Analyses of synapse formation and elimination, the cellular bases of long-term memory, with special attention to their apparent symmetry
| Project/Area Number |
19300108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Osaka University |
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Principal Investigator |
OGURA Akihiko Osaka University, 大学院・生命機能研究科, 教授 (30260631)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 分子・細胞神経科学 / 長期可塑性 / シナプス可塑性 / シナプス新生 / シナプス廃止 / 培養脳切片 / proBDNF / p75NTR / 記憶 / 海馬 / 長期記憶 / 嗅内皮質 / 脳切片培養 |
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| Research Abstract |
The purpose of this study is to analyze the mechanisms underlying long-lasting synaptic plasticity, the presumed cellular basis of long-term memory, by using the recipient's original system (stable cultures of brain slice). The long-lasting synaptic enhancement coupled with synapse formation and the long-lasting synaptic suppression coupled with synapse elimination are symmetric phenomena in many properties. Taking this symmetry as a clue for solution, the analyses reveal that the enhancement and suppression are mediated by brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF), respectively. The mechanisms are symmetric indeed.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival2009
Author(s)
Koshimizu H, Kiyosue K, Hara T, Hazama S, Suzuki S, Uegaki K, Nagappan G, Zaitsev E, Hirokawa T, Tatsu Y, Ogura A, Lu B, Kojima M
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Journal Title
Molecular Brain 2:#27(on line publication)
Related Report
Peer Reviewed
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[Journal Article] Myonucleus-related properties in soleus muscle fibers of mdx mice.2009
Author(s)
Terada, M., Lan, Y.B., Kawano, F., Ohira, T., Higo, Y., Nakai, N., Imaizumi, K., Ogura, A., Nishimoto, N., Adachi, Y.Ohira, Y.
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Journal Title
Cells Tissues Organs 191
Pages: 248-259
Related Report
Peer Reviewed
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[Journal Article] Myultiple functions of precursor BDNF to CNS neurons : negative regulation of neurite grouwth, spine formation and cell survival.2009
Author(s)
Koshimizu, H., Kiyosue, K., Hara, T., Hazama, S., Suszuki, S., Uegaki, K., Nagappan, G, Zaitsev, E., Hirokawa, T., Tatsu, Y., Ogura, A., Lu, B.Kojima, M.
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Journal Title
Related Report
Peer Reviewed
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