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Establishment of a novel morphologic and genetic classification of brain tumors for aiming at better diagnosis that corresponds to the biologic activity of tumors.

Research Project

Project/Area Number 19300123
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionGunma University

Principal Investigator

NAKAZATO Yoichi  Gunma University, 大学院・医学系研究科, 教授 (10106908)

Co-Investigator(Kenkyū-buntansha) HIRATO Junko  群馬大学, 医学部, 准教授 (60208832)
SASAKI Atsushi  埼玉医科大学, 医学部, 教授 (80225862)
YOKOO Hideaki  群馬大学, 大学院・医学系研究科, 准教授 (40282389)
ISHIUCHI Syogo  琉球大学, 医学部, 教授 (10312878)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords脳腫瘍 / 画像解析 / 遺伝子異常 / 病理診断 / 生物活性 / 脳腫病
Research Abstract

We analyzed the features of brain tumors from the view point of tissue and cellular morphology, phenotypic expression, and genetic alterations. We found that small round cells expressing nuclear transcription factor Olig2 are commonly exist in diffuse astrocytoma, oligoastrocytoma, oligodendroglioma, pilocytic astrocytoma, and glioneuronal tumors. These cells are presumed to be the progenitor cells of brain tumors. As molecular biologic markers, our analysis has shown that GFAP, Olig2, nestin, and NFP are important at protein level, and IDH1, p53, EGFR, 1p/19q, and INI-1 are crucial in genetic alterations. We have established the basis of morphologic molecular classification of brain tumors by fusion of the molecular events and histopathological diagnosis.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (97 results)

All 2011 2010 2009 2008 2007

All Journal Article (42 results) (of which Peer Reviewed: 40 results) Presentation (42 results) Book (13 results)

  • [Journal Article] Alterations in the RB1 pathway in low-grade diffuse gliomas lacking common genetic alterations.2011

    • Author(s)
      Kim YH, Lachuer J, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Nobusawa S, Nakazato Y, Tanaka Y, et al
    • Journal Title

      Brain Pathology (DOI:10.1111/j.1750-3639.2011.00492.x)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput immunohistochemical profiling of primary brain tumors and non-neoplastic systemic organs with a specific antibody against the mutant isocitrate dehydrogenase 1 R132H protein.2011

    • Author(s)
      Ikota H, Nobusawa S, Tanaka Y, Yokoo H, Nakazato Y
    • Journal Title

      Brain Tumor Pathol 28

      Pages: 107-114

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinico-pathological feature of pilomyxoid astrocytomas : Three case reports.2011

    • Author(s)
      Nagaishi M, Yokoo H, Hirato J, Yoshimoto Y, Nakazato Y
    • Journal Title

      Neuropathology 31

      Pages: 152-157

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological and immunohistochemical study of 20 choroid plexus tumors : their histological diversity and the expression of markers useful for differentiation from metastatic cancer.2011

    • Author(s)
      Ikota H, Tanaka Y, Yokoo H, Nakazato Y
    • Journal Title

      Brain Tumor Pathol (DOI:10.1007/s10014-011-0024-6)

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An immunohistochemical finding in glioneuronal lesions associated with epilepsy : The appearance of nestin-positive, CD34-positive and tau-accumulating cells.2011

    • Author(s)
      Nagaishi M, Arai M, Osawa T, Yokoo H, Hirato J, Yoshimoto Y, Nakazato Y
    • Journal Title

      Neuropathology (doi:10.1111/j.1440-1789.2010.01188.x.)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinico-pathological feature of pilomyxoid astrocytomas : Three case reports.2011

    • Author(s)
      Nagaishi M, Yokoo H, Hirato J, Yoshimoto Y, Nakazato Y.
    • Journal Title

      Neuropathology

      Volume: 31 Pages: 152-157

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in the RB1 pathway in low-grade diffuse gliomas lacking common genetic alterations.2011

    • Author(s)
      Kim YH, Lachuer J, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Nobusawa S, Nakazato Y, Tanaka Y, et al.
    • Journal Title

      Brain Pathology (DOI:10.1111/0750-3639.2011.00492.x)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput immunohistochemical profiling of primary brain tumors and non-neoplastic systemic organs with a specific antibody against the mutant isocitrate dehydrogenase 1 R13 2H protein.2011

    • Author(s)
      Ikota H, Nobusawa S, Tanaka Y, Yokoo H, Nakazato Y
    • Journal Title

      Brain Tumor Pathol

      Volume: 28 Pages: 107-114

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An immunohistochemical finding in glioneuronal lesions associated with epilepsy : The appearance of nestin-positive, CD34-positive and tau-accumulating cells.2011

    • Author(s)
      Nagaishi M, Arai M, Osawa T, Yokoo H, Hirato J, Yoshimoto Y, Nakazato Y.
    • Journal Title

      Neuropathology (doi:10.1111/j.1440-1789.2010.01188.x.)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular classification of low-grade diffuse gliomas.2010

    • Author(s)
      Kim YH, Nobusawa S, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Nakazato Y, Tanaka Y, et al
    • Journal Title

      Am J Pathol 177

      Pages: 2708-2714

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors.2010

    • Author(s)
      Fukuda T, Akiyama N, Ikegami M, Takahashi H, Sasaki A, Oka H, Komori T, Tanaka Y, Nakazato Y, et al
    • Journal Title

      J Neuropathol Exp Neurol 69

      Pages: 498-510

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polar spongioblastoma : A high-grade glioma that does not contain the IDH1 mutation or 1p/19q LOH.2010

    • Author(s)
      Nagaishi M, Tanaka Y, Iwatate K, Yokoo H, Ueki K, Hyodo A, Nakazato Y
    • Journal Title

      Neuropathology 30

      Pages: 547-552

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular classification of low-grade diffuse gliomas.2010

    • Author(s)
      Kim YH, Nobusawa S, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Nakazato Y, Tanaka Y, et al.
    • Journal Title

      Am J Pathol

      Volume: 177 Pages: 2708-2714

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors.2010

    • Author(s)
      Fukuda T, Akiyama N, Ikegami M, Takahashi H, Sasaki A, Oka H, Komori T, Tanaka Y, Nakazato Y, et al
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 69 Pages: 498-510

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tau-positive glial cytoplasmic granules in multiple system atrophy.2010

    • Author(s)
      Nagaishi M, Yokoo H, Nakazato Y.
    • Journal Title

      Neuropathology (doi:10.1111/j.1440-1789.2010.01159.x.)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polar spongioblastoma : A high-grade glioma that does not contain the IDH1 mutation or 1p/19q LOH.2010

    • Author(s)
      Nagaishi M, Tanaka Y, Iwatate K, Yokoo H, Ueki K, et al.
    • Journal Title

      Neuropathology. 2010 Jan 19.[Eupb ahead of print]

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas : implications for glioma histogenesis and biology.2009

    • Author(s)
      Rhee W, Ray S, Yokoo H, et al
    • Journal Title

      Glia 57

      Pages: 510-523

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral tumor with extensive rhabdoid features and a favorable prognosis.2009

    • Author(s)
      Ohba S, Yoshida K, Hirose Y, Ikeda E, Nakazato Y, Kawase T
    • Journal Title

      J Neurosurg 111

      Pages: 492-496

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A rosette-forming glioneuronal tumor of the spinal cord : the first case of a rosette-forming glioneuronal tumor originating from the spinal cord.2009

    • Author(s)
      Anan M, Inoue R, Ishii K, Abe T, Fujiki M, Kobayashi H, Goya T, Nakazato Y
    • Journal Title

      Hum Pathol 40

      Pages: 898-901

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas : implications for glioma histogenesis and biology2009

    • Author(s)
      Rhee W, Ray S, Yokoo H, et al.
    • Journal Title

      Glia 57

      Pages: 510-523

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Long-term survivors of glioblastoma : clinical features and molecular analysis.2009

    • Author(s)
      Sonoda Y, Kumabe T, Watanabe M, Nakazato Y, et al.
    • Journal Title

      Acta Neurochir(Wien) 151

      Pages: 1349-1358

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas : implications for glioma histogenesis and biology.2009

    • Author(s)
      Rhee W, Ray S, Yokoo H, et al.
    • Journal Title

      Glia 57

      Pages: 510-523

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral tumor with extensive rhabdoid features and a favorable prognosis.2009

    • Author(s)
      Ohba S, Yoshida K, Hirose Y, Ikeda E, Nakazato Y, Kawase T.
    • Journal Title

      J Neurosurg 111

      Pages: 492-496

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of neoadjuvant therapy for papillary tumor of the pineal region.2009

    • Author(s)
      Nakamura H, Makino K, Kochi M, Nakazato Y, Kuratsu J
    • Journal Title

      Brain Tumor Pathol 26

      Pages: 73-77

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] F-18 FDG-PET imaging of dysembryoplastic neuroepithelial tumor-like a strocytoma.2009

    • Author(s)
      Y shinohara, T Kinoshita, F Kinoshita, J Moroi, Y Yoshida, Y Nakazato.
    • Journal Title

      Clin Nucl Med 34

      Pages: 700-702

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrastructural and immunohistochemical study of an adult case of chordoid meningioma.2009

    • Author(s)
      Kano T, Nakazato Y, Tamura M, Ohye C, Zama A, et al.
    • Journal Title

      Brain Tumor Pathol 26

      Pages: 37-42

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical and ultrastructural characterization of brain tumors in S100 beta-v-erbB transgenic rats.2008

    • Author(s)
      Yokoo H, Tanaka Y, Nobusawa S, Nakazato Y, Ohgaki H
    • Journal Title

      Neuro-pathology 28

      Pages: 591-598

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of glial cell components in pilocytic astrocytoma.2008

    • Author(s)
      Tanaka Y, Sasaki A, Ishiuchi S, Nakazato Y
    • Journal Title

      Neuropathology 28

      Pages: 399-407

    • NAID

      10026608458

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low grade diffuse gliomas : Shared cellular composi-tion and morphometric differences.2008

    • Author(s)
      Kinjo S, Hirato J, Nakazato Y
    • Journal Title

      Neuro-pathology 28

      Pages: 455-465

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical and ultrastructural characterization of brain tumors in S100 beta-v-erbB transgenic rats2008

    • Author(s)
      Yokoo H, Tanaka Y, Nobusawa S, Nakazato Y, Ohgaki H
    • Journal Title

      Neuro^- pathology 28

      Pages: 591-598

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Diversity of glial cell components in pilocytic astrocytoma2008

    • Author(s)
      Tanaka Y, Sasaki A, Ishiuchi S, Nakazato Y
    • Journal Title

      Neuropathology 28

      Pages: 399-407

    • NAID

      10026608458

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Low grade diffuse gliomas : Shared cellular composi^- tion and morphometric differences2008

    • Author(s)
      Kinjo S, Hirato J, Nakazato Y
    • Journal Title

      Neuro^- pathology 28

      Pages: 455-465

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemicl and ultrastructural characterization of brain tumors in S100 beta-v-erbB transgenic rats.2008

    • Author(s)
      Yokoo H, Tanaka Y, Nobusawa S, Nakazato Y, Ohgaki H
    • Journal Title

      Neuropathology 28

      Pages: 591-598

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low grade diffuse gliomas: Shared cellular composition and morphometric differences.2008

    • Author(s)
      Kinjo S, Hirato, J, Nakazato Y
    • Journal Title

      Neuropathology 28

      Pages: 455-465

    • NAID

      10028191060

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 4th edition of WHO classification of tumours of the central nervous system published in 2007.2008

    • Author(s)
      Nakazato Y
    • Journal Title

      Neurological Surgery 36

      Pages: 473-491

    • Related Report
      2008 Annual Research Report
  • [Journal Article] A case of metaplastic meningioma with extensive xanthomatous change.2008

    • Author(s)
      Ikota H, Nakazato Y:
    • Journal Title

      Neuropathology 28

      Pages: 422-426

    • NAID

      10026608547

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pilomyxoid astrocytoma: An immunohistologic study and review.2008

    • Author(s)
      Abe T, Inoue R, Goda M, Anan M, Momii Y, et al.
    • Journal Title

      Neurosurgery Quarterly 18

      Pages: 60-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 改訂された脳腫瘍をWHO分類2008

    • Author(s)
      中里 洋一
    • Journal Title

      Brain and Nerve 60

      Pages: 59-77

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation.2007

    • Author(s)
      Ishiuchi S, Yoshida Y, Sugawara K, Aihara M, Ohtani T, Watanabe T, Saito N, Tsuzuki K, Okado H, Miwa A, Nakazato Y, Ozawa S
    • Journal Title

      J Neurosci 27

      Pages: 7987-8001

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation2007

    • Author(s)
      Ishiuchi S, Yoshida Y, Sugawara K, Aihara M, Ohtani T, Watanabe T, Saito N, Tsuzuki K, Okado H, Miwa A, Nakazato Y, Ozawa S.
    • Journal Title

      J Neurosci 27

      Pages: 7987-8001

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress is related to the formation of Antoni B patterns and osinophilic hyaline droplets in schwannomas2007

    • Author(s)
      Yokoo H, et. al.
    • Journal Title

      Neuropathology 27

      Pages: 237-244

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rare case of malignant gliomas suspected to have arisen from a cavernous sinus2007

    • Author(s)
      Taomoto K, et. al.
    • Journal Title

      Brain Tumor Pathol 24

      Pages: 75-80

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳腫瘍の治療に有益な病理診断をめざして2010

    • Author(s)
      中里洋一
    • Organizer
      第69回日本脳神経外科学会学術総会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] S100β-v-erbBトランスジェニックラットに発生する脳腫瘍の解析2010

    • Author(s)
      横尾英明、信澤純人、田中優子、伊古田勇人、中里洋一
    • Organizer
      第57回北関東医学会
    • Place of Presentation
      群馬大学刀城会館(前橋市)
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳腫瘍の病理2010

    • Author(s)
      中里洋一
    • Organizer
      第27回脳神経外科生涯教育研修会
    • Place of Presentation
      サンケイプラザ(東京都)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳腫瘍のWHO分類 -その特徴と問題点-2010

    • Author(s)
      中里洋一
    • Organizer
      月菌月重瘍2010
    • Place of Presentation
      ザ・リッツカールトン大阪(大阪市)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 再発を繰り返し、最終的に偽乳頭状構造が明瞭となった中枢神経系hemangiopericytomaの1剖検例2010

    • Author(s)
      平戸純子、金城佐和子、宮永朋実、新井秀雄、横尾英明、中里洋一
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳腫瘍のWHO分類(WHO2007)2010

    • Author(s)
      中里洋一
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Neurofibromatosis type 1を伴った高齢者の前頭葉に発生したanaplastic pilocytic astrocytomaの1例2010

    • Author(s)
      斉藤厚志、中里洋一
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市中央公会堂(大阪市)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 再発を繰り返し、最終的に偽乳頭状構造が明瞭となった中枢神経系hemangiopercytomaの1剖検例2010

    • Author(s)
      平戸純子、金城佐和子、宮永朋実、新井秀雄、横尾英明、中里洋一
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市中央公会堂(大阪市)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳腫瘍のWHO分類(WHO2007)2010

    • Author(s)
      中里洋一
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市中央公会堂(大阪市)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 診断に難渋した大脳皮質下主座脳室上衣下浸潤を認める腫瘍性病変の一生検・剖検例2010

    • Author(s)
      小林啓一、永根基雄、林基高、吉田裕毅、原田洋一、土屋一洋、平野和彦、藤岡保範、中里洋一、塩川芳昭
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市中央公会堂(大阪市)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 再発時に神経外胚葉性性格が顕在化した左頭頂葉肉腫様腫瘍の一例2010

    • Author(s)
      佐藤憲市、伊東民雄、尾崎義丸、及川光照、中村博彦、田中伸哉、中里洋一
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市中央公会堂(大阪市)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] S100β-v-erbBトランスジェニックラットに発生するグリオーマははNG2/CSPG4を発現する2010

    • Author(s)
      横尾英明、田中優子、信澤純人、永石雅也、中里洋一、Hiroko Ohgaki
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] S100β-v-erbBトランスジェニックラットに発生するグリオーマははNG2/CSPG4を発現する2010

    • Author(s)
      横尾英明、田中優子、信澤純人、永石雅也、中里洋一、Hiroko Ohgaki
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市中央公会堂(大阪市)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Multifocal oligodendro-oligoastrocytomaの一例2010

    • Author(s)
      櫻田香、佐藤篤、舟生勇人、菊地善彰、嘉山孝正、中里洋一
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市中央公会堂(大阪市)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] LAMP法を用いたグリオーマにおけるIDH1遺伝子変異の検出2010

    • Author(s)
      横尾英明、新井基展、中里洋一
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-28
    • Related Report
      2010 Final Research Report
  • [Presentation] LAMP法を用いたグリオーマにおけるIDH1遺伝子変異の検出2010

    • Author(s)
      横尾英明、新井基展、中里洋一
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗体作成による研究2010

    • Author(s)
      横尾英明、中里洋一
    • Organizer
      第51回日本神経病理学会
    • Place of Presentation
      砂防会館(東京都)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 髄膜腫内に転移した乳癌の一例2010

    • Author(s)
      田中優子、横尾英明、新井基展、大澤匡、平戸純子、鈴木豊、好本裕平、中里洋一
    • Organizer
      第51回日本神経病理学会
    • Place of Presentation
      砂防会館(東京都)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 松果体実質細胞腫瘍の腫瘍マーカー その32010

    • Author(s)
      福田隆浩、秋山挙暢丈、斉藤三郎、高橋均、岡秀宏、佐々木惇、田中雅彦、小森隆司、秋元治朗、田中優子、中里洋一
    • Organizer
      第51回日本神経病理学会
    • Place of Presentation
      砂防会館(東京都)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳腫瘍のWHO分類-その特徴と問題点-2010

    • Author(s)
      中里洋一
    • Organizer
      脳腫瘍2010
    • Place of Presentation
      大阪市
    • Related Report
      2010 Final Research Report
  • [Presentation] 左前頭葉に発生したrosette形成を伴うglioneuronal tumorの一例2009

    • Author(s)
      米澤大、大吉達樹、湯之上俊二, 他
    • Organizer
      第27回日本脳腫瘍病理学会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-05-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 星細胞腫grade3/4に対する第II相臨床試験(JCOG0305)における病理中央診断の意義2009

    • Author(s)
      渋井壮一郎、嘉山孝正、中里洋一、他
    • Organizer
      第27回日本脳腫瘍病理学会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-05-08
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 脳腫瘍の摘出から17年後、骨髄への広範な転移を起こし死亡したanaplastic oligo dendrogliomaの1例2009

    • Author(s)
      田中優子、伊藤秀明、平戸純子、中里洋一
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2009-05-01
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 脳腫瘍分類(WHO)とグリア系腫瘍2009

    • Author(s)
      中里洋一
    • Organizer
      第23回平野朝雄教授神経病理セミナー
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-18
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Olig2-positive small round cells in glial and glioneuronal tumors.2008

    • Author(s)
      Nakazato Y, Tanaka Y, Miyanaga T, Yokoo H, Hirato J
    • Organizer
      27^<th> International Congress of the International Academy of Pathology.
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-10-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Olig2-positive small round cells in glial and glioneuronal tumors2008

    • Author(s)
      Nakazato Y, Tanaka Y, Miyanaga T, Yokoo H, Hirato J
    • Organizer
      27^<th> International Congress of the International Academy of Pathology
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-10-15
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Atypical teratoid/rhabdoid tumorの臨床病理学的検討(INI-1不活性化の有無からみた中枢神経形rhabdoid tumorの臨床病理学的特徴)2008

    • Author(s)
      平戸純子、中里洋一
    • Organizer
      第28回目本小児病理研究会
    • Place of Presentation
      松本市
    • Year and Date
      2008-09-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] INI-1不活性化の有無からみた中枢神経系rhabdoid tumorの臨床病理学的特徴2008

    • Author(s)
      平戸純子、中里洋一
    • Organizer
      第26回日本脳腫瘍病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-24
    • Related Report
      2010 Final Research Report
  • [Presentation] INI-1不活性化の有無からみた中枢神経系 rhabdoid tumor の臨床病理学的特徴2008

    • Author(s)
      平戸純子, 中里洋一
    • Organizer
      第26回日本脳腫瘍病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-24
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] INI-1不活性化の有無からみた中枢神経形rhabdoidtumorの臨床病理学的特徴2008

    • Author(s)
      平戸純子、中里洋一
    • Organizer
      第26回日本脳腫瘍病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 改訂された脳腫瘍WHO分類-新しい腫瘍型の病理を中心に-2008

    • Author(s)
      中里洋一
    • Organizer
      第26回日本脳腫瘍病理学会特別講演
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 改訂された脳腫瘍WHO分類―新しい腫瘍型の病理を中心に―2008

    • Author(s)
      中里洋一
    • Organizer
      第26回日本脳腫瘍病理学会特別講演
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-23
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 改訂された脳腫瘍WHO分類-新しい腫瘍型の病理を中心に-2008

    • Author(s)
      中里洋一
    • Organizer
      第26回日本脳腫瘍病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ganglion cel1が01ig2陽性を示すgangliogliomaの2例2008

    • Author(s)
      金城佐和子、大石琢磨、横尾英明、土橋洋、福島剛、中里洋一
    • Organizer
      第26回日本脳腫瘍病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小児脳腫瘍の分類と病理-新しい腫瘍型を中心に-2008

    • Author(s)
      中里洋一
    • Organizer
      第36回日本小児神経外科学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] トルコ鞍内に発生した紡錘形細胞腫瘍の一例-pituicytoma or spindle cell oncocytoma ?-2008

    • Author(s)
      横尾英明、信澤純人、田中優子、大石琢磨、佐々木惇、他
    • Organizer
      第49回日本神経病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1p LOHを認めない多核の乏突起膠腫様形態を示す前頭葉腫瘍の1例2008

    • Author(s)
      大石琢磨、横尾英明、佐々木惇、平戸純子、菅原健一、他
    • Organizer
      第49回日本神経病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 成人の小脳虫部腫瘍の1例2008

    • Author(s)
      中里洋一
    • Organizer
      第49回日木神経病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Diffuse astrocytomaの疾患概念と病理学的多様性2008

    • Author(s)
      中里洋一、金城佐和子、田中優子
    • Organizer
      第28回日本脳神経外科コングレスシンポジウム
    • Place of Presentation
      横浜市
    • Year and Date
      2008-05-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Diffuse astrocytoma の疾患概念と病理学的多様性2008

    • Author(s)
      中里洋一, 金城佐和子, 田中優子
    • Organizer
      第28回日本脳神経外科コングレスシンポジウム
    • Place of Presentation
      横浜市
    • Year and Date
      2008-05-09
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] オリゴデンドログリオーマ細胞の形態と分化2007

    • Author(s)
      中里洋一
    • Organizer
      第25回日本脳腫瘍病理学会シンポジウム
    • Place of Presentation
      熊本市
    • Year and Date
      2007-04-19
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] オリゴデンドログリオーマ細胞の形態と分化2007

    • Author(s)
      中里 洋一
    • Organizer
      第25回日本脳腫瘍病理学会
    • Place of Presentation
      熊本市
    • Year and Date
      2007-04-19
    • Related Report
      2007 Annual Research Report
  • [Book] 脳腫瘍取扱い規約-臨床と病理カラーアトラス-第3版(日本脳神経外科学会・日本病理学会(編))(「脳腫瘍の分類」、「脳腫瘍マーカー」、「細胞診」、「組織学的分類」、「TUMORS OF NEUROEPITHELIAL TISSUE 神経上皮性腫瘍」)2010

    • Author(s)
      中里洋一
    • Publisher
      金原出版
    • Related Report
      2010 Final Research Report
  • [Book] 新時代の脳腫瘍学-診断・治療の最前線-((編)松谷雅生)(脳腫瘍のWHO分類-現状と展望-)2010

    • Author(s)
      中里洋一
    • Publisher
      日本臨床社
    • Related Report
      2010 Final Research Report
  • [Book] Annual Review神経2010((編)鈴木則宏、他)(WHO brain tumor classification 2007)2010

    • Author(s)
      中里洋一
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] Annual Review神経2008((編)柳澤信夫、他)(Gliomatosis cerebriの病態)2010

    • Author(s)
      中里洋一
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] 新時代の脳腫瘍学-診断・治療の最前線-((編)松谷雅生)2010

    • Author(s)
      中里洋一
    • Total Pages
      670
    • Publisher
      日本臨床社
    • Related Report
      2010 Annual Research Report
  • [Book] Annual Review 2010神経2010

    • Author(s)
      中里洋一
    • Total Pages
      11
    • Publisher
      中外医学社
    • Related Report
      2009 Annual Research Report
  • [Book] 脳腫瘍臨床病理カラーアトラス第3版((編)河本圭司,吉田純,中里洋一)(「脳腫瘍の組織分類」、「Desmoplastic infantile astrocytoma/ganglioglioma」、「Pineocytoma」、「Pineal parenchymal tumor of intermediate differentiation」、「Pineoblastoma」、「Meningioma grade III. Anaplastic, papillary, rhabdoid meningioma」、「Paraganglioma」、「脳腫瘍の免疫組織化学」)2009

    • Author(s)
      中里洋一
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] 脳腫瘍の組織分類.((編) 河本圭司, 吉田純, 中里洋一, 脳腫瘍臨床病理カラーアトラス第3版)2009

    • Author(s)
      中里洋一
    • Publisher
      医学書院
    • Related Report
      2009 Self-evaluation Report
  • [Book] (編)河本圭司,吉田純,中里洋一:脳腫瘍臨床病理カラーアトラス第3版2009

    • Author(s)
      中里洋一
    • Total Pages
      18
    • Publisher
      医学書院,東京
    • Related Report
      2009 Annual Research Report
  • [Book] WHO Classification of Tumours of the Central Nervous System. 4^<th> ed.(Louis DN, et al.(eds))("Diffuse astrocytoma", "Glioblastoma", "Papillary glioneuronal tumour", "Pineocytoma", "Pineal parenchymal tumour of intermediate differentiation", "Pineoblastoma", "Papillary tumour of the pineal region", "CNS germ cell tumours")2007

    • Author(s)
      Nakazato Y, et al
    • Publisher
      International Agency for Research on Cancer
    • Related Report
      2010 Final Research Report
  • [Book] Cavenee WK: Glioblastoma.(Louis DN, et al. (eds), WHO Classification of Tumours of the Central Nervous System. 4^<th> ed.)2007

    • Author(s)
      Kleihues P, Burger PC, Aldape KD, Brat DJ, Biernat W, Bigner DD, Nakazato Y, Plate KH, Giangaspero F, von Deimling A, Ohgaki H, Cavenee WK
    • Publisher
      International Agency for Research on Cancer
    • Related Report
      2009 Self-evaluation Report
  • [Book] Papillary glioneuronal tumour.(Louis DN, et al (eds), WHO Classification of Tumours of the Central Nervous System. 4th Ed.)2007

    • Author(s)
      Nakazato Y, Figarella-Branger D, Becker AJ, Scheithauer BW, Rosenblum MK
    • Publisher
      International Agency for Research on Cancer
    • Related Report
      2009 Self-evaluation Report
  • [Book] Glioblastoma. In: Louis DN, et. al.(eds) WHO Classification of Tumours of the Central Nervous System. 4th ed.2007

    • Author(s)
      Kleihues P, et. al.
    • Total Pages
      17
    • Publisher
      International Agency for Research on Cancer, Lyon
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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