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Predicting Antigenic Changes of Influenza Viruses by Discovering Patterns of Viral Evolution

Research Project

Project/Area Number 19300041
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent informatics
Research InstitutionHokkaido University

Principal Investigator

ITO Kimihito  Hokkaido University, 人獣共通感染症リサーチセンター, 准教授 (60396314)

Co-Investigator(Kenkyū-buntansha) TAKADA Ayato  北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)
MINATO Shin-ichi  北海道大学, 大学院・情報科学研究科, 准教授 (10374612)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords知識発見とデータマイニング / パターン発見 / アルゴリズム / 生体生命情報学 / インフルエンザウイルス / 感染症
Research Abstract

Human influenza viruses mutate from time to time, causing annual epidemics worldwide. Given the high mutation rate of the viral gene, it is difficult to select an effective vaccine strain prior to each influenza season. In order to elucidate the pattern of viral evolution, we introduce a bioinformatics technology that analyzes a large number of epidemic strains in a multidimensional space. We found that the relative sequence distances among past epidemic strains could be predicted by a mathematical model. Retrospective tests for 12 years showed that the model could predict the direction of viral evolution with high accuracy.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (39 results)

All 2010 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (24 results)

  • [Journal Article] Predicting the antigenic structure of the pandemic (H1N1) 2009 influenza virus hemagglutinin2010

    • Author(s)
      Igarashi, M., Ito, K., Yoshida, R., Tomabechi, D., Kida, H., Takada, A.
    • Journal Title

      PLoS ONE 5(1)

    • NAID

      120001804925

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predicting the antigenic Structure of the Pandemic(H1N1)2009 Influenza Virus Hemagglutinin2010

    • Author(s)
      Igarashi M, Ito K, Yoshida R, Tomabechi D, Kida H, Takada A
    • Journal Title

      PLoS ONE 5

    • NAID

      120001804925

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovering networks for global propagation of influenza a (H3N2) viruses by clustering2009

    • Author(s)
      Sata, K., Hirata, K., Ito, K., Kuboyama T.
    • Journal Title

      Lect. Notes Comput. Sc. 5712

      Pages: 490-497

    • NAID

      40016819277

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clustering the normalized compression distance for virus data2009

    • Author(s)
      Ito, K., Zeugmann, T., Zhu, Y.
    • Journal Title

      Proceedings of the Sixth Workshop on Learning with Logics and Logics for Learning(LLLL 2009)

      Pages: 56-67

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] インフルエンザウイルスの抗原変異予測とワクチン2009

    • Author(s)
      伊藤公人, 高田礼人
    • Journal Title

      VIRUS REPORT 2009 Vol. 6 No. 2

    • Related Report
      2009 Final Research Report
  • [Journal Article] Characterization of H3N6 avian influenza virus isolated from a wild white pelican in Zambia.2009

    • Author(s)
      Simulundu, E., Mweene, A.S., Tomabechi, D., Hang'ombe, B.M., Ishii, A., Suzuki, Y., Nakamura, I., Sawa, H., Sugimoto, C., Ito, K., Kida, H., Saiwana, L., Takada, A.
    • Journal Title

      Arch Virol 154(9)

      Pages: 1517-1522

    • NAID

      120002383247

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses2009

    • Author(s)
      Yoshida, R., Igarashi, M., Ozaki, H., Kishida, N., Tomabechi, D., Kida, H., Ito, K., Takada, A.
    • Journal Title

      PLoS Pathog 5(3)

    • NAID

      120005617294

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discovering networks for global propagation of influenza a(H3N2)viruses by clustering2009

    • Author(s)
      Sata K, Hirata K, Ito K, Kuboyama T
    • Journal Title

      Lect.Notes Comput.Sc. 5712

      Pages: 490-497

    • NAID

      40016819277

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of H3N6 avian influenza virus isolated from a wild white pelican in Zambia2009

    • Author(s)
      Simulundu E, Mweene AS, Tomabechi D, Hang'ombe BM, Ishii A, Suzuki Y, Nakamura I, Sawa H, Sugimoto C, Ito K, Kida H, Saiwana L, Takada A
    • Journal Title

      Arch Virol. 154

      Pages: 1517-1522

    • NAID

      120002383247

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses2009

    • Author(s)
      Yoshida, R., Igarashi, M., Ozaki, H., Kishida, N., Tomabechi, D., Kida, H., Ito, K., Takada, A.
    • Journal Title

      PLoS Pathogen 5

    • NAID

      120005617294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin.2008

    • Author(s)
      Igarashi, M., Ito, K., Kida, H., Takada, A.
    • Journal Title

      Virology 376(2)

      Pages: 323-329

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetically destined potentials for N-linked glycosylation associated with antigenic changes of influenza virus hemagglutinin2008

    • Author(s)
      Igarashi, M., Ito, K., Kida, H., Takada, A.
    • Journal Title

      Virology 376(2)

      Pages: 323-329

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically destined potentials for N-linked glycosylation associated with antigenic changes of influenza virus hemagglutinin2008

    • Author(s)
      Igarashi, M., Ito, K., Kida, H., Takada, A.
    • Journal Title

      Virology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Symmetric item set mining method using zero-suppressed BDDs and application to biological data2007

    • Author(s)
      Minato, S., Ito, K.
    • Journal Title

      Trans. JSAI 22

      Pages: 156-164

    • NAID

      130000058331

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Symmetric Item Set Mining Method Using Zero-suppressed BDDs and Application to Biological Data2007

    • Author(s)
      Minato, S. and Ito, K.
    • Journal Title

      Transactions of the Japanese Society for Artificial Intelligence 22

      Pages: 156-164

    • NAID

      130000058331

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ハミング距離空間の次元削減によるインフルエンザウイルス遺伝子変異の解析2010

    • Author(s)
      久保山哲二, 伊藤公人
    • Organizer
      人工知能学会第77回人工知能基本問題研究会
    • Place of Presentation
      札幌
    • Year and Date
      2010-03-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Inference of geographic transmission probability of influenza viruses from a large phylogenetic tree2009

    • Author(s)
      Yanagihashi F, Ito K, Arimura H
    • Organizer
      The 20th International Conference on Genome Informatics GIW2009
    • Place of Presentation
      PACIFICO YOKOHAMA, Yokohama, Japan
    • Year and Date
      2009-12-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルスのヘマグルチニンのMDS解析と変異予測への応用2009

    • Author(s)
      伊藤公人, 五十嵐学, 村上悌治, 喜田宏, 高田礼人
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Final Research Report
  • [Presentation] ホモロジーモデリング法による新型H1N1インフルエンザウイルスのヘマグルチニンの抗原構造の解析2009

    • Author(s)
      五十嵐学, 伊藤公人, 吉田玲子, 喜田宏, 高田礼人
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 愛知県でウズラから分離されたH7N6亜型鳥インフルエンザウイルスの遺伝子解析2009

    • Author(s)
      内田裕子, 真瀬昌司, 竹前喜洋, 廣本靖明, 五十嵐学, 伊藤公人, 高田礼人, 西藤岳彦, 津田知幸, 山口成夫
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Final Research Report
  • [Presentation] インフルエンザウイルスのヘマグルチニンのMDS解析と変異予測への応用2009

    • Author(s)
      伊藤公人, 五十嵐学, 村上悌治, 喜田宏, 高田礼人
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] ホモロジーモデリング法による新型H1N1インフルエンザウイルスのヘマグルチニンの抗原構造の解析2009

    • Author(s)
      五十嵐学, 伊藤公人, 吉田玲子, 喜田宏, 高田礼人
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 愛知県でウズラから分離されたH7N6亜型鳥インフルエンザウイルスの遺伝子解析2009

    • Author(s)
      内田裕子, 真瀬昌司, 竹前喜洋, 廣本靖明, 五十嵐学, 伊藤公人, 高田礼人, 西藤岳彦, 津田知幸, 山口成夫
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clustering the normalized compression distance for virus data2009

    • Author(s)
      Ito K, Zeugmann T, Zhu Y
    • Organizer
      The Sixth Workshop on Learning with Logics and Logics for Learning(LLLL 2009)
    • Place of Presentation
      Kyodai Kaikan, Kyoto, Japan
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 木の最適ラベリング問題とその進化系統樹への応用2009

    • Author(s)
      柳橋史成, 伊藤公人, 有村博紀
    • Organizer
      第16回バイオ情報学研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-06
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Inference of Geographic Transmission Probability of Influenza Viruses from a Large Phylogenetic Tree2009

    • Author(s)
      Yanagihashi, F., Ito, K., Arimura, H.
    • Organizer
      The 20th International Conference on Genome Informatics GIW2009
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] インフルエンザウイルスHA遺伝子の塩基配列上に潜在する糖鎖付加ポテンシャルの解析2008

    • Author(s)
      五十嵐学, 伊藤公人, 喜田宏, 高田礼人
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-26
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 順序付き部分グループ列分割のためのコントラストセットマイニングアルゴリズム2008

    • Author(s)
      谷口剛, 伊藤公人, 原口誠
    • Organizer
      第22回人工知能学会全国大会
    • Place of Presentation
      旭川
    • Year and Date
      2008-06-13
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 塩基およびアミノ酸配列における共変異集合を列挙する高速アルゴリズム2008

    • Author(s)
      伊藤公人, 谷口剛, 村上悌治, 有村博紀, 原口誠
    • Organizer
      第12回バイオ情報学研究会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-04
    • Related Report
      2009 Final Research Report
  • [Presentation] 塩基およびアミノ酸配列における共変異集合を列挙する高速アルゴリズム2008

    • Author(s)
      伊藤公人, 谷口剛, 村上悌治, 有村博紀, 原口誠
    • Organizer
      第12回バイオ情報学研究会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2008-03-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] コントラストセットマイニングに基づく順序付きグループ列分割手法2008

    • Author(s)
      谷口剛, 原口誠, 伊藤公人
    • Organizer
      第68回人工知能基本問題研究会 (SIG-FPAI-A703)
    • Place of Presentation
      札幌
    • Year and Date
      2008-01-17
    • Related Report
      2009 Final Research Report
  • [Presentation] コントラストセットマイニングに基づく順序付きグループ列分割手法2008

    • Author(s)
      谷口剛, 原口誠, 伊藤公人
    • Organizer
      第68回人工知能基本問題研究会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2008-01-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] グループ列分割に基づくインフルエンザウイルスのアミノ酸置換における時代的変化の解析2007

    • Author(s)
      谷口剛, 原口誠, 伊藤公人
    • Organizer
      第11回バイオ情報学研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-21
    • Related Report
      2009 Final Research Report
  • [Presentation] グループ列分割に基づくインフルエンザウイルスのアミノ酸置換における時代的変化の解析2007

    • Author(s)
      谷口剛, 原口誠, 伊藤公人
    • Organizer
      第11回バイオ情報学研究会
    • Place of Presentation
      産業技術総合研究所(東京都)
    • Year and Date
      2007-12-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] アイテム集合間の相関変化検出によるインフルエンザウイルス遺伝子データの解析2007

    • Author(s)
      谷口剛, 伊藤公人, 五十嵐学, 村上悌治, 原口誠
    • Organizer
      第21回人工知能学会全国大会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-06-21
    • Related Report
      2009 Final Research Report
  • [Presentation] アイテム集合間の相関変化検出によるインフルエンザウイルス遣伝子データの解析2007

    • Author(s)
      谷口 剛, 伊藤公人, 五十嵐学, 村上悌治, 原口 誠
    • Organizer
      第21回人工知能学会全国大会
    • Place of Presentation
      ワールドコンベンションセンターサミット(宮崎市)
    • Year and Date
      2007-06-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pattern Mining from a Large Phylogenetic Tree of Influenza Viruses2007

    • Author(s)
      Ito, K.
    • Organizer
      2nd International Conference on Perspectives of Intelligent System's Assistance
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetically destined potentials for N-linked glycosylation associated with antigenic changes of influenza virus hemagglutinin2007

    • Author(s)
      Igarashi, M., Ito, K., Kida, H., Takada, A.
    • Organizer
      In : Proceedings of the International Conference on Options for the Control of Influenza IV
    • Place of Presentation
      Toronto, Ontario, Canada
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetically destined potentials for N-linked glycosylation associated with antigenic changes of influenza virus hemagglutinin2007

    • Author(s)
      Igarashi, M., Ito, K., Kida, H., Takada, A.
    • Organizer
      The International Conference on Options for the Control of Influenza IV
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto, Canada
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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