Integration of multiple information and quantitative processing of neural representation in the lateral prefrontal cortex.

• Project/Area Number: 19300110
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Tamagawa University
• Principal Investigator: TANJI Jun Tamagawa University, 脳科学研究所, 教授 (10001885)
• Co-Investigator(Kenkyū-buntansha): 射場 美智代 玉川大学, 脳科学研究所, 助教 (00270695)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2007: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
• Keywords: 前頭前野 / 情報統合 / 数量表現 / 感覚情報 / 脳高次機能 / 行動発現 / 神経細胞 / 霊長類

Research Abstract

We found that prefrontal neurons are involved in integrating sensory information of multiple modalities to transform into numerical information required to regulate future actions. We also found that prefrontal neurons play a role in categorizing patterns of future actions. Furthermore, we found an activity focus in the medial prefrontal cortex while human subjects were engaged in identifying a behavioral rule out of multiple candidates.

Research Products

• [Journal Article] Motor and non-motor projections from the cerebellum to rostrocaudally distinct sectors of the dorsal premotor cortex in macaques (2010)
  • Author(s): Hashimoto M
  • Journal Title: Eur J Neurosci 31 Pages: 1402-1413
  • Peer Reviewed
• [Journal Article] Processing of visual signals for direct specification of motor targets and for conceptual representation of action targets in the dorsal and ventral premotor cortex. (2009)
  • Author(s): Yamagata T, Nakayama Y, Tanji J, Hoshi E
  • Journal Title: J Neurophysiol 102 Pages: 3280-3294
• [Journal Article] Relating neuronal firing patterns to functional differentiation of cerebral cortex. (2009)
  • Author(s): Shinomoto S, Kim H, Tanji J, Toyama K
  • Journal Title: PLoS Comput Biol. 5
• [Journal Article] Neural activity in the human brain signals logical rule identification. (2009)
  • Author(s): Tachibana K, Suzuki K, Mori E, Miura N, Kawashima R, Horie K, Sato S, Tanji J, Mushiake H
  • Journal Title: J Neurophysiol 102(3) Pages: 1526-37
• [Journal Article] Interval time coding by neurons in the presupplementary and supplementary motor areas. (2009)
  • Author(s): Mita A, Mushiake H, Shima K, Matsuzaka Y, Tanji J
  • Journal Title: Nat Neurosci 12 Pages: 502-507
• [Journal Article] Covert representation of second-next movement in the pre-supplementary motor area of monkeys. (2009)
  • Author(s): Nakajima T, Hosaka R, Mushiake H, Tanji J
  • Journal Title: J Neurophysiol 101 Pages: 1883-1889
• [Journal Article] Covert Representation of Second-Next Movement in the Pre-Supplementary Motor Area of Monkeys (2009)
  • Author(s): Nakajima T
  • Journal Title: J.Nurophysiol 101 Pages: 1883-1889
  • Peer Reviewed
• [Journal Article] Interval time coding by neurons in the presupplementary and supplementary motor areas (2009)
  • Author(s): Mita A
  • Journal Title: Nat Neurosci 12 Pages: 502-507
  • Peer Reviewed
• [Journal Article] Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behavior (2009)
  • Author(s): Abe N
  • Journal Title: Brain 132 Pages: 1386-1395
  • Peer Reviewed
• [Journal Article] Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment (2009)
  • Author(s): Hosokai Y
  • Journal Title: Movement Disorder 24 Pages: 854-862
  • Peer Reviewed
• [Journal Article] Which object appeared longer? (2009)
  • Author(s): Tanji J
  • Journal Title: Neuron Jul30;63(2) Pages: 148-149
  • Peer Reviewed
• [Journal Article] On somatotopical organization of cortical motor areas (2009)
  • Author(s): Tanji J
  • Journal Title: Brain Nerve Dec;61(12) Pages: 1363-1371
  • NAID: 40016922915
  • Peer Reviewed
• [Journal Article] Involvement of the prefrontal cortex in problem solving (2009)
  • Author(s): Mushiake H
  • Journal Title: Int Rev Neurobiol 85 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Relating neuronal firing patterns to functional differentiation of cerebral cortex (2009)
  • Author(s): Shinomoto S
  • Journal Title: PLoS Comput Biol Jul;5(7)
  • Peer Reviewed
• [Journal Article] Neural activity in the human brain signals logical rule identification (2009)
  • Author(s): Tachibana K
  • Journal Title: J Neurophysiol Sep;102(3) Pages: 1526-1537
  • Peer Reviewed
• [Journal Article] Covert Representation of Second-Next Movement in the Pre-Supplementary Motor Area of Monkeys. (2009)
  • Author(s): Nakajima T
  • Journal Title: J. Nurophysiol 101 Pages: 1883-1889
  • Peer Reviewed
• [Journal Article] Interval time coding by neurons in the presupplementary and supplementary motor areas. (2009)
  • Author(s): Mita A
  • Journal Title: Nat Neurosci 12 Pages: 502-507
  • Peer Reviewed
• [Journal Article] Role of the lateral prefrontal cortex in executive behavioral control. (2008)
  • Author(s): Tanji J, Hoshi E
  • Journal Title: Physiol Rev. 88(1) Pages: 37-57
• [Journal Article] Transformation of a virtual action plan into a motor plan in the premotor cortex. (2008)
  • Author(s): Nakayama Y, Yamagata T, Tanji J, Hoshi E
  • Journal Title: J Neurosci. 28(41) Pages: 10287-10297
• [Journal Article] Discharge synchrony during the transition of behavioral goal representations encoded by discharge rates of prefrontal neurons. (2008)
  • Author(s): sakamoto K, Mushiake H, Saito N, Aihara K, Yano M, Tanji J
  • Journal Title: Cereb Cortex. 18(9) Pages: 2036-2045
• [Journal Article] Discharge synchrony during the transition of behavioral goal representations encoded by discharge rates of prefrontal neurons. (2008)
  • Author(s): Sakamoto K
  • Journal Title: Cereb Cortex 18 Pages: 2036-2045
  • Peer Reviewed
• [Journal Article] Transformation of a virtual action plan into a motor plan in the premotor cortex. (2008)
  • Author(s): Nakayama Y
  • Journal Title: J. Neurosci 28 Pages: 10287-10297
  • Peer Reviewed
• [Journal Article] Role of the lateral prefrontal cortex in executive behavioral control. (2008)
  • Author(s): Tanji J.
  • Journal Title: Physiol Rev. 88(1) Pages: 37-57
  • Peer Reviewed
• [Journal Article] Discharge Synchrony during the Transition of Behavioral Goal Representations Encoded by Discharge Rates of Prefrontal Neurons. (2008)
  • Author(s): Sakamoto K.
  • Journal Title: Cereb Cortex (印刷中)
  • Peer Reviewed
• [Journal Article] Categorization of behavioral sequences in the prefrontal cortex. (2007)
  • Author(s): Shima K, Isoda M, Mushiake H, Tanji, J
  • Journal Title: Nature 445 Pages: 315-318
• [Journal Article] Concept-based behavioral planning and the lateral prefrontal cortex. (2007)
  • Author(s): Tanji J.
  • Journal Title: Trends Cogn Sci. 11(12) Pages: 528-534
  • Peer Reviewed
• [Journal Article] Distinctions between dorsal and ventral premotor areas: anatomical connectivity and functional properties. (2007)
  • Author(s): Hoshi E.
  • Journal Title: Curr Opin Neurobiol 17(2) Pages: 234-242
  • Peer Reviewed
• [Journal Article] Decoding higher-order motor information from primate non-primary motor cortices. (2007)
  • Author(s): Nakajima T.
  • Journal Title: Technol Health Care 15(2) Pages: 103-110
  • Peer Reviewed
• [Presentation] Visual, auditory, and tacgtile sensory responses of neurons in the lateral prefrontal cortex(1PFC)in macaques (2009)
  • Author(s): Saga Y
  • Organizer: Soc.Neurosci.Abstr.677.18(39^<th> Annual meeting of the Society for Neuroscience)
  • Place of Presentation: McCormick Place Chicago, U.S.A
  • Year and Date: 2009-10-20
• [Presentation] Involvement of dorsal and ventral sectors of the lateral prefrontal cortex in a concept-based action (2009)
  • Author(s): Yamagata, T
  • Organizer: Soc.Neurosci.Abstr.677.13(39^<th> Annual meeting of the Society for Neuroscience)
  • Place of Presentation: McCormick Place Chicago, U.S.A
  • Year and Date: 2009-10-20
• [Presentation] Response properties of neurons in the premotor and prefrontal cortices to the appearance of visuospatial and instruction signals. (2009)
  • Author(s): Yamagata T, Nakayama Y, Tanji J, Hoshi E
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 京都
• [Presentation] Reference frame of action-related neuronal activity in the pre-supplementary motor area (2008)
  • Author(s): Nakajima T
  • Organizer: 38^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D. C (米国)
  • Year and Date: 2008-11-18
• [Presentation] Involvement of the dorsal and ventral premotor cortex (PMd andPMv) in direct vs. indirect visuomotor behavior. (2008)
  • Author(s): Yamagata T
  • Organizer: 38^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D. C (米国)
  • Year and Date: 2008-11-17
• [Presentation] Differential involvement of the dorsal premotor cortex (PMd) and the primary motor cortex (MI) in indirect visuomotor behavior. (2008)
  • Author(s): Nakayama Y
  • Organizer: 38^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D. C (米国)
  • Year and Date: 2008-11-17
• [Presentation] The dorsal aspect of area 46 (area 46d) and dorsal premotor cortex (PMd) receive specific, as well as common, inputs from the frontal and parietal cortex. (2008)
  • Author(s): Saga Y
  • Organizer: 38^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D. C (米国)
  • Year and Date: 2008-11-16
• [Presentation] A new look at the workings of premotor and prefrontal cortex (2008)
  • Author(s): Tanji J
  • Organizer: 16^<th> International Conference on Biomagnetism
  • Place of Presentation: 札幌ロイトンホテル (北海道)
  • Year and Date: 2008-08-25
• [Presentation] サル前頭前野における錐体細胞・介在細胞のゴール表現の遷移 (2007)
  • Author(s): 坂本和弘, 吉田隼, 虫明元, 合原一幸, 丹治順
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 随意運動と大脳皮質 (2007)
  • Author(s): 丹治順
  • Organizer: 第22回日本大脳基底核研究会
  • Place of Presentation: 旭川
  • Year and Date: 2007-08-26
• [Presentation] スポーツにおける脳の役割 (2007)
  • Author(s): 丹治 順
  • Organizer: 第14回 日本運動・スポーツ学会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-17
• [Presentation] 運動と行動発現における大脳前頭葉の役割 (2007)
  • Author(s): 丹治順
  • Organizer: 第42回日本理学療法学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2007-05-26
• [Presentation] Involvement of caudate nucleus and posteriof medial prefrontal cortex in behavioral rule identification. (2007)
  • Author(s): Tachibana K, Suzuki K, Mori E, Tanji J, Mushiake H
  • Organizer: 第37回北米神経科学会
  • Place of Presentation: サンディエゴ
• [Presentation] 運動と行動発現における大脳前頭葉の役割 (2007)
  • Author(s): 丹治 順
  • Organizer: 第42回 日本理学療法学術大会
  • Place of Presentation: 新潟
• [Presentation] 随意運動と大脳皮質 (2007)
  • Author(s): 丹治 順
  • Organizer: 第22回 日本大脳基底核研究会
  • Place of Presentation: 旭川
• [Presentation] サル前頭前野における錐体細胞・介在細胞のゴール表現の遷移 (2007)
  • Author(s): 坂本 和弘
  • Organizer: 第30回 日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Involvement of caudate nucleus and posteriof medial prefrontal cortex in behavioral rule identification. (2007)
  • Author(s): Tachibana, K.
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: SanDiego,USA
• [Book] Premotor areas: medial. Encyclopedia of Neuroscience. (2009)
  • Author(s): Tanji J, Hoshi E
  • Publisher: Elsevier
• [Remarks]
  • URL: http://www.tamagawa.ac.jp/sisetu/gakujutu/brain/tanji/
• [Remarks]
  • URL: http://www.tamagawa.ac.jp/sisetu/gakujutu/brain/tanji/