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Local circuit differentiation of frontal cortex dependent on subcortical projection

Research Project

Project/Area Number 19300111
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

KAWAGUCHI Yasuo  National Institute for Physiological Sciences, 大脳皮質機能研究系, 教授 (40169694)

Co-Investigator(Kenkyū-buntansha) 高田 美絵子 (森島 美絵子)  生理学研究所, 大脳皮質機能研究系, 助教 (30435531)
Co-Investigator(Renkei-kenkyūsha) TAKADA Mieko  生理学研究所, 大脳皮質機能研究系, 助教 (30435531)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Keywords新皮質 / レイヤー / 錐体細胞 / 発火様式 / 橋核 / 線条体 / シナプス結合 / サブネットワーク / 前頭皮質 / 海馬 / アセチルコリン / ムスカリン / 細胞内カルシウム / SKチャネル / 過分極
Research Abstract

大脳皮質錐体細胞の機能的分化を生理学・薬理学的に検索した。錐体細胞は皮質外投射先によって発火特性やアセチルコリン作用が異なることを見つけた。新皮質の2/3層から5層錐体細胞への興奮性結合は5層錐体細胞サブタイプによって、シナプス結合の確率・結合細胞の空間分布・発散結合の選択性が異なることが分かった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (42 results)

All 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (27 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Firing-Pattern dependent specificity of cortical excitatory feed-forward subnetworks.2008

    • Author(s)
      Otsuka T. & Kawaguchi Y.
    • Journal Title

      J.Neurosci. 28

      Pages: 11186-11195

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two distinct activity patterns of fast-spiking interneurons during neocortical UP-states.2008

    • Author(s)
      Puig M.V., Ushimaru M. & Kawaguchi Y.
    • Journal Title

      Proc. Natl. Acad. Sci. USA105

      Pages: 8428-8433

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative chemical composition of cortical GABAergic neurons revealed in transgenic Venus-expressing rats.2008

    • Author(s)
      Uematsu M., Hirai Y., Karube F., Ebihara S., Kato M., Abe K., Obata K., Yoshida S., Hirabayashi M., Yanagawa Y. & Kawaguchi Y.
    • Journal Title

      Cereb. Cortex 18

      Pages: 315-330

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative chemical composition of cortical GABAergic neurons revealed in transgenic Venus-expressing rats2008

    • Author(s)
      Masakazu Uematsu
    • Journal Title

      Cereb. Cortex 18

      Pages: 315-330

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two distinct activity patterns of fast-spiking interneurons during neocortical UP-states2008

    • Author(s)
      Maria Victoria Puig
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 8428-8433

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Firing-pattern dependent specificity of cortical excitatory feed-forward subnetworks2008

    • Author(s)
      Takeshi Otsuka
    • Journal Title

      J. Neurosci. 28

      Pages: 11186-11195

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neocortical inhibitory terminals innervate dendritic spines targeted by thalamocortical afferents.2007

    • Author(s)
      Kubota Y., Hatada S., Kondo S., Karube F. & Kawaguchi Y.
    • Journal Title

      J. Neurosci. 27

      Pages: 1139-1150

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of phasic cholinergic signalling in neocortical neurons.2007

    • Author(s)
      Gulledge A.T., Park S.B., Kawaguchi Y. & Stuart G.
    • Journal Title

      J. Neurophysiol 97

      Pages: 2215-2229

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phasic cholinergic signaling in the hippocampus : functional homology with the neocortex ?2007

    • Author(s)
      Gulledge A.T. & Kawaguchi Y.
    • Journal Title

      Hippocampus 17

      Pages: 327-332

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neocortical inhibitory terminals innervate dendritic spines targeted bthalamocortical afferents2007

    • Author(s)
      Yioshiyuki Kubota
    • Journal Title

      Journal of Neuroscience 27

      Pages: 1139-1150

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of phasic cholinergic signalling in neocortical neurons2007

    • Author(s)
      Allan T. Gulledge
    • Journal Title

      Journal of Neurophysiology 97

      Pages: 2215-2229

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phasic cholinergic signalng in the hippocampus:functional honlology with the neocortex?2007

    • Author(s)
      Allan T. Gulledge
    • Journal Title

      Hippocampus 17

      Pages: 327-332

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] The excitatory and inhibitory synapse densities on various GABAergic nonpyramidal cells in the rat cerebral cortex2008

    • Author(s)
      Yoshiyuki Kubota
    • Organizer
      38th Annual Meeting Society For Neuroscience
    • Place of Presentation
      Washington D.C.
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大脳皮質のニューロン多様性と特異的振動2008

    • Author(s)
      川口泰雄
    • Organizer
      第39回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Excitatory and inhibitory recurrent connections dependent on pyramidal cell subtypes in layer 5 of frontal cortex2008

    • Author(s)
      Mieko Morishima
    • Organizer
      第31回日本神経学会科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pyramidal neuron subtypes of rat frontal cortex projecting to the perirhinal cortex2008

    • Author(s)
      Yasuharu Hirai
    • Organizer
      第31回日本神経学会科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Specificity of excitatory connections from layer 2/3 to layer 5 cortical cells2008

    • Author(s)
      Takeshi Otsuka
    • Organizer
      第31回日本神経学会科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Connections of GABAergic interneurons to corticospinal neurons in the cerebral cortex2008

    • Author(s)
      Yasuyo Tanaka
    • Organizer
      第31回日本神経学会科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大脳皮質ニューロンタイプとアセチルコリン作用2008

    • Author(s)
      川口泰雄
    • Organizer
      基礎生物学研究所研究会 大脳皮質の発生と可塑性 II
    • Place of Presentation
      岡崎
    • Year and Date
      2008-03-07
    • Related Report
      2008 Final Research Report
  • [Presentation] 大脳皮質ニューロンタイプとシナプス結合2008

    • Author(s)
      川口泰雄
    • Organizer
      第3回生理学研究所・名古屋大学環境医学研究所合同シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2008-02-13
    • Related Report
      2008 Final Research Report
  • [Presentation] The excitatory and inhibitory synapse densities on various GABAergic nonpyramidal cells in the rat cerebral cortex.2008

    • Author(s)
      Kubota Y, Hatada S, Sekigawa A, Shigematsu N, Kawaguchi Y
    • Organizer
      38th Annual Meeting Society for Neuroscience
    • Place of Presentation
      Washington D.C. USA
    • Related Report
      2008 Final Research Report
  • [Presentation] 大脳皮のニューロン多様性と特異的振動2008

    • Author(s)
      川口泰雄
    • Organizer
      第39回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] Exciatory and inhibitory recurrent connections dependent on pyramidal cell subtypes in layer 5 of frontal cortex.2008

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Pyramidal neuron subtypes of rat frontal cortex projecting to the perirhinal cortex.2008

    • Author(s)
      Hirai Y, Morishima M, Kawaguchi Y
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Specificity of excitatory connections from layer 2/3 to layer 5 cortical cells.2008

    • Author(s)
      Otsuka T, Kawaguchi Y
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Connections of GABAergic interneurons to corticospinal neurons in the cerebral cortex.2008

    • Author(s)
      Tanaka Y, Tanaka Y, Furuta T, Yanagawa Y, Kawaguchi Y, Kaneko T
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 大脳皮質錐体細胞の多様性と結合特異性2008

    • Author(s)
      川口泰雄,大塚岳,森島美絵子,平井康治,重松直樹
    • Organizer
      第113回日本解剖学会総会・全国学術集会
    • Place of Presentation
      大分
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 皮質局所神経回路における興奮・抑制結合の多様性2007

    • Author(s)
      川口 泰雄
    • Organizer
      第30回日本神経学会科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大脳皮質非錐体細胞の樹状突起特性の解析2007

    • Author(s)
      窪田 芳之
    • Organizer
      第30回日本神経学会科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大脳皮質回路における発火パタンに依存した結合特異性2007

    • Author(s)
      大塚 岳
    • Organizer
      第30回日本神経学会科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大脳皮質非錐体細胞への興奮性・抑制性シナプス入力比2007

    • Author(s)
      関川 明生
    • Organizer
      第30回日本神経学会科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phasic cholinergic signaling in the hippocampus : functional homology with the neocortex ?2007

    • Author(s)
      Gulledge A, Kawaguchi Y
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Dendritic dimensions of cortical nonpyramidal cells.2007

    • Author(s)
      Kubota Y, Karube F, Sekigawa A, Nomura M, Aoyagi T, Mochizuki A, Kawaguchi Y
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Electrophysiological membrane properties of inhibitory neurons in the prepositus hypoglossi nucleus in transgenic Venus-expressing rats.2007

    • Author(s)
      Shino M, Yanagawa Y, Kawaguchi Y, Ozawa S, Saito Y
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] 皮質局所神経回路における興奮・抑制結合の多様性2007

    • Author(s)
      川口泰雄
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 大脳皮質非錐体細胞の樹状突起特性の解析2007

    • Author(s)
      窪田芳之, 苅部冬紀, 野村真樹, 青柳富誌生, 望月敦史, 川口泰雄
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 大脳皮質回路における発火パタンに依存した結合特異性2007

    • Author(s)
      大塚岳, 森島美絵子, 川口泰雄
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 大脳皮質非錐体細胞への興奮性・抑制性シナプス入力比2007

    • Author(s)
      関川明生, 窪田芳之, 畑田小百合, 川口泰雄
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 舌下神経前位核における抑制性ニューロンの膜特性 -VGAT-Venus transgenic rat を用いた解析-2007

    • Author(s)
      紫野正人, 柳川右千夫, 川口泰雄, 小澤瀞司, 齋藤康彦
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Book] Structures and Circuits : Cerebral Cortex, Inhibitory cells. In The New Encyclopedia of Neuroscience (ed Squire L).2008

    • Author(s)
      Kawaguchi Y. & Karube F.
    • Total Pages
      9
    • Publisher
      Elsevier, Amsterdam.
    • Related Report
      2008 Final Research Report
  • [Book] The New Encyclopedia of Neuroscience 「Structures and Circuits : Cerebral Cortex, Inhibitory cells.」2008

    • Author(s)
      Yasuo Kawaguchi
    • Total Pages
      9
    • Publisher
      Elsevier
    • Related Report
      2008 Annual Research Report
  • [Remarks] 部門HP

    • URL

      http://www.nips.ac.jp/circuit/

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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