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Development of statistical methodology for detecting factors of disease mechanism based on clinical omics data

Research Project

Project/Area Number 19300100
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Statistical science
Research InstitutionJapanese Foundation For Cancer Research

Principal Investigator

MATSUURA Masaaki  Japanese Foundation For Cancer Research, がんゲノム研究部, 部長 (40173794)

Co-Investigator(Kenkyū-buntansha) EGUCHI Shinto  統計数理研究所, 数理推測研究系, 教授 (10168776)
FUJISAWA Hironori  統計数理研究所, 数理推測研究系, 準教授 (00301177)
HOSHIKAWA Yutaka  財団法人癌研究会, 癌研究所がんゲノム研究部, 研究員 (80280626)
ISOMURA Minoru  財団法人癌研究会, ゲノムセンター, 研究員 (40272497)
MIYATA Satoshi  財団法人癌研究会, ゲノムセンター, 研究員 (60360343)
USHIJIMA Masaru  財団法人癌研究会, ゲノムセンター, 研究員 (60328565)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywords統計数学 / ゲノム / マイクロアレイ / プロテオーム / 生体生命情報学 / 統計数単 / 遺伝子発現 / オミックスデータ / 機械学習
Research Abstract

マイクロアレイデータと臨床情報を用いて疾患のメカニズムに関連する候補遺伝子を探索するために、生物学的情報を加味した遺伝子評価法を開発し、複数の予測モデルを組み合わせた論理和予測モデルを用いて予測性能の検証も行った。また、各患者で50万箇所以上におよぶ一塩基多型(SNP)データに対して、特定の複数SNPを組合わせた場合にのみ、表現型と関連するSNPの組を探索するための高速な統計的手法の開発に成功し、特許申請を行っ

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (34 results)

All 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (19 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Inference on biological mechanisms using an integrated phenotype prediction model2008

    • Author(s)
      Enomoto Y, Ushijima M, Miyata S, Matsuura M. Ohtaki M
    • Journal Title

      Hiroshima Journal of Medical Sciences 57

      Pages: 7-15

    • NAID

      120005323916

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the molecular mechanisms for dedifferentiation at the invasion front of colorectal cancer by a gene expression analysis2008

    • Author(s)
      Oku Y, Matsuura M(15人中10番目), Miyata S(11番目), et al
    • Journal Title

      Clinical Cancer Research 22

      Pages: 7215-7222

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predictive factors for efficacy of capecitabine in heavily pretreated patients with metastatic breast cancer2008

    • Author(s)
      Osako T, Ushijima M(8人中2番目), Matsuura M(7番目) et al
    • Journal Title

      Cancer Chemother Pharmacol 63

      Pages: 865-871

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL12RB2 gene and ABCA1 gene are associated with susceptibility to radiation dermatitis2008

    • Author(s)
      Isomura M(20人中1番目). Et al
    • Journal Title

      Clinical Cancer Research 14

      Pages: 6683-6689

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Robust parameter estimation with a small bias against heavy contamination2008

    • Author(s)
      Fujisawa H. and Eguchi S
    • Journal Title

      Journal of Multivariate Analysis 99

      Pages: 2053-2081

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the molecular mechanisms for dedifferentiation at the invasion front of colorectal cancer by a gene expression analysis2008

    • Author(s)
      Oku, Y., Miyata, S., Matsuura M., et al.
    • Journal Title

      Clinical Cancer Research 22

      Pages: 7215-7222

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive factors for efficacy of capecitabine in heavily pretreated patients with metastatic breast cancer2008

    • Author(s)
      Osako T, Ushijima M, Matsuura M., et al.
    • Journal Title

      Cancer Chemother Pharmacol 63

      Pages: 865-871

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL12RB2 gene and ABCA1 gene are associated with susceptibility to radiation dermatitis2008

    • Author(s)
      Isomura M., et al.
    • Journal Title

      Clinical Cancer Research 14

      Pages: 6683-6689

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust parameter estimation with a small bias against heavy contamination2008

    • Author(s)
      Fujisawa, H., Eguchi, S.
    • Journal Title

      Journal of Multivariate Analysis 99

      Pages: 2053-2081

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inference on biological mechanisms using an integrated phenotype prediction model2008

    • Author(s)
      Enomoto, Y., Ushijima, M., Miyata, S, et. al.
    • Journal Title

      Hiroshima Journal of Medical Sciences Vol57(1)

      Pages: 7-15

    • NAID

      120005323916

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ファーマコゲノミクス、バイオインフォマティクス2007

    • Author(s)
      松浦正明
    • Journal Title

      バイオスタティスティクス臨床医薬 23

      Pages: 295-325

    • Related Report
      2008 Final Research Report
  • [Journal Article]

    • Author(s)
      牛嶋大, 宮田敏, 松浦正明
    • Journal Title

      「マイクロアレイデータ解析法」,遺伝子医学MOOK10号「DNAチップ/マイクロアレイ臨床応用の実際-基礎・最新技術、臨床・創薬応用への実際から今後の展開・問題まで-」(株式会社メディカルドゥ、東京) 2008

    • Related Report
      2008 Annual Research Report
  • [Presentation] A simple method for detecting epistasis in genome-wide association studies2009

    • Author(s)
      Ushijima M, Isomura M, Miki Y, Matsuura M
    • Place of Presentation
      Tokyo University of Science(Japan)
    • Year and Date
      2009-03-27
    • Related Report
      2008 Final Research Report
  • [Presentation] A simple method for detecting epistasis in genome-wide association studies2009

    • Author(s)
      Ushijima M., Isomura M., Miki Y., Matsuura M.
    • Organizer
      6th International Conference on Multiple Comparison Procedures
    • Place of Presentation
      Tokyo University of Science, Japan
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] コネクティヴィティマップを用いた潜在的に有効な抗がん剤の遺伝子発現印章に基づく識別2008

    • Author(s)
      宮田敏、牛嶋大、松浦正明
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Genome-wide survey of genetic polymorphisms associated with cytotoxicity of paclitaxel using HapMap cell lines2008

    • Author(s)
      磯村 実、松浦正明、野田哲生、三木義男
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] プロテオームデータ解析の現状および統計的諸問題2008

    • Author(s)
      牛嶋大、宮田敏、松浦正明
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Genome-wide survey of genetic polymorphisms associated with cytotoxicity of paclitaxel using HapMap cell lines derived from Japanese population2008

    • Author(s)
      Isomura M, Matsuura M, Usijima M, Miyata S., et al
    • Organizer
      Second JCA-AACR Special Joint Conference. The Latest Advances in Breast Cancer Research
    • Place of Presentation
      Awaji Yumebutai International Conference Center,(Japan)
    • Year and Date
      2008-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Genome-wide survey of genetic polymorphisms associated with cytotoxicity of paclitaxel using HapMap cell lines derived from Japanese population2008

    • Author(s)
      Isomura, M., Matsuura, M., Usijima M., Miyata, S., et al.
    • Organizer
      Second JCA-AACR Special Joint Conference. The Latest Advances in Breast Cancer Research
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genome-wide survey of genetic polymorphisms associated with cytotoxicity of paclitaxel using HapMap cell lines derived from Japanese population2008

    • Author(s)
      Isomura M, Matsuura M, Noda T, Miki Y
    • Organizer
      Annual meeting of American Association for Cancer Research
    • Place of Presentation
      Diego (USA)
    • Year and Date
      2008-04-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Genome-wide survey of genetic polymorphisms associated with cytotoxicity of paclitaxel using HapMap cell lines derived from Japanese population2008

    • Author(s)
      Isomura, M., Matsuura, M., Noda, T., Miki, Y.
    • Organizer
      Annual meeting of American Association for Cancer Research
    • Place of Presentation
      USA, San Diego
    • Year and Date
      2008-04-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] A unified method for detecting single feature polymorphisms and gene expression level differences2008

    • Author(s)
      Fujisawa H, Horiuchi Y, Harushima Y, Eguchi S, Mochizuki T, Sakaguchi T, Kurata N
    • Organizer
      Pasific Symposium on Biocomputing
    • Place of Presentation
      Hawaii (USA)
    • Year and Date
      2008-01-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Inference on biological mechanisms using an integrated phenotype prediction model2008

    • Author(s)
      Enomoto Y, Ushijima M, Miyata S, Matsuura M
    • Organizer
      The Pacific Symposium on Biocomputing(PSB)
    • Place of Presentation
      Hawaii (USA)
    • Year and Date
      2008-01-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Inference on biological mechanisms using an integrated phenotype prediction model2008

    • Author(s)
      Ushijma, et. al.
    • Organizer
      The Pacific Symposium on Biocomputing (PSB) 2008
    • Place of Presentation
      Hawaii(USA)
    • Year and Date
      2008-01-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bioinformatics for cancer research2007

    • Author(s)
      松浦正明
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Omicsデータを用いた治療効果予測の高精度化2007

    • Author(s)
      牛嶋大、宮田敏、長崎光一、三木義男、野田哲生、松浦正明
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 多変量解析手法を用いた表現型判定システムの構築法及び表現型規定メカニズムの推測法の検討2007

    • Author(s)
      榎本友美、宮田敏、牛嶋大、松浦正明
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 多変量確率分布を用いたエクソンアレイデータの解析2007

    • Author(s)
      宮田 敏、松浦正明
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 質量分析計データを用いた判別解析とバイオマーカー探索2007

    • Author(s)
      牛嶋大、宮田敏、松浦正明
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      神戸大学
    • Year and Date
      2007-09-07
    • Related Report
      2008 Final Research Report
  • [Presentation] SNPを考慮した遺伝子発現データ解析2007

    • Author(s)
      藤澤洋徳,堀内陽子,春島嘉章,江口真透,望月孝子,坂口隆之,倉田のり
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      神戸大学
    • Year and Date
      2007-09-07
    • Related Report
      2008 Final Research Report
  • [Presentation] 遺伝子座間の相互作用による生殖的隔離障壁の検出と多重性調整2007

    • Author(s)
      栗木哲, 春島嘉章, 藤澤洋徳, 倉田のり
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      神戸大学
    • Year and Date
      2007-09-07
    • Related Report
      2008 Final Research Report
  • [Book] DNAチップ/マイクロアレイ臨床応用の実際-基礎・最新技術、臨床・創薬応用への実際から今後の展開・問題まで-(遺伝子医学MOOK10号)2008

    • Author(s)
      牛嶋 大、宮田 敏、松浦正明
    • Publisher
      株式会社メディカルドゥ
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 網羅的ゲノムワイドSNP情報に基づくエピスタシス効果の探索アルゴリズム2009

    • Inventor(s)
      松浦正明、牛嶋大、磯村実, 他
    • Industrial Property Rights Holder
      財団法人癌研究会、NECソフト株式会社
    • Industrial Property Number
      2009-070753
    • Filing Date
      2009-03-23
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 網羅的ゲノムワイドSNP情報に基づくエピスタシス効果の探索アルゴリズム2009

    • Inventor(s)
      松浦正明, 牛嶋大, 磯村実, 他
    • Industrial Property Rights Holder
      財団法人癌研究会、NECソフト株式会社
    • Industrial Property Number
      2009-070753
    • Filing Date
      2009-03-23
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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