjoba C, Alten B, Asada M, Jerome D, Matsumoto Y, Samiye D, R.R.M.L.R.Siyambalagoda, R.P.V.J.Rajapakse, Matsumoto Y.
  • Journal Title: J.of Vector Ecology. 36(1)
  • Peer Reviewed
• [Journal Article] Recent collections of Sergentomyia squamirostris (Newstead)(Diptera : Psychodidae) in Japan, with descriptions and illustrations. (2011)
  • Author(s): Sanjoba C, et al.
  • Journal Title: Med Entomol Zool Volume: 62 Pages: 77-77
  • Peer Reviewed
• [Journal Article] Distribution and Ecological Aspects of Sand Fly (Diptera : Psychodidae) Species in Sri Lanka. (2011)
  • Author(s): Ozbel Y, et al.
  • Journal Title: Journal of Vector Ecology Volume: 36 Pages: 77-86
  • Peer Reviewed
• [Journal Article] Chapter 8-The Potential of Urinary Tests in the Management ofKala-Azar. (2011)
  • Author(s): Noiri E, et al.
  • Journal Title: Kala Azar in South Asia-current status and challenges ahead, Springer Pages: 69-90
• [Journal Article] Chapter 10-Polymorphism of Leishmaniasis caused by Leishmania donovani s.l.in Asia. (2011)
  • Author(s): Matsumoto Y, et al.
  • Journal Title: Kala Azar in South Asia-current status and challenges ahead, Springer Pages: 101-110
• [Journal Article] Phlebotomine sand flies in Japan (2010)
  • Author(s): Sanjoba C, Matsumoto Y.
  • Journal Title: Jpn.J.Vet.Parasitol. 9(2) Pages: 104-109
• [Journal Article] Intranasal immunization with Leish-111f induces IFN-gamma production and protects mice from Leishmania major infection (2010)
  • Author(s): Sakai S, Takashima Y, Matsumoto Y, Reed SG, Hayashi Y, Matsumoto Y.
  • Journal Title: Vaccine 28(10) Pages: 2207-13
  • Peer Reviewed
• [Journal Article] Intranasal immunization with Leish-111f induces IFN-gamma production and protects mice from Leishmania major infection. (2010)
  • Author(s): Sakai S, et al.
  • Journal Title: Vaccine Volume: 28 Pages: 2207-2213
  • Peer Reviewed
• [Journal Article] Intranasal immunization with Leish-111f induces IFN-gamma production and protects mice from Leishmania major infection (2010)
  • Author(s): Sakai S, Takashima Y, Matsumoto Y, Reed SG, Hayashi Y, Matsumoto Y
  • Journal Title: Vaccine 28(10) Pages: 2207-13
  • Peer Reviewed
• [Journal Article] Intranasal immunization with Leish-111f induces IFN-pamma production and protects mice from Leishmania major infection. (2010)
  • Author(s): Sakai, et al.
  • Journal Title: Vaccine 28・10 Pages: 2207-2213
  • Peer Reviewed
• [Journal Article] Pretreatment of macrophages with the combination of IFN-gamma and IL-12 induces resistance to Leishmania major at the early phase of infection (2008)
  • Author(s): Ota H, Takashima Y, Matsumoto Y, Hayashi Y, Matsumoto Y.
  • Journal Title: J Vet Med Sci. 70(6) Pages: 589-593
  • Peer Reviewed
• [Journal Article] Adhesion of MRP8/14 to amastigotes in skin lesions of Leishmania major-infected mice. (2008)
  • Author(s): Goto Y, Sanjoba C, Asada M, Saeki K, Onodera T, Matsumoto Y.
  • Journal Title: Exp Parasitol. 199(1) Pages: 80-86
  • Peer Reviewed
• [Journal Article] Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliate. (2008)
  • Author(s): Nakao Y, Kawatsu S, Okamoto M, Matsumoto Y, Matsunaga S, van Soest RW, Fusetani N.
  • Journal Title: J Nat Prod. 71(3) Pages: 469-472
  • Peer Reviewed
• [Journal Article] Adhesion of MRP8/14 to amastigotes in skin lesions of Leishmania major-infected mice (2008)
  • Author(s): Goto Y, Sanjoba C, Asada M, Saeki K, Onodera T, Matsumoto Y
  • Journal Title: Exp Parasitol 199(1) Pages: 80-86
  • Peer Reviewed
• [Journal Article] Pretreatment of macrophages with the combination of IFN-gamma and IL-12 induces resistance to Leishmania major at the early phase of infection (2008)
  • Author(s): Ota H, Takashima Y, Matsumoto Y, Hayashi Y, Matsumoto Y
  • Journal Title: J Vet Med Sci. 70(6) Pages: 589-593
  • Peer Reviewed
• [Journal Article] Adhesion of MRP8/14 to amastigotes in skin lesions of Leishmania major-infected mice. (2008)
  • Author(s): Yasuyuki Goto et al.
  • Journal Title: Experimental Parasitology 119・1 Pages: 80-86
  • Peer Reviewed
• [Journal Article] Pretreatment of Macrophages with the Combination of IFN-γand IL-12 Induces Resistance to Leishmania major at the Early Phase of Infection (2008)
  • Author(s): Haruko Ota et al.
  • Journal Title: Journal of Veterinary Medical Science 70・6 Pages: 589-593
  • Peer Reviewed
• [Journal Article] Adhesion of MRP8/14 to amastigotes in skin lesions of Leishmania major-infected mice (2008)
  • Author(s): Yasuyuki Goto, et al.
  • Journal Title: Experimental Parasitology 119・1 Pages: 80-86
  • Peer Reviewed
• [Journal Article] Pretreatment of Macrophages with the Combination of IFN-γ and IL-12 Induces Resistance to Leishmania major at the Early Phase of Infection (2008)
  • Author(s): Haruko Ota, et al.
  • Journal Title: Journal of Veterinary Medical Science 70・6 Pages: 589-593
  • Peer Reviewed
• [Journal Article] Accumulation of macrophages expressing MRP8 and MRP14 in skin lesions during Leishmania major infection in BALB/c and RAG-2 knockout mice (2007)
  • Author(s): Goto Y, Sanjoba C, Arakaki N, Okamoto M, Saeki K, Onodera T, Ito M, Matsumoto Y.
  • Journal Title: Parasitol Int. 56 Pages: 231-234
  • Peer Reviewed
• [Presentation] Efficacy of permethrin treated long-lasting insecticidal nets against phlebotomine sand flies. (2011)
  • Author(s): Sanjoba C, et al.
  • Organizer: Japan-US Joint Conference on Parasitic Diseases
  • Place of Presentation: 国立感染症砺究所(東京)
  • Year and Date: 2011-01-10
• [Presentation] A phybgeny of Leishmania major s.l.inferred from nagt sequences. (2011)
  • Author(s): Gantuya S, et al.
  • Organizer: Japan-US Joint Conference on Parasitic Diseases
  • Place of Presentation: 国立感染症研究所(東京)
  • Year and Date: 2011-01-10
• [Presentation] A phylogeny of Leishmania turanica, a parasite of great gerbils (2011)
  • Author(s): Gantuya S
  • Organizer: 第151回日本獣医学会学術集会
  • Place of Presentation: 東京
• [Presentation] Commonness and uniqueness of tandem repeat antigens in the trypanosomatid parasites (2011)
  • Author(s): Goto Y
  • Organizer: 45th Annual Japan-U.S. Joint Conference on Parasitic Diseases
  • Place of Presentation: Tokyo
• [Presentation] A phylogeny of Leishmania major s.l. inferred from nagt sequences (2011)
  • Author(s): Gantuya S
  • Organizer: 45th Annual Japan-U.S. Joint Conference on Parasitic Diseases
  • Place of Presentation: Tokyo
• [Presentation] Efficacy of permethrin treater long-lasting insecticidal nets against phlebotomine sand flies (2011)
  • Author(s): Sanjoba C
  • Organizer: 45th Annual Japan-U.S. Joint Conference on Parasitic Diseases
  • Place of Presentation: Tokyo
• [Presentation] Leishmania donovani感染Rag2遺伝子ノックアウトマウス血液からの原虫検出 (2010)
  • Author(s): 長田康孝
  • Organizer: 第70回日本寄生虫学会東日本支部大会
  • Place of Presentation: 栃木
  • Year and Date: 2010-10-02
• [Presentation] Leishmania donovani感染Rag2遺伝子ノックアウトマウス血液からの原虫検出 (2010)
  • Author(s): 長田康孝, ら
  • Organizer: 日本寄生虫学会東日本支部大会
  • Place of Presentation: 獨協医科大学(栃木)
  • Year and Date: 2010-10-02
• [Presentation] Leishmania major感染時の発症防御効果に違いのみられるリーシュマニア原虫由来抗原の経鼻および皮下免疫マウスにおける原虫ペプチド認識Th 1に注目した解析 (2010)
  • Author(s): 玄文宏, ら
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] IFN-Y/IL-12前処理マクロファージにみられるリーシュマニア原虫感染初期におけるNOに依存しない原虫殺傷能 (2010)
  • Author(s): 綱島るみ, ら
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] Anti-protozoan Agents from Marine Invertebrates (2010)
  • Author(s): Nakao Y
  • Organizer: The 1st Anniversary Symposium of Waseda Bioscience Research Institute in Singapore (WABIOS)
  • Place of Presentation: Singapore
  • Year and Date: 2010-09-15
• [Presentation] Anti-protozoan Agents from Marine Invertebrates. (2010)
  • Author(s): Nakao Y, et al.
  • Organizer: The l st Anniversary Symposium of Waseda Bioscience Research Institute in Singapore
  • Place of Presentation: シンガポール、シンガポール
  • Year and Date: 2010-09-15
• [Presentation] Different parasite inflow levels between mice infected with Leishmania major into tail base and footpad. (2010)
  • Author(s): Iwasaki Y, et al.
  • Organizer: 国際獣医免疫学シンポジウム
  • Place of Presentation: 東京都江戸川区タワーホール船堀(東京)
  • Year and Date: 2010-08-19
• [Presentation] The site of infection influences the performance of Leish-111f intranasal immunization in Leishmania major infection (2010)
  • Author(s): Gen F, etal.
  • Organizer: 国際獣医免疫学シンポジウム
  • Place of Presentation: 東京都江戸川区タワーホール船堀(東京)
  • Year and Date: 2010-08-19
• [Presentation] Nitric oxide-independent early parasite-killing of Leishmania major in cytokine-treated murine macrophages. (2010)
  • Author(s): Tsunashima R, et al.
  • Organizer: 国際獣医免疫学シンポジウム
  • Place of Presentation: 東京都江戸川区タワーホール船堀(東京)
  • Year and Date: 2010-08-19
• [Presentation] Leishmania donovani におけるミトコンドリアペルオキシレドキシンの発現及びその免疫原性 (2010)
  • Author(s): 麻田正仁, ら
  • Organizer: 日本寄生虫学会大会
  • Place of Presentation: 旭川市大雪クリスタルホール(北海道)
  • Year and Date: 2010-05-20
• [Presentation] Phlebotomine sand fly in Japan (2010)
  • Author(s): 三條場千寿, ら
  • Organizer: 日本寄生虫学会大会
  • Place of Presentation: 旭川市大雪クリスタルホール(北海道)
  • Year and Date: 2010-05-20
• [Presentation] IFN-y/IL-12前処理マクロファージにみられるリーシュマニア原虫感染初期におけるNOに依存しない感染抵抗性 (2010)
  • Author(s): 綱島るみ, ら
  • Organizer: 日本寄生虫学会大会
  • Place of Presentation: 旭川市大雪クリスタルホール(北海道)
  • Year and Date: 2010-05-20
• [Presentation] 日本産のサシチョウバエ(Diptera : Psychodidae, Phlebotominae)について (2010)
  • Author(s): 三條場千寿, ら
  • Organizer: 日本衛生動物学会大会
  • Place of Presentation: 鹿児島大学(鹿児島)
  • Year and Date: 2010-04-03
• [Presentation] Sero-reactivity of Mongolian great gerbils against L. turanica, L. gerbilii and L. major (2010)
  • Author(s): Gantuya S
  • Organizer: 第149回日本獣医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28
• [Presentation] Sero-reactivity of Mongolian great gerbils against L.turanica, L.gerbilii and L. major (2010)
  • Author(s): Sambuu Gantuya, et al.
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28
• [Presentation] Leishmania major感染時の発症防御効果に違いのみられるリーシュマニア原虫由来抗原の経鼻および皮下免疫マウスにおける原虫ペプチド認識Th1に注目した解析 (2010)
  • Author(s): 玄文宏
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広
• [Presentation] IFN-γ/IL-12前処理マクロファージにみられるリーシュマニア原虫感染初期におけるNOに依存しない原虫殺傷能 (2010)
  • Author(s): 綱島るみ
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広
• [Presentation] Nitric oxide-independent early parasite-killing of Leishmania major in cytokine-treated mirine macrophages (2010)
  • Author(s): Tsunashima R
  • Organizer: 第9回国際獣医免疫学シンポジウム
  • Place of Presentation: 東京
• [Presentation] The site of infection influences the performance of Leish-111f intranasal immunization in Leishmania major infection (2010)
  • Author(s): Gen F
  • Organizer: 第9回国際獣医免疫学シンポジウム
  • Place of Presentation: 東京
• [Presentation] Different parasite inflow levels between mice infected with Leishmania major into tail base and footpad (2010)
  • Author(s): Iwasaki Y
  • Organizer: 第9回国際獣医免疫学シンポジウム
  • Place of Presentation: 東京
• [Presentation] IFN-γ/IL-12前処理マクロファージにみられるリーシュマニア原虫感染初期に見られるNOに依存しない原虫抵抗性 (2010)
  • Author(s): 綱島るみ
  • Organizer: 第79回日本寄生虫学会大会
  • Place of Presentation: 旭川
• [Presentation] Leishmania donovaniにおけるミトコンドリアペルオキシレドキシンの発現及びその免疫原性 (2010)
  • Author(s): 麻田正仁
  • Organizer: 第79回日本寄生虫学会大会
  • Place of Presentation: 旭川
• [Presentation] Phlebotomine sand fly in Japan (2010)
  • Author(s): Sanjoba C
  • Organizer: 第79回日本寄生虫学会大会
  • Place of Presentation: 旭川
• [Presentation] 日本産のサシチョウバエ(Diptera:Psychodidae,Phlebotominae)について (2010)
  • Author(s): 三條場千寿
  • Organizer: 第62回日本衛生動物学会大会
  • Place of Presentation: 鹿児島
• [Presentation] 日本産のPhlebotomus属サシチョウバエについて (2009)
  • Author(s): 三條場千寿
  • Organizer: 第61回日本衛生動物学会東日本支部大会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-17
• [Presentation] 日本産のPhlebotomus属サシチョウバエについて (2009)
  • Author(s): 三條場千寿, ら
  • Organizer: 日本衛生動物学会東日本支部
  • Place of Presentation: 東京
  • Year and Date: 2009-10-17
• [Presentation] Leishmania turanica : Experimental infections in inbred gerbils (MGS/Sea) and BALB/c mice (2009)
  • Author(s): Gantuya S
  • Organizer: 第69回日本寄生虫学会東日本支部大会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] Aaptos ciliataから単離されたリポタンパクciliatamideの人工合成化合物のin vitroにおけるプロマスティゴート増殖抑制効果の評価 (2009)
  • Author(s): 長田康孝
  • Organizer: 第69回日本寄生虫学会東日本支部大会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] ミトコンドリアペルオキシドキシンはリーシュマニア属原虫において特有の分子構造を持ち高度に保存されている (2009)
  • Author(s): 麻田正仁
  • Organizer: 第69回日本寄生虫学会東日本支部大会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] Leish-111f経鼻投与のリーシュマニア症防御効果の感染部位による違い (2009)
  • Author(s): 玄文宏
  • Organizer: 第69回日本寄生虫学会東日本支部大会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] LPS刺激マウス脾臓マクロファージのリーシュマニア原虫感染初期における感染抵抗性 (2009)
  • Author(s): 網島るみ
  • Organizer: 第69回日本寄生虫学会東日本支部大会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] LPS刺激マウス脾臓マクロファージのリーシュマニア原虫感染初期における感染抵抗性 (2009)
  • Author(s): 網島るみ, ら
  • Organizer: 日本寄生虫学会東日本支部
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] Leish-111f経鼻投与のリーシュマニア症防御効果の感染部位による違い (2009)
  • Author(s): 玄文宏, ら
  • Organizer: 日本寄生虫学会東日本支部
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] ミトコンドリアペルオキシドキシンはリーシュマニア属原虫において特有の分子構造を持ち高度に保存されている (2009)
  • Author(s): 麻田正仁, ら
  • Organizer: 日本寄生虫学会東日本支部
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] Aaptos ciliataから単離されたリポタンパクciliatamideの人工合成化合物のin vitroにおけるプロマスティゴート増殖抑制効果の評価 (2009)
  • Author(s): 長田康孝, ら
  • Organizer: 日本寄生虫学会東日本支部
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] Leishmania turanica : Experimental infections in inbred gerbils (MGS/Sea) and BALB/C mice (2009)
  • Author(s): Sambuu Gantuya, et al.
  • Organizer: 日本寄生虫学会東日本支部
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] ミトコンドリアペルオキシドキシンのリーシュマニア原虫アマスティゴートにおける発現及び局在 (2009)
  • Author(s): 麻田正仁
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] Leish-111f経鼻投与後のリーシュマニア原虫感染防御効果の感染部位特異性について (2009)
  • Author(s): 玄文宏
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] 尾根部および足蹠部へ接種したリーシュマニア原虫の体内移行動態 (2009)
  • Author(s): 岩崎雄亮
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] 尾根部および足蹠部へ接種したリーシュマニア原虫の体内移行動態 (2009)
  • Author(s): 岩崎雄亮, ら
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] Leish-111f経鼻投与後のリーュマニア原虫感染防御効果の感染部位特異性について (2009)
  • Author(s): 玄文宏, ら
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] ミトコンドリアペルオキシドキシンのリーシュマニア原虫アマスティゴートにおける発現及び局在 (2009)
  • Author(s): 麻田正仁, ら
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] Aaptos Ciliataから単離されたリーシュマニア活性リポタンパクCiliatamideの合成と構造活性相関の検討 (2009)
  • Author(s): 大森裕史
  • Organizer: 日本化学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-04
• [Presentation] リーシュマニア原虫抗原の経鼻及び皮下接種により活性化されるBALB/cマウスIFNγ産生T細胞の認識エピトープ解析 (2009)
  • Author(s): 玄文宏
  • Organizer: 第147回日本獣医学会学術集会
  • Place of Presentation: 栃木
  • Year and Date: 2009-04-03
• [Presentation] EGFP遺伝子導入Leishmania majorを用いたリーシュマニア治療薬のin vitroにおけるプロマスティゴート増殖抑制効果の評価 (2009)
  • Author(s): 長田康孝
  • Organizer: 第147回日本獣医学会学術集会
  • Place of Presentation: 栃木
  • Year and Date: 2009-04-03
• [Presentation] EGFP遺伝子導入Leishmania majorを用いたリーシュマニア治療薬のin vitroにおけるプロマスティゴート増殖抑制効果の評価 (2009)
  • Author(s): 長田康孝, ら
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 栃木
  • Year and Date: 2009-04-03
• [Presentation] リーシュマニア原虫抗原の経鼻及び皮下接種により活性化されるBALB/cマウスIFNγ産生T細胞の認識エピトープ解析 (2009)
  • Author(s): 玄文宏, ら
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 栃木
  • Year and Date: 2009-04-03
• [Presentation] Different T-cell recognition patterns of Leish-111f epitopes in BALB/c mice immunized intranasally or subcutaneously (2009)
  • Author(s): Yasunobu Matsumoto et al.
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: インド・ラクナウ
  • Year and Date: 2009-02-06
• [Presentation] Leishmania mitochondrial peroxidoxin.Analyses using monospecific anti body (2009)
  • Author(s): Masahito Asada et al.
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: インド・ラクナウ
  • Year and Date: 2009-02-05
• [Presentation] Observational Study of Urinary Indicators in Kala-azar (2009)
  • Author(s): Eisei Noiri et al.
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: インド・ラクナウ
  • Year and Date: 2009-02-05
• [Presentation] Leishmania mitochondrial peroxidoxin. Analyses using monospecific antibody (2009)
  • Author(s): Masahito Asada, et al.
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: インド・ラクナウ
  • Year and Date: 2009-02-05
• [Presentation] Zoonotic Leishmania infection among great gerbils in Mongolia (2009)
  • Author(s): Sambuu Gantuya
  • Organizer: The 4^<th> World Congress on Leishmaniasis (WL4)
  • Place of Presentation: インド
  • Year and Date: 2009-02-04
• [Presentation] Pathogenesis of post kala-azar dermal leishmaniasis (2009)
  • Author(s): Masahito Asada et al.
  • Organizer: The Japan-United States Cooperative Medical Science Program
  • Place of Presentation: 東京
  • Year and Date: 2009-01-08
• [Presentation] Zoonotic Leishmania parasites of great gerbils, Rhombomys opimus in Mongolia (2009)
  • Author(s): Sambuu Gantuya et al.
  • Organizer: The Japan-United States Cooperative Medical Science Program
  • Place of Presentation: 東京
  • Year and Date: 2009-01-08
• [Presentation] Pathogenesis of post kala-azar dermal leishmaniasis (2009)
  • Author(s): Masahimto Asada
  • Organizer: 第43回日米医学協力研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-07
• [Presentation] Nucleotide sequence of the actin-encoding gene of Leishmania parasites from great gerbils in Mongolia (2009)
  • Author(s): Gantuya S
  • Organizer: 第78回日本寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] ミトコンドリアペルオキシドキシンのLeishmaniaアマスティゴート及びプロマスティゴートにおける発現 (2009)
  • Author(s): 麻田正仁
  • Organizer: 第78回日本寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] Different T-cell recognition patterns of Leish-111f epitopes in BALB/c mice immunized intranasally or subcutaneously (2009)
  • Author(s): Matsumoto Y
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: Lucknow, India
• [Presentation] Observational Study of Urinary Indicators in Kala-azar (2009)
  • Author(s): Noiri E
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: Lucknow, India
• [Presentation] Zoonotic Leishmania infection among great gerbils in Mongolia (2009)
  • Author(s): Gantuya S
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: Lucknow, India
• [Presentation] Leishmania mitochondrial peroxidoxin.Analyses using monospecific antibody (2009)
  • Author(s): Asada M
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: Lucknow, India
• [Presentation] Molecular characterization of Lishmania major s.l. (2009)
  • Author(s): Sanjoba C
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: Lucknow, India
• [Presentation] Different inducible efficiency of antigen-specific T-cells by intranasal and subcutaneous immunizations (2009)
  • Author(s): Matsumoto Y
  • Organizer: The Japan-United States Cooperative Medical Science Program, 43rd Joint Conference on Parasitic Disease
  • Place of Presentation: Tokyo, Japan
• [Presentation] Pathogenesis of post kala-azar dermal leishmaniasis (2009)
  • Author(s): Asada M
  • Organizer: The Japan-United States Cooperative Medical Science Program, 43rd Joint Conference on Parasitic Disease
  • Place of Presentation: Tokyo, Japan
• [Presentation] Zoonotic Leishmania parasites of great gerbils, Rhombomys opimus in Mongolia (2009)
  • Author(s): Gantuya S
  • Organizer: The Japan-United States Cooperative Medical Science Program, 43rd Joint Conference on Parasitic Disease
  • Place of Presentation: Tokyo, Japan
• [Presentation] PKDL(Post kala-azar dermal leishmaniasis)患者nodulartype皮膚病変からのリーシュマニア原虫の検出 (2008)
  • Author(s): 麻田正仁ら
  • Organizer: 日本熱帯医学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-25
• [Presentation] PKDL(Post kala-azar dermal leishmaniasis)患者 nodular type 皮膚病変からのリーシュマニア原虫の検出 (2008)
  • Author(s): 麻田正仁, ら
  • Organizer: 日本熱帯医学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-25
• [Presentation] PKDL(Post kala-azar dermal leishmaniasis)患者nodular type皮膚病変からのリーシュマニア原虫の検出 (2008)
  • Author(s): 麻田正仁
  • Organizer: 第49回日本熱帯学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-05
• [Presentation] Leish-111fの経鼻接種により誘導されるIFNγ産生T細胞の認識エピトープ解析 (2008)
  • Author(s): Nimsphan B
  • Organizer: 第68回日本寄生虫学会東日本支部大会
  • Place of Presentation: 静岡
  • Year and Date: 2008-10-05
• [Presentation] Zoonotic leishmaniasis is endemic in Mongolian great gerbil (2008)
  • Author(s): Gantuya S
  • Organizer: 第68回日本寄生虫学会東日本支部大会
  • Place of Presentation: 静岡
  • Year and Date: 2008-10-05
• [Presentation] Zoonotic leishmaniasis is endemic in Mongolian great gerbil (2008)
  • Author(s): Sambuu Gantuya et al.
  • Organizer: 日本寄生虫学会東日本支部
  • Place of Presentation: 浜松
  • Year and Date: 2008-10-04
• [Presentation] Leishmania majorプロマスティゴートにおけるミトコンドリア並びに細胞質ペルオキシドキシンの発現 (2008)
  • Author(s): 麻田正仁ら
  • Organizer: 日本寄生虫学会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-04
• [Presentation] Leishmania major プロマスティゴートにおけるミトコンドリア並びに細胞質ペルオキシドキシンの発現 (2008)
  • Author(s): 麻田正仁, ら
  • Organizer: 日本寄生虫学会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-04
• [Presentation] Leishmania donovani s.l. における Csystein protease 遺伝子の多様性 (2008)
  • Author(s): 三條場千寿
  • Organizer: 第77回日本寄生虫学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-03
• [Presentation] Leishmania donovani s. l. におけるCystein protease遺伝子の多様性 (2008)
  • Author(s): 三條場千寿ら
  • Organizer: 日本寄生虫学会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-03
• [Presentation] Leishmania donovani s. l. における Cystein protease 遺伝子の多様性 (2008)
  • Author(s): 三條場千寿, ら
  • Organizer: 日本寄生虫学会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-03
• [Presentation] Nucleotide sequence of the actin-encoding gene of Leishmania parasites from great gerbils in Mongolia (2008)
  • Author(s): Sambuu Gantuya et al.
  • Organizer: 日本寄生虫学会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-28
• [Presentation] Zoonotic Leishmania infection among great gerbils in Mongolia (2008)
  • Author(s): Sambuu Gantuya et al.
  • Organizer: The 4th World Congress on Leishmaniasis WL4)
  • Place of Presentation: インド・ラクナウ
  • Year and Date: 2008-02-04
• [Presentation] Zoonotic Leishmania infection among great gerbils in Mongolia (2008)
  • Author(s): Sambuu Gantuya, et al.
  • Organizer: The 4th World Congress on Leishmaniasis (WL4)
  • Place of Presentation: インド・ラクナウ
  • Year and Date: 2008-02-04
• [Presentation] Leishmania majorプロマスティゴートにおけるミトコンドリア並びに細胞質ペルオキシドキシンの発現 (2008)
  • Author(s): 麻田正仁
  • Organizer: 第77回日本寄生虫学会大会
  • Place of Presentation: 長崎
• [Presentation] Distribution and Ecological Aspect of Sand Fly (Diptera : Psychodidae) Species in Sri Lanka (2008)
  • Author(s): Ozbel Y
  • Organizer: 第77回日本寄生虫学会大会
  • Place of Presentation: 長崎
• [Presentation] Leishmania donovani s.l.におけるCsystein protease遺伝子の多様性 (2008)
  • Author(s): 三條場千寿
  • Organizer: 第77回日本寄生虫学会大会
  • Place of Presentation: 長崎
• [Presentation] The Research on Vectors of Human Cutaneous Leishmaniasis Endemic Areas in Sri Lanka (2008)
  • Author(s): Ozbel Y
  • Organizer: 第145回日本獣医学会学術集会
  • Place of Presentation: 神奈川
• [Presentation] Phlebotomus spp.におけるcytochrome-c oxidase subunit 1(CO-1)遺伝子塩基配列の相違 (2008)
  • Author(s): 麻田正仁
  • Organizer: 第145回日本獣医学会学術集会
  • Place of Presentation: 神奈川
• [Presentation] L. donovani s.l.による非定型皮膚型リーシュマニア症 (2007)
  • Author(s): 三條場千寿
  • Organizer: 第67回日本寄生虫学会東日本支部大会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-06
• [Presentation] スリランカにおけるLeishmania donovani s.l.による皮膚型リーシュマニア症の保虫宿主の血清学的探索 (2007)
  • Author(s): 麻田正仁
  • Organizer: 第144回日本獣医学会
  • Place of Presentation: 札幌
• [Book] The Potential of Urinary Tests in the Management of Kala-Azar. Kala Azar in South Asia, Part III. 8 (2011)
  • Author(s): Noiri E, Hamasaki Y, Negishi K, Sugaya T, Doi K, Fujita T, Osada Y, Matsumoto Y, Kazi M.Jamil
  • Publisher: Springer, Tokyo
• [Book] Polymorphism of Leishmaniasis Caused by Leishmania donovani Sensu Lato in Asia. Kala Azar in South Asia, Part IV. 10 (2011)
  • Author(s): Matsumoto Y, Sanjoba C, Asada M, Osada Y, Matsumoto Y
  • Publisher: Springer, Tokyo
• [Patent(Industrial Property Rights)] 抗リーシュマニア化合物及び抗リーシュマニア薬 (2011)
  • Inventor(s): 木村純二,堀江将平,丸島春美,松本芳嗣,三條場千寿,長田康孝
  • Industrial Property Rights Holder: 学校法人青山学院
  • Filing Date: 2011-03-08
• [Patent(Industrial Property Rights)] 抗リーシュマニア化合物及び抗リーシュマニア薬 (2011)
  • Inventor(s): 松本芳嗣, ら
  • Industrial Property Rights Holder: 学校法人青山学院
  • Filing Date: 2011-03-08
  • Overseas
• [Patent(Industrial Property Rights)] 内臓型リーシュマニア症疾患活動性モニタリング法 (2010)
  • Inventor(s): 野入英世、根岸康介、松本芳嗣、三條場千寿
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Acquisition Date: 2010-04-20
• [Patent(Industrial Property Rights)] 抗リーシュマニア薬 (2010)
  • Inventor(s): 木村純二,堀江将平,丸島春美,松本芳嗣,三條場千寿,長田康孝
  • Industrial Property Rights Holder: 学校法人青山学院
  • Industrial Property Number: 2010-234923
  • Filing Date: 2010-10-19
• [Patent(Industrial Property Rights)] 抗リーシュマニア化合物及び抗リーシュマニア薬 (2010)
  • Inventor(s): 松本芳嗣, ら
  • Industrial Property Rights Holder: 学校法人 青山学院
  • Industrial Property Number: 2010-234923
  • Filing Date: 2010-10-19