Burst temporal coding in the retina

• Project/Area Number: 19300116
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: HOSOYA TOSHIHIKO (HOSOYA Toshihiko) The Institute of Physical and Chemical Research, 局所神経回路研究チーム, チームリーダー (70272466)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 網膜 / 神経発火 / 時間コーディング / バースト / 神経節細胞 / 相関 / 情報伝達 / バースト発火 / 神経科学 / 脳・神経

Research Abstract

Output neurons of the retina (retinal ganglion cells) generate action potentials in response to tens to hundreds of milliseconds of visual input. These action potentials have non-random temporal patterns at the scale of milliseconds. The roles of the temporal patterns in information transmission were analyzed. Molecular mechanisms of information processing in the On-and Off-pathways and maintenance of retinal neurons were also investigated.

Research Products

• [Journal Article] Mismatched decoding in the brain (2010)
  • Author(s): M.Oizumi, T.Ishii, K.ISHIBASHI, T.Hosoya, M.Okada
  • Journal Title: The Journal of Neuroscience 30(13) Pages: 4815-4826
  • Peer Reviewed
• [Journal Article] The habenula is crucial for experience-dependent modification of fear responses in zebrafish (2010)
  • Author(s): Agetsuma Masakazu
  • Journal Title: Nature Neuroscience Volume: 13 Pages: 1354-1356
  • Peer Reviewed
• [Journal Article] Mismatched Decoding in the Brain (2010)
  • Author(s): Masafumi Oizumi, Toshiyuki Ishii, Kazuya Ishibashi, Toshihiko Hosoya, Masato Okada
  • Journal Title: The Journal of Neuroscience 30(13) Pages: 4815-4826
  • Peer Reviewed
• [Journal Article] Mismatched decoding in the brain (2010)
  • Author(s): Masafumi OIZUMI
  • Journal Title: Journal of Neuroscience (In press)
  • Peer Reviewed
• [Journal Article] Mutation of cGMP phosphodiesterase 6α-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish (2008)
  • Author(s): Y.Nishiwaki, A.Komori, H.Sagara, E.Suzuki, T.Manabe, T.Hosoya, Y.Nojima, H.Wada, H.Tanaka, H.Okamoto, I.Masai
  • Journal Title: Mechanisms of Development 125 Pages: 932-946
  • Peer Reviewed
• [Journal Article] Estimating receptive fields from responses to natural stimuli with asymmetric intensity distributions (2008)
  • Author(s): Lesica Nicholas, T.Ishii, Stanley Garrett, T.Hosoya
  • Journal Title: PLoS One 3(8)
  • Peer Reviewed
• [Journal Article] Pathway-dependent modulation by P2X-purinoceptors in the mouse retina (2008)
  • Author(s): M.Kaneda, T.Ishii, T.Hosoya
  • Journal Title: European Journal of Neuroscience 28(1) Pages: 128-136
  • Peer Reviewed
• [Journal Article] Mutation of cGMP phosphodiesterase 6α-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish (2008)
  • Author(s): Yuko NISHIWAKI, Atsuko KOMORI, Hiroshi SAGARA, Emiko SUZUKI, Tomonori MANABE, Toshihiko HOSOYA, Yasuhiro NOJIMA, Hironori WADA, Hideomi TANAKA, Hitoshi OKAMOTO, Ichiro MASAI
  • Journal Title: Mechanisms of Development 125 Pages: 932-946
  • Peer Reviewed
• [Journal Article] Estimating receptive fields from responses to natural stimuli with asymmetric intensity distributions (2008)
  • Author(s): Nicholas A LESICA, Toshiyuki ISHII, Garrett B STANLEY, Toshihiko HOSOYA
  • Journal Title: PLoS One 3
  • Peer Reviewed
• [Journal Article] Pathway-dependent modulation by P2-purinoceptors in the mouse retina (2008)
  • Author(s): Makoto KANEDA, Toshiyuki ISHII, Toshihiko HOSOYA
  • Journal Title: European Journal of Neuroscience 28 Pages: 128-136
  • Peer Reviewed
• [Journal Article] Pathway dependent modulation by P2X-purinoceptors in the mouse retina (2008)
  • Author(s): Makoto Kaneda
  • Journal Title: European J. Neurosci. 28 Pages: 128-136
  • Peer Reviewed
• [Journal Article] A simple method for estimating receptive fields from responses to natural stimuli with asymmetric intensity distributions (2008)
  • Author(s): Nicholas A. Lesica
  • Journal Title: Pros One 2
  • Peer Reviewed
• [Presentation] Mammalian glial cells missing genes induce Hes5 and are required for neural stem cell generation (2010)
  • Author(s): Hitoshi S
  • Organizer: 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-14
• [Presentation] 大脳新皮質の新しい微細秩序構造 (2009)
  • Author(s): 細谷俊彦
  • Organizer: 頭部形成研究会2009
  • Place of Presentation: 修善寺(日本)
  • Year and Date: 2009-11-18
• [Presentation] Novel visual functions of the retina (2009)
  • Author(s): 細谷俊彦
  • Organizer: International Symposium Topical problems of Biophotonics-2009
  • Place of Presentation: Nizhny Novgorod, Russia
  • Year and Date: 2009-07-23
• [Presentation] Novel visual functions of the retina (2009)
  • Author(s): 細谷俊彦
  • Organizer: Topical problems of Biophotonics-2009
  • Place of Presentation: Nizhny Novgorod(Russia)
  • Year and Date: 2009-07-23
• [Presentation] Periodic structure of neocortical layer V formed by microcolumns of a major subtype of pyramidal neurons (2009)
  • Author(s): 細谷俊彦
  • Organizer: German-Japanese symposium on computational and system Neuroscience, Berlin
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2009-05-26
• [Presentation] How far the decoding process in the brain can be simplified? (2009)
  • Author(s): 大泉匡史
  • Organizer: Computational and systems neuroscience 2009
  • Place of Presentation: 米国 ソルトレイク市
  • Year and Date: 2009-02-26
• [Presentation] How far the decoding process in the brain can be simplified ? (2009)
  • Author(s): M.Oizumi, T.Ishii, K.Ishibashi, T.Hosoya, M.Okada
  • Organizer: 6th Meeting Computational and Systems Neuroscience (COSYNE 2009)
  • Place of Presentation: Salt Lake City ,USA
• [Presentation] A general framework for investigating how far the decoding process in the brain can be simplified (2008)
  • Author(s): 大泉匡史
  • Organizer: Neural Information Processing Systems Conference 2008
  • Place of Presentation: カナダ、バンクーバー市
  • Year and Date: 2008-12-10
• [Presentation] 脳内情報の符号化はどれだけ簡略化され得るのか? (2008)
  • Author(s): 大泉匡史
  • Organizer: 日本神経回路学会第18回全国大会
  • Place of Presentation: つくば市
  • Year and Date: 2008-11-21
• [Presentation] Transmission of burst patterns at the retinogeniculate synapse (2008)
  • Author(s): 真鍋友則
  • Organizer: 日本神経科学学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] A general framework for investigating how far the decoding process in the brain can be simplified (2008)
  • Author(s): M.Oizumi, T.Ishii, K.Ishibashi, T.Hosoya, M.Okada
  • Organizer: Neural Information Processing Systems Conference (NIPS 2008)
  • Place of Presentation: Vancouver Canada
• [Presentation] 脳内情報の符合化はどれだけ簡略化され得るのか? (2008)
  • Author(s): 大泉匡史, 石井俊行, 石橋和也 ,細谷俊彦, 岡田真人
  • Organizer: 日本神経回路学会第18回全国大会(JNNS2008)
  • Place of Presentation: つくば,日本
• [Presentation] Transmission of burst patterns at the retinogeniculate synapses (2008)
  • Author(s): 真鍋 友則 ,石井 俊行, 細谷 俊彦
  • Organizer: Meeting of the Japanese Socfor Neuroscience
  • Place of Presentation: 東京,日本
• [Presentation] Mutation of cGMP phosphodiesterase 6 alpha' -subunit gene causes progressive degeneration of cone photoreceptors in zebrafish (2008)
  • Author(s): Y.Nishiwaki, A.Komori, H.Sagara, E.Suzuki, T.Hosoya, H.Okamoto, I.Masai
  • Organizer: 8th International Meeting oZebrafish Development and Genetics
  • Place of Presentation: Madison, USA
• [Presentation] Retinal spike bursts encode multiple quantities in a time-compressive manner (2007)
  • Author(s): 細谷 俊彦
  • Organizer: 理論と実験の融合による神経回路機能の統合的理解
  • Place of Presentation: 岡崎
  • Year and Date: 2007-11-30
• [Presentation] 網膜遺伝病のモデルとなるゼブラフィッシュ視細胞変性突然変異体の解析 (2007)
  • Author(s): 西脇優子,小森敦子,相良洋,鈴木えみ子,真鍋智則,細谷俊彦,野島康弘,和田浩則,田中英臣,岡本仁,政井一郎
  • Organizer: [科学技術振興機構(JST)戦略的創造研究推進事業(CREST)研究領域 生物の発生・分化・再生]第6回公開シンポジウム
  • Place of Presentation: 東京,日本
  • Year and Date: 2007-11-20
• [Presentation] Burst ISI coding is conserved across species (2007)
  • Author(s): 石井 俊行
  • Organizer: SFN2007
  • Place of Presentation: サンデイエゴ(米国)
  • Year and Date: 2007-11-05
• [Presentation] Burst ISI coding is conserved across species (2007)
  • Author(s): 石井 俊行
  • Organizer: Neuro2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
• [Presentation] A new approach to estimating receptive fields from response to natural stimuli (2007)
  • Author(s): Lesica N.A.
  • Organizer: Neuro2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] Precisely timed inhibition can modulate the internal structure of bursts in salamander retina (2007)
  • Author(s): Jin Xin
  • Organizer: Neuro2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] Retinal spike bursts encode multiple quantities in a time-compressive manner (2007)
  • Author(s): 細谷俊彦
  • Organizer: 平成19年度生理学研究所研究会「理論と実験の融合による神経回路機能の統合的理解」
  • Place of Presentation: 岡崎,日本
• [Presentation] Burst ISI coding is conserved across species (2007)
  • Author(s): T.Ishii, T.Manabe, T.Hosoya
  • Organizer: 37th Annual Meeting of Society for Neuroscience (Neuroscience 2007)
  • Place of Presentation: San Diego, USA
• [Presentation] A new approach to estimating receptive fields from response to natural stimuli Lesica Nicolas (2007)
  • Author(s): 細谷俊彦
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会(Neuro2007)
  • Place of Presentation: 横浜,日本
• [Presentation] Precisely timed inhibition can modulate the internal structure of bursts in salamander retina (2007)
  • Author(s): Jin Xin, 細谷俊彦
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会 (Neuro2007)
  • Place of Presentation: 横浜,日本
• [Presentation] Burst ISI coding is conserved across species (2007)
  • Author(s): T.Ishii, T.Hosoya
  • Organizer: Neuro2007 Satellite Symposium : The 2nd MCCS-Asia Symposium``Unraveling HigheBrain functions:Recent Progress with Animal Models II"
  • Place of Presentation: Yokohama, Japan