| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Research Abstract |
The purpose of this study is to analyze the mechanisms underlying long-lasting synaptic plasticity, the presumed cellular basis of long-term memory, by using the recipient's original system (stable cultures of brain slice). The long-lasting synaptic enhancement coupled with synapse formation and the long-lasting synaptic suppression coupled with synapse elimination are symmetric phenomena in many properties. Taking this symmetry as a clue for solution, the analyses reveal that the enhancement and suppression are mediated by brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF), respectively. The mechanisms are symmetric indeed.
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