| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Research Abstract |
The purpose of the study is to find polyphenol, which reduce cerebral β-amyloid deposition, a causative factor of the Alzheimer disease. We administrated tannic acid to transgenic mice which develop cerebral β-amyloid deposition, and examined neuropathologically and behavior-physiologically. We found that tannic acid reduce cerebral β-amyloid deposition and also reduce mental deficit. Moreover, we demonstrated new findings as follows : accumulation of protofibril at synaptic area ; influence of ganglioside on amyloid angiopathy ; and β-amyloid deposition in tamarin.
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