Statistical genetics for designing multistage genome-wide association studies to detect genetic risk factors

• Project/Area Number: 19300095
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Statistical science
• Research Institution: Niigata University
• Principal Investigator: AKAZAWA Kohei Niigata University, 医歯学総合病院, 教授 (10175771)
• Co-Investigator(Kenkyū-buntansha): TOYABE Shin-ichi 新潟大学, 危機管理室, 教授 (20227648) ; KUWANO Ryozo 新潟大学, 脳研究所, 教授 (20111734) ; MIYASHITA Akinori 新潟大学, 脳研究所, 助教 (60323995)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: 医薬生物統計 / 疾患感受性遺伝子 / 症例-対照関連解析 / 多段階関連解析法 / Replication-based analysis / Joint analysis / 統計学的検出力 / 陽性反応適中度 / 遺伝子解析 / シミュレーション

Research Abstract

本研究では、SNPsデータを用いて疾患関連遺伝子を同定するための多段階デザイン症例-対照相関解析の統計学的性質を詳細に検討した。研究成果として以下が挙げられる。1. R言語を使い、多段階デザイン症例-対照研究の検出力を推定するプログラムを開発した。2. 3段階法において、各ステージの症例割合を種々変化させたときの検出力とタイピング数を調べた. これらの結果は、国際学術誌Bioinformatics、Journal of Human Geneticsに掲載された。

Research Products

• [Journal Article] Programs for calculating the statistical powers of detecting susceptibility genes in case-control studies based on multistage designs (2009)
  • Author(s): Kitamura N, Akazawa K, Miyashita A, Kuwano R, Toyabe SI, Nakamura J, Nakamura N, Sato T, Hoque MA
  • Journal Title: Bioinformatics 25(2) Pages: 272-273
  • Peer Reviewed
• [Journal Article] Programs for calculating the statistical powers of detecting susceptibility genes in case-control studies based on multistage designs. (2009)
  • Author(s): Kitamura N
  • Journal Title: Bioinformatics 25(2) Pages: 272-273
  • Peer Reviewed
• [Journal Article] Prediction of Disease-associated Single Nucleotide Polymorphisms Using Virtual Genomes Constructed from a Public Haplotype Database (2008)
  • Author(s): Toyabe S, Miyashita A, Kitamura N, Kuwano R, Akazawa K
  • Journal Title: Methods Inf Med 47(6) Pages: 522-528
  • Peer Reviewed
• [Journal Article] Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease susceptibility genes (2008)
  • Author(s): Kitamura N, Akazawa K, Toyabe SI, Miyashita A, Kuwano R, Nakamura J
  • Journal Title: J Hum Genet 53(5) Pages: 390-400
  • NAID: 10021248775
  • Peer Reviewed
• [Journal Article] Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease suscepti bility genes. (2008)
  • Author(s): Kitamura N
  • Journal Title: J Hum Genet 53(5) Pages: 390-400
  • Peer Reviewed
• [Journal Article] Prediction of Disease-associated Single Nucleotide Polymorph isms Using Virtual Genomes Constructed from a Public Haplotype Database. (2008)
  • Author(s): Toyabe S
  • Journal Title: Methods Inf Med. 47(6) Pages: 522-528
  • Peer Reviewed
• [Journal Article] Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease susceptibility genes. (2008)
  • Author(s): Kitamura N, Akazawa K, Toyabe SI, Miyashita A, Kuwano R, Nakamura J
  • Journal Title: Journal of Human Genetics (印刷中)
  • NAID: 10021248775
  • Peer Reviewed
• [Journal Article] Genetic association of CTNNA3 with late-onset Alzheimer's disease in females (2007)
  • Author(s): Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R
  • Journal Title: Human Molecular Genetics 16(23) Pages: 2854-69
  • Peer Reviewed
• [Journal Article] Genetic association of CTNNA3 with late-onset Alzheimer's disease in females (2007)
  • Author(s): Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R.
  • Journal Title: Human Molecular Genetics 16(23) Pages: 2854-69
  • Peer Reviewed
• [Journal Article] SNPデータに基づく疾患感受性遺伝子同定のための多段階症例-対照研究デザインの特性
  • Author(s): 北村信隆、赤澤宏平
  • Journal Title: 新潟医学会雑誌 (印刷中)
  • Peer Reviewed
• [Presentation] SNPデータに基づく疾患感受性遺伝子同定のための多段階症例-対照研究デザインの特性 (2008)
  • Author(s): 北村信隆
  • Organizer: 2008年度統計関連学会連合大会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2008-09-09